Harlequin Baby is an unlockable passive item.
Effects[ | ]
- Spawns a familiar that follows Isaac around and fires two tears at once in a V-pattern which deal 4 damage each.
Harlequin Baby shoots once per second.- Harlequin Baby shoots 1.36 times a second.
- This item belongs to the Conjoined set. Collecting three items from this set will transform Isaac into a three-faced version of himself.
Harlequin Baby shoots once per second.
Harlequin Baby shoots 1.36 times a second.
This item belongs to the 
Notes[ | ]
- Familiars that follow behind Isaac have a certain priority in how close their position is to him over other familiars, with Harlequin Baby having 5th priority.
Synergies[ | ]
- Mongo Baby: Will copy Harlequin Baby’s spread double shot effect.
- Tainted Forgotten: The momentum from the skeleton being tossed makes Harlequin Baby's tears launch at abnormally high shot speed.
In-game Footage[ | ]
Trivia[ | ]
- This item refers to a condition called Harlequin Ichthyosis, which is a rare skin condition from birth, which on babies gives puffy red eyes, green or red crackled/scaly skin, and stretched out lips.
 The Binding of Isaac: Rebirth
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