Anemic is a passive item.
Effects[ | ]
- Upon taking damage, Isaac leaves a trail of red creep that damages enemies until he leaves the room.
- The creep deals 2 damage per tick (6 damage per second) to enemies that walk over it.
+5 range.- +1.5 range.
+5 
+1.5 Notes[ | ]
- The effects of this item do not stack if multiple copies of the item or its effects are acquired; Isaac only gets the range bonus once.
- Lazarus, or anyone holding Lazarus' Rags, is resurrected with this item upon his first death.
- After Backasswards (challenge #31) is beaten, Lazarus will start with Anemic, and Lazarus Risen will have its increased range and creep trail effect permanently active, regardless of whether he possesses the item.
After In-game Footage[ | ]
Trivia[ | ]
- Anemia is a decrease in the blood's ability to carry oxygen. This can either be caused by a decrease in hemoglobin in blood cells, or red blood cells altogether.
- This item is used in Bloody Mary (challenge #37).
- Glass Cannon invokes the effects of Anemic for the current room when Isaac takes damage.
 The Binding of Isaac: Rebirth
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