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Item icon
Item altar
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Added in Afterbirth †

Adrenaline is a passive item added in Afterbirth †.

Effects[edit | edit source]

  • Increases damage by 0.2 for each empty red heart container Isaac has.
    • Half-full heart containers do not increase damage.

Notes[edit | edit source]

  • This item has no effect on The Lost and ??? because they can't have any red heart containers.
  • This item affects the Keeper; empty coin hearts increase damage.
  • As The Forgotten, empty bone hearts increase damage, but if the bone hearts are broken the damage buff is taken away.

In-game Footage[edit | edit source]

Trivia[edit | edit source]

  • Prior to v1.06.0190, Adrenaline was named Adderline.
  • Adrenaline is a hormone produced by the body in situations of high stress that increases blood circulation, breathing, and other things in preparation of the natural flight or fight reflex.
  • Adrenaline causes characters to have an animation that makes them look like they are breathing rapidly.

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