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Item icon
Item altar
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Character appearance
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Shop Shop
Greed mode only Shop Shop
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Added in Afterbirth(page 3, column 3, row 1)
Removed in Afterbirth(page 3, column 3, row 5)

BFFS! is a passive item.

Effects[edit | edit source]

  • Increases the size and doubles damage of familiars that deal damage through tears and contact damage.
    • The size change is only cosmetic: familiars' hitbox for blocking damage or attacking is not affected.
    • Other familiars can be affected in non obvious ways.

Notes[edit | edit source]

  • For certain pickup-generating familiars, BFFS! increases the frequency that they drop pickups.
  • Familiars summoned by a trinket or by Monster Manual Monster ManualCollectible Monster Manual icon.png3 roomsSummons a random familiar for the current room. Can summon familiars not yet unlocked. are also affected by this item.
  • The blue flies and blue spiders benefit from Hive Mind Hive MindCollectible Hive Mind icon.pngIncreases the size of blue spiders and blue flies and doubles the amount of damage they deal. instead.

Interactions[edit | edit source]

  • Added in AfterbirthEvil Eye Evil EyeCollectible Evil Eye Afterbirth icon.pngWhile firing tears, Isaac has a chance to fire an eye across the screen with a very slow shot speed, which will fire tears of its own in the same direction as Isaac. The eye will be destroyed if it comes into contact with an enemy or obstacle.: The eyes are not treated as familiars and therefore will not synergize with BFFS!

Synergies[edit | edit source]

  • BBF BBFCollectible BBF icon.pngSpawns a familiar that flies around the room in a manner similar to the Boom Fly and explodes on contact with an enemy. Respawns after ten seconds./Bob's Brain Bob's BrainCollectible Bob's Brain icon.pngSpawns a familiar that charges forward when shooting tears and explodes upon contact with an enemy, damaging and poisoning them. The familiar respawns after a few seconds.: Doubles impact damage and increases explosive damage by 25.
  • Added in AfterbirthIncubus IncubusCollectible Incubus icon.pngA demonic familiar that follows Isaac and shoots tears identical to Isaac's in terms of damage, range, fire rate, and effects.: Incubus deals double Isaac's damage instead of copying it.
  • Juicy Sack Juicy SackCollectible Juicy Sack icon.pngA familiar that follows behind Isaac. It drips a trail of creep, which slows enemies, and spawns 1-2 blue spiders after each room.: Spawns an extra blue spider.
  • Added in AfterbirthLil Chest Lil ChestCollectible Lil Chest icon.pngSpawns a chest familiar that follows Isaac and drops a random pickup every few rooms.: Increases the chance to spawn a pickup or trinket by 25%.
  • Orbitals: The damage is doubled as expected, but otherwise the hitbox does not increase for additional protection or reach.
  • Added in AfterbirthSpider Mod Spider ModSpider Mod Icon.pngDisplays Isaac's tear damage and enemy health bars. Spawns a gray spider familiar that wanders around and inflicts a random status effect on any enemies it comes into contact with. Occasionally spawns a blue spider upon clearing a room.: Increases the chance for Spider Mod to spawn a battery or blue spider upon clearing a room from 10% to 12.5%.

In-game Footage[edit | edit source]

Trivia[edit | edit source]

  • BFF stands for Best Friends Forever.
  • This item is used in challenge #19 (The Family Man).

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