Familiar

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Familiars are small companions, usually generated by passive items, that follow and assist the character. Effects of familiars include (but are not limited to) pickup generation, shooting familiars that fire their own tears at enemies, and orbitals that act as projectile shields and/or deal contact damage.

Temporary familiars[edit | edit source]

Blue Flies[edit | edit source]

Blue Fly.png

Blue Flies are familiars that will orbit around Isaac and rush towards nearby enemies, dealing damage and dying in the process. Blue flies deal double Isaac's current tear damage.

Name ID Icon Quote Description
Added in Afterbirth † Compost 480
Compost
2 rooms
Gain more friends! Spawns a blue spider or fly. Turns pickups in the room into blue spiders or flies.
Guppy's Head 145
Guppy's Head
1 rooms
Reusable fly hive Spawns 2-4 blue flies to damage enemies.
Added in Afterbirth Jar of Flies 434
Jar of Flies
Unlimited
Gotta catch 'em all? Every time Isaac kills an enemy, a fly will be added to the jar, up to a maximum of 20. Using the Jar of Flies will release all the flies that are currently in the jar as friendly blue flies that will damage enemies.
Name ID Icon Quote Description
Infestation 148 Infestation They grow inside 1-3 Blue flies randomly spawn every time Isaac gets hit.
The Mulligan 151 The Mulligan They grow inside Tears have a 1/6 chance of spawning allied blue flies when they hit an enemy.
Rotten Baby 268 Rotten Baby Infested friend A familiar that spawns blue flies.
Added in Afterbirth † Parasitoid 461 Parasitoid Egg tears! Adds a chance to fire an egg sack which spawns slowing creep and spawns a blue fly or spider upon hitting an enemy.
Name ID Icon Quote Description
Fish Head 29 Fish Head It stinks Spawns a blue fly every time Isaac takes damage.
Added in Afterbirth Lil Larva 86 Lil Larva The poop is moving... Spawns a blue fly from every pile of poop Isaac destroys.
Added in Afterbirth † Fish Tail 94 Fish Tail It also stinks! Items and trinkets that generate blue flies or blue spiders will generate twice as many.

Other sources of Blue Flies

  • Red Chests: Has a chance to spawn 3 blue flies.
  • Dark Blue Champion: Will create 3 blue flies when defeated.
  • Guppy transformation: Isaac will create blue flies whenever his tears or his familiars' tears hit enemies.
  • Beelzebub transformation: All enemy flies become blue flies.
  • Rune of Berkano: Spawns 3 blue flies and 3 blue spiders upon use.
  • Added in Afterbirth "Friends Till The End!" Pill: Spawns three blue flies.
  • Added in Afterbirth As Keeper, all heart pickups turn into blue flies.
  • Added in Afterbirth † Black Rune: Turns pickups into blue flies and blue spiders.

Locusts Added in Afterbirth †[edit | edit source]

Red Fly.png Green Fly.png Yellow Fly.png Black Fly (Familiar).png White Fly.png

Locusts are variants of Blue Flies that are spawned by Locust trinkets. They behave like regular Blue Flies but have additional special effects.

Name ID Icon Quote Description
Added in Afterbirth † 7 Seals 526 7 Seals Lil harbingers! Grants a random Harbinger familiar that changes every 10 seconds.
Name ID Icon Quote Description
Added in Afterbirth † Locust of War 113 Locust of War I bring War Upon entering a room with enemies, spawns a Red Locust which detonates upon impact with enemies.
Added in Afterbirth † Locust of Pestilence 114 Locust of Pestilence I bring Pestilence Upon entering a room with enemies, spawns a Green Locust which damages and poisons enemies.
Added in Afterbirth † Locust of Famine 115 Locust of Famine I bring Famine Upon entering a room with enemies, spawns a Yellow Locust that damages and slows enemies.
Added in Afterbirth † Locust of Death 116 Locust of Death I bring Death Upon entering a room with enemies, spawns a Black Locust that does a very high amount of damage.
Added in Afterbirth † Locust of Conquest 117 Locust of Conquest I bring Conquest Upon entering a room with enemies, spawns 2-5 White Locusts which damage enemies.

Blue Spiders[edit | edit source]

Blue Spider.png

Blue Spiders are familiars similar to blue flies that crawl erratically and rush towards nearby enemies, dealing damage and dying in the process. Blue spiders deal 2.5 times Isaac's current tear damage. Unlike blue flies, blue spiders cannot attack over obstacles such as rocks and pits.

Bug Bug!  3DS  Exiting the game and re-entering will cause all blue spiders to disappear.
Name ID Icon Quote Description
Box of Spiders 288
Box of Spiders
2 rooms
It's a box of spiders Summons 2-4 blue spiders.
Added in Afterbirth † Compost 480
Compost
2 rooms
Gain more friends! Spawns a blue spider or fly. Turns pickups in the room into blue spiders or flies.
Name ID Icon Quote Description
Dark Bum 278 Dark Bum He wants to take your life Spawns a familiar that follows Isaac around and collects red hearts. For every one-and-a-half red hearts collected, Dark Bum will generate one soul heart, one hostile Spider or one friendly blue spider.
Infestation 2 234 Infestation 2 Infestation shot Spawns allied blue spiders from killed enemies.
Juicy Sack 266 Juicy Sack Sticky babies A familiar that follows behind Isaac. It drips a trail of creep, which slows enemies, and spawns 1-2 blue spiders after each room.
Added in Afterbirth Louse 70 Louse Itchy, tasty... Occasionally spawns a Blue Spider.
Mom's Wig 217 Mom's Wig You feel itchy... Adds a chance to spawn blue spiders when firing tears. Restores 1 red heart.
Added in Afterbirth † Parasitoid 461 Parasitoid Egg tears! Adds a chance to fire an egg sack which spawns slowing creep and spawns a blue fly or spider upon hitting an enemy.
Sissy Longlegs 280 Sissy Longlegs She loves you Wanders about the room, occasionally spawning blue spiders.
Spider Baby 211 Spider Baby Spider revenge When hit, spawns up to 2 blue spiders.
Added in Afterbirth Spider Mod 403 Spider Mod Mod buddy! Displays Isaac's tear damage and enemy health bars. Spawns a gray spider familiar that wanders around and inflicts a random status effect on any enemies it comes into contact with. Occasionally spawns a blue spider upon clearing a room.
Added in Afterbirth Sticky Bombs 367 Sticky Bombs Egg sack bombs! +5 bombs. Bombs stick to enemies and spawn 2-4 blue spiders if they kill an enemy.
Name ID Icon Quote Description
Added in Afterbirth † Fish Tail 94 Fish Tail It also stinks! Items and trinkets that generate blue flies or blue spiders will generate twice as many.

Other sources of Blue Spiders

  • Rune of Berkano: Spawns 3 blue flies and 3 blue spiders upon use.
  • Infested? pill: Spawns blue spiders equal to the number of enemies in the room.
  • Infested! pill: Spawns a blue spider under Isaac and every pile of poop in the room.

Chasing familiars[edit | edit source]

Familiars in this category actively chase enemies, dealing contact damage to them.

Name ID Icon Quote Description
The Pinking Shears 107
The Pinking Shears
6 rooms
Cut and Run Separates Isaac's head and body for the current room. Isaac's head, which now has flight, will be under the player's control, while his body will seek out enemies to attack by contact damage.
Name ID Icon Quote Description
Ball of Bandages 207 Ball of Bandages Gotta lick 'em all! Orbiting familiar that deals damage to enemies. If collected while already having one, makes the familiar evolve. Only drops from Horsemen. Similar to Cube of Meat.
Added in Afterbirth Bumbo 385 Bumbo Bumbo want coin! Spawns a beggar familiar which floats around the room and picks up any nearby coins, leveling up after collecting several coins. At level 2, Bumbo gains a body. At level 3, it begins to fire tears. At level 4, Bumbo chases enemies slowly, dealing contact damage.
Cube of Meat 73 Cube of Meat Gotta meat 'em all! Orbiting familiar that blocks enemy shots and deals damage to enemies. If collected while already having one, makes the familiar evolve. Only drops from Horsemen. Similar to Ball of Bandages.
Daddy Longlegs 170 Daddy Longlegs Daddy's love Daddy Long Legs' shadow follows Isaac and stomps on enemies.
Dead Bird 117 Dead Bird Protective buddy Spawns a flying familiar for the current room that chases enemies whenever Isaac takes damage.
Eve's Bird Foot 60 Eve's Bird Foot Revenge from beyond 5% chance to spawn a Dead Bird familiar for the current room each time an enemy dies.
Gemini 318 Gemini Conjoined friend Suture becomes attached to Isaac, and does touch damage to enemies within its attacking range.
Leech 270 Leech Blood sucker Spawns a friendly familiar leech on the ground that hunts down enemies and heals you for half a heart each time it eats one.
Lil Haunt 277 Lil Haunt Fear him A familiar that damages enemies by chasing them as well as inducing the fear effect.
Smart Fly 264 Smart Fly Revenge fly After Isaac takes damage, this fly will deal continuous touch damage to whatever enemy caused the damage until it is dead. The fly will then systematically attack 1 enemy at a time until the room is cleared.

Note: Only third and fourth stage Cube of Meat and Ball of Bandages chase enemies.

Note: Only fourth stage Bumbo chases enemies.

Orbital familiars[edit | edit source]

Familiars that orbit Isaac, absorbing enemy projectiles and dealing contact damage.

Name ID Icon Quote Description
Ball of Bandages 207 Ball of Bandages Gotta lick 'em all! Orbiting familiar that deals damage to enemies. If collected while already having one, makes the familiar evolve. Only drops from Horsemen. Similar to Cube of Meat.
Best Bud 274 Best Bud Sworn protector When hit, summons a white attack fly similar to Distant Admiration for the current room.
Big Fan 279 Big Fan Fat protector Spawns a large orbital familiar that blocks enemy projectiles and deals slight contact damage to enemies.
Added in Afterbirth † Bloodshot Eye 509 Bloodshot Eye Bloody friend Spawns an orbiting eye familiar that fires tears every 2 seconds.
Cube of Meat 73 Cube of Meat Gotta meat 'em all! Orbiting familiar that blocks enemy shots and deals damage to enemies. If collected while already having one, makes the familiar evolve. Only drops from Horsemen. Similar to Ball of Bandages.
Distant Admiration 57 Distant Admiration Attack fly A red attack fly circles further out than the Halo of Flies / Pretty Flies, but closer than Forever Alone. Deals more damage than Forever Alone.
Forever Alone 128 Forever Alone Attack fly Spawns a blue attack fly that orbits a long distance from Isaac.
Added in Afterbirth Friend Zone 364 Friend Zone Friendly fly A white orbiting fly which deals 3 contact damage per tick to enemies. This familiar orbits Isaac at a middle length distance somewhere between Distant Admiration and Forever Alone.
Guardian Angel 112 Guardian Angel Extra protection Spawns an orbital familiar that blocks enemy projectiles, deals contact damage to enemies, and increases the speed of all orbital familiars.
Halo of Flies 10 Halo of Flies Projectile protection Spawns two pretty fly familiars that block enemy shots and deal contact damage to enemies.
Added in Afterbirth † Mom's Razor 508 Mom's Razor It's sharp! Spawns an orbiting razor that damages enemies it touches and inflicts bleeding on enemies, causing them to slowly take damage over time.
Sacrificial Dagger 172 Sacrificial Dagger My fate protects me Dagger orbits Isaac, dealing very high damage.
Added in Afterbirth † Slipped Rib 542 Slipped Rib Projectile shield Spawns a bone familiar that circles around Isaac and reflects enemy shots.
Smart Fly 264 Smart Fly Revenge fly After Isaac takes damage, this fly will deal continuous touch damage to whatever enemy caused the damage until it is dead. The fly will then systematically attack 1 enemy at a time until the room is cleared.
Added in Afterbirth Sworn Protector 363 Sworn Protector Protective friend An orbital angel which does 7 contact damage per tick and blocks enemy shots. Upon blocking 10 shots in a room it drops an eternal heart.
Added in Afterbirth † Tonsil 474 Tonsil Gross... Grants a familiar that can block enemy shots.

Pills / Slot Machine[edit | edit source]

Name Description
Pretty Fly Grants 1 fly orbital that circles the player, blocking projectiles and damaging fly-type enemies on touch.

Notes[edit | edit source]

  • A maximum of three Pretty Flies can orbit around Isaac.
    • It is possible to have more than three orbitals if one has access to co-op mode. If a co-op baby or multiple co-op babies temporarily hold all but two orbitals while Isaac picks up another, and then the co-op baby or co-op babies sign out or die, Isaac will receive their orbitals as well.
  • Cube of Meat, Ball of Bandages, and Sacrificial Dagger take up a pretty fly slot.
    • For example, If Isaac has three pretty flies and picks up a Cube of Meat, the Cube of Meat will replace one of the flies.
    • Only first and second stage Cube of Meat and Ball of Bandages are orbitals. Therefore, upgrading from level 2 to level 3 will free up a pretty fly slot.
  • Duplicated orbitals, such as Forever Alone being copied with the Box of Friends or Diplopia, will fly directly opposite the original (having three copies will cause them to fly 120 degrees apart, four will fly at 90 degrees and so on).

Trivia[edit | edit source]

  • Pretty fly is a play on the phrase "pretty fly" as a descriptor.

Pickup generation familiars[edit | edit source]

Familiars that generate pickups when certain conditions are met.

Name ID Icon Quote Description
Added in Afterbirth † Acid Baby 491 Acid Baby Pills pills pills! Spawns a familiar that drops random pills every 2 rooms cleared. Upon using a pill, all enemies in the room are poisoned.
Bomb Bag 131 Bomb Bag Gives bombs Isaac is followed by a small bag that drops a Bomb, 1+1 Free, or a Troll Bomb every 3 rooms.
Added in Afterbirth Bumbo 385 Bumbo Bumbo want coin! Spawns a beggar familiar which floats around the room and picks up any nearby coins, leveling up after collecting several coins. At level 2, Bumbo gains a body. At level 3, it begins to fire tears. At level 4, Bumbo chases enemies slowly, dealing contact damage.
Bum Friend 144 Bum Friend He's greedy A portable beggar who follows Isaac, picks up coins for himself, and occasionally drops a pickup after collecting a coin. Does not spawn collectibles.
Added in Afterbirth Charged Baby 372 Charged Baby Bbbzzzzzt! A familiar that drops a Little Battery every 4 rooms. Has a small chance to freeze all enemies in the room when hit.
Dark Bum 278 Dark Bum He wants to take your life Spawns a familiar that follows Isaac around and collects red hearts. For every one-and-a-half red hearts collected, Dark Bum will generate one soul heart, one hostile Spider or one friendly blue spider.
Added in Afterbirth Key Bum 388 Key Bum He wants your keys! Spawns a portable key master that follows Isaac and collects keys, giving random chests in return.
Added in Afterbirth Lil Chest 362 Lil Chest What's in the box? Spawns a chest familiar that follows Isaac and drops a random pickup every few rooms.
Little C.H.A.D. 96 Little C.H.A.D. Gives kisses A familiar who will drop a half red heart every 2 rooms.
Mystery Sack 271 Mystery Sack ? Spawns a familiar that follows Isaac around and has a chance to drop a heart, coin, bomb, or key after clearing a room.
The Relic 98 The Relic Soul generator Isaac is followed by a small blue cross that will drop a Soul Heart every 4 rooms.
Added in Afterbirth Rune Bag 389 Rune Bag Rune generator A bag that follows Isaac and drops a random rune every 3 rooms.
Sack of Pennies 94 Sack of Pennies Gives money Isaac is followed by a small bag that drops a coin every 2 rooms.
Added in Afterbirth † Sack of Sacks 500 Sack of Sacks Gives sacks Spawns a sack familiar that has a chance to drop a sack upon clearing a room.

Spawning familiars[edit | edit source]

Familiars that spawn friendly Blue Spiders or Blue Flies.

Name ID Icon Quote Description
Dark Bum 278 Dark Bum He wants to take your life Spawns a familiar that follows Isaac around and collects red hearts. For every one-and-a-half red hearts collected, Dark Bum will generate one soul heart, one hostile Spider or one friendly blue spider.
Juicy Sack 266 Juicy Sack Sticky babies A familiar that follows behind Isaac. It drips a trail of creep, which slows enemies, and spawns 1-2 blue spiders after each room.
Rotten Baby 268 Rotten Baby Infested friend A familiar that spawns blue flies.
Sissy Longlegs 280 Sissy Longlegs She loves you Wanders about the room, occasionally spawning blue spiders.

Shooting familiars[edit | edit source]

Familiars that attack with their own tears as long as Isaac is attacking or charging a shot.

Name ID Icon Quote Description
Scissors 325
Scissors
6 rooms
Lose your head Upon use, turns Isaac's head into a stationary familiar for the current room which fires normal tears that deal 3.5 damage.
Name ID Icon Quote Description
???'s Soul 57 ???'s Soul Imaginary Friend Spawns a familiar that floats slowly around the room on a pattern similar to The Peeper and fires spectral and homing tears.
Abel 188 Abel Mirrored buddy A familiar that mirrors the player's movements and shoots in the opposite direction.
Ball of Bandages 207 Ball of Bandages Gotta lick 'em all! Orbiting familiar that deals damage to enemies. If collected while already having one, makes the familiar evolve. Only drops from Horsemen. Similar to Cube of Meat.
Brother Bobby 8 Brother Bobby Friends 'till the end Follows Isaac around shooting normal tears.
Added in Afterbirth † Buddy in a Box 518 Buddy in a Box What could it be?! Grants a familiar with a random tear effect. The familiar is randomized at the start of each floor.
Cain's Other Eye 319 Cain's Other Eye Near sighted friend Spawns a familiar that floats slowly around the room on a zig-zag pattern similar to The Peeper and shoots normal tears in the same direction as Isaac.
Cube of Meat 73 Cube of Meat Gotta meat 'em all! Orbiting familiar that blocks enemy shots and deals damage to enemies. If collected while already having one, makes the familiar evolve. Only drops from Horsemen. Similar to Ball of Bandages.
Demon Baby 113 Demon Baby Auto-turret friend Follows Isaac and automatically fires at enemies in its reach.
Added in Afterbirth Fate's Reward 361 Fate's Reward Your fate beside you A blue head familiar that will follow Isaac and fire tears copying his tear effects and damage.
Ghost Baby 163 Ghost Baby Spectral buddy Spawns a familiar that follows Isaac around and fires spectral tears.
Harlequin Baby 167 Harlequin Baby Double shot buddy Spawns a familiar that follows Isaac around and fires two tears at once in a V-pattern.
Added in Afterbirth Incubus 360 Incubus Dark friend A demonic familiar that follows Isaac and shoots tears identical to Isaac's in terms of damage, range, fire rate, and effects.
Isaac's Head 54 Isaac's Head Dead friend Gives the player Isaac's severed head as a tear-firing familiar. Fires piercing tears.
Lil Brimstone 275 Lil Brimstone Evil Friend A Familiar that shoots a thin Brimstone beam. Must charge like Brimstone before shooting.
Added in Afterbirth Lil' Loki 435 Lil' Loki 4-way buddy! A Loki familiar that follows Isaac and shoots 4 tears in a cross pattern.
Added in Afterbirth † Lil Monstro 471 Lil Monstro Ain't he cute? Spawns a familiar that fires clusters of tears. Must be charged before shooting.
Little Gish 99 Little Gish Sticky friend Spawns a familiar that follows Isaac around and fires slowing tears, impeding enemies' speed.
Little Steven 100 Little Steven Psychic friend Spawns a familiar that follows Isaac around and fires homing tears.
Mongo Baby 322 Mongo Baby Mongo Friend Summons a familiar that copies the tears of Isaac's other familiars.
Rainbow Baby 174 Rainbow Baby Random buddy Spawns a familiar that follows Isaac around and fires tears with random effects.
Robo-Baby 95 Robo-Baby Friends 'till the bbbbzzzt Follows Isaac around, shooting enemies with an eye laser similar to Technology.
Robo-Baby 2.0 267 Robo-Baby 2.0 We worked out all the kinks Fires lasers at any enemy in its line of sight and moves based on the direction Isaac is firing tears.
Added in Afterbirth Seraphim 390 Seraphim Sworn friend An angel familiar which follows Isaac and fires homing tears which deal 10 damage at -25% shot speed and a reduced fire rate.
Sister Maggy 67 Sister Maggy Friends 'till the end A familiar that follows Isaac around shooting blood tears.
Umbilical Cord 33 Umbilical Cord Fetal Protection When Isaac's health is brought to half a red heart and no soul hearts, a Little Steven familiar spawns for the current room.

Note: Only second stage Cube of Meat and Ball of Bandages shoot tears.
Note: Demon Baby shoots tears even when Isaac is not attacking.

Others[edit | edit source]

Familiars that don't fit into any of the above categories or that produce multiple effects.

Name ID Icon Quote Description
Added in Afterbirth † Brown Nugget 504
Brown Nugget
7 seconds
Friendly fly Spawns a stationary fly familiar that fires tears at nearby enemies.
Added in Afterbirth † Sprinkler 516
Sprinkler
4 rooms
Sprinkles. Upon use, spawns a sprinkler that rotates and fires tears.
Name ID Icon Quote Description
1up! 11 1up! Extra life Gives an extra life. Upon death, you will respawn in the previous room with full health and lose the 1up!.
Added in Afterbirth † 7 Seals 526 7 Seals Lil harbingers! Grants a random Harbinger familiar that changes every 10 seconds.
Added in Afterbirth † Angelic Prism 528 Angelic Prism Eclipsed by the moon Grants a prism orbital with a large orbital radius. Tears that pass through the prism split into four multi-colored tears.
Added in Afterbirth † Angry Fly 511 Angry Fly He's violent Spawns a fly familiar that orbits around a random enemy and deals 5 damage per tick to enemies it comes in contact with.
BBF 272 BBF Big Beautiful Fly Spawns a familiar that flies around the room in a manner similar to the Boom Fly and explodes on contact with an enemy. Respawns after ten seconds.
Added in Afterbirth † Big Chubby 473 Big Chubby Chub chub Spawns a familiar that slowly charges forward and damages enemies in its path.
Bob's Brain 273 Bob's Brain Explosive thoughts Spawns a familiar that charges forward when shooting tears and explodes upon contact with an enemy, damaging and poisoning them. The familiar respawns after a few seconds.
Added in Afterbirth Censer 387 Censer Peace be with you Gives Isaac a golden censer familiar which creates a huge aura of light that slows down any enemies and enemy shots inside it.
Dead Cat 81 Dead Cat 9 lives Sets the amount of red heart containers to 1, but gives Isaac 9 extra lives. After dying, Isaac is teleported to the last safe room. New heart containers can be obtained after picking up this item, but after each death, the number of heart containers is set to 1 again.
Added in Afterbirth † Depression 469 Depression :( Spawns a cloud familiar that leaves a trail of tears that damages enemies. Has a chance to spawn damaging beams of light onto enemies that touch the cloud.
Dry Baby 265 Dry Baby Immortal Friend Spawns a familiar that follows Isaac around and blocks enemy projectiles. Upon blocking a shot, it has a chance of triggering The Necronomicon effect.
Added in Afterbirth Farting Baby 404 Farting Baby It farts! A familiar that follows Isaac and blocks tears. If a tear hits Farting Baby, there is a high chance for it to fart, which will either knock back, poison, or charm all nearby enemies.
Added in Afterbirth † Finger! 467 Finger! Watch where you point that! Spawns a finger familiar that points at enemies, dealing constant damage.
Added in Afterbirth GB Bug 405 GB Bug Game breaking bug, right away! A glitch familiar that bounces around the room and applies a random status effect to any enemies it comes into contact with and has a chance to re-roll pickups that it passes over.
Guppy's Hair Ball 187 Guppy's Hair Ball Swing it Loosely follows behind Isaac. Can be swung like a flail by rapidly spinning Isaac in a circle. Grows bigger by killing enemies.
Added in Afterbirth † Hallowed Ground 543 Hallowed Ground Portable sanctuary Spawns a white poop familiar, which turns into a white poop when Isaac is hurt.
Headless Baby 269 Headless Baby Bloody Friend Familiar that follows Isaac, leaving blood creep on the ground.
Holy Water 178 Holy Water Splash! When Isaac receives damage, the bottle breaks and a puddle of blue creep forms, which damages non-flying enemies, similar to Lemon Mishap. The bottle is reformed upon entering a different room.
Added in Afterbirth † Hushy 470 Hushy Lil hush! Spawns a Hush familiar that bounces around the room and deals contact damage. While firing tears, it stops moving.
Isaac's Heart 276 Isaac's Heart Protect It Isaac himself is now immune to all damage, and a heart familiar appears and follows Isaac. If the heart is hurt, Isaac is hurt.
Added in Afterbirth † Jaw Bone 548 Jaw Bone Fetch! Spawns a familiar that flies the room while firing, dealing double Isaac's tear damage to enemies that come in contact and retrieving pickups.
Key Piece 1 238 Key Piece 1 ??? Combined with Key Piece 2, unlocks the golden gate in the starting room of The Chest and Dark Room to fight Mega Satan.
Key Piece 2 239 Key Piece 2 ??? Combined with Key Piece 1, unlocks the golden gate in the starting room of The Chest and Dark Room to fight Mega Satan.
Added in Afterbirth † King Baby 472 King Baby Lord of the dead! Spawns a familiar that follows Isaac and makes other familiars follow it. While firing tears, it stops moving.
Added in Afterbirth † Lil Delirium 519 Lil Delirium Delirious friend Grants a familiar that transforms into another random familiar every 10 seconds.
Added in Afterbirth Lil Gurdy 384 Lil Gurdy A gurd of your own! Gives Isaac a Gurdy familiar that will charge around the room dealing contact damage to enemies. Lil Gurdy is charged by holding down a fire button and letting go. The longer the button is held, the faster Lil Gurdy will fling itself across the screen. Lil Gurdy can pass over objects and obstacles in the room.
Added in Afterbirth † Lil Spewer 537 Lil Spewer Puking buddy Spawns a random pill, and grants a small Spewer familiar that charges up and fires different types of creep.
Little Chubby 88 Little Chubby Attack Buddy A familiar that charges forward and deals touch damage to any enemies in its path.
Added in Afterbirth Lost Fly 365 Lost Fly Lost protector A familiar fly that moves in a straight line and attaches itself to the first obstacle or wall it comes into contact with in each room. If any enemies walk into its path, it will deal 7 contact damage per tick. If the obstacle it is attached to is destroyed then it will continue rolling in the direction it was previously travelling until it meets another wall or obstacle.
Added in Afterbirth Milk! 436 Milk! Don't cry over it... A glass of milk follows Isaac and spills on the floor upon taking damage. After the milk spills, Isaac's tear delay is decreased by 2 for the rest of the room.
Mom's Toenail 16 Mom's Toenail ??? Mom's foot randomly stomps down somewhere in the room. 1 minute intervals.
Added in Afterbirth Multidimensional Baby 431 Multidimensional Baby ydduB Buddy Spawns a familiar that will follow Isaac's movements on a 2.5 second delay. Tears that pass through the baby will be doubled and increase in speed.
Added in Afterbirth † Mystery Egg 539 Mystery Egg Sacrificial insemination Spawns an egg familiar, which cracks and turns into a random charmed enemy when Isaac is hurt. The egg regenerates upon entering a different room.
Added in Afterbirth Obsessed Fan 426 Obsessed Fan Follows my every move... A purple fly familiar that follows Isaac's movements on a 3 second delay and deals contact damage to enemies.
Added in Afterbirth Papa Fly 430 Papa Fly Turret follower A blue fly familiar follows Isaac's movements on a 3 second delay. Papa Fly will fire tears at nearby enemies.
The Peeper 155 The Peeper Plop! Spawns a familiar that floats slowly around the room on a zig-zag pattern similar to Boom Flies damaging enemies it passes through.
Added in Afterbirth † Pointy Rib 544 Pointy Rib Stabbing time Spawns a bone familiar that can be aimed with the fire buttons and does contact damage.
Punching Bag 281 Punching Bag Scape Goat Spawns a Mulligan Familiar that will wander the room randomly. Enemies will attack the Mulligan if it's closer.
Samson's Chains 321 Samson's Chains The ol' ball and chain Pull a chain and ball behind you that will damage enemies on contact and is able to break stones.
Added in Afterbirth † Shade 468 Shade It follows Spawns a shadow familiar that follows Isaac's movements on a 1 second delay and deals contact damage to enemies.
Added in Afterbirth Spider Mod 403 Spider Mod Mod buddy! Displays Isaac's tear damage and enemy health bars. Spawns a gray spider familiar that wanders around and inflicts a random status effect on any enemies it comes into contact with. Occasionally spawns a blue spider upon clearing a room.
Added in Afterbirth Succubus 417 Succubus Damage booster Spawns a flying familiar that bounces around the room with a black aura, dealing rapid damage to any enemies inside it. While standing in the aura, Isaac gains a 1.5x tear damage multiplier.
Added in Afterbirth † Tonsil 97 Tonsil Sick... When hit, there is a small chance a removed tonsil familiar starts following Isaac, blocking enemy shots.
Added in Afterbirth † YO LISTEN! 492 YO LISTEN! Yo listen! +1 luck. Spawns a fairy familiar that points out secret room entrances and tinted rocks.

Unlockable Achievements[edit | edit source]


The Binding of Isaac: Rebirth The Binding of Isaac: Rebirth The Binding of Isaac: Rebirth
MainPageAchievements.png Achievements MainPageAttributes.png Attributes MainPageBosses.png Bosses TarotCard.png Cards and Runes MainPageChallenges.png Challenges MainPageChapters.png Chapters
Isaac App.png Characters MainPageBabies.png Co-op MainPageItems Small.png Items Item Pools Item Pools MainPageMonsters.png Monsters MainPageObjects.png Objects
Red heart.png Pickups BlueBlue.png Pills MainPageRooms.png Rooms MainPageSeeds2.png Seeds Guppy App.png Transformations The Left Hand Icon.png Trinkets

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