A Card Against Humanity

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Special Cards
Rebirth Suicide King Chaos Card Credit Card Rules Card A Card Against Humanity
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Card Against Humanity Complete challenge #12Card Against HumanityCard Against Humanity

A Card Against Humanity is a special card.

Effects[edit | edit source]

  • Fills the entire room with poop.

Notes[edit | edit source]

  • Poop will not fill tiles with obstacles, even if they have already been destroyed.
  • The process is not instant and the room will not get filled if Isaac leaves before it's done filling.
  • It is more beneficial to use the card in a large-sized room as it will create more poop piles.
  • Using A Card Against Humanity in the Ultra Greedier fight will result in golden poops spawning after defeating the boss.
  • Using A Card Against Humanity in the Ultra Greed fight can trap the Gapers after Key Coins appear, preventing Ultra Greed from attacking.

Synergies[edit | edit source]

  • Added in Afterbirth †Hallowed Ground Hallowed GroundHallowed Ground Icon.pngSpawns a white poop familiar, which turns into a white poop when Isaac is hurt.: Spawned poops have a high chance to turn into white poop.
  • Added in  Afterbirth Infested! Pill: Every pile of poop spawns a blue spider.
  • Leo LeoLeo Icon.pngAllows you to crush rocks when you walk over them./The Nail The NailThe Nail Icon.png6 roomsAdds one soul heart and allows the breaking of rocks and damaging enemies by simply walking over them. Increases damage and decreases speed. All effects except for the Soul Heart wear off upon leaving the room./Thunder Thighs Thunder ThighsThunder Thighs Icon.pngDestroys rocks upon contact with Isaac. Adds one heart container and lowers Speed.: Allows all the poop to be easily destroyed.
  • Added in  AfterbirthLil Larva Lil LarvaLil Larva Icon.pngSpawns a blue fly from every pile of poop Isaac destroys.: Every pile of poop spawns a blue Fly.
  • Midas' Touch Midas' TouchMidas' Touch Icon.pngEnemies that touch you are stunned and turn gold. Any enemy killed while in this state will drop a coin.: Spawned poops have a great chance to turn into golden poops.
  • Petrified Poop Petrified PoopPetrified Poop Icon.pngGreatly increases the chances of a pickup dropping when destroying poop.: Greatly increases the chance of finding a pickup when destroying poop.

Interactions[edit | edit source]

  • Added in  AfterbirthBrown Cap Brown CapBrown Cap Icon.pngPoop will explode after being destroyed.: All the poop explodes in a chain reaction once one is destroyed.
  • Dr. Fetus Dr. FetusDr. Fetus Icon.pngTears are replaced by bombs that benefit from bomb-enhancing effects and slide for a fixed time after being fired./Ipecac IpecacIpecac Icon.pngReplaces tears with explosive and poisoning projectiles fired in an arc from the mouth.: If Isaac has no other means of destroying poop than his explosive tears, he will have to hurt himself to clear out a path through the poop unless he has acquired Pyromaniac PyromaniacPyromaniac Icon.pngIsaac heals 1 heart instead of taking damage from an explosive source. Adds 5 bombs. or Added in  AfterbirthHost Hat Host HatHost Hat Icon.pngA host familiar that sits on Isaac's head and has a random chance to block enemy shots and retaliate with 3 tears. Grants immunity to explosions..

Trivia[edit | edit source]

  • The item is a reference to Cards Against Humanity, a satirical card game whose name in turn references "crimes against humanity". Specifically, it refers to the way the first player is chosen: Whoever was the last to poop goes first.
  • In the pop-up (if not disabled) for unlocking this card, the text on it reads "A room full of poop".
    • This actually contradicts the original card game, as black cards are prompts while the white cards are answers to the prompt.


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