View source for Achievements

''For tips and strategies on completing achievements, see [[achievement tip]]s.''

'''Achievements''' are unlocked for players after completing [[challenge]]s, reaching certain [[completion mark|milestones]], achieving hidden goals, or unlocking certain [[item]]s. In the PC version, every Steam achievement exactly corresponds to one secret in-game, whereas only a handful of secrets are represented by PSN trophies in the Playstation version of the game.

If you are unable to unlock achievements, a small icon of a crossed-out trophy {{no unlocks}} will be displayed below your [[key]]s counter. Conditions which can disable the ability to unlock achievements include:
* Using a pre-determined [[seed]]. {{dlc|a}} Certain cosmetic and difficulty-increasing [[seed|special seeds]] will still allow unlocks.
* {{dlc|a+}} Playing with any enabled [[mod]] (unless you have beaten [[Mom]]).
* {{dlc|a+}} During [[Victory Lap]]s.

Rebirth has a total of 178 unlockable secrets. {{dlc|a}} [[Afterbirth]] added 98 new secrets, for a total of 276. {{dlc|a+}} [[Afterbirth †]] added 63 new secrets, for a total of 339. {{dlc|a+}} [[Booster Pack #5]] added 64 new secrets, for a total of 403.

At the stats screen, pressing Alt + F2 will sync your unlocks with your steam achievements. Should you have steam achievements for secrets you haven't unlocked ingame, they will be unlocked by doing this.

__FORCETOC__

== All Achievements ==
=== [[The Binding of Isaac: Rebirth|Rebirth]] ===
{{table | achievement |
{{infobox achievement
 | name        = Magdalene
 | link        = Magdalene
 | description = Unlocked a new character.
 | unlocked by = Have 7 or more Red [[Heart container]]s at one time
 | id          = 1
}} {{infobox achievement
 | name        = Cain
 | link        = Cain
 | description = Unlocked a new character.
 | unlocked by = Hold 55 [[coin]]s at one time
 | id          = 2
}} {{infobox achievement
 | name        = Judas
 | link        = Judas
 | description = Unlocked a new character.
 | unlocked by = Defeat [[Satan]]
 | id          = 3
}} {{infobox achievement
 | name        = The Womb
 | description = Chapter 4 - The Womb unlocked.
 | unlocked by = Defeat [[Mom]]
 | id          = 4
}} {{infobox achievement
 | name        = The Harbingers
 | link        = The Harbingers
 | description = The horsemen are loose.
 | unlocked by = Defeat [[Mom]]
 | id          = 5
}} {{infobox achievement
 | name        = A Cube of Meat
 | link        = Cube of Meat
 | description = Unlocked a new item. (Also unlocks the [[Ball of Bandages]])
 | unlocked by = Defeat [[Mom]]
 | id          = 6
}} {{infobox achievement
 | name        = The Book of Revelations
 | link        = Book of Revelations
 | description = Unlocked a new item.
 | unlocked by = Defeat a [[The Harbingers|Harbinger]]
 | id          = 7
}} {{infobox achievement
 | name        = A Noose
 | link        = Transcendence
 | description = Unlocked a new item.
 | unlocked by = Defeat [[Mom's Heart]] 3 times
 | id          = 8
}} {{infobox achievement
 | name        = The Nail
 | link        = The Nail
 | description = Unlocked a new item.
 | unlocked by = Complete the [[Boss Rush]] as [[Azazel]]
 | id          = 9
}} {{infobox achievement
 | name        = A Quarter
 | link        = A Quarter
 | description = Unlocked a new item.
 | unlocked by = Defeat [[Mom's Heart]] 8 times
 | id          = 10
}} {{infobox achievement
 | name        = A Fetus in a Jar
 | link        = Dr. Fetus
 | description = Unlocked a new item.
 | unlocked by = Defeat [[Mom's Heart]] 9 times
 | id          = 11
}} {{infobox achievement
 | name        = A Small Rock
 | link        = The Small Rock
 | description = Unlocked a new item.
 | unlocked by = Destroy 100 [[Tinted Rock]]s
 | id          = 12
}} {{infobox achievement
 | name        = Monstro's Tooth
 | link        = Monstro's Tooth
 | description = Unlocked a new item.
 | unlocked by = Beat [[chapter 1]]
 | id          = 13
}} {{infobox achievement
 | name        = Lil' Chubby
 | link        = Little Chubby
 | description = Unlocked a new item.
 | unlocked by = Beat [[chapter 2]]
 | id          = 14
}} {{infobox achievement
 | name        = Loki's Horns
 | link        = Loki's Horns
 | description = Unlocked a new item.
 | unlocked by = Defeat [[Lokii]]
 | id          = 15
}} {{infobox achievement
 | name        = Something From The Future
 | link        = Steven
 | description = New boss in the basement!
 | unlocked by = Beat {{s|The Basement}} 40 times
 | id          = 16
}} {{infobox achievement
 | name        = Something Cute
 | link        = C.H.A.D.
 | description = New boss in the caves!
 | unlocked by = Beat [[chapter 2]] 30 times
 | id          = 17
}} {{infobox achievement
 | name        = Something Sticky
 | link        = Gish
 | description = New boss in the depths!
 | unlocked by = Beat [[chapter 3]] 20 times
 | id          = 18
}} {{infobox achievement
 | name        = A Bandage
 | link        = Super Bandage
 | description = Unlocked a new item.
 | unlocked by = Make a Super Bandage Girl by picking up 4 [[Ball of Bandages|Balls of Bandages]] in one run; see [[unlocking Super Meat Boy & Super Bandage Girl]]
 | id          = 19
}} {{infobox achievement
 | name        = A Cross
 | link        = The Relic
 | description = Unlocked a new item.
 | unlocked by = Defeat [[Isaac (Boss)|Isaac]] as [[Magdalene]]
 | id          = 20
}} {{infobox achievement
 | name        = A Bag of Pennies
 | link        = Sack of Pennies
 | description = Unlocked a new item.
 | unlocked by = Defeat [[Isaac (Boss)|Isaac]] as [[Cain]]
 | id          = 21
}} {{infobox achievement
 | name        = The Book of Sin
 | link        = The Book of Sin
 | description = Unlocked a new item.
 | unlocked by = Defeat all [[7 deadly sins]]
 | id          = 22
}} {{infobox achievement
 | name        = Little Gish
 | link        = Little Gish
 | description = Unlocked a new item.
 | unlocked by = Defeat [[Gish]]
 | id          = 23
}} {{infobox achievement
 | name        = Little Steven
 | link        = Little Steven
 | description = Unlocked a new item.
 | unlocked by = Defeat [[Steven]]
 | id          = 24
}} {{infobox achievement
 | name        = Little C.H.A.D.
 | link        = Little C.H.A.D.
 | description = Unlocked a new item.
 | unlocked by = Defeat [[C.H.A.D.]]
 | id          = 25
}} {{infobox achievement
 | name        = A Gamekid
 | link        = The Gamekid
 | description = Unlocked a new item.
 | unlocked by = Visit 10 [[Arcade]]s
 | id          = 26
}} {{infobox achievement
 | name        = A Halo
 | link        = The Halo
 | description = Unlocked a new item.
 | unlocked by = Defeat [[Mom]], [[Mom's Heart]] or [[It Lives]] using {{i|The Bible}}
 | id          = 27
}} {{infobox achievement
 | name        = Mr. Mega
 | link        = Mr. Mega
 | description = Unlocked a new item.
 | unlocked by = Destroy 10 [[Tinted Rock]]s
 | id          = 28
}} {{infobox achievement
 | name        = The D6
 | link        = The D6
 | description = Isaac now holds the D6!
 | unlocked by = Defeat [[Isaac (Boss)|Isaac]] as [[??? (Character)|???]]
 | id          = 29
}} {{infobox achievement
 | name        = The Scissors
 | link        = Scissors
 | description = Unlocked a new item.
 | unlocked by = [[death|Die]] 100 times
 | id          = 30
}} {{infobox achievement
 | name        = The Parasite
 | link        = The Parasite
 | description = Unlocked a new item.
 | unlocked by = Pick up any 2 of the following items in a single run: {{i|Bob's Rotten Head}}, {{i|Dead Cat}}, {{i|Cricket's Head}}, {{i|Tammy's Head}}
 | id          = 31
}} {{infobox achievement
 | name        = ???
 | link        = ??? (Character)
 | image       = achievement Blue Baby Character icon.png
 | description = Unlocked a new character.
 | unlocked by = Defeat [[Mom's Heart]] 10 times
 | id          = 32
}} {{infobox achievement
 | name        = Everything Is Terrible!!!
 | description = The game just got harder!
 | unlocked by = Defeat [[Mom's Heart]] 5 times
 | id          = 33
}} {{infobox achievement
 | name        = It Lives!
 | link        = It Lives
 | description = Your future's past waits.
 | unlocked by = Defeat [[Mom's Heart]] 11 times
 | id          = 34
}} {{infobox achievement
 | name        = Mom's Contact
 | link        = Mom's Contacts
 | description = Unlocked a new item.
 | unlocked by = Obtain three [[:category:Yes Mother? items|Yes Mother? items]] in one run
 | id          = 35
}} {{infobox achievement
 | name        = The Necronomicon
 | link        = The Necronomicon
 | description = Unlocked a new item.
 | unlocked by = Use [[XIII - Death]] 4 times
 | id          = 36
}} {{infobox achievement
 | name        = Basement Boy
 | description = Beat basement without taking damage.
 | unlocked by = Beat [[chapter 1]] without taking damage
 | id          = 37
}} {{infobox achievement
 | name        = Spelunker Boy
 | description = Beat caves without taking damage.
 | unlocked by = Beat [[chapter 2]] without taking damage
 | id          = 38
}} {{infobox achievement
 | name        = Dark Boy
 | description = Beat depths without taking damage.
 | unlocked by = Beat [[chapter 3]] without taking damage
 | id          = 39
}} {{infobox achievement
 | name        = Mama's Boy
 | description = Beat womb without taking damage.
 | unlocked by = Beat [[chapter 4]] without taking damage
 | id          = 40
}} {{infobox achievement
 | name        = Golden God!
 | description = You are the best!!
 | unlocked by = Defeat [[??? (Boss)|???]] and [[The Lamb]]
 | id          = 41
}} {{infobox achievement
 | name        = Eve
 | link        = Eve
 | description = Unlocked a new character.
 | unlocked by = Don't pick up any [[heart]]s for 2 floors in a row
 | id          = 42
}} {{infobox achievement
 | name        = Mom's Knife
 | link        = Mom's Knife
 | description = Unlocked a new item.
 | unlocked by = Defeat [[Satan]] as [[Isaac]]
 | id          = 43
}} {{infobox achievement
 | name        = The Razor
 | link        = Razor Blade
 | description = Unlocked a new item.
 | unlocked by = Defeat [[Satan]] as [[Eve]]
 | id          = 44
}} {{infobox achievement
 | name        = Guardian Angel
 | link        = Guardian Angel
 | description = Unlocked a new item.
 | unlocked by = Defeat [[Satan]] as [[Magdalene]]
 | id          = 45
}} {{infobox achievement
 | name        = A Bag of Bombs
 | link        = Bomb Bag
 | description = Unlocked a new item.
 | unlocked by = Defeat [[Satan]] as [[Cain]]
 | id          = 46
}} {{infobox achievement
 | name        = Demon Baby
 | link        = Demon Baby
 | description = Unlocked a new item.
 | unlocked by = Defeat [[The Lamb]] as [[Azazel]]
 | id          = 47
}} {{infobox achievement
 | name        = Forget Me Now
 | link        = Forget Me Now
 | description = Unlocked a new item.
 | unlocked by = Defeat [[Satan]] as [[??? (Character)|???]]
 | id          = 48
}} {{infobox achievement
 | name        = The D20
 | link        = D20
 | description = Unlocked a new item.
 | unlocked by = Defeat [[??? (Boss)|???]] as [[Isaac]]
 | id          = 49
}} {{infobox achievement
 | name        = Celtic Cross
 | link        = Celtic Cross
 | description = Unlocked a new item.
 | unlocked by = Defeat [[??? (Boss)|???]] as [[Magdalene]]
 | id          = 50
}} {{infobox achievement
 | name        = Abel
 | link        = Abel
 | description = Unlocked a new item.
 | unlocked by = Defeat [[The Lamb]] as [[Cain]]
 | id          = 51
}} {{infobox achievement
 | name        = Curved Horn
 | link        = Curved Horn
 | description = Unlocked a new item.
 | unlocked by = Defeat [[The Lamb]] as [[Judas]]
 | id          = 52
}} {{infobox achievement
 | name        = Sacrificial Dagger
 | link        = Sacrificial Dagger
 | description = Unlocked a new item.
 | unlocked by = Defeat [[??? (Boss)|???]] as [[Eve]]
 | id          = 53
}} {{infobox achievement
 | name        = Bloody Lust
 | link        = Bloody Lust
 | description = Unlocked a new item.
 | unlocked by = Defeat [[Isaac (Boss)|Isaac]] as [[Samson]]
 | id          = 54
}} {{infobox achievement
 | name        = Blood Penny
 | link        = Bloody Penny
 | description = Unlocked a new item.
 | unlocked by = Defeat [[??? (Boss)|???]] as [[Samson]]
 | id          = 55
}} {{infobox achievement
 | name        = Blood Rights
 | link        = Blood Rights
 | description = Unlocked a new item.
 | unlocked by = Defeat [[Satan]] as [[Samson]]
 | id          = 56
}} {{infobox achievement
 | name        = The Polaroid
 | link        = The Polaroid
 | description = Unlocked a new item.
 | unlocked by = Defeat [[Isaac (Boss)|Isaac]] 5 times
 | id          = 57
}} {{infobox achievement
 | name        = Dad's Key
 | link        = Dad's Key
 | description = Unlocked a new item.
 | unlocked by = Pick up both Key Pieces from the [[Angel]]s in one run
 | id          = 58
}} {{infobox achievement
 | name        = Blue Candle
 | link        = The Candle
 | description = Unlocked a new item.
 | unlocked by = Donate 900 coins to the [[Donation Machine]]
 | id          = 59
}} {{infobox achievement
 | name        = Burnt Penny
 | link        = Burnt Penny
 | description = Unlocked a new item.
 | unlocked by = Complete [[Beans!|Beans! (challenge #13)]]
 | id          = 60
}} {{infobox achievement
 | name        = Lucky Toe
 | link        = Lucky Toe
 | description = Unlocked a new item.
 | unlocked by = Blow up 20 [[Shopkeeper]]s
 | id          = 61
}} {{infobox achievement
 | name        = Epic Fetus
 | link        = Epic Fetus
 | description = Unlocked a new item.
 | unlocked by = Complete [[The Family Man|The Family Man (challenge #19)]]
 | id          = 62
}} {{infobox achievement
 | name        = SMB Super Fan
 | link        = SMB Super Fan
 | description = Unlocked a new item.
 | unlocked by = Complete [[It's in the Cards|It's in the Cards (challenge #14)]]
 | id          = 63
}} {{infobox achievement
 | name        = Counterfeit Coin
 | link        = Counterfeit Penny
 | description = Unlocked a new item.
 | unlocked by = Play the [[Shell Game]] 100 times
 | id          = 64
}} {{infobox achievement
 | name        = Guppy's Hairball
 | link        = Guppy's Hair Ball
 | description = Unlocked a new item.
 | unlocked by = Become [[Guppy]]
 | id          = 65
}} {{infobox achievement
 | name        = A Forgotten Horseman
 | link        = Conquest
 | description = Unlocked a new boss!
 | unlocked by = Take 10 [[Angel Room (Item Pool)|items from Angel Rooms]]
 | id          = 66
}} {{infobox achievement
 | name        = Samson
 | link        = Samson
 | description = Unlocked a new character.
 | unlocked by = Complete 2 floors in a row without taking damage
 | id          = 67
}} {{infobox achievement
 | name        = Something Icky
 | link        = Triachnid
 | description = New boss in the womb!
 | unlocked by = Defeat [[Isaac (Boss)|Isaac]] 10 times
 | id          = 68
}} {{infobox achievement
 | name        = !Platinum God!
 | description = OMG!
 | unlocked by = [[collection page|Collect]] all non-DLC items in the game, unlock all of the secrets and [[ending]]s minus [[The Lost]] and his 6 unlockable items
 | id          = 69
}} {{infobox achievement
 | name        = Isaac's Head
 | link        = Isaac's Head
 | description = Unlocked a new item.
 | unlocked by = Complete the [[Boss Rush]] as [[Isaac]]
 | id          = 70
}} {{infobox achievement
 | name        = Maggy's Faith
 | link        = Maggy's Faith
 | description = Unlocked a new item.
 | unlocked by = Defeat [[The Lamb]] as [[Magdalene]]
 | id          = 71
}} {{infobox achievement
 | name        = Judas' Tongue
 | link        = Judas' Tongue
 | description = Unlocked a new item.
 | unlocked by = Defeat [[Satan]] as [[Judas]]
 | id          = 72
}} {{infobox achievement
 | name        = ???'s Soul
 | link        = ???'s Soul
 | image       = achievement Blue Baby's Soul_icon.png
 | description = Unlocked a new item.
 | unlocked by = Defeat [[The Lamb]] as [[??? (Character)|???]]
 | id          = 73
}} {{infobox achievement
 | name        = Samson's Lock
 | link        = Samson's Lock
 | description = Unlocked a new item.
 | unlocked by = Defeat [[The Lamb]] as [[Samson]]
 | id          = 74
}} {{infobox achievement
 | name        = Cain's Eye
 | link        = Cain's Eye
 | description = Unlocked a new item.
 | unlocked by = Defeat [[??? (Boss)|???]] as [[Cain]]
 | id          = 75
}} {{infobox achievement
 | name        = Eve's Bird Foot
 | link        = Eve's Bird Foot
 | description = Unlocked a new item.
 | unlocked by = Defeat [[Isaac (Boss)|Isaac]] as [[Eve]]
 | id          = 76
}} {{infobox achievement
 | name        = The Left Hand
 | link        = The Left Hand
 | description = Unlocked a new item.
 | unlocked by = Defeat [[Ultra Pride]] as any character, or [[??? (Boss)|???]] as [[Judas]]
 | id          = 77
}} {{infobox achievement
 | name        = The Negative
 | link        = The Negative
 | description = Unlocked a new item.
 | unlocked by = Defeat [[Satan]] 5 times
 | id          = 78
}} {{infobox achievement
 | name        = Azazel
 | link        = Azazel
 | description = Unlocked a new character.
 | unlocked by = Make 3 [[Devil Room|deals with the Devil]] in one run
 | id          = 79
}} {{infobox achievement
 | name        = Lazarus
 | link        = Lazarus
 | description = Unlocked a new character.
 | unlocked by = Have 4 or more [[Soul Heart]]s at one time
 | id          = 80
}} {{infobox achievement
 | name        = Eden
 | link        = Eden
 | description = Unlocked a new character.
 | unlocked by = Complete [[chapter 4]]
 | id          = 81
}} {{infobox achievement
 | name        = The Lost
 | link        = The Lost
 | description = Unlocked a new character.
 | unlocked by = {{dlc|na}} [[The Lost#Unlocking The Lost in Rebirth|It's complicated]]<br>{{dlc|a}} Die in a [[Sacrifice Room]] while holding {{t|Missing Poster}}
 | id          = 82
}} {{infobox achievement
 | name        = Dead Boy
 | description = Beat Chest or Dark Room without taking damage.
 | unlocked by = Complete [[chapter 6]] without taking damage
 | id          = 83
}} {{infobox achievement
 | name        = The Real Platinum God
 | description = 111% now stop playing!
 | unlocked by = [[Collection Page|Collect]] every non-DLC [[item]] and unlock every [[ending]].
 | id          = 84
}} {{infobox achievement
 | name        = Lucky Rock
 | link        = Lucky Rock
 | description = Destroy 100 rocks.
 | unlocked by = Destroy 100 [[rock]]s
 | id          = 85
}} {{infobox achievement
 | name        = The Cellar
 | link        = The Cellar
 | description = Alt stage to the basement.
 | unlocked by = Beat all [[The Basement#Bosses|The Basement bosses]] (not restricted to beating bosses ''in'' The Basement)
 | id          = 86
}} {{infobox achievement
 | name        = The Catacombs
 | link        = The Catacombs
 | description = Alt stage to the caves.
 | unlocked by = Beat all [[The Caves#Bosses|The Caves bosses]] (not restricted to beating bosses ''in'' The Caves)
 | id          = 87
}} {{infobox achievement
 | name        = The Necropolis
 | link        = Necropolis
 | description = Alt stage to the depths.
 | unlocked by = Beat all [[The Depths#Bosses|The Depths bosses]] (not restricted to beating bosses ''in'' The Depths)
 | id          = 88
}} {{infobox achievement
 | name        = Rune of Hagalaz
 | link        = Runes
 | description = Unlocked a new item.
 | unlocked by = Complete [[Pitch Black|Pitch Black (challenge #1)]]
 | id          = 89
}} {{infobox achievement
 | name        = Rune of Jera
 | link        = Runes
 | description = Unlocked a new item.
 | unlocked by = Complete [[High Brow|High Brow (challenge #2)]]
 | id          = 90
}} {{infobox achievement
 | name        = Rune of Ehwaz
 | link        = Runes
 | description = Unlocked a new item.
 | unlocked by = Complete [[Head Trauma|Head Trauma (challenge #3)]]
 | id          = 91
}} {{infobox achievement
 | name        = Rune of Dagaz
 | link        = Runes
 | description = Unlocked a new item.
 | unlocked by = Complete [[Darkness Falls|Darkness Falls (challenge #4)]]
 | id          = 92
}} {{infobox achievement
 | name        = Rune of Ansuz
 | link        = Runes
 | description = Unlocked a new item.
 | unlocked by = Complete [[The Tank|The Tank (challenge #5)]]
 | id          = 93
}} {{infobox achievement
 | name        = Rune of Perthro
 | link        = Runes
 | description = Unlocked a new item.
 | unlocked by = Complete [[Solar System|Solar System (challenge #6)]]
 | id          = 94
}} {{infobox achievement
 | name        = Rune of Berkano
 | link        = Runes
 | description = Unlocked a new item.
 | unlocked by = Complete [[Purist|Purist (challenge #20)]]
 | id          = 95
}} {{infobox achievement
 | name        = Rune of Algiz
 | link        = Runes
 | description = Unlocked a new item.
 | unlocked by = Complete [[Cat Got Your Tongue|Cat Got Your Tongue (challenge #8)]]
 | id          = 96
}} {{infobox achievement
 | name        = Chaos Card
 | link        = Chaos Card
 | description = Unlocked a new item.
 | unlocked by = Complete [[Demo Man|Demo Man (challenge #9)]]
 | id          = 97
}} {{infobox achievement
 | name        = Credit Card
 | link        = Credit Card
 | description = Unlocked a new item.
 | unlocked by = Complete [[Cursed!|Cursed (challenge #10)]]
 | id          = 98
}} {{infobox achievement
 | name        = Rules Card
 | link        = Rules Card
 | description = Unlocked a new item.
 | unlocked by = Complete [[Glass Cannon (Challenge)|Glass Cannon (challenge #11)]]
 | id          = 99
}} {{infobox achievement
 | name        = Card Against Humanity
 | link        = A Card Against Humanity
 | description = Unlocked a new item.
 | unlocked by = Complete [[When Life Gives You Lemons|When Life Gives You Lemons (challenge #12)]]
 | id          = 100
}} {{infobox achievement
 | name        = Swallowed Penny
 | link        = Swallowed Penny
 | description = Unlocked a new item.
 | unlocked by = Complete [[Slow Roll|Slow Roll (challenge #15)]]
 | id          = 101
}} {{infobox achievement
 | name        = Robo-Baby 2.0
 | link        = Robo-Baby 2.0
 | description = Unlocked a new item.
 | unlocked by = Complete [[Computer Savvy|Computer Savvy (challenge #16)]]
 | id          = 102
}} {{infobox achievement
 | name        = Death's Touch
 | link        = Death's Touch
 | description = Unlocked a new item.
 | unlocked by = Complete [[Waka Waka|Waka Waka (challenge #17)]]
 | id          = 103
}} {{infobox achievement
 | name        = Technology .5
 | link        = Tech.5
 | description = Unlocked a new item.
 | unlocked by = Complete [[The Host|The Host (challenge #18)]]
 | id          = 104
}} {{infobox achievement
 | name        = Missing No.
 | link        = Missing No.
 | description = Unlocked a new item.
 | unlocked by = Complete the [[Boss Rush]] as [[Lazarus]]
 | id          = 105
}} {{infobox achievement
 | name        = Isaac's Tears
 | link        = Isaac's Tears
 | description = Unlocked a new item.
 | unlocked by = Defeat [[Isaac (Boss)|Isaac]] as [[Isaac]]
 | id          = 106
}} {{infobox achievement
 | name        = Guillotine
 | link        = Guillotine
 | description = Unlocked a new item.
 | unlocked by = Defeat [[Isaac (Boss)|Isaac]] as [[Judas]]
 | id          = 107
}} {{infobox achievement
 | name        = Judas' Shadow
 | link        = Judas' Shadow
 | description = Unlocked a new item.
 | unlocked by = Complete the [[Boss Rush]] as [[Judas]]
 | id          = 108
}} {{infobox achievement
 | name        = Maggy's Bow
 | link        = Maggy's Bow
 | description = Unlocked a new item.
 | unlocked by = Complete the [[Boss Rush]] as [[Magdalene]]
 | id          = 109
}} {{infobox achievement
 | name        = Cain's Other Eye
 | link        = Cain's Other Eye
 | description = Unlocked a new item.
 | unlocked by = Complete the [[Boss Rush]] as [[Cain]]
 | id          = 110
}} {{infobox achievement
 | name        = Black Lipstick
 | link        = Black Lipstick
 | description = Unlocked a new item.
 | unlocked by = Defeat [[The Lamb]] as [[Eve]]
 | id          = 111
}} {{infobox achievement
 | name        = Eve's Mascara
 | link        = Eve's Mascara
 | description = Unlocked a new item.
 | unlocked by = Complete the [[Boss Rush]] as [[Eve]]
 | id          = 112
}} {{infobox achievement
 | name        = Fate
 | link        = Fate
 | description = Unlocked a new item.
 | unlocked by = Defeat [[??? (Boss)|???]] as [[??? (Character)|???]]
 | id          = 113
}} {{infobox achievement
 | name        = ???'s Only Friend
 | link        = ???'s Only Friend
 | image       = achievement Blue Baby's Only_Friend_icon.png
 | description = Unlocked a new item.
 | unlocked by = Complete the [[Boss Rush]] as [[??? (Character)|???]]
 | id          = 114
}} {{infobox achievement
 | name        = Samson's Chains
 | link        = Samson's Chains
 | description = Unlocked a new item.
 | unlocked by = Complete the [[Boss Rush]] as [[Samson]]
 | id          = 115
}} {{infobox achievement
 | name        = Lazarus' Rags
 | link        = Lazarus' Rags
 | description = Unlocked a new item.
 | unlocked by = Defeat [[Isaac (Boss)|Isaac]] as [[Lazarus]]
 | id          = 116
}} {{infobox achievement
 | name        = Broken Ankh
 | link        = Broken Ankh
 | description = Unlocked a new item.
 | unlocked by = Defeat [[Satan]] as [[Lazarus]]
 | id          = 117
}} {{infobox achievement
 | name        = Store Credit
 | link        = Store Credit
 | description = Unlocked a new item.
 | unlocked by = Defeat [[??? (Boss)|???]] as [[Lazarus]]
 | id          = 118
}} {{infobox achievement
 | name        = Pandora's Box
 | link        = Pandora's Box
 | description = Unlocked a new item.
 | unlocked by = Defeat [[The Lamb]] as [[Lazarus]]
 | id          = 119
}} {{infobox achievement
 | name        = Suicide King
 | link        = Suicide King
 | description = Unlocked a new item.
 | unlocked by = Complete [[Suicide King (Challenge)|Suicide King (challenge #7)]]
 | id          = 120
}} {{infobox achievement
 | name        = Blank Card
 | link        = Blank Card
 | description = Unlocked a new item.
 | unlocked by = Defeat [[Isaac (Boss)|Isaac]] as [[Eden]]
 | id          = 121
}} {{infobox achievement
 | name        = Book of Secrets
 | link        = Book of Secrets
 | description = Unlocked a new item.
 | unlocked by = Defeat [[Satan]] as [[Eden]]
 | id          = 122
}} {{infobox achievement
 | name        = Mysterious Paper
 | link        = Mysterious Paper
 | description = Unlocked a new item.
 | unlocked by = Beat [[??? (Boss)|???]] as [[Eden]]
 | id          = 123
}} {{infobox achievement
 | name        = Mystery Sack
 | link        = Mystery Sack
 | description = Unlocked a new item.
 | unlocked by = Defeat [[The Lamb]] as [[Eden]]
 | id          = 124
}} {{infobox achievement
 | name        = Undefined
 | link        = Undefined
 | description = Unlocked a new item.
 | unlocked by = Complete the [[Boss Rush]] as [[Eden]]
 | id          = 125
}} {{infobox achievement
 | name        = Satanic Bible
 | link        = Satanic Bible
 | description = Unlocked a new item.
 | unlocked by = Defeat [[Isaac (Boss)|Isaac]] as [[Azazel]]
 | id          = 126
}} {{infobox achievement
 | name        = Daemon's Tail
 | link        = Daemon's Tail
 | description = Unlocked a new item.
 | unlocked by = Defeat [[Satan]] as [[Azazel]]
 | id          = 127
}} {{infobox achievement
 | name        = Abaddon
 | link        = Abaddon
 | description = Unlocked a new item.
 | unlocked by = Defeat [[??? (Boss)|???]] as [[Azazel]]
 | id          = 128
}} {{infobox achievement
 | name        = Isaac's Heart
 | link        = Isaac's Heart
 | description = Unlocked a new item.
 | unlocked by = Defeat [[Isaac (Boss)|Isaac]] as [[The Lost]]
 | id          = 129
}} {{infobox achievement
 | name        = The Mind
 | link        = The Mind
 | description = Unlocked a new item.
 | unlocked by = Defeat [[Satan]] as [[The Lost]]
 | id          = 130
}} {{infobox achievement
 | name        = The Body
 | link        = The Body
 | description = Unlocked a new item.
 | unlocked by = Defeat [[??? (Boss)|???]] as [[The Lost]]
 | id          = 131
}} {{infobox achievement
 | name        = The Soul
 | link        = The Soul
 | description = Unlocked a new item.
 | unlocked by = Defeat [[The Lamb]] as [[The Lost]]
 | id          = 132
}} {{infobox achievement
 | name        = The D100
 | link        = D100
 | description = Unlocked a new item.
 | unlocked by = Complete the [[Boss Rush]] as [[The Lost]]
 | id          = 133
}} {{infobox achievement
 | name        = Blue Map
 | link        = Blue Map
 | description = Unlocked a new item.
 | unlocked by = Donate 10 coins to the [[Donation Machine]]
 | id          = 134
}} {{infobox achievement
 | name        = There's Options
 | link        = There's Options
 | description = Unlocked a new item.
 | unlocked by = Donate 50 coins to the [[Donation Machine]]
 | id          = 135
}} {{infobox achievement
 | name        = Black Candle
 | link        = Black Candle
 | description = Unlocked a new item
 | unlocked by = Donate 150 coins to the [[Donation Machine]]
 | id          = 136
}} {{infobox achievement
 | name        = Red Candle
 | link        = Red Candle
 | description = Unlocked a new item.
 | unlocked by = Donate 400 coins to the [[Donation Machine]]
 | id          = 137
}} {{infobox achievement
 | name        = Stop Watch
 | link        = Stop Watch
 | description = Unlocked a new item
 | unlocked by = Donate 999 coins to the [[Donation Machine]]
 | id          = 138
}} {{infobox achievement
 | name        = Wire Coat Hanger
 | link        = Wire Coat Hanger
 | description = Unlocked a new item.
 | unlocked by = Defeat [[Mom's Heart]] 4 times
 | id          = 139
}} {{infobox achievement
 | name        = Ipecac
 | link        = Ipecac
 | description = Unlocked a new item.
 | unlocked by = Defeat [[Mom's Heart]] 6 times
 | id          = 140
}} {{infobox achievement
 | name        = Experimental Treatment
 | link        = Experimental Treatment
 | description = Unlocked a new item.
 | unlocked by = Defeat [[Mom's Heart]] 7 times
 | id          = 141
}} {{infobox achievement
 | name        = Krampus
 | link        = Krampus
 | description = Unlocked another miniboss!
 | unlocked by = Take 20 [[Devil Room (Item Pool)|items from Devil Rooms]]
 | id          = 142
}} {{infobox achievement
 | name        = Head of Krampus
 | link        = Head of Krampus
 | description = Unlocked a new item.
 | unlocked by = Defeat [[Krampus]]
 | id          = 143
}} {{infobox achievement
 | name        = Super Meat Boy
 | link        = Cube of Meat
 | description = Built him out of meat cubes.
 | unlocked by = Make a Super Meat Boy by picking up {{i|Cube of Meat}} 4 times in one run; see [[Cube of Meat#Methods to create a Super Meat Boy|methods to create a Super Meat Boy]]
 | id          = 144
}} {{infobox achievement
 | name        = Butter Bean
 | link        = Butter Bean
 | description = Unlocked a new item.
 | unlocked by = Destroy 100 [[poop]]s
 | id          = 145
}} {{infobox achievement
 | name        = Little Baggy
 | link        = Little Baggy
 | description = Unlocked a new item.
 | unlocked by = Collect 2 of either {{i|Roid Rage}}, {{i|The Virus}}, {{i|Growth Hormones}}, {{i|Experimental Treatment}} or {{i|Speed Ball}} 
 | id          = 146
}} {{infobox achievement
 | name        = Blood Bag
 | link        = Blood Bag
 | description = Unlocked a new item.
 | unlocked by = Use the [[Blood Donation Machine]] 30 times
 | id          = 147
}} {{infobox achievement
 | name        = The D4
 | link        = D4
 | description = Unlocked a new item.
 | unlocked by = Blow up 30 [[Arcade]] machines
 | id          = 148
}} {{infobox achievement
 | name        = Missing Poster
 | link        = Missing Poster
 | description = Unlocked a new item.
 | unlocked by = Defeat [[The Lamb]] as [[Isaac]]
 | id          = 149
}} {{infobox achievement
 | name        = Rubber Cement
 | link        = Rubber Cement
 | description = Unlocked a new item.
 | unlocked by = Defeat [[Mom's Heart]] 2 times
 | id          = 150
}} {{infobox achievement
 | name        = Store Upgrade lv.1
 | link        = Donation machine
 | description = Donated 20 pennies to the shop.
 | unlocked by = Donate 20 coins to the [[Donation Machine]]
 | id          = 151
}} {{infobox achievement
 | name        = Store Upgrade lv.2
 | link        = Donation machine
 | description = Donated 100 pennies to the shop.
 | unlocked by = Donate 100 coins to the [[Donation Machine]]
 | id          = 152
}} {{infobox achievement
 | name        = Store Upgrade lv.3
 | link        = Donation machine
 | description = Donated 200 pennies to the shop.
 | unlocked by = Donate 200 coins to the [[Donation Machine]]
 | id          = 153
}} {{infobox achievement
 | name        = Store Upgrade lv.4
 | link        = Donation machine
 | description = Donated 600 pennies to the shop.
 | unlocked by = Donate 600 coins to the [[Donation Machine]]
 | id          = 154
}} {{infobox achievement
 | name        = Angels
 | link        = Angel
 | description = They are waiting.
 | unlocked by = Complete [[chapter 6]]
 | id          = 155
}} {{infobox achievement
 | name        = Godhead
 | link        = Godhead
 | description = Unlocked a new item.
 | unlocked by = Earn all {{dlc|na}} 5 / {{dlc|ana+}} 9 (except the cent sign for [[Ultra Greed]]) / {{dlc|a+}} 10 [[completion mark]]s on [[Hard mode]] as [[The Lost]]
 | id          = 156
}} {{infobox achievement
 | name        = Darkness Falls
 | link        = Darkness Falls
 | description = Unlocked Challenge #4.
 | unlocked by = Defeat [[Mom's Heart]] 11 times
 | id          = 157
}} {{infobox achievement
 | name        = The Tank
 | link        = The Tank
 | description = Unlocked Challenge #5.
 | unlocked by = Have 7 or more Red [[Heart container]]s at one time
 | id          = 158
}} {{infobox achievement
 | name        = Solar System
 | link        = Solar System
 | description = Unlocked Challenge #6.
 | unlocked by = Defeat [[Mom's Heart]] 3 times
 | id          = 159
}} {{infobox achievement
 | name          = Suicide King 2
 | override name = Suicide King
 | link          = Suicide King (Challenge)
 | description   = Unlocked Challenge #7.
 | unlocked by   = Defeat [[Mom's Heart]] 11 times
 | id            = 160
}} {{infobox achievement
 | name        = Cat Got Your Tongue
 | link        = Cat Got Your Tongue
 | description = Unlocked Challenge #8.
 | unlocked by = Become [[Guppy]]
 | id          = 161
}} {{infobox achievement
 | name        = Demo Man
 | link        = Demo Man
 | description = Unlocked Challenge #9.
 | unlocked by = Defeat [[Mom's Heart]] 9 times
 | id          = 162
}} {{infobox achievement
 | name        = Cursed!
 | link        = Cursed!
 | description = Unlocked Challenge #10.
 | unlocked by = Have 7 or more Red [[Heart Container]]s at one time
 | id          = 163
}} {{infobox achievement
 | name        = Glass Cannon
 | link        = Glass Cannon (Challenge)
 | description = Unlocked Challenge #11.
 | unlocked by = Beat [[The Family Man|The Family Man (challenge #19)]] and defeat [[Lokii]]
 | id          = 164
}} {{infobox achievement
 | name        = The Family Man
 | link        = The Family Man
 | description = Unlocked Challenge #19.
 | unlocked by = Pick up both Key Pieces from the [[Angel]]s in one run
 | id          = 165
}} {{infobox achievement
 | name        = Purist
 | link        = Purist
 | description = Unlocked Challenge #20.
 | unlocked by = Defeat [[Mom]]
 | id          = 166
}} {{infobox achievement
 | name        = Lost Baby
 | link        = Babies
 | description = Unlocked a new co-player baby.
 | unlocked by = Defeat [[Mom's Heart]] on [[Hard mode]] as [[Isaac]]
 | id          = 167
}} {{infobox achievement
 | name        = Cute Baby
 | link        = Babies
 | description = Unlocked a new co-player baby.
 | unlocked by = Defeat [[Mom's Heart]] on [[Hard mode]] as [[Magdalene]]
 | id          = 168
}} {{infobox achievement
 | name        = Crow Baby
 | link        = Babies
 | description = Unlocked a new co-player baby.
 | unlocked by = Defeat [[Mom's Heart]] on [[Hard mode]] as [[Eve]]
 | id          = 169
}} {{infobox achievement
 | name        = Shadow Baby
 | link        = Babies
 | description = Unlocked a new co-player baby.
 | unlocked by = Defeat [[Mom's Heart]] on [[Hard mode]] as [[Judas]]
 | id          = 170
}} {{infobox achievement
 | name        = Glass Baby
 | link        = Babies
 | description = Unlocked a new co-player baby.
 | unlocked by = Defeat [[Mom's Heart]] on [[Hard mode]] as [[Cain]]
 | id          = 171
}} {{infobox achievement
 | name        = Wrapped Baby
 | link        = Babies
 | description = Unlocked a new co-player baby.
 | unlocked by = {{dlc|na+}} Defeat [[Mom's Heart]] on [[Hard mode]] as [[Azazel]]<br>{{dlc|a+}} Defeat [[Mom's Heart]] on [[Hard mode]] as [[Lazarus]]
 | id          = 172
}} {{infobox achievement
 | name        = Begotten Baby
 | link        = Babies
 | description = Unlocked a new co-player baby.
 | unlocked by = {{dlc|na+}} Defeat [[Mom's Heart]] on [[Hard mode]] as [[Lazarus]]<br>{{dlc|a+}} Defeat [[Mom's Heart]] on [[Hard mode]] as [[Azazel]]
 | id          = 173
}} {{infobox achievement
 | name        = Dead Baby
 | link        = Babies
 | description = Unlocked a new co-player baby.
 | unlocked by = Defeat [[Mom's Heart]] on [[Hard mode]] as [[??? (Character)|???]]
 | id          = 174
}} {{infobox achievement
 | name        = -0- Baby
 | link        = Babies
 | description = Unlocked a new co-player baby.
 | unlocked by = Defeat [[Mom's Heart]] on [[Hard mode]] as [[The Lost]]
 | id          = 175
}} {{infobox achievement
 | name        = Glitch Baby
 | link        = Babies
 | description = Unlocked a new co-player baby.
 | unlocked by = Defeat [[Mom's Heart]] on [[Hard mode]] as [[Eden]]
 | id          = 176
}} {{infobox achievement
 | name        = Fighting Baby
 | link        = Babies
 | description = Unlocked a new co-player baby.
 | unlocked by = Defeat [[Mom's Heart]] on [[Hard mode]] as [[Samson]]
 | id          = 177
}} {{infobox achievement
 | name        = Lord of the Flies
 | link        = Beelzebub
 | description = You became Lord of the Flies.
 | unlocked by = Become [[Beelzebub]]
 | id          = 178
}}
}}

=== [[The Binding of Isaac: Afterbirth|Afterbirth]] ===
{{table | achievement |
{{infobox achievement
 | dlc         = a
 | name        = Fart Baby
 | link        = Farting Baby
 | description = Unlocked a new item.
 | unlocked by = Defeat [[Hush]] as [[Isaac]]
 | id          = 179
}} {{infobox achievement
 | dlc         = a
 | name        = Purity
 | link        = Purity
 | description = Unlocked a new item.
 | unlocked by = Defeat [[Hush]] as [[Magdalene]]
 | id          = 180
}} {{infobox achievement
 | dlc         = a
 | name        = D12
 | link        = D12
 | description = Unlocked a new item.
 | unlocked by = Defeat [[Hush]] as [[Cain]]
 | id          = 181
}} {{infobox achievement
 | dlc         = a
 | name        = Betrayal
 | link        = Betrayal
 | description = Unlocked a new item.
 | unlocked by = Defeat [[Hush]] as [[Judas]]
 | id          = 182
}} {{infobox achievement
 | dlc         = a
 | name        = Fate's Reward
 | link        = Fate's Reward
 | description = Unlocked a new item.
 | unlocked by = Defeat [[Hush]] as [[??? (Character)|???]]
 | id          = 183
}} {{infobox achievement
 | dlc         = a
 | name        = Athame
 | link        = Athame
 | description = Unlocked a new item.
 | unlocked by = Defeat [[Hush]] as [[Eve]]
 | id          = 184
}} {{infobox achievement
 | dlc         = a
 | name        = Blind Rage
 | link        = Blind Rage
 | description = Unlocked a new item.
 | unlocked by = Defeat [[Hush]] as [[Samson]]
 | id          = 185
}} {{infobox achievement
 | dlc         = a
 | name        = Maw of the Void
 | link        = Maw of the Void
 | description = Unlocked a new item.
 | unlocked by = Defeat [[Hush]] as [[Azazel]]
 | id          = 186
}} {{infobox achievement
 | dlc         = a
 | name        = Empty Vessel
 | link        = Empty Vessel
 | description = Unlocked a new item.
 | unlocked by = Defeat [[Hush]] as [[Lazarus]]
 | id          = 187
}} {{infobox achievement
 | dlc         = a
 | name        = Eden's Blessing
 | link        = Eden's Blessing
 | description = Unlocked a new item.
 | unlocked by = Defeat [[Hush]] as [[Eden]]
 | id          = 188
}} {{infobox achievement
 | dlc         = a
 | name        = Sworn Protector
 | link        = Sworn Protector
 | description = Unlocked a new item.
 | unlocked by = Defeat [[Hush]] as [[The Lost]]
 | id          = 189
}} {{infobox achievement
 | dlc         = a
 | name        = Incubus
 | link        = Incubus
 | description = Unlocked a new item.
 | unlocked by = Defeat [[Hush]] as [[Lilith]]
 | id          = 190
}} {{infobox achievement
 | dlc         = a
 | name        = Keeper now holds... A Penny!
 | link        = Keeper
 | full link   = [[Keeper]] now holds... A [[Penny]]!
 | description = Unlocked a new item.
 | unlocked by = Defeat [[Hush]] as [[Keeper]]
 | id          = 191
}} {{infobox achievement
 | dlc         = a
 | name        = Lil' Chest
 | link        = Lil Chest
 | description = Unlocked a new item.
 | unlocked by = Defeat [[Ultra Greed]] as [[Isaac]]
 | id          = 192
}} {{infobox achievement
 | dlc         = a
 | name        = Censer
 | link        = Censer
 | description = Unlocked a new item.
 | unlocked by = Defeat [[Ultra Greed]] as [[Magdalene]]
 | id          = 193
}} {{infobox achievement
 | dlc         = a
 | name        = Evil Eye
 | link        = Evil Eye
 | description = Unlocked a new item.
 | unlocked by = Defeat [[Ultra Greed]] as [[Cain]]
 | id          = 194
}} {{infobox achievement
 | dlc         = a
 | name        = My Shadow
 | link        = My Shadow
 | description = Unlocked a new item.
 | unlocked by = Defeat [[Ultra Greed]] as [[Judas]]
 | id          = 195
}} {{infobox achievement
 | dlc         = a
 | name        = Cracked Dice
 | link        = Cracked Dice
 | description = Unlocked a new item.
 | unlocked by = Defeat [[Ultra Greed]] as [[??? (Character)|???]]
 | id          = 196
}} {{infobox achievement
 | dlc         = a
 | name        = Black Feather
 | link        = Black Feather
 | description = Unlocked a new item.
 | unlocked by = Defeat [[Ultra Greed]] as [[Eve]]
 | id          = 197
}} {{infobox achievement
 | dlc         = a
 | name        = Lusty Blood
 | link        = Lusty Blood
 | description = Unlocked a new item.
 | unlocked by = Defeat [[Ultra Greed]] as [[Samson]]
 | id          = 198
}} {{infobox achievement
 | dlc         = a
 | name        = Lilith
 | link        = Lilith
 | description = Unlocked a new character.
 | unlocked by = Defeat [[Ultra Greed]] as [[Azazel]]
 | id          = 199
}} {{infobox achievement
 | dlc         = a
 | name        = Key Bum
 | link        = Key Bum
 | description = Unlocked a new item.
 | unlocked by = Defeat [[Ultra Greed]] as [[Lazarus]]
 | id          = 200
}} {{infobox achievement
 | dlc         = a
 | name        = GB Bug
 | link        = GB Bug
 | description = Unlocked a new item.
 | unlocked by = Defeat [[Ultra Greed]] as [[Eden]]
 | id          = 201
}} {{infobox achievement
 | dlc         = a
 | name        = Zodiac
 | link        = Zodiac
 | description = Unlocked a new item.
 | unlocked by = Defeat [[Ultra Greed]] as [[The Lost]]
 | id          = 202
}} {{infobox achievement
 | dlc         = a
 | name        = Box of Friends
 | link        = Box of Friends
 | description = Unlocked a new item.
 | unlocked by = Defeat [[Ultra Greed]] as [[Lilith]]
 | id          = 203
}} {{infobox achievement
 | dlc         = a
 | name        = Rib of Greed
 | link        = Rib of Greed
 | description = Unlocked a new item.
 | unlocked by = Defeat [[Ultra Greed]] as [[Keeper]]
 | id          = 204
}} {{infobox achievement
 | dlc         = a
 | name        = Cry Baby
 | link        = Babies
 | description = Unlocked a new co-player baby.
 | unlocked by = Defeat [[Mega Satan]] as [[Isaac]]
 | id          = 205
}} {{infobox achievement
 | dlc         = a
 | name        = Red Baby
 | link        = Babies
 | description = Unlocked a new co-player baby.
 | unlocked by = Defeat [[Mega Satan]] as [[Magdalene]]
 | id          = 206
}} {{infobox achievement
 | dlc         = a
 | name        = Green Baby
 | link        = Babies
 | description = Unlocked a new co-player baby.
 | unlocked by = Defeat [[Mega Satan]] as [[Cain]]
 | id          = 207
}} {{infobox achievement
 | dlc         = a
 | name        = Brown Baby
 | link        = Babies
 | description = Unlocked a new co-player baby.
 | unlocked by = Defeat [[Mega Satan]] as [[Judas]]
 | id          = 208
}} {{infobox achievement
 | dlc         = a
 | name        = Blue Baby
 | link        = Babies
 | description = Unlocked a new co-player baby.
 | unlocked by = Defeat [[Mega Satan]] as [[??? (Character)|???]]
 | id          = 209
}} {{infobox achievement
 | dlc         = a
 | name        = Lil' Baby
 | link        = Babies
 | description = Unlocked a new co-player baby.
 | unlocked by = Defeat [[Mega Satan]] as [[Eve]]
 | id          = 210
}} {{infobox achievement
 | dlc         = a
 | name        = Rage Baby
 | link        = Babies
 | description = Unlocked a new co-player baby.
 | unlocked by = Defeat [[Mega Satan]] as [[Samson]]
 | id          = 211
}} {{infobox achievement
 | dlc         = a
 | name        = Black Baby
 | link        = Babies
 | description = Unlocked a new co-player baby.
 | unlocked by = Defeat [[Mega Satan]] as [[Azazel]]
 | id          = 212
}} {{infobox achievement
 | dlc         = a
 | name        = Long Baby
 | link        = Babies
 | description = Unlocked a new co-player baby.
 | unlocked by = Defeat [[Mega Satan]] as [[Lazarus]]
 | id          = 213
}} {{infobox achievement
 | dlc         = a
 | name        = Yellow Baby
 | link        = Babies
 | description = Unlocked a new co-player baby.
 | unlocked by = Defeat [[Mega Satan]] as [[Eden]]
 | id          = 214
}} {{infobox achievement
 | dlc         = a
 | name        = White Baby
 | link        = Babies
 | description = Unlocked a new co-player baby.
 | unlocked by = Defeat [[Mega Satan]] as [[The Lost]]
 | id          = 215
}} {{infobox achievement
 | dlc         = a
 | name        = Big Baby
 | link        = Babies
 | description = Unlocked a new co-player baby.
 | unlocked by = Defeat [[Mega Satan]] as [[Lilith]]
 | id          = 216
}} {{infobox achievement
 | dlc         = a
 | name        = Noose Baby
 | link        = Babies
 | description = Unlocked a new co-player baby.
 | unlocked by = Defeat [[Mega Satan]] as [[Keeper]]
 | id          = 217
}} {{infobox achievement
 | dlc         = a
 | name        = Rune Bag
 | link        = Rune Bag
 | description = Unlocked a new item.
 | unlocked by = Defeat [[Isaac (Boss)|Isaac]] as [[Lilith]]
 | id          = 218
}} {{infobox achievement
 | dlc         = a
 | name        = Cambion Conception
 | link        = Cambion Conception
 | description = Unlocked a new item.
 | unlocked by = Defeat [[??? (Boss)|???]] as [[Lilith]]
 | id          = 219
}} {{infobox achievement
 | dlc         = a
 | name        = Serpent's Kiss
 | link        = Serpent's Kiss
 | description = Unlocked a new item.
 | unlocked by = Defeat [[Satan]] as [[Lilith]]
 | id          = 220
}} {{infobox achievement
 | dlc         = a
 | name        = Succubus
 | link        = Succubus
 | description = Unlocked a new item.
 | unlocked by = Defeat [[The Lamb]] as [[Lilith]]
 | id          = 221
}} {{infobox achievement
 | dlc         = a
 | name        = Immaculate Conception
 | link        = Immaculate Conception
 | description = Unlocked a new item.
 | unlocked by = Complete the [[Boss Rush]] as [[Lilith]]
 | id          = 222
}} {{infobox achievement
 | dlc         = a
 | name        = Goat Head Baby
 | link        = Babies
 | description = Unlocked a new co-player baby.
 | unlocked by = Defeat [[Mom's Heart]] on [[Hard mode]] as [[Lilith]]
 | id          = 223
}} {{infobox achievement
 | dlc         = a
 | name        = Gold Heart
 | link        = Hearts (Pickup)
 | description = Unlocked a new item.
 | unlocked by = Complete [[XXXXXXXXL|XXXXXXXXL (challenge #21)]]
 | id          = 224
}} {{infobox achievement
 | dlc         = a
 | name        = Get out of Jail Free Card
 | link        = Get out of Jail Free Card
 | description = Unlocked a new item.
 | unlocked by = Complete [[SPEED!|SPEED! (challenge #22)]]
 | id          = 225
}} {{infobox achievement
 | dlc         = a
 | name        = Gold Bomb
 | link        = Gold Bomb
 | description = Unlocked a new item.
 | unlocked by = Complete [[Blue Bomber|Blue Bomber (challenge #23)]]
 | id          = 226
}} {{infobox achievement
 | dlc         = a
 | name        = 2 new pills
 | link        = Pill
 | description = Unlocked a new item.
 | unlocked by = Complete [[PAY TO PLAY|PAY TO PLAY (challenge #24)]]
 | id          = 227
}} {{infobox achievement
 | dlc           = a
 | name          = 2 new pills 2
 | override name = 2 new pills
 | link          = Pill
 | description   = Unlocked a new item.
 | unlocked by   = Complete [[Have a Heart|Have a Heart (challenge #25)]]
 | id            = 228
}} {{infobox achievement
 | dlc         = a
 | name        = Poker Chip
 | link        = Poker Chip
 | description = Unlocked a new item.
 | unlocked by = Complete [[I RULE!|I RULE! (challenge #26)]]
 | id          = 229
}} {{infobox achievement
 | dlc         = a
 | name        = Stud Finder
 | link        = Stud Finder
 | description = Unlocked a new item.
 | unlocked by = Complete [[BRAINS!|BRAINS! (challenge #27)]]
 | id          = 230
}} {{infobox achievement
 | dlc         = a
 | name        = D8
 | link        = D8
 | description = Unlocked a new item.
 | unlocked by = Complete [[PRIDE DAY!|PRIDE DAY! (challenge #28)]]
 | id          = 231
}} {{infobox achievement
 | dlc         = a
 | name        = Kidney Stone
 | link        = Kidney Stone
 | description = Unlocked a new item.
 | unlocked by = {{dlc|na+}} Complete [[The Guardian|The Guardian (challenge #30)]]<br>{{dlc|a+}} Complete [[Onan's Streak|Onan's Streak (challenge #29)]]
 | id          = 232
}} {{infobox achievement
 | dlc         = a
 | name        = Blank Rune
 | link        = Blank Rune
 | description = Unlocked a new item.
 | unlocked by = {{dlc|na+}} Complete [[Onan's Streak|Onan's Streak (challenge #29)]]<br>{{dlc|a+}} Complete [[The Guardian|The Guardian (challenge #30)]]
 | id          = 233
}} {{infobox achievement
 | dlc         = a
 | name        = Blue Womb
 | link        = Blue Womb
 | description = Unlocked a hidden chapter.
 | unlocked by = Defeat [[Mom's Heart]] 10 times
 | id          = 234
}} {{infobox achievement
 | dlc         = a
 | name        = 1001%
 | description = Nerd x 1000000
 | unlocked by = Unlock all of the secrets and [[ending]]s, and [[collection page|collect]] every item in the game
 | id          = 235
}} {{infobox achievement
 | dlc         = a
 | name        = Keeper holds Wooden Nickel
 | link        = Keeper
 | full link   = [[Keeper]] holds [[Wooden Nickel]]
 | description = Unlocked a new starting item.
 | unlocked by = Defeat [[Isaac (Boss)|Isaac]] as [[Keeper]]
 | id          = 236
}} {{infobox achievement
 | dlc         = a
 | name        = Keeper holds Store Key
 | link        = Keeper
 | full link   = [[Keeper]] holds [[Store Key]]
 | description = Unlocked a new starting item.
 | unlocked by = Defeat [[Satan]] as [[Keeper]]
 | id          = 237
}} {{infobox achievement
 | dlc         = a
 | name        = Deep Pockets
 | link        = Deep Pockets
 | description = Unlocked a new item.
 | unlocked by = Defeat [[??? (Boss)|???]] as [[Keeper]]
 | id          = 238
}} {{infobox achievement
 | dlc         = a
 | name        = Karma
 | link        = Karma
 | description = Unlocked a new item.
 | unlocked by = Defeat [[The Lamb]] as [[Keeper]]
 | id          = 239
}} {{infobox achievement
 | dlc         = a
 | name        = Sticky Nickels
 | link        = Sticky nickel
 | description = Unlocked a new item.
 | unlocked by = Complete the [[Boss Rush]] as [[Keeper]]
 | id          = 240
}} {{infobox achievement
 | dlc         = a
 | name        = Super Greed Baby
 | link        = Babies
 | description = Unlocked a new co-player baby.
 | unlocked by = Defeat [[Mom's Heart]] on [[Hard mode]] as [[Keeper]]
 | id          = 241
}} {{infobox achievement
 | dlc         = a
 | name        = Lucky Pennies
 | link        = Lucky penny
 | description = Unlocked a new item.
 | unlocked by = Donate 1 coin to the [[Greed Donation Machine]]
 | id          = 242
}} {{infobox achievement
 | dlc         = a
 | name        = Special Hanging Shopkeepers
 | link        = Special shopkeeper
 | description = Unlocked a secret.
 | unlocked by = Donate 10 coins to the [[Greed Donation Machine]]
 | id          = 243
}} {{infobox achievement
 | dlc         = a
 | name        = Wooden Nickel
 | link        = Wooden Nickel
 | description = Unlocked a new item.
 | unlocked by = Donate 30 coins to the [[Greed Donation Machine]]
 | id          = 244
}} {{infobox achievement
 | dlc         = a
 | name        = Cain holds Paperclip
 | link        = Cain
 | full link   = [[Cain]] holds [[Paper Clip|Paperclip]]
 | description = Unlocked a new starting item.
 | unlocked by = Donate 68 coins to the [[Greed Donation Machine]]
 | id          = 245
}} {{infobox achievement
 | dlc         = a
 | name        = Everything is Terrible 2!!!
 | link        = Ultra Greed
 | description = Greed just got harder!
 | unlocked by = Donate 111 coins to the [[Greed Donation Machine]]
 | id          = 246
}} {{infobox achievement
 | dlc         = a
 | name        = Special Shopkeepers
 | link        = Special shopkeeper
 | description = Unlocked a secret.
 | unlocked by = Donate 234 coins to the [[Greed Donation Machine]]
 | id          = 247
}} {{infobox achievement
 | dlc         = a
 | name        = Eve now holds Razor Blade
 | link        = Eve
 | full link   = [[Eve]] now holds [[Razor Blade]]
 | description = Unlocked a new starting item.
 | unlocked by = Donate 439 coins to the [[Greed Donation Machine]]
 | id          = 248
}} {{infobox achievement
 | dlc         = a
 | name        = Store Key
 | link        = Store Key
 | description = Unlocked a new item.
 | unlocked by = Donate 666 coins to the [[Greed Donation Machine]]
 | id          = 249
}} {{infobox achievement
 | dlc         = a
 | name        = Lost holds Holy Mantle
 | link        = The Lost
 | full link   = [[The Lost|Lost]] holds [[Holy Mantle]]
 | description = Unlocked a new starting item.
 | unlocked by = Donate 879 coins to the [[Greed Donation Machine]]
 | id          = 250
}} {{infobox achievement
 | dlc         = a
 | name        = Keeper
 | link        = Keeper
 | description = Unlocked a new character.
 | unlocked by = Donate 1000 coins to the [[Greed Donation Machine]]
 | id          = 251
}} {{infobox achievement
 | dlc         = a
 | name        = Hive Baby
 | link        = Babies
 | description = Unlocked a new co-player baby.
 | unlocked by = Earn all [[Hard mode]] [[completion mark]]s as [[??? (Character)|???]]
 | id          = 252
}} {{infobox achievement
 | dlc         = a
 | name        = Buddy Baby
 | link        = Babies
 | description = Unlocked a new co-player baby.
 | unlocked by = Earn all [[Hard mode]] [[completion mark]]s as [[Isaac]]
 | id          = 253
}} {{infobox achievement
 | dlc         = a
 | name        = Colorful Baby
 | link        = Babies
 | description = Unlocked a new co-player baby.
 | unlocked by = Earn all [[Hard mode]] [[completion mark]]s as [[Magdalene]]
 | id          = 254
}} {{infobox achievement
 | dlc         = a
 | name        = Whore Baby
 | link        = Babies
 | description = Unlocked a new co-player baby.
 | unlocked by = Earn all [[Hard mode]] [[completion mark]]s as [[Eve]]
 | id          = 255
}} {{infobox achievement
 | dlc         = a
 | name        = Cracked Baby
 | link        = Babies
 | description = Unlocked a new co-player baby.
 | unlocked by = Earn all [[Hard mode]] [[completion mark]]s as [[Eden]]
 | id          = 256
}} {{infobox achievement
 | dlc         = a
 | name        = Dripping Baby
 | link        = Babies
 | description = Unlocked a new co-player baby.
 | unlocked by = Earn all [[Hard mode]] [[completion mark]]s as [[Lazarus]]
 | id          = 257
}} {{infobox achievement
 | dlc         = a
 | name        = Blinding Baby
 | link        = Babies
 | description = Unlocked a new co-player baby.
 | unlocked by = Use {{i|Blank Card}} while holding {{p|XIX - The Sun}}
 | id          = 258
}} {{infobox achievement
 | dlc         = a
 | name        = Sucky Baby
 | link        = Babies
 | description = Unlocked a new co-player baby.
 | unlocked by = Earn all [[Hard mode]] [[completion mark]]s as [[Azazel]]
 | id          = 259
}} {{infobox achievement
 | dlc         = a
 | name        = Dark Baby
 | link        = Babies
 | description = Unlocked a new co-player baby.
 | unlocked by = Earn all [[Hard mode]] [[completion mark]]s as [[Lilith]]
 | id          = 260
}} {{infobox achievement
 | dlc         = a
 | name        = Picky Baby
 | link        = Babies
 | description = Unlocked a new co-player baby.
 | unlocked by = Earn all [[Hard mode]] [[completion mark]]s as [[Cain]]
 | id          = 261
}} {{infobox achievement
 | dlc         = a
 | name        = Revenge Baby
 | link        = Babies
 | description = Unlocked a new co-player baby.
 | unlocked by = Earn all [[Hard mode]] [[completion mark]]s as [[Samson]]
 | id          = 262
}} {{infobox achievement
 | dlc         = a
 | name        = Belial Baby
 | link        = Babies
 | description = Unlocked a new co-player baby.
 | unlocked by = Earn all [[Hard mode]] [[completion mark]]s as [[Judas]]
 | id          = 263
}} {{infobox achievement
 | dlc         = a
 | name        = Sale Baby
 | link        = Babies
 | description = Unlocked a new co-player baby.
 | unlocked by = Earn all [[Hard mode]] [[completion mark]]s as [[Keeper]]
 | id          = 264
}} {{infobox achievement
 | dlc         = a
 | name        = XXXXXXXXL
 | link        = XXXXXXXXL
 | description = Unlocked Challenge #21.
 | unlocked by = Defeat [[Mom]]
 | id          = 265
}} {{infobox achievement
 | dlc         = a
 | name        = SPEED!
 | link        = SPEED!
 | description = Unlocked Challenge #22.
 | unlocked by = Defeat [[Mom]]
 | id          = 266
}} {{infobox achievement
 | dlc         = a
 | name        = Blue Bomber
 | link        = Blue Bomber
 | description = Unlocked Challenge #23.
 | unlocked by = Destroy 10 [[Tinted Rock]]s and defeat [[Mom's Heart]] 11 times
 | id          = 267
}} {{infobox achievement
 | dlc         = a
 | name        = PAY TO PLAY
 | link        = PAY TO PLAY
 | description = Unlocked Challenge #24.
 | unlocked by = Defeat [[Isaac (Boss)|Isaac]] as [[Cain]]
 | id          = 268
}} {{infobox achievement
 | dlc         = a
 | name        = Have a Heart
 | link        = Have a Heart
 | description = Unlocked Challenge #25.
 | unlocked by = Defeat [[Mom]]
 | id          = 269
}} {{infobox achievement
 | dlc         = a
 | name        = I RULE!
 | link        = I RULE!
 | description = Unlocked Challenge #26.
 | unlocked by = Defeat [[??? (Boss)|???]] or [[The Lamb]], and defeat [[Satan]] as [[Isaac]]
 | id          = 270
}} {{infobox achievement
 | dlc         = a
 | name        = BRAINS!
 | link        = BRAINS!
 | description = Unlocked Challenge #27.
 | unlocked by = Defeat [[Isaac (Boss)|Isaac]] 5 times
 | id          = 271
}} {{infobox achievement
 | dlc         = a
 | name        = PRIDE DAY!
 | link        = PRIDE DAY!
 | description = Unlocked Challenge #28.
 | unlocked by = Defeat [[Mom]]
 | id          = 272
}} {{infobox achievement
 | dlc         = a
 | name        = Onan's Streak
 | link        = Onan's Streak
 | description = Unlocked Challenge #29.
 | unlocked by = Defeat [[Mom]]
 | id          = 273
}} {{infobox achievement
 | dlc         = a
 | name        = The Guardian
 | link        = The Guardian
 | description = Unlocked Challenge #30.
 | unlocked by = Defeat [[Mom]]
 | id          = 274
}} {{infobox achievement
 | dlc         = a
 | name        = Generosity
 | link        = Greed machine
 | description = If only everyone was as generous as you are...
 | unlocked by = Donate 999 coins to the [[Greed Donation Machine]]
 | id          = 275
}} {{infobox achievement
 | dlc         = a
 | name        = Mega
 | link        = Mega Blast
 | description = Unlocked...
 | unlocked by = Defeat [[Mega Satan]] as every character
 | id          = 276
}}
}}

=== [[The Binding of Isaac: Afterbirth †|Afterbirth †]] ===
{{table | achievement |
{{infobox achievement
 | dlc         = a+
 | name        = Backasswards
 | link        = Backasswards
 | description = Unlocked a new challenge.
 | unlocked by = Defeat [[??? (Boss)|???]] or [[The Lamb]]
 | id          = 277
}} {{infobox achievement
 | dlc         = a+
 | name        = Aprils fool
 | link        = Aprils Fool
 | description = Unlocked a new challenge.
 | unlocked by = Defeat [[Mom]]
 | id          = 278
}} {{infobox achievement
 | dlc         = a+
 | name        = Pokey Mans
 | link        = Pokey Mans
 | description = Unlocked a new challenge.
 | unlocked by = Defeat [[Mom's Heart]] 11 times
 | id          = 279
}} {{infobox achievement
 | dlc         = a+
 | name        = Ultra Hard
 | link        = Ultra Hard
 | description = Unlocked a new challenge.
 | unlocked by = Defeat [[??? (Boss)|???]] or [[The Lamb]]. Possession of {{i|The Polaroid}}/{{i|The Negative}} is required, barring getting to {{s|Dark Room}} through a [[Sacrifice Room]].
 | id          = 280
}} {{infobox achievement
 | dlc         = a+
 | name        = PONG
 | link        = Pong
 | description = Unlocked a new challenge.
 | unlocked by = Defeat [[Isaac (Boss)|Isaac]] 5 times
 | id          = 281
}} {{infobox achievement
 | dlc         = a+
 | name        = D Infinity
 | link        = D Infinity
 | description = Unlocked a new item.
 | unlocked by = Defeat [[Delirium]] as [[Isaac]]
 | id          = 282
}} {{infobox achievement
 | dlc         = a+
 | name        = Eucharist
 | link        = Eucharist
 | description = Unlocked a new item.
 | unlocked by = Defeat [[Delirium]] as [[Magdalene]]
 | id          = 283
}} {{infobox achievement
 | dlc         = a+
 | name        = Silver Dollar
 | link        = Silver Dollar
 | description = Unlocked a new item.
 | unlocked by = Defeat [[Delirium]] as [[Cain]]
 | id          = 284
}} {{infobox achievement
 | dlc         = a+
 | name        = Shade
 | link        = Shade
 | description = Unlocked a new item. 
 | unlocked by = Defeat [[Delirium]] as [[Judas]]
 | id          = 285
}} {{infobox achievement
 | dlc         = a+
 | name        = King Baby
 | link        = King Baby
 | description = Unlocked a new co-player baby.
 | unlocked by = Defeat [[Delirium]] as [[??? (Character)|???]]
 | id          = 286
}} {{infobox achievement
 | dlc         = a+
 | name        = Bloody Crown
 | link        = Bloody Crown
 | description = Unlocked a new item.
 | unlocked by = Defeat [[Delirium]] as [[Samson]]
 | id          = 287
}} {{infobox achievement
 | dlc         = a+
 | name        = Dull Razor
 | link        = Dull Razor
 | description = Unlocked a new item.
 | unlocked by = Defeat [[Delirium]] as [[Eve]]
 | id          = 288
}} {{infobox achievement
 | dlc         = a+
 | name        = Eden's Soul
 | link        = Eden's Soul
 | description = Unlocked a new item.
 | unlocked by = Defeat [[Delirium]] as [[Eden]]
 | id          = 289
}} {{infobox achievement
 | dlc         = a+
 | name        = Dark Prince's Crown
 | link        = Dark Prince's Crown
 | description = Unlocked a new item.
 | unlocked by = Defeat [[Delirium]] as [[Azazel]]
 | id          = 290
}} {{infobox achievement
 | dlc         = a+
 | name        = Compound Fracture
 | link        = Compound Fracture
 | description = Unlocked a new item.
 | unlocked by = Defeat [[Delirium]] as [[Lazarus]]
 | id          = 291
}} {{infobox achievement
 | dlc         = a+
 | name        = Euthanasia
 | link        = Euthanasia
 | description = Unlocked a new item.
 | unlocked by = Defeat [[Delirium]] as [[Lilith]]
 | id          = 292
}} {{infobox achievement
 | dlc         = a+
 | name        = Holy Card
 | link        = Holy Card
 | description = Unlocked a new item.
 | unlocked by = Defeat [[Delirium]] as [[The Lost]]
 | id          = 293
}} {{infobox achievement
 | dlc         = a+
 | name        = Crooked Penny
 | link        = Crooked Penny
 | description = Unlocked a new item.
 | unlocked by = Defeat [[Delirium]] as [[Keeper]]
 | id          = 294
}} {{infobox achievement
 | dlc         = a+
 | name        = Void
 | link        = Void
 | description = Unlocked a new item.
 | unlocked by = Defeat [[Delirium]] as [[Apollyon]]
 | id          = 295
}} {{infobox achievement
 | dlc         = a+
 | name        = D1
 | link        = D1
 | description = Unlocked a new item.
 | unlocked by = Defeat [[Ultra Greedier]] as [[Isaac]]
 | id          = 296
}} {{infobox achievement
 | dlc         = a+
 | name        = Glyph of Balance
 | link        = Glyph of Balance
 | description = Unlocked a new item.
 | unlocked by = Defeat [[Ultra Greedier]] as [[Magdalene]]
 | id          = 297
}} {{infobox achievement
 | dlc         = a+
 | name        = Sack of Sacks
 | link        = Sack of Sacks
 | description = Unlocked a new item.
 | unlocked by = Defeat [[Ultra Greedier]] as [[Cain]]
 | id          = 298
}} {{infobox achievement
 | dlc         = a+
 | name        = Eye of Belial
 | link        = Eye of Belial
 | description = Unlocked a new item.
 | unlocked by = Defeat [[Ultra Greedier]] as [[Judas]]
 | id          = 299
}} {{infobox achievement
 | dlc         = a+
 | name        = Meconium
 | link        = Meconium
 | description = Unlocked a new item.
 | unlocked by = Defeat [[Ultra Greedier]] as [[??? (Character)|???]]
 | id          = 300
}} {{infobox achievement
 | dlc         = a+
 | name        = Stem Cell
 | link        = Stem Cell
 | description = Unlocked a new item.
 | unlocked by = Defeat [[Ultra Greedier]] as [[Samson]]
 | id          = 301
}} {{infobox achievement
 | dlc         = a+
 | name        = Crow Heart
 | link        = Crow Heart
 | description = Unlocked a new item.
 | unlocked by = Defeat [[Ultra Greedier]] as [[Eve]]
 | id          = 302
}} {{infobox achievement
 | dlc         = a+
 | name        = Metronome
 | link        = Metronome
 | description = Unlocked a new item.
 | unlocked by = Defeat [[Ultra Greedier]] as [[Eden]]
 | id          = 303
}} {{infobox achievement
 | dlc         = a+
 | name        = Bat Wing
 | link        = Bat Wing
 | description = Unlocked a new item.
 | unlocked by = Defeat [[Ultra Greedier]] as [[Azazel]]
 | id          = 304
}} {{infobox achievement
 | dlc         = a+
 | name        = Plan C
 | link        = Plan C
 | description = Unlocked a new item.
 | unlocked by = Defeat [[Ultra Greedier]] as [[Lazarus]]
 | id          = 305
}} {{infobox achievement
 | dlc         = a+
 | name        = Duality
 | link        = Duality
 | description = Unlocked a new item.
 | unlocked by = Defeat [[Ultra Greedier]] as [[Lilith]]
 | id          = 306
}} {{infobox achievement
 | dlc         = a+
 | name        = Dad's Lost Coin
 | link        = Dad's Lost Coin
 | description = Unlocked a new item.
 | unlocked by = Defeat [[Ultra Greedier]] as [[The Lost]]
 | id          = 307
}} {{infobox achievement
 | dlc         = a+
 | name        = Eye of Greed
 | link        = Eye of Greed
 | description = Unlocked a new item.
 | unlocked by = Defeat [[Ultra Greedier]] as [[Keeper]]
 | id          = 308
}} {{infobox achievement
 | dlc         = a+
 | name        = Black Rune
 | link        = Black Rune
 | description = Unlocked a new item.
 | unlocked by = Defeat [[Ultra Greedier]] as [[Apollyon]]
 | id          = 309
}} {{infobox achievement
 | dlc         = a+
 | name        = Locust of Wrath
 | link        = Locust of War
 | description = Unlocked a new item.
 | unlocked by = Defeat [[Isaac (Boss)|Isaac]] as [[Apollyon]]
 | id          = 310
}} {{infobox achievement
 | dlc         = a+
 | name        = Locust of Pestilence
 | link        = Locust of Pestilence
 | description = Unlocked a new item.
 | unlocked by = Defeat [[Satan]] as [[Apollyon]]
 | id          = 311
}} {{infobox achievement
 | dlc         = a+
 | name        = Locust of Famine
 | link        = Locust of Famine
 | description = Unlocked a new item.
 | unlocked by = Defeat [[??? (Boss)|???]] as [[Apollyon]]
 | id          = 312
}} {{infobox achievement
 | dlc         = a+
 | name        = Locust of Death
 | link        = Locust of Death
 | description = Unlocked a new item.
 | unlocked by = Defeat [[The Lamb]] as [[Apollyon]]
 | id          = 313
}} {{infobox achievement
 | dlc         = a+
 | name        = Locust of Conquest
 | link        = Locust of Conquest
 | description = Unlocked a new item.
 | unlocked by = Complete the [[Boss Rush]] as [[Apollyon]]
 | id          = 314
}} {{infobox achievement
 | dlc         = a+
 | name        = Hushy
 | link        = Hushy
 | description = Unlocked a new item.
 | unlocked by = Defeat [[Hush]] as [[Apollyon]]
 | id          = 315
}} {{infobox achievement
 | dlc         = a+
 | name        = Brown Nugget
 | link        = Brown Nugget
 | description = Unlocked a new item.
 | unlocked by = Defeat [[Ultra Greed]] as [[Apollyon]]
 | id          = 316
}} {{infobox achievement
 | dlc         = a+
 | name        = Mort Baby
 | link        = Babies
 | description = Unlocked a new co-player baby.
 | unlocked by = Defeat [[Mega Satan]] as [[Apollyon]]
 | id          = 317
}} {{infobox achievement
 | dlc         = a+
 | name        = Smelter
 | link        = Smelter
 | description = Unlocked a new item.
 | unlocked by = Defeat [[Mom's Heart]] or [[It Lives!]] on [[Hard mode]] as [[Apollyon]]
 | id          = 318
}} {{infobox achievement
 | dlc         = a+
 | name        = Apollyon Baby
 | link        = Babies
 | description = Unlocked a new co-player baby.
 | unlocked by = Earn all [[Hard mode]] [[completion mark]]s as [[Apollyon]]
 | id          = 319
}} {{infobox achievement
 | dlc         = a+
 | name        = New Area
 | link        = The Void
 | description = Unlocked a new area.
 | unlocked by = Defeat [[Hush]]
 | id          = 320
}} {{infobox achievement
 | dlc         = a+
 | name        = Once More with Feeling!
 | link        = Gulp!
 | description = Unlocked a new item.
 | unlocked by = Complete a [[Victory Lap]], defeating [[The Lamb]]
 | id          = 321
}} {{infobox achievement
 | dlc         = a+
 | name        = Hat trick!
 | link        = Ace of Clubs
 | description = Unlocked a new item.
 | unlocked by = Get a 3-win streak
 | id          = 322
}} {{infobox achievement
 | dlc         = a+
 | name        = 5 Nights at Mom's
 | link        = Super special rock
 | description = Unlocked super special rocks.
 | unlocked by = Get a 5-win streak, using a different character for each win
 | id          = 323
}} {{infobox achievement
 | dlc         = a+
 | name        = Sin collector
 | link        = Feels Like I'm Walking on Sunshine!
 | description = Unlocked a new item.
 | unlocked by = Collect every entry in the Bestiary (bugged v190 - Mobs that don't exist in the bestiary are being counted. This allows Sin Collector to be unlocked without a complete bestiary) <!-- Mobs that don't exist in the bestiary are being counted towards the 281 bestiary total. E.g. Envy is being counted 4 times but only counts for 1 entry in the bestiary. There are 282 entities marked as bestiary in entities2.xml(Minus Moms guts due to 0 basehp). This issue was introduced in v188. -->
 | id          = 324
}} {{infobox achievement
 | dlc         = a+
 | name        = Dedication
 | link        = Horf!
 | description = Unlocked a new item.
 | unlocked by = Participate in 31 [[daily challenge]]s (they don't have to be consecutive; it will still count if you die in the first room)
 | id          = 325
}} {{infobox achievement
 | dlc         = a+
 | name        = ZIP!
 | link        = Ace of Diamonds
 | description = Unlocked a new item.
 | unlocked by = Defeat [[The Lamb]] in under 20 minutes
 | id          = 326
}} {{infobox achievement
 | dlc         = a+
 | name        = It's the Key
 | link        = Ace of Spades (Card)
 | description = Unlocked a new item.
 | unlocked by = Defeat [[The Lamb]] without taking hearts, coins, and bombs through an entire run
 | id          = 327
}} {{infobox achievement
 | dlc         = a+
 | name        = Mr. Resetter!
 | link        = Half soul heart
 | description = Unlocked a new item.
 | unlocked by = Reset 7 times in a row<br>{{plat|Switch}}{{plat|PS4}} Get a minus 10-win streak
 | id          = 328
}} {{infobox achievement
 | dlc         = a+
 | name        = Living on the edge
 | link        = Ace of Hearts
 | description = Unlocked a new item.
 | unlocked by = Complete a floor after The Basement I, start-to-finish, with only half a heart of health (can use [[The Lost]])
 | id          = 329
}} {{infobox achievement
 | dlc         = a+
 | name        = U Broke It!
 | link        = Vurp!
 | description = Unlocked a new item.
 | unlocked by = Obtain 50 items on a run (e.g., via two {{i|Steam Sale}} and {{i|Restock}} - Duplicate passives/familiars count towards the total, e.g., multiple {{i|Breakfast}})
 | id          = 330
}} {{infobox achievement
 | dlc         = a+
 | name        = Laz Bleeds More!
 | link        = Lazarus
 | full link   = [[Lazarus|Laz]] [[Anemic|Bleeds More]]!
 | description = Unlocked a new starting item.
 | unlocked by = Complete [[Backasswards|Backasswards (challenge #31)]]
 | id          = 331
}} {{infobox achievement
 | dlc         = a+
 | name        = Maggy Now Holds a Pill!
 | link        = Magdalene
 | full link   = [[Magdalene|Maggy]] Now Holds a [[Pill]]!
 | description = Unlocked a new starting item.
 | unlocked by = Complete [[Aprils Fool|Aprils Fool (challenge #32)]]
 | id          = 332
}} {{infobox achievement
 | dlc         = a+
 | name        = Charged Key
 | link        = Charged Key
 | description = Unlocked a new item.
 | unlocked by = Complete [[Pokey Mans|Pokey Mans (challenge #33)]]
 | id          = 333
}} {{infobox achievement
 | dlc         = a+
 | name        = Samson Feels Healthy!
 | link        = Samson
 | full link   = [[Samson]] Feels [[Child's Heart|Healthy]]!
 | description = Unlocked a new starting item.
 | unlocked by = Complete [[Ultra Hard|Ultra Hard (challenge #34)]]
 | id          = 334
}} {{infobox achievement
 | dlc         = a+
 | name        = Greed's Gullet
 | link        = Greed's Gullet
 | description = Unlocked a new item.
 | unlocked by = Complete [[Pong|Pong (challenge #35)]]
 | id          = 335
}} {{infobox achievement
 | dlc         = a+
 | name        = The Marathon
 | link        = Cracked Crown
 | description = Unlocked a new item.
 | unlocked by = Get a 5-win streak in the [[daily challenge]]s
 | id          = 336
}} {{infobox achievement
 | dlc         = a+
 | name        = RERUN
 | link        = RERUN
 | description = Unlocked the power of RERUN.
 | unlocked by = Complete 3 [[Victory Lap]]s and start a 4th
 | id          = 337
}} {{infobox achievement
 | dlc         = a+
 | name        = Delirious
 | link        = Delirious
 | description = Unlocked a new item.
 | unlocked by = Defeat [[Delirium]]
 | id          = 338
}} {{infobox achievement
 | dlc         = a+
 | name        = 1000000%
 | description = Just Stop!
 | unlocked by = [[Collection Page (Afterbirth †)|Collect]] every item in the game, unlock all secrets and [[ending]]s, and complete the [[bestiary]] (minus anything added in [[Booster Pack]]s; as of Booster Pack #5, all achievements from Booster Packs, as well as the renewed bestiary, need to completed)
 | id          = 339
}} {{infobox achievement
 | dlc         = a+
 | name        = Apollyon
 | link        = Apollyon
 | description = Unlocked a new character.
 | unlocked by = Defeat [[Mega Satan]]
 | id          = 340
}} {{infobox achievement
 | dlc         = a+
 | name        = Greedier!
 | link        = Greedier Mode
 | description = New mode unlocked!
 | unlocked by = Donate 500 coins to the [[Greed Donation Machine]]
 | id          = 341
}} {{infobox achievement
 | dlc         = a+
 | name        = Burning Basement
 | link        = Burning Basement
 | description = Alt stage to the basement.
 | unlocked by = Defeat [[Mom's Heart]] 11 times
 | id          = 342
}} {{infobox achievement
 | dlc         = a+
 | name        = Flooded Caves
 | link        = Flooded Caves
 | description = Alt stage to the caves.
 | unlocked by = Defeat [[It Lives]] 16 times
 | id          = 343
}} {{infobox achievement
 | dlc         = a+
 | name        = Dank Depths
 | link        = Dank Depths
 | description = Alt stage to the depths.
 | unlocked by = Defeat [[It Lives]] 21 times
 | id          = 344
}} {{infobox achievement
 | dlc         = a+
 | name        = Scarred Womb
 | link        = Scarred Womb
 | description = Alt stage to the womb.
 | unlocked by = Defeat [[It Lives]] 30 times
 | id          = 345
}} {{infobox achievement
 | dlc         = a+
 | name        = Something wicked this way comes!
 | link        = The Binding of Isaac: Afterbirth#Bosses
 | description = Unlocked new bosses!
 | unlocked by = Defeat [[??? (Boss)|???]] as 3 different [[character]]s
 | id          = 346
}} {{infobox achievement
 | dlc         = a+
 | name        = Something wicked this way comes+!
 | link        = The Binding of Isaac: Afterbirth †#Bosses
 | image = Achievement_Something_Wicked_This_Way_Comes_†_icon.png
 | description = Unlocked even more bosses!
 | unlocked by = Defeat [[??? (Boss)|???]] as 6 different [[character]]s
 | id          = 347
}} {{infobox achievement
 | dlc         = a+
 | name        = The gate is open!
 | link        = Monsters#Afterbirth †
 | description = Unlocked new enemies!
 | unlocked by = Defeat [[The Lamb]]
 | id          = 348
}} {{infobox achievement
 | dlc         = a+
 | name        = Black Hole
 | link        = Black Hole
 | description = Unlocked a new item.
 | unlocked by = Defeat 20 [[portal]]s
 | id          = 349<br>{{plat|PS4}}&nbsp;340
}} {{infobox achievement
 | dlc         = a+
 | name        = Mystery Gift
 | link        = Mystery Gift
 | description = Unlocked a new item.
 | unlocked by = Destroy 500 [[rock]]s
 | id          = 350<br>{{plat|PS4}}&nbsp;341
}} {{infobox achievement
 | dlc         = a+
 | name        = Sprinkler
 | link        = Sprinkler
 | description = Unlocked a new item.
 | unlocked by = Beat [[chapter 1]] without taking damage
 | id          = 351<br>{{plat|PS4}}&nbsp;342
}} {{infobox achievement
 | dlc         = a+
 | name        = Angry Fly
 | link        = Angry Fly
 | description = Unlocked a new item.
 | unlocked by = Become [[Beelzebub]]
 | id          = 352<br>{{plat|PS4}}&nbsp;343
}} {{infobox achievement
 | dlc         = a+
 | name        = Bozo
 | link        = Bozo
 | description = Unlocked a new item.
 | unlocked by = Destroy 5 [[rainbow poop]]s
 | id          = 353<br>{{plat|PS4}}&nbsp;344
}} {{infobox achievement
 | dlc         = a+
 | name        = Broken Modem
 | link        = Broken Modem
 | description = Unlocked a new item.
 | unlocked by = Complete 7 (30 on console, 7 on {{plat|Switch|no break}}) [[daily challenge]]s (by touching the trophy at the end)
 | id          = 354<br>{{plat|PS4}}&nbsp;345
}} {{infobox achievement
 | dlc         = a+
 | name        = Buddy in a Box
 | link        = Buddy in a Box
 | description = Unlocked a new item.
 | unlocked by = Pick up 5 [[familiar]]s in a single run
 | id          = 355<br>{{plat|PS4}}&nbsp;346
}} {{infobox achievement
 | dlc         = a+
 | name        = Fast Bombs
 | link        = Fast Bombs
 | description = Unlocked a new item.
 | unlocked by = Defeat [[Little Horn]] 20 times
 | id          = 356<br>{{plat|PS4}}&nbsp;347
}} {{infobox achievement
 | dlc         = a+
 | name        = Lil Delirium
 | link        = Lil Delirium
 | description = Unlocked a new item.
 | unlocked by = Defeat [[Delirium]] for the 1st time
 | id          = 357<br>{{plat|PS4}}&nbsp;348
}} {{infobox achievement
 | dlc         = a+
 | name        = Hairpin
 | link        = Hairpin
 | description = Unlocked a new item.
 | unlocked by = Recharge using [[Lil' Battery|Lil' Batteries]] 20 times
 | id          = 358<br>{{plat|PS4}}&nbsp;349
}} {{infobox achievement
 | dlc         = a+
 | name        = Wooden Cross
 | link        = Wooden Cross
 | description = Unlocked a new item.
 | unlocked by = Sleep in a [[bed]]
 | id          = 359<br>{{plat|PS4}}&nbsp;350
}} {{infobox achievement
 | dlc         = a+
 | name        = Butter!
 | link        = Butter!
 | description = Unlocked a new item.
 | unlocked by = Complete 2 [[Victory Lap]]s and start a 3rd
 | id          = 360<br>{{plat|PS4}}&nbsp;351
}} {{infobox achievement
 | dlc         = a+
 | name        = Huge Growth
 | link        = Huge Growth
 | description = Unlocked a new item.
 | unlocked by = Increase in size 5 times in a single run. Sources of increased size include "One Makes you Larger" pills, [[XI - Strength]], and [[Magic Mushroom]]
 | id          = 361<br>{{plat|PS4}}&nbsp;352
}} {{infobox achievement
 | dlc         = a+
 | name        = Ancient Recall
 | link        = Ancient Recall
 | description = Unlocked a new item.
 | unlocked by = Use [[cards]] and [[runes]] 20 times
 | id          = 362<br>{{plat|PS4}}&nbsp;353
}} {{infobox achievement
 | dlc         = a+
 | name        = Era Walk
 | link        = Era Walk
 | description = Unlocked a new item.
 | unlocked by = Have both the {{i|Broken Watch}} and the {{i|Stop Watch}} in your collection
 | id          = 363<br>{{plat|PS4}}&nbsp;354
}} {{infobox achievement
 | dlc         = a+
 | name        = Coupon
 | link        = Coupon
 | description = Unlocked a new item.
 | unlocked by = Purchase from [[Shop]]s, [[Devil deal]]s or [[Black Market]]s 50 times
 | id          = 364<br>{{plat|PS4}}&nbsp;355
}} {{infobox achievement
 | dlc         = a+
 | name        = Telekinesis
 | link        = Telekinesis
 | description = Unlocked a new item.
 | unlocked by = Beat [[chapter 2]] without taking damage
 | id          = 365<br>{{plat|PS4}}&nbsp;356
}} {{infobox achievement
 | dlc         = a+
 | name        = Moving Box
 | link        = Moving Box
 | description = Unlocked a new item.
 | unlocked by = Use {{i|Pandora's Box}} in {{s|Dark Room}}
 | id          = 366<br>{{plat|PS4}}&nbsp;357
}} {{infobox achievement
 | dlc         = a+
 | name        = Jumper Cables
 | link        = Jumper Cables
 | description = Unlocked a new item.
 | unlocked by = Pick up any 3 of the following items/trinkets in a single run: {{i|9 Volt}}, {{i|The Battery}}, {{i|Car Battery}}, {{t|AAA Battery}}, {{t|Watch Battery}}
 | id          = 367<br>{{plat|PS4}}&nbsp;358
}} {{infobox achievement
 | dlc         = a+
 | name        = Leprosy
 | link        = Leprosy
 | description = Unlocked a new item.
 | unlocked by = Beat [[chapter 3]] without taking damage
 | id          = 368<br>{{plat|PS4}}&nbsp;359
}} {{infobox achievement
 | dlc         = a+
 | name        = Technology Zero
 | link        = Technology Zero
 | description = Unlocked a new item.
 | unlocked by = Pick up two [[Tech (disambiguation)|technology]] items in one run
 | id          = 369<br>{{plat|PS4}}&nbsp;360
}} {{infobox achievement
 | dlc         = a+
 | name        = Filigree Feather
 | link        = Filigree Feather
 | description = Unlocked a new item.
 | unlocked by = Acquire both key pieces
 | id          = 370<br>{{plat|PS4}}&nbsp;361
}} {{infobox achievement
 | dlc         = a+
 | name        = Mr. ME!
 | link        = Mr. ME!
 | description = Unlocked a new item.
 | unlocked by = Open 20 [[Locked Chest]]s
 | id          = 371<br>{{plat|PS4}}&nbsp;362
}} {{infobox achievement
 | dlc         = a+
 | name        = 7 Seals
 | link        = 7 Seals
 | description = Unlocked a new item.
 | unlocked by = Defeat all 5 [[Harbinger]]s
 | id          = 372<br>{{plat|PS4}}&nbsp;363
}} {{infobox achievement
 | dlc         = a+
 | name        = Angelic Prism
 | link        = Angelic Prism
 | description = Unlocked a new item.
 | unlocked by = Defeat an [[Angel]] 10 times
 | id          = 373<br>{{plat|PS4}}&nbsp;364
}} {{infobox achievement
 | dlc         = a+
 | name        = Pop!
 | link        = Pop!
 | description = Unlocked a new item.
 | unlocked by = Beat [[chapter 4]] without taking damage
 | id          = 374<br>{{plat|PS4}}&nbsp;365
}}{{infobox achievement
 | dlc         = a+
 | name        = Door Stop
 | link        = Door Stop
 | description = Unlocked a new item.
 | unlocked by = Blow up doors and [[Secret Room]] walls 50 times
 | id          = 375<br>{{plat|PS4}}&nbsp;366
}} {{infobox achievement
 | dlc         = a+
 | name        = Death's List
 | link        = Death's List
 | description = Unlocked a new item.
 | unlocked by = Take 25 [[Devil deal]]s
 | id          = 376
}} {{infobox achievement
 | dlc         = a+
 | name        = Haemolacria
 | link        = Haemolacria
 | description = Unlocked a new item.
 | unlocked by = Acquire {{i|Blood Clot}} 10 times
 | id          = 377
}} {{infobox achievement
 | dlc         = a+
 | name        = Lachryphagy
 | link        = Lachryphagy
 | description = Unlocked a new item.
 | unlocked by = Collect 10 "tears up" items or pills in one run
 | id          = 378
}} {{infobox achievement
 | dlc         = a+
 | name        = Schoolbag
 | link        = Schoolbag
 | description = Unlocked a new item.
 | unlocked by = Enter every [[Shop]] from [[chapter 1]] through [[chapter 3]] in one run
 | id          = 379
}} {{infobox achievement
 | dlc         = a+
 | name        = Trisagion
 | link        = Trisagion
 | description = Unlocked a new item.
 | unlocked by = Take 25 [[Angel Room (Item Pool)|items from Angel Rooms]]
 | id          = 380
}} {{infobox achievement
 | dlc         = a+
 | name        = Extension Cord
 | link        = Extension Cord
 | description = Unlocked a new item.
 | unlocked by = Have {{i|The Battery}}, {{i|9 Volt}}, and {{i|Car Battery}} in your collection
 | id          = 381
}} {{infobox achievement
 | dlc         = a+
 | name        = Flat Stone
 | link        = Flat Stone
 | description = Unlocked a new item.
 | unlocked by = Acquire {{i|Rubber Cement}} 5 times
 | id          = 382
}} {{infobox achievement
 | dlc         = a+
 | name        = Sacrificial Altar
 | link        = Sacrificial Altar
 | description = Unlocked a new item.
 | unlocked by = Take 50 [[Devil deal]]s
 | id          = 383
}} {{infobox achievement
 | dlc         = a+
 | name        = Lil Spewer
 | link        = Lil Spewer
 | description = Unlocked a new item.
 | unlocked by = Die to your own explosion from {{i|Ipecac}}, {{i|Bob's Rotten Head}}, or [[Horf!]] pill
 | id          = 384
}} {{infobox achievement
 | dlc         = a+
 | name        = Blanket
 | link        = Blanket
 | description = Unlocked a new item.
 | unlocked by = Sleep in 10 [[bed]]s
 | id          = 385
}} {{infobox achievement
 | dlc         = a+
 | name        = Marbles
 | link        = Marbles
 | description = Unlocked a new item.
 | unlocked by = Use 5 [[Gulp!]] pills in one run
 | id          = 386
}} {{infobox achievement
 | dlc         = a+
 | name        = Mystery Egg
 | link        = Mystery Egg
 | description = Unlocked a new item.
 | unlocked by = Spawn three charmed enemies in the same room
 | id          = 387
}} {{infobox achievement
 | dlc         = a+
 | name        = Rotten Penny
 | link        = Rotten Penny
 | description = Unlocked a new item.
 | unlocked by = Have 20 [[Blue Fly|Blue Flies]] at the same time
 | id          = 388
}} {{infobox achievement
 | dlc         = a+
 | name        = Baby-Bender
 | link        = Baby-Bender
 | description = Unlocked a new item.
 | unlocked by = Use {{p|I - The Magician}} or {{i|Telepathy for Dummies}} while already having [[homing tears]]
 | id          = 389
}} {{infobox achievement
 | dlc         = a+
 | name        = The Forgotten
 | link        = The Forgotten
 | description = Unlocked a new character.
 | unlocked by = [[The Forgotten#Unlocking the Forgotten|It's complicated]]
 | id          = 390
}} {{infobox achievement
 | dlc         = a+
 | name        = Bone Heart
 | link        = Hearts (Pickup)
 | description = Unlocked a new item.
 | unlocked by = [[The Forgotten#Unlocking the Forgotten|It's complicated]]
 | id          = 391
}} {{infobox achievement
 | dlc         = a+
 | name        = Marrow
 | link        = Marrow
 | description = Unlocked a new item.
 | unlocked by = Defeat [[Mom's Heart]] or [[It Lives!]] on [[Hard mode]] as [[The Forgotten]]
 | id          = 392
}} {{infobox achievement
 | dlc         = a+
 | name        = Slipped Rib
 | link        = Slipped Rib
 | description = Unlocked a new item.
 | unlocked by = Defeat [[Isaac (Boss)|Isaac]] as [[The Forgotten]]
 | id          = 393
}} {{infobox achievement
 | dlc         = a+
 | name        = Pointy Rib
 | link        = Pointy Rib
 | description = Unlocked a new item.
 | unlocked by = Defeat [[Satan]] as [[The Forgotten]]
 | id          = 394
}} {{infobox achievement
 | dlc         = a+
 | name        = Jaw Bone
 | link        = Jaw Bone
 | description = Unlocked a new item.
 | unlocked by = Defeat [[??? (Boss)|???]] as [[The Forgotten]]
 | id          = 395
}} {{infobox achievement
 | dlc         = a+
 | name        = Brittle Bones
 | link        = Brittle Bones
 | description = Unlocked a new item.
 | unlocked by = Defeat [[The Lamb]] as [[The Forgotten]]
 | id          = 396
}} {{infobox achievement
 | dlc         = a+
 | name        = Divorce Papers
 | link        = Divorce Papers
 | description = Unlocked a new item.
 | unlocked by = Complete the [[Boss Rush]] as [[The Forgotten]]
 | id          = 397
}} {{infobox achievement
 | dlc         = a+
 | name        = Hallowed Ground
 | link        = Hallowed Ground
 | description = Unlocked a new item.
 | unlocked by = Defeat [[Hush]] as [[The Forgotten]]
 | id          = 398
}} {{infobox achievement
 | dlc         = a+
 | name        = Finger Bone
 | link        = Finger Bone
 | description = Unlocked a new item.
 | unlocked by = Defeat [[Ultra Greed]] as [[The Forgotten]]
 | id          = 399
}} {{infobox achievement
 | dlc         = a+
 | name        = Dad's Ring
 | link        = Dad's Ring
 | description = Unlocked a new item.
 | unlocked by = Defeat [[Ultra Greedier]] as [[The Forgotten]]
 | id          = 400
}} {{infobox achievement
 | dlc         = a+
 | name        = Book of the Dead
 | link        = Book of the Dead
 | description = Unlocked a new item.
 | unlocked by = Defeat [[Delirium]] as [[The Forgotten]]
 | id          = 401
}} {{infobox achievement
 | dlc         = a+
 | name        = Bone Baby
 | link        = Babies
 | description = Unlocked a new co-player baby.
 | unlocked by = Earn all [[Hard mode]] [[completion mark]]s as [[The Forgotten]]
 | id          = 402
}} {{infobox achievement
 | dlc         = a+
 | name        = Bound Baby
 | link        = Babies
 | description = Unlocked a new co-player baby.
 | unlocked by = Defeat [[Mega Satan]] as [[The Forgotten]]
 | id          = 403
}}
}}

== PlayStation Trophies ==
{{trophy list}}

== Trivia ==
* Each achievement is color-coded based on the requirements for unlocking their respective secrets:
** Tan: Random/Miscellaneous unlocks
** Tan with blood stain: [[Mom's Heart]]/[[It Lives!]] on Hard unlocks
** Olive-Green: character unlocks
** Dark Red: Mom's Heart/[[The Womb|Womb]] ending unlocks
** Grey: [[Isaac (Boss)|Isaac]] unlocks
** Black: [[Satan]] unlocks
** Dark Blue: [[??? (Boss)|???]] unlocks
** Purple: [[The Lamb]] unlocks
** Pale Green: [[Boss Rush]] unlocks
** Pale Blue: [[Hush]] unlocks
** Orange: [[Greed Mode]] unlocks
** Orange with blood stain: [[Greedier mode]] unlocks
** White: [[Delirium]] unlocks
** Red: [[Mega Satan]] unlocks/accomplishments
** Dark Yellow: All [[Hard Mode]] marks unlocks
** Bright Yellow: [[Greed Donation Machine]] unlocks
** Bluish Purple: [[Challenge]] unlocks
** Despite being a Boss Rush unlock for [[Lazarus]], {{i|Missing No.}}'s achievement color is bluish purple, a color normally used for challenge-related unlocks.
* {{dlc|a+}} Although not technically an achievement, getting 1000000% for all 3 save files will result in a special 3,000,000%!!! [[Savefile Images|graphic on the save file]] selection screen.
* {{dlc|a+}} The 5 Nights at Mom's achievement is a reference to [[wikipedia:Five Nights at Freddy's (series)|Five Nights at Freddy's]].
* {{dlc|a+}} The Mr. Resetter achievement may be a reference to Mr. Resetti from the [[wikipedia:Animal Crossing|Animal Crossing]] series.
* {{dlc|a+}} The Something Wicked This Way Comes quote is most likely a reference to the same quote from one of the witches from Shakespeare's play "Macbeth."
* {{dlc|a+}} Afterbirth+'s [[Booster Pack #5]] added 64 secrets. Interestingly, this is a single secret more than Afterbirth+'s original count of 63 secrets. Thus, this update more than doubled the amount of secrets added to the game.
* {{plat|PS4}} {{dlc|a+}} Achievements 340-348 don't exist in the PS4 version, resulting in the content already being "unlocked" even on new save files.

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