Pestilence

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Pestilence
Boss Pestilence.png
Base HP
280
Stage HP
0
Found In
Boss
Stage caves.pngStage catacombs.png
DLC Indicator.pngStage flooded caves.png
Mini-Boss
(Later Floors)
Dropped Items
Ball of Bandages
Cube of Meat

Pestilence is a boss that can appear in The Caves or The Catacombs. It is one of the four Harbingers, and the horseman of Chapter 2.

Behavior[edit | edit source]

Phase 1[edit | edit source]

  • Pestilence will float around the room, leaving a trail of poison.
  • In addition to the trail of poison, it will fire explosive projectiles at Isaac which too, leave poison.
  • Pestilence can also summon up to four Chargers or Spitties.

Phase 2[edit | edit source]

  • Pestilence is now headless.
  • It will keep firing the explosive projectiles at Isaac.
  • Instead of Chargers or Spitties, Pestilence will summon Attack Flies.

Champion versions[edit | edit source]

  • White: This version leaves a trail of white creep, which slows the player down and shoots 6 bullets away from itself instead of explosive shots. It spawns Spiders instead of flies in Phase 2.

Unlockable achievements[edit | edit source]

Gallery[edit | edit source]

Trivia[edit | edit source]

  • Pestilence appeared in the original Binding of Isaac.
  • Pestilence, while very often portrayed as one of the Four Horsemen of the Apocalypse in popular culture, is actually not present in the Bible at all (see Rev 6:2) and is an example of incorrect interpretation. The canonical Four Horsemen are Conquest (white), War (red), Famine (black) and Death (pale).
  • Pestilence means a virulent or fatal disease epidemic.
    • The entirety of Pestilence's offense deals with poison and bugs that are associated with rot.
  • Pestilence is the only Harbinger that does not have a charge attack.


Bosses Boss Monstro.png
Chapter 1 Blighted OvumDingleThe Duke of FliesFamineFistulaGeminiGurdy Jr.GurglingsThe HauntLarry Jr.MonstroPinStevenWidow
DLC Indicator.png DangleLittle HornRag ManTurdlings
Chapter 2 C.H.A.D.ChubDark OneGurdyGurdy Jr.The HollowThe HuskMega FattyMega MawPeepPestilencePolycephalusCarrion QueenThe Wretched
DLC Indicator.png The ForsakenThe FrailThe Stain
Afterbirth† Indicator.png Big HornRag Mega
Chapter 3 The AdversaryThe BloatThe CageCarrion QueenThe GateGishLokiMask of InfamyMonstro IIWarThe WretchedMom
DLC Indicator.png Brownie
Afterbirth† Indicator.png Sisters Vis
Chapter 4 BlastocystThe BloatConquestDaddy Long LegsDeathIt LivesLokiiMama GurdyMom's HeartMr. FredScolexTeratomaTriachnid
DLC Indicator.png Blue Womb DLC Indicator.png Hush
Chapter 5 The FallenIsaacSatan
Chapter 6 ???The LambMega Satan
DLC Indicator.png Greed Mode DLC Indicator.png Ultra Greed
Afterbirth† Indicator.png Ultra Greedier
Afterbirth† Indicator.png The Void Afterbirth† Indicator.png Delirium
Chapters 1-4 The FallenThe Headless Horseman

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