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All Bosses (Bosses)

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Bosses
Chapter 1 Chapter 2 Chapter 3 Chapter 4 Added in Afterbirth  Blue Womb Chapter 5 Chapter 6 Added in Afterbirth †  The Void
Universal Devil and Angel Room Seven Deadly Sins Added in Afterbirth  Greed Mode All Mini-Bosses All Bosses

Bosses[edit | edit source]

Boss Blighted Ovum.png
Boss Dingle.png
Boss The Duke of Flies.png
Boss Fistula.png
Blighted Ovum Dingle The Duke of Flies Fistula
Boss Gemini.png
Boss Gurglings.png
Boss The Haunt.png
Boss Larry Jr..png
Gemini Gurglings The Haunt Larry Jr.
Boss Monstro.png Boss Pin.png
Boss Widow.png
 Boss Steven.png
Monstro Pin Widow Steven Needs to be unlocked
Boss Carrion Queen.png
Boss Chub.png
Boss Dark One.png
Boss Gurdy.png
Carrion Queen Chub Dark One Gurdy
Boss Gurdy Jr..png
Boss The Hollow.png
Boss The Husk.png
Boss Mega Fatty.png
Gurdy Jr. The Hollow The Husk Mega Fatty
Boss Mega Maw.png
Boss Peep.png
Boss Polycephalus.png
Boss The Wretched.png
Mega Maw Peep Polycephalus The Wretched
Boss C.H.A.D..png
Boss The Adversary.png
Boss The Bloat.png
Boss The Cage.png
C.H.A.D. Needs to be unlocked The Adversary The Bloat The Cage
Boss The Gate.png
Boss Loki.png
Boss Mask Of Infamy.png
Boss Monstro II.png
The Gate Loki Mask of Infamy Monstro II
Boss Gish.png
Boss Blastocyst.png
Boss Daddy Long Legs.png
Boss Lokii.png
Gish Needs to be unlocked Blastocyst Daddy Long Legs Lokii
Boss Mama Gurdy.png
Boss Mr. Fred.png
Boss Scolex.png
Mama Gurdy Mr. Fred Scolex
Boss Teratoma.png
Boss Triachnid.png
Boss The Fallen.png
Teratoma Triachnid Needs to be unlocked The Fallen Requires previous entry into a devil room

Afterbirth Added in Afterbirth[edit | edit source]

Boss Dangle.png
Boss Little Horn.png
Boss Rag Man.png
Boss Turdlings.png
Dangle Added in Afterbirth Needs to be unlocked Little Horn Added in Afterbirth Needs to be unlocked Rag Man Added in Afterbirth Needs to be unlocked Turdlings Added in Afterbirth Needs to be unlocked
Boss Brownie.png
Boss The Forsaken.png
Boss The Frail.png
Boss The Stain.png
Brownie Added in Afterbirth Needs to be unlocked The Forsaken Added in Afterbirth Needs to be unlocked The Frail Added in Afterbirth Needs to be unlocked The Stain Added in Afterbirth Needs to be unlocked

Afterbirth+ Added in Afterbirth †[edit | edit source]

Boss Big Horn.png
Boss Rag Mega.png
Boss Sisters Vis.png
Boss The Matriarch.png
Big Horn Added in Afterbirth † Needs to be unlocked Rag Mega Added in Afterbirth † Needs to be unlocked Sisters Vis Added in Afterbirth † Needs to be unlocked The Matriarch Added in Afterbirth † Needs to be unlocked

The Harbingers Needs to be unlocked[edit | edit source]

Boss Famine.png
Boss Pestilence.png
Boss War.png
Famine Pestilence War
Boss Death.png
Boss Conquest.png
Boss The Headless Horseman.png
Death Conquest The Headless Horseman

Final Bosses[edit | edit source]

Boss Mom.png
Boss Mom's Heart.png
Boss It Lives.png
Mom Mom's Heart It Lives Needs to be unlocked
Boss Satan.png
Boss Isaac (Boss).png
Boss The Lamb.png
???
Satan Isaac The Lamb ???
Boss Mega Satan.png
Boss Hush.png
Boss Delirium.png
Mega Satan Hush Added in Afterbirth Delirium Added in Afterbirth †
Boss Ultra Greed.png
Boss Ultra Greedier.png
Ultra Greed Added in Afterbirth Ultra Greedier Added in Afterbirth †


Bosses Boss Monstro.png
Chapter 1
Stage The Basement icon.pngStage The Cellar icon.pngStage Burning Basement icon.png 		Blighted Ovum • Dingle • The Duke of Flies • Famine • Fistula • Gemini • Gurglings • The Haunt • Larry Jr. • Monstro • Pin • Steven • Widow • The Fallen • The Headless Horseman
Added in Afterbirth Dangle • Little Horn • Rag Man • Turdlings
Chapter 2
Stage The Caves icon.pngStage The Catacombs icon.pngStage Flooded Caves icon.png 		Carrion Queen • C.H.A.D. • Chub • Dark One • Gurdy • Gurdy Jr. • The Hollow • The Husk • Mega Fatty • Mega Maw • Peep • Pestilence • Polycephalus • The Wretched • The Fallen • The Headless Horseman
Added in Afterbirth The Forsaken • The Frail • The Stain
Added in Afterbirth † Big Horn • Rag Mega
Chapter 3
Stage The Depths icon.pngStage Necropolis icon.pngStage Dank Depths icon.png 		The Adversary • The Bloat • The Cage • The Gate • Gish • Loki • Mask Of Infamy • Monstro II • War • The Fallen • The Headless Horseman • Mom
Added in Afterbirth Brownie
Added in Afterbirth † Sisters Vis
Chapter 4
Stage The Womb icon.pngStage Utero icon.pngStage Scarred Womb icon.png 		Blastocyst • The Bloat • Conquest • Daddy Long Legs • Death • Lokii • Mama Gurdy • Mr. Fred • Scolex • Teratoma • Triachnid • The Fallen • The Headless Horseman • Mom's Heart • It Lives
Added in Afterbirth † Sisters Vis • The Matriarch
Added in Afterbirth Blue Womb
??? 		Added in Afterbirth Hush
Chapter 5
Stage Sheol icon.pngStage Cathedral icon.png 		Satan • Isaac
Chapter 6
Stage Dark Room icon.pngStage The Chest icon.png 		??? • The Lamb • Mega Satan
Added in Afterbirth † The Void
Stage The Void icon.png 		Added in Afterbirth † Delirium
Added in Afterbirth Greed Mode
Ultra Greed 		Added in Afterbirth Ultra Greed
Added in Afterbirth † Ultra Greedier
The Binding of Isaac: Rebirth The Binding of Isaac: Rebirth The Binding of Isaac: Rebirth
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