Challenges

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Challenges are unique runs in the game. Challenges typically start the player off with one or more specific items which make normal play more difficult. You will not find Treasure Rooms (with the exception of a select few challenges). Completing one of the thirty five challenges unlocks new content for the game, such as Runes.

General Strategy[edit | edit source]

Most challenges are geared to make a run difficult in some form. Sometimes, these challenges are easy, like Computer Savvy. Other times, they can be vicious, like Solar System. Each challenge has a certain strategy that can make the run easier. However, there are a few strategies that can apply to all challenges.

  • You can play in co-op for every challenge, making it easier for the ones where you cannot fire tears - especially for Cat Got Your Tongue, since it will spawn flies.
  • Because of the lack of Treasure Rooms, Devil Rooms become much more valuable. Some challenges can be made much easier by making just one deal.
  • You can also be more liberal with your use of keys for the same reason. Trinkets and Items that generate more coins, along with upgraded shops, can help reduce the difficulty in many challenge runs.
  • The Bible can make the end of some runs extremely easy. Because of how some challenges operate, the run may only require defeating Mom or Mom's Heart / It Lives. Since The Bible is a one-hit kill against these, getting it when you have the chance is usually a good investment for these runs.
  • Curse Rooms gain value since they can spawn items. You may wish to restart on the first floor until your Curse Room spawns an item worth 1 heart of damage.
  • Dice Rooms and the D4 are very useful, as in some cases you can reroll your entire build and remove (or add) difficulty.
    • DLC Indicator.png Dice rooms do not re-roll starter challenge items or remove Blindfolded.
  • In Blindfolded challenges, familiars can make the run easier, as they are your only source of conventional damage. Powerful familiars like Daddy Longlegs, Lil' Brimstone, and DLC Indicator.png Incubus are very good items to pick up. Some of the strongest familiars need to be unlocked first, so it may be wise to take the time to unlock them beforehand.
  • DLC Indicator.png In challenges that remove Treasure Rooms, Chaos has more potential to be useful by potentially making Treasure Room (among other rare items) items purchasable from the shop. On the downside, it may replace the Devil/Angel Room items with something less valuable.

Notes[edit | edit source]

  • New content, other than the Challenge Reward, cannot be unlocked. Likewise, you will not find a Donation Machine anywhere.
  • The Challenge reward will not be unlocked unless you pick up the trophy, meaning if a Devil Room or Angel Room appears and allows you to go to Sheol or the Cathedral you will be forfeiting the unlock if you fail to complete the floor.
  • Any challenge featuring Isaac will not start with the D6.

Challenge list[edit | edit source]

Name Conditions Goal Unlocked by Unlocks
Rebirth
1. Pitch Black You cannot see your health and rooms are darker.

Treasure rooms available. No shops.

Mom Default Rune of Hagalaz
2. High Brow Starts with: Number One, E Coli, Butt Bombs, Flush!, Petrified Poop trinket.

No treasure rooms. Shops available.

Mom Default Rune of Jera
3. Head Trauma Starts with: Tiny Planet, Soy Milk, Small Rock, Iron Bar.

No treasure rooms. Shops available.

Mom Default Rune of Ehwaz
4. Darkness Falls This challenge is done as Eve. Starts with: Pentagram, Dead Bird, Whore Of Babylon, Razor Blade, Sacrificial Dagger, Dark Matter.

No treasure rooms. Shops available.

Satan Unlocking 'It Lives' and Eve. Rune of Dagaz
5. The Tank This challenge is done as Magdalene. Starts with: Bucket Of Lard, Infamy, Yum Heart, Thunder Thighs.

No treasure rooms. Shops available.

Mom Unlocking Magdalene Rune of Ansuz
6. Solar System Starts with: Transcendence, Distant Admiration, Forever Alone, Halo of Flies.

Start as Lord of the Flies, granting flight and causing all small flies to become Blue Flies which help Isaac.

Blindfolded (cannot use tears). Flies and babies are your only damage output.

No treasure rooms. Shops available.

Mom's Heart Unlocking Transcendence. Rune of Perthro
7. Suicide King This challenge is done as Lazarus. Starts with: Ipecac, Mr. Mega, My Reflection.

No treasure rooms. Shops available.

Isaac Unlocking 'It Lives' Suicide King
8. Cat Got Your Tongue Starts with: Guppy's Head, Guppy's Tail, Guppy's Hair Ball.

Start as Guppy, granting flight and creating Blue Flies with attacks.

Blindfolded (cannot use tears). Damage must be done initially with the hairball and flies generated by Guppy's Head.

No treasure rooms. Shops available.

Mom Transforming into Guppy Rune of Algiz
9. Demo Man Starts with: Dr. Fetus, Remote Detonator, Match Stick trinket.

No treasure rooms. Shops available.

Mom's Heart Unlocking Dr. Fetus The Chaos Card
10. Cursed! This challenge is done as Magdalene. Starts with: Yum Heart, Raw Liver, The Compass, Treasure Map, Blue Map, Child's Heart trinket.

Entering/exiting all normal rooms will damage you.

Treasure rooms available. Shops available.

Mom Unlocking Magdalene Credit Card
11. Glass Cannon This challenge is done as Judas. Starts with: Epic Fetus, Loki's Horns.

No treasure rooms. Shops available.

Satan Unlocking Epic Fetus (Challenge #19) and Loki's Horns Rules Card
12. When Life Gives You Lemons Starts with: Lemon Mishap, 9 Volt, Habit, 1 Lemon Party Pill.

No treasure rooms. Shops available.

Mom Default A Card Against Humanity
13. Beans! Starts with: Pyro, The Bean, The Black Bean, 9 Volt, Butt Bombs.

Blindfolded (cannot use tears). Only damage output comes from bombs and The Bean.

No treasure rooms. Shops available.

Mom Default Burnt Penny
14. It's in the Cards Starts with: Deck of Cards, Starter Deck, The Battery, 9 Volt, 2 random tarot cards.

No treasure rooms. Shops available.

Mom Default SMB Super Fan
15. Slow Roll Starts with: Polyphemus, My Reflection, Cupid's Arrow.

No treasure rooms. Shops available.

Mom Default Swallowed Penny
16. Computer Savvy Starts with: Technology, Technology 2, Spoon Bender.

No treasure rooms. Shops available.

Mom Default Robo-Baby 2.0
17. Waka Waka Starts with: Strange Attractor, Anti-Gravity.

No treasure rooms. Shops available.

Mom Default Death's Touch
18. The Host Starts with: Spider Baby, The Mulligan, The Tick trinket.

No treasure rooms. Shops available.

Mom Default Technology .5
19. The Family Man Starts with: Brother Bobby, Sister Maggy, Dad's Key, BFFS!, Rotten Baby.

Blindfolded (cannot use tears). Followers are the only damage output.

No treasure rooms. Shops available.

Isaac Unlocking Dad's Key and 'It Lives' Epic Fetus
20. Purist Starts with no items.

No treasure rooms. Shops available.

Mom's Heart Killing Mom for the first time Rune of Berkano
DLC Indicator.png Afterbirth
21. XXXXXXXXL Every floor is the size of an XL Womb floor, but does not combine the floors of each chapter.

Treasure rooms available. Shops available.

Mom's Heart Killing Mom for the first time Gold Heart
22. SPEED! Everything is sped up like the Broken Watch effect. 16 minute time limit.

Treasure rooms available. Shops available.

Mom's Heart Killing Mom for the first time Get out of Jail Free Card
23. Blue Bomber This challenge is done as ???. Starts with: Pyromaniac, Kamikaze!, Mr. Mega, and Brother Bobby.

Blindfolded (cannot use tears).

No treasure rooms. Shops available.

Satan Unlocking ???, Mr. Mega and It Lives! Gold Bomb
24. PAY TO PLAY Starts with: Sack of Pennies, Money = Power, 50 cents.

Every door costs 1 cent to enter. Isaac drops money when hit. Isaac dies if you run out of money.

No treasure rooms. Shops available.

Isaac Unlocking Sack of Pennies and It Lives! 2 new Pills

(Percs! and Addicted!)

25. Have a Heart Starts with: Charm of the Vampire.

Starts with 12 red heart containers, only 1 of which is filled. Pennies drop instead of red hearts. Many items that restore red hearts have no effect.

Treasure rooms available. Shops available.

Mom's Heart Killing Mom for the first time 2 new Pills

(Re-Lax and ???)

26. I RULE! Starts with: Key Piece 1, Key Piece 2, Trinity Shield, Mom's Knife, The Ladder, The Boomerang.

No treasure rooms. Shops available.

Mega Satan Killing ??? or The Lamb for the first time, and unlocking Mom's Knife. Poker Chip
27. BRAINS! This challenge is done as ???. Starts with: 3 Bob's Brains, Thunder Thighs, The Poop.

Blindfolded (cannot use tears).

No treasure rooms. Shops available.

??? Unlocking The Polaroid Stud Finder
28. PRIDE DAY! Starts with: 3 Dollar Bill, Rainbow Baby, Rainbow Worm.

Cannot drop or replace Rainbow Worm.

No treasure rooms. Shops available.

Mom's Heart Killing Mom for the first time D8
29. Onan's Streak This challenge is done as Judas. Starts with: Chocolate Milk.

Missing a shot deals damage to Judas.

Treasure rooms available. Shops available.

Isaac Unlocking Judas Kidney Stone
30. The Guardian Starts with: Holy Grail, Punching Bag, Isaac's Heart, Spear Of Destiny.

Isaac's Heart will follow the Punching Bag instead of Isaac.

Blindfolded (cannot use tears).

No treasure rooms. Shops available.

Mom's Heart Killing Mom for the first time Blank Rune
Afterbirth† Indicator.png Afterbirth †
31. Backasswards Isaac starts at Mega Satan fight with 10 random items.

All Chapters progress in reverse order, losing 1 item and 1 red heart container each floor you ascend.

No treasure rooms. Shops available.

The Basement Killing ??? or The Lamb for the first time Lazarus bleeds more.
32. Aprils Fool The minimap displays the floor's layout accurately, but displays Isaac's position inaccurately.

Pedestal items and pickups are not what they appear to be. Active item, pill, card, and rune effects are randomized upon each use, making them very unreliable or deadly (for example Suicide King). Items with no charge time (i.e. How To Jump, IV Bag, etc) can be used repeatedly for random effects. Trinkets function normally.

Every boss is The Bloat.

Isaac's health is not what it appears to be. Key and bomb numbers are accurate.

Treasure Rooms and Shops available.

Mom's Heart Killing Mom for the first time Magdalene starts with a Speed Up Pill.
33. Pokey Mans Starts with: Friendly Ball and Mom's Eyeshadow.

Each use of Friendly Ball causes a random monster to be spawned. Friendly Ball instantly charges once the spawned monster is killed.

No treasure rooms. Shops available.

Isaac (Boss) Unlocking It Lives! Charged Key
34. Ultra Hard Starts with: Key Piece 1 and Key Piece 2.

Permanent Curse of the Labyrinth, Curse of the Blind, Curse of the Lost, and Curse of the Maze.

All enemies spawn as champions if possible.

Boss fights will be double trouble if possible.

No heart pickups drop.

Treasure Rooms and Shops available.

Mega Satan Killing ??? or The Lamb for the first time Samson starts with the Child's Heart
35. Pong Starts with: Rubber Cement, Cupid's Arrow.

Damage fixed at 100, tear delay fixed at 150.

No treasure rooms. Shops available.

??? Unlocking The Polaroid Greed's Gullet


SmallIsaac.png The Binding of Isaac: Rebirth SmallIsaac.png

MainPageAchievements.png Achievements MainPageAttributes.png Attributes MainPageBosses.png Bosses TarotCard.png Cards and Runes MainPageChallenges.png Challenges MainPageChapters.png Chapters
Isaac App.png Characters MainPageBabies.png Co-op Magic Mushroom Icon.png Items Isaac's Tears Icon.png Item Pools MainPageMonsters.png Monsters MainPageObjects.png Objects
Red heart.png Pickups BlueBlue.png Pills MainPageRooms.png Rooms MainPageSeeds2.png Seeds Guppy App.png Transformations The Left Hand Icon.png Trinkets