Callus is a trinket.
Effects[ | ]
Notes[ | ]
- Also grants immunity to slowdown from black and white creep, but not from Cobwebs.
- Does not prevent any damage from
Curse Room doors. - Does not prevent damage from Spiked Chests.
- Does not prevent damage from Greed mode's stop button.
- Does not prevent damage from Spiked Rocks.
- Prevents the use of Sacrifice Rooms, unlike flight.
- Can use Sacrifice Rooms now. Can also use the spikes created by Sanguine Bond.
Does not prevent damage from 
Does not prevent damage from Spiked Rocks.
Prevents the use of 
In-game Footage[ | ]
Trivia[ | ]
- A callus is an area of thickened skin that forms as a response to repeated friction, pressure, or other irritation.
 The Binding of Isaac: Rebirth
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