A Card Against Humanity

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Special Cards
Rebirth Suicide King Chaos Card Credit Card Rules Card A Card Against Humanity
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Card Against Humanity Complete challenge #12Card Against HumanityCard Against Humanity

A Card Against Humanity is a special card.

Effects[edit | edit source]

  • Fills the entire room with poop.

Notes[edit | edit source]

  • Poop will not fill tiles with obstacles, even if they have already been destroyed.
  • The process is not instant and the room will not get filled if Isaac leaves before it's done filling.
  • It is more beneficial to use the card in a large-sized room as it will create more poop piles.
  • Using A Card Against Humanity in the Ultra Greedier fight will result in golden poops spawning after defeating the boss.
  • Using A Card Against Humanity in the Ultra Greed fight can trap the Gapers after Key Coins appear, preventing Ultra Greed from attacking.

Synergies[edit | edit source]

  • Added in Afterbirth †Hallowed Ground Hallowed Ground: Spawned poops have a high chance to turn into white poop.
  • Added in Afterbirth Infested! Pill: Every pile of poop spawns a blue spider.
  • Leo Leo/The Nail The Nail/Thunder Thighs Thunder Thighs: Allows all the poop to be easily destroyed.
  • Added in AfterbirthLil Larva Lil LarvaTrinket Lil Larva icon.pngSpawns a blue fly from every pile of poop that Isaac destroys.: Every pile of poop spawns a blue Fly.
  • Midas' Touch Midas' Touch: Spawned poops have a great chance to turn into golden poops.
  • Petrified Poop Petrified PoopTrinket Petrified Poop icon.pngGreatly increases the chances of a pickup dropping when destroying poop.: Greatly increases the chance of finding a pickup when destroying poop.

Interactions[edit | edit source]

  • Added in AfterbirthBrown Cap Brown CapTrinket Brown Cap icon.pngPoop blocks will explode after being destroyed.: All the poop explodes in a chain reaction once one is destroyed.
  • Dr. Fetus Dr. Fetus/Ipecac Ipecac: If Isaac has no other means of destroying poop than his explosive tears, he will have to hurt himself to clear out a path through the poop unless he has acquired Pyromaniac Pyromaniac or Added in AfterbirthHost Hat Host Hat.

Trivia[edit | edit source]

  • The item is a reference to Cards Against Humanity, a satirical card game whose name in turn references "crimes against humanity". Specifically, it refers to the way the first player is chosen: Whoever was the last to poop goes first.
  • In the pop-up (if not disabled) for unlocking this card, the text on it reads "A room full of poop".
    • This actually contradicts the original card game, as black cards are prompts while the white cards are answers to the prompt.


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