???'s Only Friend

Treasure Room Key Master Treasure Room   (page 3, column 15, line 4) (page 4, column 5, line 2)   Complete the Boss Rush as ??????'s Only Friend

???'s Only Friend is an unlockable passive item.

Effects

• Gives Isaac a controllable follower that damages enemies on touch, dealing 2.5 damage per tick. Works similar to The Ludovico TechniqueInstead of firing tears, Isaac controls one floating tear that hover over obstacles. This tear deals constant damage when held in place over an enemy. and Robo-Baby 2.0Fires lasers at any enemy in its line of sight and moves based on the direction Isaac is firing tears..
• This item belongs to the Beelzebub

  Flight. Converts small enemy flies into blue flies.

  set. Collecting three items from this set will transform Isaac into a giant humanoid fly.

Notes

• Unlike The Ludovico TechniqueInstead of firing tears, Isaac controls one floating tear that hover over obstacles. This tear deals constant damage when held in place over an enemy., you can't control it with your mouse if you enabled the mouse control in the config files.
• Holding two opposite fire keys (both left and right or both up and down) at the same time will keep the familiar in place, while making Isaac fire in the direction of whichever fire key was pressed second.
  • This can help during combats with bosses who do not move a lot, as the familiar can continuously damage the boss when kept stationary.
  • On some keyboards, holding opposite fire keys may cause other keys to become unresponsive.

Seeds

 PC  HC7F QZAT (Treasure Room adjacent to spawn)

 PC  J6S4 VMQM (Treasure Room adjacent to spawn)

 PC  6CQZ CL2Y (Treasure Room adjacent to spawn)

 PS4  Y4FW NYCX (First floor treasure room)

 Switch  6RS1 FT1H (First Golden Treasure Room)

Fly Items

• SkatoleAll types of fly except Boom Fly and Red Boom Fly become passive and slowly move towards Isaac. Does not prevent contact damage.
• Halo of FliesSpawns two pretty fly familiars that block enemy shots and deal contact damage to enemies.
• Distant AdmirationA red attack fly circles further out than the Halo of Flies / Pretty Flies, but closer than Forever Alone. Deals more damage than Forever Alone.
• Forever AloneSpawns a blue attack fly that orbits a long distance from Isaac.
• Infestation1-3 Blue flies randomly spawn every time Isaac gets hit.
• The MulliganTears have a 1/6 chance of spawning allied blue flies when they hit an enemy.
• Hive MindIncreases the size of blue spiders and Blue Flies and doubles the amount of damage they deal.
• Smart FlyAfter Isaac takes damage, this fly will deal continuous touch damage to whatever enemy caused the damage until it is dead. The fly will then systematically attack 1 enemy at a time until the room is cleared.
• BBFSpawns a familiar that flies around the room in a manner similar to the Boom Fly and explodes on contact with an enemy. Respawns after ten seconds.
• Best BudWhen hit, summons a white attack fly similar to Distant Admiration for the current room.
• Big FanSpawns a large orbital familiar that blocks enemy projectiles and deals slight contact damage to enemies.
• ???'s Only FriendSummons a big attack fly that can be controlled with the shooting direction-keys.
• Friend ZoneA white orbiting fly which deals 3 contact damage per tick to enemies. This familiar orbits Isaac at a middle length distance somewhere between Distant Admiration and Forever Alone.
• Lost FlyA familiar fly that moves in a straight line and attaches itself to the first obstacle or wall it comes into contact with in each room. If any enemies walk into its path, it will deal 7 contact damage per tick. If the obstacle it is attached to is destroyed then it will continue rolling in the direction it was previously travelling until it meets another wall or obstacle.
• Obsessed FanA purple fly familiar that follows Isaac's movements on a 3 second delay and deals contact damage to enemies.
• Papa FlyA blue fly familiar follows Isaac's movements on a 3 second delay. Papa Fly will fire tears at nearby enemies.
• Jar of FliesEvery time Isaac kills an enemy, a fly will be added to the jar, up to a maximum of 20. Using the Jar of Flies will release all the flies that are currently in the jar as friendly blue flies that will damage enemies.
• Angry FlySpawns a fly familiar that orbits around a random enemy and deals 5 damage per tick to enemies it comes in contact with.