BRAINS!

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BRAINS!
Added in Afterbirth
Challenge number
27
Character
???
HUD Soul Heart.pngHUD Soul Heart.pngHUD Soul Heart.png
Blindfolded App.png Blindfolded
Starting Items
3 Bob's Brain Bob's BrainBob's Brain Icon.pngSpawns a familiar that charges forward when shooting tears and explodes upon contact with an enemy, damaging and poisoning them. The familiar respawns after a few seconds.
Thunder Thighs Thunder ThighsThunder Thighs Icon.pngDestroys rocks upon contact with Isaac. Adds one heart container and lowers Speed.
Available rooms
Item Pool Treasure Room.png: no          Item Pool Shop.png: yes
Goal
???
Unlocks
Added in AfterbirthStud Finder Stud FinderStud FinderComplete challenge #27
Unlocked by
Added in AfterbirthBRAINS! Defeat Isaac 5 timesBRAINS!BRAINS!

BRAINS! is Challenge #27, added in the Afterbirth DLC. In this challenge, you play as ??? and start blindfolded, with 3 Bob's Brain Bob's BrainBob's Brain Icon.pngSpawns a familiar that charges forward when shooting tears and explodes upon contact with an enemy, damaging and poisoning them. The familiar respawns after a few seconds. and Thunder Thighs Thunder ThighsThunder Thighs Icon.pngDestroys rocks upon contact with Isaac. Adds one heart container and lowers Speed.. Your goal is to defeat ???. Treasure Rooms do not spawn in this Challenge.

Difficulty[edit | edit source]

Bob's Brain Bob's BrainBob's Brain Icon.pngSpawns a familiar that charges forward when shooting tears and explodes upon contact with an enemy, damaging and poisoning them. The familiar respawns after a few seconds. is a difficult item to use, as it is not only easy to deal self-damage when fighting enemies, it also leaves you exposed while waiting for the brains to respawn. Adding to the problem is that playing as ??? means you can't make as many mistakes due to not being able to use red hearts. With no treasure rooms and having to reach all the way to The Chest, you will need all the skill and luck you can get to beat this challenge.

Strategy[edit | edit source]

  • Make sure to pick The Polaroid The PolaroidThe Polaroid Icon.pngIf the character has half a red heart or no red hearts after taking damage, it triggers the Book Of Shadows effect, creating a shield that nullifies all types of damage for 5 seconds. Also allows entrance into The Chest. after the fight against Mom. If The Negative The NegativeThe Negative Icon.pngIf the character has half a red heart or no red hearts after taking damage, it triggers The Necronomicon effect, damaging all enemies in the room. Also allows entrance into the Dark Room. is chosen instead, ??? will not be teleported to The Chest after the Cathedral. You will not be able to fight ??? and the challenge will be over.
    • Added in Afterbirth †You can only take The Polaroid The PolaroidThe Polaroid Icon.pngIf the character has half a red heart or no red hearts after taking damage, it triggers the Book Of Shadows effect, creating a shield that nullifies all types of damage for 5 seconds. Also allows entrance into The Chest., as The Negative The NegativeThe Negative Icon.pngIf the character has half a red heart or no red hearts after taking damage, it triggers The Necronomicon effect, damaging all enemies in the room. Also allows entrance into the Dark Room. won't spawn.
  • Try to space out your shots with Bob's Brain Bob's BrainBob's Brain Icon.pngSpawns a familiar that charges forward when shooting tears and explodes upon contact with an enemy, damaging and poisoning them. The familiar respawns after a few seconds. so you don't have to wait as long for one to spawn. If you can get a cycle going, it becomes easier to efficiently kill enemies, especially bosses, without taking as much damage.
  • Pyromaniac PyromaniacPyromaniac Icon.pngIsaac heals 1 heart instead of taking damage from an explosive source. Adds 5 bombs. and Host Hat Host HatHost Hat Icon.pngA host familiar that sits on Isaac's head and has a random chance to block enemy shots and retaliate with 3 tears. Grants immunity to explosions. make this challenge much easier, as ??? no longer takes damage from the brain's explosions.
  • Use Thunder Thighs Thunder ThighsThunder Thighs Icon.pngDestroys rocks upon contact with Isaac. Adds one heart container and lowers Speed. to break rocks, as this can sometimes open a crawl space with items such as Pyromaniac PyromaniacPyromaniac Icon.pngIsaac heals 1 heart instead of taking damage from an explosive source. Adds 5 bombs..
  • Keep an eye out for tinted rocks, as Thunder Thighs Thunder ThighsThunder Thighs Icon.pngDestroys rocks upon contact with Isaac. Adds one heart container and lowers Speed. allows you to break them for free and obtain valuable soul hearts.
  • Speed items help keep distance from chasing enemies, making it easier to avoid taking splash damage from a brain's explosion. Since Thunder Thighs slows you down, at least one or two Speed items are necessary to outrun most enemies.
  • Flying is very useful to give yourself more breathing room by preventing you from becoming cornered in a bad room layout, as well as negating the threat of spikes or creep.
  • Once The Polaroid The PolaroidThe Polaroid Icon.pngIf the character has half a red heart or no red hearts after taking damage, it triggers the Book Of Shadows effect, creating a shield that nullifies all types of damage for 5 seconds. Also allows entrance into The Chest. is obtained, orbitals start becoming more useful. Since the shield will always trigger from any damage, it will give you a little time to run into enemies and deal contact damage, preferably against weaker enemies to save the brains for stronger ones.
  • Like any blindfolded run, familiars are useful for this challenge. Not only are they required to put out fires, they can help take care of weak or weakened enemies while the brains respawn.
    • Most of Lilith's unlockables are especially valuable in this run, since weaker familiars won't be able to kill all but the weakest enemies alone. Taking the time to unlock familiars like Incubus IncubusIncubus Icon.pngA demonic familiar that follows Isaac and shoots tears identical to Isaac's in terms of damage, range, fire rate, and effects. and Succubus SuccubusSuccubus Icon.pngSpawns a flying familiar that bounces around the room with a black aura, dealing rapid damage to any enemies inside it. While standing in the aura, Isaac gains a 1.5x tear damage multiplier. can make the run much easier.
    • Since Demon Baby Demon BabyDemon Baby Icon.pngFollows Isaac and automatically fires at enemies in its reach. fires on its own, it has slightly increased usefulness over other familiars.
  • The damaging trails from the Bob transformation or Headless Baby Headless BabyHeadless Baby Icon.pngFamiliar that follows Isaac, leaving blood creep on the ground. can be useful, allowing chasing enemies to be killed without the risk of taking damage from Bob's Brain.
  • Added in Afterbirth † If you enter The Void once you kill Mom or Mom's Heart/It Lives you can collect the trophy by defeating Delirium though this is extremely unadvisable unless you have had a very good run up to the Mom fight.
  • IV - The Emperor IV - The EmperorIV - The Emperor Icon.pngTeleports you into the Boss Room of a floor. can be extremely valuable, especially in the late game because it allows you to skip difficult floors like the Cathedral and the Chest and go straight to the boss, minimizing the amount of fighting required.
  • Buying The Candle The CandleThe Candle Icon.png4 secondsThrows out a blue flame that can pass over gaps (but not through rocks). The flame damages anything in its path. or Red Candle Red CandleRed Candle Icon.png4 secondsThrows a persistent flame that deals high damage and diminishes as it damages enemies or blocks shots. from the shop can make this challenge a lot easier, since you do not have to rely on your Bob's Brains to do the damage.
  • Orbitals, such as Cube of Meat Cube of MeatCube of Meat Icon.pngOrbiting familiar that blocks enemy shots and deals damage to enemies. If collected while already having one, makes the familiar evolve. Only drops from Horsemen. Similar to Ball of Bandages. or Sacrificial Dagger Sacrificial DaggerSacrificial Dagger Icon.pngDagger orbits Isaac, dealing very high damage., can be a good source of damage.
  • Keep an eye out for Libraries, since there are many good defensive or health-related items you can obtain, like Book of Revelations Book of RevelationsBook of Revelations Icon.png6 roomsAdds 1 soul heart, increases the chance for a Devil or Angel Room to appear, and increases the chance for the next boss to be a Horseman (except on XL floors and floors with fixed bosses such as Mom). or Book of Shadows Book of ShadowsBook of Shadows Icon.png3 roomsUpon use, creates a protective shield nullifying all types of damage for 10 seconds..

Reward[edit | edit source]


The Binding of Isaac: Rebirth The Binding of Isaac: Rebirth The Binding of Isaac: Rebirth
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