Cards and Runes
Cards[edit | edit source]
Major Arcana Cards[edit | edit source]
|0 - The Fool||1||"Where journey begins"||Teleports you back to the starting room of a floor.|
|I - The Magician||2||"May you never miss your goal"||Grants homing tears for the current room.|
|II - The High Priestess||3||"Mother is watching you"||Mom's dismembered leg is called down to deal 300 damage to anything it stomps. It will always stomp on the enemy with the most health. If used in an empty room or during the fight with Mom, it will stomp Isaac instead.|
|III - The Empress||4||"May your rage bring power"||Triggers the Whore Of Babylon effect.|
|IV - The Emperor||5||"Challenge me!"||Teleports you into the Boss Room of a floor.|
|V - The Hierophant||6||"Two prayers for the lost"||Spawns 2 Soul Hearts.|
|VI - The Lovers||7||"May you prosper and be in good health"||Drops 2 full red hearts. If used in a Black Heart or Eternal Heart-containing Super Secret Room, it will spawn those types of hearts instead.|
|VII - The Chariot||8||"May nothing stand before you"||Grants the temporary invulnerability effect of My Little Unicorn.|
|VIII - Justice||9||"May your future become balanced"||Spawns one of each consumable drop (a heart, a key, a bomb, and a coin).|
|IX - The Hermit||10||"May you see what life has to offer"||Teleports you to the shop. If there is no shop, this will act as a random teleport. If the shop has not yet been accessed, this card will unlock the door without requiring a key (as long as the player exits through the main entrance).|
|X - Wheel of Fortune||11||"Spin the wheel of destiny"||Spawns an arcade machine (Slot Machine or Fortune Teller).|
|XI - Strength||12||"May your power bring rage"||Upon use, increases all of Isaac's stats except tears and adds one (temporary) heart container for the current room.|
|XII - The Hanged Man||13||"May you find enlightenment"||Removes Isaac's body, allowing him to fly around similar to Transcendence.|
|XIII - Death||14||"Lay waste to all that oppose you"||Deals 40 damage to all enemies in the room.|
|XIV - Temperance||15||"May you be pure in heart"||Spawns a Blood Donation Machine.
Spawns a Devil Beggar in Greed Mode.
|XV - The Devil||16||"Revel in the power of darkness"||Increases your damage by 2 until you leave the room (same effect as the Book of Belial).|
|XVI - The Tower||17||"Destruction brings creation"||Spawns 6 troll bombs randomly around the room.|
|XVII - The Stars||18||"May you find what you desire"||Teleports the player to the Treasure Room. If there is no Treasure Room, this will act as a random teleport. Randomly chooses a Treasure Room on Curse of the Labyrinth. If the Treasure Room has not yet been accessed, this card will unlock the door without requiring a key (as long as the player exits through the main entrance).|
|XVIII - The Moon||19||"May you find all you have lost"||Teleports the player to the Secret Room. This card will open one random wall once inside the Secret Room, so you can leave even if you don't have any bombs available.|
|XIX - The Sun||20||"May the light heal and enlighten you"||Restores full health, deals 100 damage to all enemies in the room, and reveals the map for the current floor, except the Super Secret Room.|
|XX - Judgement||21||"Judge lest ye be judged"||Spawns a Beggar.|
|XXI - The World||22||"Open your eyes and see"||Reveals the entire floor, except for the Super Secret Room. Has no effect if under the effect of Curse of the Lost or Amnesia.|
Playing Cards[edit | edit source]
|2 of Clubs||23||"Item multiplier"||Doubles your bombs. If you have no bombs, gives you 2 instead.|
|2 of Diamonds||24||"Item multiplier"||Doubles your coins. If you have no coins, gives you 2 instead.|
|2 of Spades||25||"Item multiplier"||Doubles your keys. If you have no keys, gives you 2 instead.|
|2 of Hearts||26||"Item multiplier"||Doubles Isaac's current number of red hearts. Soul and Black hearts are unaffected. Doesn't add new heart containers, just fills empty ones.|
|Ace of Clubs||27||"Convert all"||Turns all pickups and chests in the room into bombs.|
|Ace of Diamonds||28||"Convert all"||Turns all pickups and chests in the room into coins.|
|Ace of Spades||29||"Convert all"||Turns all pickups and chests in the room into keys.|
|Ace of Hearts||30||"Convert all"||Turns all pickups and chests in the room into random heart pickups.|
|Joker||31||"???"||Teleports you to the Devil Room or Angel Room.|
Special Cards[edit | edit source]
|Chaos Card||42||"???"||Throws the card to kill anything in its path. Opens normal doors.|
|Credit Card||43||"Charge it!"||Converts all items in the Shop or Devil Room into pickups or items on pedestals, allowing them to be picked up for free. This card's effect lasts for the entire floor, but only affects the room it was used in. Wasted if used outside the shop or the devil room. Allows devil room items to be obtained without affecting the chance of an angel room appearing.|
|Rules Card||44||"???"||Displays a cryptic statement on the screen, similar to a Fortune Teller. These messages (often) provide hints on bosses, bonus areas, etc.|
|A Card Against Humanity||45||"Something stinks..."||Covers the entire room with poop. The process is not instant, and the room will not get filled if you leave it before it's done filling.|
|Suicide King||46||"A true ending?"||Kills Isaac and spawns lots of pickups, items, and/or chests in the same room.|
|Get out of Jail Free Card||47||"Open sesame"||Upon use, opens all doors in the current room (including the golden door at The Chest / Dark Room), similar to Dad's Key.|
|? Card||48||"Double Active"||When used, copies the effect of Isaac's currently held activated collectible item.|
|Holy Card||51||"You feel protected"||Gives Holy Mantle effect for current room|
Runes[edit | edit source]
Left Pointing Runes[edit | edit source]
|Rune||ID||Icon||Message||Unlocked by completing||Effect|
1. Pitch Black
Destroys all breakable objects in the room. Does not affect Key Blocks.
2. High Brow
Clones all pickups and chests in a room (even shop pickups; the clones can then be picked up for free). Cloned chests will contain exactly the same type of items: if the original contains a pickup, so will the clone; the same is true for Collectibles. Cannot clone other Jera runes and trinkets.
3. Head Trauma
Creates a trapdoor leading to the next floor. Has an estimated 1/12 (8%) chance to spawn a door to a Crawl Space instead.
Right Pointing Runes[edit | edit source]
|Rune||ID||Icon||Message||Unlocked by completing||Effect|
5. The Tank
6. Solar System
Rerolls all pedestal items in the room. (This is the same effect as the D6.)
Grants a shield which lasts for 30 seconds.
30. The Guardian
Grants a random rune effect. Has a 25% chance to spawn another Blank Rune upon use.
Other Runes[edit | edit source]
Other[edit | edit source]
These are items other than cards and runes (and pills) that take up the consumable slot. When on the ground, each of these items are uniquely identifiable by their respective icon.
|Dice Shard||49||"D6 + D20"||Upon use, activates the effects of the D6 and the D20 at the same time.|
|Emergency Contact||50||"Help from above"||When used, will cause two Mom's Hands to come down and grab two random enemies.|
Notes[edit | edit source]
- The game counts runes as cards for the purposes of Starter Deck, Blank Card and Tarot Cloth.
- Using the Blank Card with the ? Card teleports the player to the I AM ERROR room of the current floor. This consumes both the Blank Card and the ? Card.
- Using the Joker card in The Womb II or Utero II will instantly teleport the player to the Devil Room or Angel Room with a trapdoor leading to Sheol or to the Cathedral. This can be used to skip Mom's Heart or It Lives and will not count as a kill.
- Using The Joker card can allow Isaac to encounter Devil Rooms or Angel Rooms on floors they otherwise cannot appear on.
- If you use the Strength card with only one spirit heart left, and lose the spirit heart while in the same room, you retain the full heart container that Strength grants after you leave.
Unlockable Achievements[edit | edit source]
Trivia[edit | edit source]
- In the expansion of the original game, Wrath of the Lamb, there was a positive pill effect called "Friends Till The End", which summoned 3 blue attack flies. This effect was improved, given to the rune Berkano in Rebirth, and added again in Afterbirth with the original effects.
- The Suicide King card is a reference to the King of Hearts card, which is usually called that way because it depicts a king in a way that he appears to be sticking his sword into his head.
- The Chaos Card is a reference to the Magic: The Gathering card "Chaos Orb", which also instantly destroys enemies that it touches.
- The Get out of Jail Free card is a reference to a card with the same name that appears in the table game Monopoly.
- The "A Card Against Humanity" card is a reference to the card game "Cards Against Humanity".
Bugs[edit | edit source]
|Achievements||Attributes||Bosses||Cards and Runes||Challenges||Chapters|