| Date | Event, if any | Peculiarities |
|---|---|---|
| January 1st | New Years | Bomb pool, starting with Pyro, no tears |
| January 14th | Starting as Guppy, no item rooms | |
| January 16th | National Nothing Day | No item rooms, no shops |
| January 27th | No item rooms, no shops, Poop pool | |
| February 2nd | Groundhog day | Same seed as the day before |
| February 9th | National Toothache Day | 51 luck, Tooth items, no item rooms |
| February 11th | National "Don't Cry Over Spilled Milk" Day | Starting with Soy Milk and Milk! |
| February 14th | Valentine's day | High luck, Mom's items |
| February 18th | National Battery Day | Starting with battery-related items |
| March 2nd | Edmund's birthday | Isaac to Mega Satan, Undroppable The Left Hand |
| March 4th | Holy Experiment Day | Maggie to Mom. No Item Rooms, starting with Immaculate Conception, Eucharist and Seraphim |
| March 17th | St. Patrick's day | Cain to Mega Satan via The Chest, starts with high luck |
| March 20th | National Alien Abduction Day | Isaac, starts with Cone Head, The Parasite and Tractor Beam. No item rooms. |
| March 22nd | National "Goof off" day | Isaac, starts with extreme range; tears follow random patterns |
| Easter | Easter | Lazarus, Blood of the Martyr, Stigmata, no item rooms |
| April 1st | April fools | Old Keeper, random trinkets and items upon pickups |
| April 10th | National siblings day | Lilith, starts with Mongo Baby, Little Steven, Little Gish, Ghost Baby, Brother Bobby and Sister Maggy |
| April 15th | Lazarus, starts with Tick, Bob's Brain, Dead Cat, Curse of the Tower and Cursed Eye; no item rooms | |
| April 22nd | National Jelly Bean day | Magdalene to Sheol, starts with Wait What?, Linger Bean, The Black Bean and 9 Volt; no item rooms |
| May 4th | May the 4th be with you! | Isaac to The Womb, starts with Technology and the Spear of Destiny |
| May 8th | Mothers' day | Isaac, Mom transformation, no item rooms |
| May 13th | National "Stamp Out Hunger" and Frog Jump day | Magdalene, starts with Thunder Thighs and How to Jump. No item rooms |
| May 17th | National "Pack Rat Day" | Isaac, starts with Sack Head and D20 |
| May 30th | Memorial day | The Lost, no tears, 3 familiars and Conjoined |
| June 2nd | Magdalene, starting with Blank Card and High Priestess, no item rooms | |
| June 5th | ???, starting Restock and Gnawed Leaf | |
| June 18th | Fathers' day | Cain, A Dollar |
| June 19th | Fathers' day | Cain, Daddy Longlegs, Dad's Key |
| June 25th | Pride day | The Lost, rainbow items |
| July 4th | Independence day | Samson, Dr. Fetus, bomb pool |
| October 31st | Halloween | Eve, Sack Head |
| November 1st | Day of the dead | The Lost w/o Holy Mantle, Dead Cat |
| November 11th | Veterans' day | The Lost, no item rooms |
| November XXth | Thanksgiving | Cupid's Arrow, Rotten Meat |
| December 5th | ||
| December 6th | Satoru Iwata's birthday | Iwata's sprite, The Gamekid |
| December 25th | Christmas | A Quarter, A Lump of Coal, Xmas hat |
The full list of the remaining undisclosed dailies isn't published to avoid spoiling content.