Challenge Room

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There are two types of Challenge Rooms. They will only spawn on a floor if you have full health upon entering the floor. (Full health is defined by the same criteria that causes a normal Challenge Room door to open.)

Normal Challenge Room[edit | edit source]

Challenge Room.png

Can only be entered if Isaac's total health (red, black, and soul hearts) is equal to or greater than his number of heart containers.

Picking up its contents will spawns 3 waves of enemies when opened. While in Chapter 4 (Womb/Utero), 3 waves of bosses will be spawned (usually bosses from Basement/Caves).

A Challenge Room can contain :

The enemies that spawn depend on the current chapter, and each chapter has two different possible sets of enemies:

Floor Wave 1 Wave 2 Wave 3
The Basement 3 Hoppers 3 Horfs 2 Clotties
5 Attack Flies 5 Pooters 4 Gapers
The Cellar 3 Fattys 3 Round Worms 5 Dips
3 Gapers 3 Horfs 3 Fatties
The Caves 5 Chargers 4 Globins 4 Maws
5 Spitties 3 Hives 3 Hosts
The Catacombs 2 Bonies 2 Tumors 3 Wall Creeps
4 Round Worms 3 Nightcrawlers 1 Grub
The Depths 3 Vis 4 Leapers 4 Globins
4 Babies 5 Hoppers 4 Knights
Necropolis 4 Knights 3 Mom's Hands 3 Fat Sacks
4 Bonies 2 Squirts 3 Nulls
The Womb
Cathedral
Utero
Sheol
3 Larry Jrs Chub and 3 Chargers 2 Monstros
Fistula Loki Chub

Notes[edit | edit source]

  • DLC Indicator.png The three waves appear in random orders rather than the orders listed above.
  • If Isaac has some way to teleport out of the room, the contents of the Challenge Room can be taken without fighting the enemies.
  • If a Secret Room is next to a Challenge Room, it can be entered by using a bomb in the Secret Room on the wall separating the two rooms. However, the entrance to the Secret Room from the Challenge Room closes itself, meaning Isaac cannot escape through the Secret Room entrance.

Boss Challenge Room[edit | edit source]

Boss Challenge Room Door.png

Boss Challenge Rooms can only be entered if Isaac has one or less red heart. Its contents are similar to the normal Challenge Room, but there is a chance it will contain an item from the Boss Item Pool.

After opening a chest or taking a pedestal item inside the room, a boss will spawn. After beating the first boss, a second will spawn.

The bosses that spawn depend on the current chapter. Alternate floors have two possible sets of bosses that could spawn:

Floor Wave 1 Wave 2
The Basement Monstro Larry Jr.
The Cellar Pin Gurglings
Dingle Gemini
The Caves Chub Peep
The Catacombs Mega Fatty Mega Maw
Fistula The Haunt
The Depths Loki Monstro II
Necropolis Mega Maw The Husk
Dark One Loki

Notes[edit | edit source]

  • In Chapter 4 and beyond, the bosses spawned in the Boss Challenge Room are the same as those spawned in the standard Challenge Room.
  • If a Secret Room is next to a Boss Challenge Room, it can be entered by using a bomb in the Secret Room on the wall separating the two rooms. However, the entrance to the Secret Room from the Boss Challenge Room closes itself, meaning Isaac cannot escape through the Secret Room entrance.
  • Because of the health requirements, both types of Challenge Room will always be open for The Lost and Blue Baby.

Bugs[edit | edit source]

Bug Bug! If the game crashes or you close it before you finish the challenge room it will crash every time you try to continue that run.

SmallIsaac.png Rooms SmallIsaac.png

Boss Room Icon.png
Boss Room
Mini-Boss Room Icon.png
Mini-Boss Room
Treasure Room Icon.png
Treasure Room
Shop Icon.png
Shop
Arcade Icon.png
Arcade
Challenge Room Icon.png
Challenge Room
Boss Challenge Room Icon.png
Boss Challenge Room
Curse Room Icon.png
Curse Room
Sacrifice Room Icon.png
Sacrifice Room
Secret Room Icon.png
Secret Room
Super Secret Room Icon.png
Super Secret Room
Library Icon.png
Library
Devil Room Icon.png
Devil Room
Angel Room Icon.png
Angel Room
Vault Icon.png
Vault
Dice Room Icon.png
Dice Room
Bedroom Icon.png Bedroom2 Icon.png
Bedroom
Super Secret Room Icon.png
I AM ERROR
Super Secret Room Icon.png
Boss Rush
Super Secret Room Icon.png
Crawl Space
Super Secret Room Icon.png
Black Market