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Guppy Beelzebub DLC Indicator.png Super Bum DLC Indicator.png Yes Mother DLC Indicator.png Bob DLC Indicator.png Fun Guy DLC Indicator.png Leviathan DLC Indicator.png Conjoined DLC Indicator.png Spun DLC Indicator.png Seraphim DLC Indicator.png Oh Crap Afterbirth† Indicator.png Bookworm Afterbirth† Indicator.png Spider Baby Afterbirth† Indicator.png Adult

Transformations alter Isaac's appearance and grant him special abilities.

A Transformation occurs when obtaining at least three collectibles from a particular set of items.
These collectibles always share a particular theme that corresponds with the transformation.

Transformation sets[edit | edit source]

The Binding of Isaac: Rebirth[edit source]

Transformation Appearance Transformation effect Item Icon Item effect Recharge
Beelzebub Beelzebub App.png
???'s Only Friend
Blue Baby's Only Friend Icon.pngSummons a big attack fly that can be controlled with the shooting direction-keys.
BBF Icon.pngSpawns a familiar that flies around the room in a manner similar to the Boom Fly and explodes on contact with an enemy. Respawns after ten seconds.
Best Bud
Best Bud Icon.pngWhen hit, summons a white attack fly similar to Distant Admiration for the current room.
Big Fan
Big Fan Icon.pngSpawns a large orbital familiar that blocks enemy projectiles and deals slight contact damage to enemies.
Distant Admiration
Distant Admiration Icon.pngA red attack fly circles further out than the Halo of Flies / Pretty Flies, but closer than Forever Alone. Deals more damage than Forever Alone.
Forever Alone
Forever Alone Icon.pngSpawns a blue attack fly that orbits a long distance from Isaac.
Halo of Flies
Halo of Flies Icon.pngSpawns two pretty fly familiars that block enemy shots and deal contact damage to enemies.
Hive Mind
Hive Mind Icon.pngIncreases the size of Blue Spiders and Blue Flies and doubles the amount of damage they deal.
Skatole Icon.pngAll types of fly except Boom Fly and Red Boom Fly become passive and slowly move towards Isaac. Does not prevent contact damage.
Smart Fly
Smart Fly Icon.pngAfter Isaac takes damage, this fly will deal continuous touch damage to whatever enemy caused the damage until it is dead. The fly will then systematically attack 1 enemy at a time until the room is cleared.
The Mulligan
The Mulligan Icon.pngTears have a 1/6 chance of spawning allied blue flies when they hit an enemy.
Infestation Icon.png1-3 Blue Flies randomly spawn every time Isaac gets hit.
Friend Zone
Friend Zone Icon.pngA white orbiting fly which deals 3 contact damage per tick to enemies. This familiar orbits Isaac at a middle length distance somewhere between Distant Admiration and Forever Alone.
Lost Fly
Lost Fly Icon.pngA familiar fly that moves in a straight line and attaches itself to the first obstacle or wall it comes into contact with in each room. If any enemies walk into its path, it will deal 7 contact damage per tick. If the obstacle it is attached to is destroyed then it will continue rolling in the direction it was previously travelling until it meets another wall or obstacle.
Papa Fly
Papa Fly Icon.pngA blue fly familiar follows Isaac's movements on a 3 second delay. Papa Fly will fire tears at nearby enemies.
Obsessed Fan
Obsessed Fan Icon.pngA purple fly familiar that follows Isaac's movements on a 3 second delay and deals contact damage to enemies.
Guppy! Guppy App.png
Guppy's Head
Guppy's Head Icon.pngSpawns 2-4 Blue Flies to damage enemies.1
Guppy's Paw
Guppy's Paw Icon.pngRemoves one Heart Container in exchange for gaining 3 Soul Hearts.0
Dead Cat
Dead Cat Icon.pngSets the amount of red heart containers to 1, but gives Isaac 9 extra lives. After dying, Isaac is teleported to the last safe room. New heart containers can be obtained after picking up this item, but after each death, the number of heart containers is set to 1 again.
Guppy's Collar
Guppy's Collar Icon.pngPermanent 50% chance to respawn with 1/2 heart after death.
Guppy's Tail
Guppy's Tail Icon.pngIncreases chance of finding gold chests and normal chests, but reduces chance of finding pickups.
Guppy's Hair Ball
Guppy's Hair Ball Icon.pngLoosely follows behind Isaac. Can be swung like a flail by rapidly spinning Isaac in a circle. Grows bigger by killing enemies.

The Binding of Isaac: Afterbirth[edit source]

Transformation Appearance Transformation effect Item Icon Item effect Recharge
Bob Bob Transformation.png
Bob's Rotten Head
Bob's Rotten Head Icon.pngUpon use, Isaac holds a poison bomb which can be thrown towards any of the four cardinal points and explodes on impact.3
Bob's Brain
Bob's Brain Icon.pngSpawns a familiar that charges forward when shooting tears, explodes upon contact with an enemy and poisons them. Respawns after few seconds.
Bob's Curse
Bob's Curse Icon.pngGives 5 bombs and grants all bombs poison effect.
Ipecac Icon.pngReplaces tears with explosive and poisoning projectiles fired in an arc from the mouth.
Conjoined Baby Transformation.png
  • When attacking, the tumor faces shoot tears diagonally outwards, similar to the effect of The Wiz.
  • -0.3 damage.
  • Slightly decreases tears.
Brother Bobby
Brother Bobby Icon.pngFollows Isaac around shooting normal tears.
Harlequin Baby
Harlequin Baby Icon.pngSpawns a familiar that follows Isaac around and fires two tears at once in a V-pattern.
Headless Baby
Headless Baby Icon.pngFamiliar that follows Isaac, leaving blood creep on the ground.
Little Steven
Little Steven Icon.pngSpawns a familiar that follows Isaac around and fires homing tears.
Mongo Baby
Mongo Baby Icon.pngSummons a familiar that copies the tears of Isaac's other familiars.
Rotten Baby
Rotten Baby Icon.pngA familiar that spawns Blue Flies.
Sister Maggy
Sister Maggy Icon.pngA Familiar that follows Isaac around shooting blood tears.
Fun Guy Mushroom Transformation.png
God's Flesh
God's Flesh Icon.pngTears now have a random chance to apply a shrinking effect, causing enemies to shrink in size and also run away from Isaac. Shrunk enemies can be crushed and killed by walking over them.
Mini Mush
Mini Mush Icon.pngIncreases Speed and Shot Height and decreases Isaac's size, but lowers Range.
Magic Mushroom
Magic Mushroom Icon.pngIncreases all stats and enlargens Isaac
Odd Mushroom (Thin)
Odd Mushroom (Thin) Icon.pngIncreases Tears and Speed while reducing Damage.
Odd Mushroom (Large)
Odd Mushroom (Large) Icon.pngGrants an empty heart container. Increases damage, range and shot height while reducing speed.
1up! Icon.pngGives an extra life. Upon death, you will respawn in the previous room with full health and lose the 1up!.
Blue Cap
Blue Cap Icon.pngGrants 1 heart container and increases tears, but decreases shot speed.
Leviathan Evil Angel Transformation.png
The Nail
The Nail Icon.pngAdds one Soul Heart and allows the breaking of Rocks and damaging enemies by simply walking over them. Increases Damage and decreases Speed. All effects except for the Soul Heart wear off upon leaving the room.6
The Mark
The Mark Icon.pngIncreases Damage and Speed, plus adds one Soul Heart.
Missing Page 2
Missing Page 2 Icon.pngGives 1 black heart. Upon taking damage that reduces Isaac's health to one heart or less, activates The Necronomicon effect, dealing 40 damage to all enemies in the room.
The Pact
The Pact Icon.pngIncreases damage by 0.5, tears by 0.7 and grants two soul hearts upon pickup.
Pentagram Icon.pngIncreases Damage and increases chances of the Devil Room appearing.
Spirit Of The Night
Spirit Of The Night Icon.pngGrants spectral tears and flight.
Maw Of The Void
Maw Of The Void Icon.png+1.0 Damage Up. After continuously firing tears for 3 seconds, a red cross appears on Isaac's head that, upon releasing the fire button, creates a black ring which deals a lot of damage to any enemies inside it. The ring rapidly deals damage equal to Isaac's tear damage to any enemies in contact with it.
Abaddon Icon.pngIncreases damage and speed, removes all red heart containers, grants six black hearts, and adds a chance to shoot fear tears.
Brimstone Icon.pngTears are replaced by a laser beam that pierces through all enemies and obstacles in its path and deals high damage. Can only be fired after a short charge-up period.
Oh Crap Poop Transformation.png
  • Whenever a pile of poop is destroyed, health is replenished by half a heart.
Flush! Icon.pngChanges all enemies in the room into poop. Does not work on all enemies (Knights and bosses are immune). Instantly kills Dingle, Dangle, and Brownie.6
The Poop
The Poop Icon.pngSpawns a pile of poop where the character is standing and knocks nearby monsters back. May yield pickups like regular poop.1
E Coli
E Coli Icon.pngGives "Turdy Touch" Effect. Enemies that touch Isaac are changed into poop.
Seraphim Angel Transformation.png
The Bible
The Bible Icon.pngUpon activation, Isaac gains Flight, allowing him to pass over all obstacles in the current room. Instantly kills Mom, Mom's Heart, and It Lives when activated, but will kill Isaac when activated while fighting Satan.6
Dead Dove
Dead Dove Icon.pngGrants spectral tears and flight.
Guardian Angel
Guardian Angel Icon.pngSpawns an orbital familiar that blocks enemy projectiles, deals contact damage to enemies and increases the speed of all orbital familiars.
Holy Grail
Holy Grail Icon.pngGrants flight and one heart container.
Holy Mantle
Holy Mantle Icon.pngAutomatically negates first taken damage in every room.
Mitre Icon.pngGrants a chance of converting any red hearts pickups into soul hearts instead.
Rosary Icon.pngAdds 3 Soul Hearts and increases the chance for The Bible to appear in any item pool.
Sworn Protector
Sworn Protector Icon.pngAn orbital angel which does 7 contact damage per tick and blocks enemy shots. When it blocks a shot, it has a very small chance to drop an eternal heart.
The Halo
The Halo Icon.pngGrants one Heart Container, +0.3 Damage, +0.2 Tears, +0.25 Range, +0.3 Speed, and +0.5 Tear Height.
Spun Drugs Transformation.png
Adrenaline Icon.pngIncreases damage based on how many empty heart containers Isaac has.
Euthanasia Icon.pngAdds a chance to fire needles. If a needle kills an enemy, it bursts into more needles.
Experimental Treatment
Experimental Treatment Icon.pngRandomly increases and decreases some of the character's stats. There will always be at least one stat increase and one decrease and the same stats can be increased/decreased multiple times.
Growth Hormones
Growth Hormones Icon.pngIncreases damage by 1 and speed by 0.4.
Roid Rage
Roid Rage Icon.pngIncreases speed by 0.6, range by 5.25, and tear height by 0.5.
Speed Ball
Speed Ball Icon.pngIncreases speed by 0.3 and shot speed by 20%.
Synthoil Icon.pngIncreases damage by 1, range by 5.25, and tear height by 0.5.
The Virus
The Virus Icon.pngInflicts poison to enemies who make contact with Isaac. Speed down.
Yes, Mother? Mom Transformation.png
  • Isaac gains a stationary knife that trails directly behind him. It synergizes like Mom's Knife would.
Mom's Bottle Of Pills
Mom's Bottle Of Pills Icon.pngGives Isaac a random Pill, and will cause him to drop any held Q-slot item (If any). The player will only receive six different pill types in one playthrough.6
Mom's Bra
Mom's Bra Icon.pngUpon use, petrifies all enemies in the current room for approximately 4 seconds.3
Mom's Pad
Mom's Pad Icon.pngUpon use, inflicts fear to all enemies in the room for 5 seconds.3
Mom's Wig
Mom's Wig Icon.pngAdds a chance to spawn Blue Spiders when firing tears. Restores 1 red heart.
Mom's Eye
Mom's Eye Icon.pngAllows Isaac to fire tears from the back of his head.
Mom's Purse
Mom's Purse Icon.pngAllows Isaac to hold 1 additional trinket.
Mom's Contacts
Mom's Contacts Icon.pngAdds a chance to shoot petrifying tears, which stop enemies in place and prevent them from moving or attacking. Range up.
Mom's Knife
Mom's Knife Icon.pngIsaac's tears are replaced by a knife that pierces enemies, can travel through obstacles, and can hurt enemies while Isaac is holding it. Holding down the fire button before firing increases its range and power.
Mom's Heels
Mom's Heels Icon.pngIncreases range.
Mom's Eyeshadow
Mom's Eyeshadow Icon.pngTears have a chance to charm enemies.
Mom's Perfume
Mom's Perfume Icon.pngAdds a chance to shoot fear tears and increases Tears by 0.16.
Mom's Key
Mom's Key Icon.pngSpawns 2 keys. Generates additional pickups from chests.
Mom's Lipstick
Mom's Lipstick Icon.pngIncreases range and shot height.
Mom's Underwear
Mom's Underwear Icon.pngIncreases range.
Mom's Coin Purse
Mom's Coin Purse Icon.pngSpawns 4 random Pills around Isaac.
Mom's Pearls
Mom's Pearls Icon.png+1.25 Range Up. +0.5 Tear Height. +1 Luck Up.
Mom's Razor
Mom's Razor Icon.pngSpawns an orbiting razor that damages enemies it touches and inflicts bleeding on enemies, causing them to slowly take damage over time.
Super Bum Super Bum.png
Bum Friend
Bum Friend Icon.pngA portable Beggar who follows Isaac, picks up coins for himself, and occasionally drops a Pickup after collecting a coin. Does not spawn Collectibles.
Dark Bum
Dark Bum Icon.pngSpawns a familiar that follows Isaac around and collects Red Hearts. For every one-and-a-half red hearts collected, Dark Bum will generate one Soul Heart, one hostile Spider or one friendly Blue Spider.
Key Bum
Key Bum Icon.pngSpawns a portable Key Master that follows Isaac and collects keys, giving random chests in return.
1: Image depicts the familiar. This transformation does not alter Isaac's appearance.

The Binding of Isaac: Afterbirth†[edit source]

Transformation Appearance Transformation effect Item Icon Item effect Recharge
Bookworm Bookworm Transformation.png
  • Sometimes Isaac shoots two tears at once, like 20/20. The character also gains stat increases depending on which book they are holding.
Anarchist Cookbook
Anarchist Cookbook Icon.pngSpawns six troll bombs around the room.3
Book of Revelations
Book of Revelations Icon.pngAdds 1 Soul Heart and increases the chance for the next boss to be a Horseman (except on XL floors and floors with fixed bosses such as Mom).6
Book of Secrets
Book of Secrets Icon.pngUpon use, gives the effect of Treasure Map, The Compass, or Blue Map for the duration of the current floor.6
Book of Shadows
Book of Shadows Icon.pngUpon use, creates a protective shield nullifying all types of damage for 10 seconds.3
How To Jump
How To Jump Icon.pngGives Isaac the ability to jump (over gaps, spikes, etc.).0
Satanic Bible
Satanic Bible Icon.pngUpon activation, Isaac gains a black heart.6
Telepathy For Dummies
Telepathy For Dummies Icon.pngUpon activation, grants homing tears for the current room.2
The Bible
The Bible Icon.pngUpon activation, Isaac gains Flight, allowing him to pass over all obstacles in the current room. Instantly kills Mom, Mom's Heart, and It Lives when activated, but will kill Isaac when activated while fighting Satan.6
The Book of Belial
The Book of Belial Icon.pngGuarantees a Devil Room or Angel Room will be open after beating a boss while holding it. Upon use increases damage by 2 for the current room and by a further +50% if the character also has the Blood Of The Martyr.3
The Book of Sin
The Book of Sin Icon.pngSpawns a random Pick Up, Pill, Card, or Trinket.4
The Necronomicon
The Necronomicon Icon.pngDamages all enemies in the room significantly.6
Spider Baby Spider Baby Transformation.png
  • Spawns a spider familiar that applies random status effects to enemies it comes in contact with.
Box of Spiders
Box of Spiders Icon.pngSummons 2-4 Blue Spiders.2
Mutant Spider
Mutant Spider Icon.pngGrants quadruple shot but decreases tears.
Spider Baby
Spider Baby Icon.pngWhen hit, spawns up to 2 Blue Spiders.
Spider Bite
Spider Bite Icon.pngAdds a chance to shoot slowing tears, reducing speed of enemy movement and any projectile fired by them.
Spider Butt
Spider Butt Icon.pngDamages all enemies in the room and slows them and their projectiles down.2
Spider Mod
Spider Mod Icon.pngDisplays Isaac's tear damage and enemy health bars. Spawns a gray spider familiar that wanders around and inflicts a random status effect on any enemies it comes into contact with. Occasionally spawns a blue spider upon clearing a room.
Adult Adult Transformation.png
  • Grants a heart container.
  • Mom's foot will occasionally come down and stomp on enemies.
3 Puberty pills

Notes[edit | edit source]

  • Activated items (e.g. Guppy's Head) only need to be touched in order to count. Keeping them, or even activating them once, is not required.
  • Rerolling items with a Dice Room, the D4, or the D100 will not remove progress towards the transformation.
  • Transformations can be combined with each other, keeping the effects of any and all transformations with no effects overriding others.
  • Transforming into Beelzebub for the first time will unlock the Lord of the Flies achievement.
  • Since none of the Afterbirth transformations unlock an achievement or item, attaining them is not required for 100% completion of the game in terms of achievements.
  • Many of the Afterbirth transformations override the charge animations of items such as Monstro's Lung and Brimstone, potentially making them more difficult to use.
  • Familiars gained from Cambion Conception or Immaculate Conception do not count towards transformation progress.

Trivia[edit | edit source]

  • There are two transformations in the base game and nine more in the Afterbirth DLC.
  • In the original The Binding of Isaac flash game, the transformation into Guppy was the only one available, making it chronologically the first.
  • Rebirth introduced Beelzebub as the chronologically second transformation.

SmallIsaac.png The Binding of Isaac: Rebirth SmallIsaac.png

MainPageAchievements.png Achievements MainPageAttributes.png Attributes MainPageBosses.png Bosses TarotCard.png Cards and Runes MainPageChallenges.png Challenges MainPageChapters.png Chapters
Isaac App.png Characters MainPageBabies.png Co-op Magic Mushroom Icon.png Items Isaac's Tears Icon.png Item Pools MainPageMonsters.png Monsters MainPageObjects.png Objects
Red heart.png Pickups BlueBlue.png Pills MainPageRooms.png Rooms MainPageSeeds2.png Seeds Guppy App.png Transformations The Left Hand Icon.png Trinkets