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Font TeamMeat B.pngFont TeamMeat R.pngFont TeamMeat A.pngFont TeamMeat I.pngFont TeamMeat N.pngFont TeamMeat S.pngFont TeamMeat emark.png
Full soul heartFull soul heartFull soul heartFull soul heart
Blindfolded.png Blindfolded
Table dividing line 1.png
3 Bob's Brain Bob's Brain
Thunder Thighs Thunder Thighs
Item Pool Treasure Room.png: no          Item Pool Shop.png: yes
Stud Finder Stud Finder
BRAINS! Defeat Isaac 5 times
Added in Afterbirth

BRAINS! is Challenge #27, added in The Binding of Isaac: Afterbirth. This challenge is played as ??? and start blindfolded, with 3 Bob's Brain Bob's Brain and Thunder Thighs Thunder Thighs. The goal is to defeat ???. Treasure Rooms do not spawn in this Challenge.

Difficulty[edit | edit source]

Bob's Brain is a difficult item to use, as it is not only easy to do one full heart of self-damage when fighting enemies, it also leaves ??? exposed while waiting for the brains to respawn. Adding to the problem is that playing as ??? which forbids him from obtaining Red Hearts. With no Treasure Rooms and having to reach The Chest The Chest, lots of skill and luck are necessary to beat this challenge.

Strategy[edit | edit source]

  • Make sure to pick The Polaroid The Polaroid after the fight against Mom. If The Negative The Negative is chosen instead, ??? will not be teleported to The Chest The Chest after the Cathedral Cathedral. And will not be able to fight ??? and the challenge will be over.
    • Added in Afterbirth † Can only take The Polaroid, as The Negative won't spawn.
  • Try to space out the shots with Bob's Brain so the respawn time isn't as long. Achieving a rhythm makes it much easier to efficiently kill enemies, especially bosses, without taking as much damage.
  • Any method of damaging enemies besides Bob's Brain is incredibly helpful.
    • Added in Afterbirth †Sharp Straw Sharp Straw is incredibly useful as it can be used multiple times per room, does high amounts of damage to any enemy including bosses, may drop Half Soul Hearts and may not require aim to use it. For it to be obtained, however, need to purchase Chaos Chaos from a Shop, or survive until reaching The Chest The Chest.
    • Like any blindfolded run, familiars are useful for this challenge. Not only can they safely extinguish fires (except Rotten Baby Rotten Baby), they can help take care of weak or weakened enemies while the brains respawn. However, they do have to hold the firing keys to make them attack (excluding Succubus Succubus), increasing the risk of harming ??? by one of the brains. Most strong familiars are also exclusive to Devil Rooms, so ??? must maintain health if wanting them without putting the run at risk.
      • Most of Lilith's unlockables are especially valuable in this run; Incubus Incubus and Succubus are among the most powerful familiars, while Box of Friends Box of Friends can double any familiars. Taking the time to unlock these can be beneficial for this challenge.
      • Other good familiars aside from Incubus and Succubus include Demon Baby Demon Baby, who fires on its own, Lil Brimstone Lil Brimstone, who can hit multiple enemies per shot, and Rotten Baby, whose flies will home in onto enemies.
    • The damaging trails from the Bob transformation or Headless Baby Headless Baby can be useful, allowing chasing enemies to be killed without the risk of taking damage from Bob's Brain. However, this method takes a lot of time and is useless against flying enemies.
    • Buying The Candle The Candle or Red Candle Red Candle from the Shop can make this challenge a lot easier, since both do a lot of damage and can be used multiple times in a room.
    • Orbitals, such as Cube of Meat Cube of Meat and Sacrificial Dagger Sacrificial Dagger, can be a good source of damage. But make sure to not press the firing keys while orbitals do damage, as it will harm ??? if having at least one brain.
      • Once The Polaroid The Polaroid is obtained, orbitals start becoming more useful. Since the shield will always trigger from any damage, it will give a little time to run into enemies and deal contact damage, preferably against weaker enemies to save the brains for stronger ones.
  • Pyromaniac Pyromaniac and Host Hat Host Hat make this challenge much easier, as ??? no longer takes damage from the brain's explosions.
  • Use Thunder Thighs to break Rocks, as this can sometimes open a Crawl Space with items such as Pyromaniac.
    • Also, keep an eye out for Tinted Rocks, as they can have valuable Soul Hearts, as well as pickups and items via Locked Chests. Thunder Thighs allows ??? to break them for free, so there is no reason to skip any of them. But it is not advised to pick up The Small Rock The Small Rock unless having items that depend on the damage stat, as it lowers already low speed.
  • Speed items help keep a distance from chasing enemies, making it easier to avoid taking splash damage from a brain's explosion. Since Thunder Thighs slows ??? down, at least one or two speed items are necessary to outrun most enemies.
  • Flying is very useful to give more breathing room by preventing ??? from becoming cornered in a troublesome room layout, as well as negating the threat of Spikes or creep.
  • IV - The Emperor IV - The Emperor can be extremely valuable, especially in the late game because it allows skipping of difficult floors like the Cathedral Cathedral and The Chest The Chest and go straight to the boss, minimizing the amount of fighting required.
  • Keep an eye out for Libraries, since there are many good defensive or health-related items that can be obtained, like Book of Revelations Book of Revelations and Book of Shadows Book of Shadows.
  • If damage via an enemy is unavoidable, collide with the enemy first and then blow it up with a brain while invincibility frames last. ??? will get hurt either way, but he will only lose half a heart instead of a full heart. However, this strategy does not work against Champion enemies (if it does two full hearts of damage, it is a better idea blowing it up instead) and enemies that naturally do one full heart of damage (like Chubbers), and will always take a full heart of damage anyway starting from The Womb The Womb.
  • Isaac can bridge one-tile gaps by pushing Poop or Rocks into them, using Thunder Thighs or The Poop.

Notes[edit | edit source]

  • Added in Afterbirth † If entering The Void The Void after killing Mom or Mom's Heart/It Lives, it is still possible to collect the trophy by defeating Delirium. However, this is extremely inadvisable unless having a very good run-up to the Mom fight and want an extra challenge.

Reward[edit | edit source]

MainPageChallenges.png Challenges MainPageChallenges.png

1. Pitch Black 2. High Brow 3. Head Trauma 4. Darkness Falls 5. The Tank 6. Solar System 7. Suicide King 8. Cat Got Your Tongue
9. Demo Man 10. Cursed! 11. Glass Cannon 12. When Life Gives You Lemons 13. Beans! 14. It's in the Cards 15. Slow Roll 16. Computer Savvy
17. Waka Waka 18. The Host 19. The Family Man 20. Purist
21. XXXXXXXXL 22. SPEED! 23. Blue Bomber 24. PAY TO PLAY 25. Have a Heart 26. I RULE! 27. BRAINS! 28. PRIDE DAY!
29. Onan's Streak 30. The Guardian
Afterbirth †
31. Backasswards 32. Aprils Fool 33. Pokey Mans 34. Ultra Hard 35. Pong
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