Boils start off as small red spheres that slowly grow to full size. When at their full size, they can spurt out short-ranged blood shots at Isaac, similar to one of Monstro's attacks. Boils decrease in size when hit, but will regenerate to their full size until fully destroyed.
Boils are nearly harmless on their own, as they can simply be killed from a distance and do not deal damage on contact. With other enemies, however, they are far more dangerous: If entering a room with a large crowd of enemies and several Boils providing covering fire, taking out enough of the Boils to give yourself breathing room should be a big priority, especially when fighting Gurdy.
Variants
Gut
Guts can replace Boils or Sacks. Instead of firing multiple short-ranged blood shots, Guts fire Ipecac shots at Isaac that do not damage themselves.
They can easily be a nuisance if there are other enemies backing them. However, they are rather easy to manipulate into destroying rocks or finding Secret Rooms without using a bomb.
Sack
Sacks don't shoot projectiles; instead, they periodically spawn Spiders when fully swollen. Therefore, damaging them will prevent them from spawning Spiders, making them easy to kill. They can commonly be found in early floors.
Blue Boil
Blue Boils are only spawned during the Hush fight. Instead of spraying spurts of blood, they fire normal blood shots towards Isaac. They also regain their health 10x faster than regular Boils if they are damaged but not killed.
Notes
Blue Boils can rarely appear in The Depths, Necropolis, or the Dank Depths.
- Blue Boils that appear in regular rooms can be Champions.
Gush
Gushes were added in Booster Pack #4.
Gushes are stationary enemies similar in appearance to black Boils. They are stationary, do not deal contact damage, and do not attack. Instead, they continually create slowing black creep around them. Unlike other Boil variants, they do not shrink or regenerate.
Although the black creep is relatively harmless on its own, Tar Boys can use their special attack if Isaac is standing on the creep.
Walking Boil
Walking Boils act like Boils but randomly wander around the room, can deal half a heart of contact damage and don't shrink or regenerate.
Walking Gut
Walking Guts act like Guts but randomly wander around the room, can deal half a heart of contact damage and don't shrink and regenerate.
Walking Sack
Walking Sacks act like Sacks but randomly wander around the room, can deal half a heart of contact damage and don't shrink or regenerate.
Notes
- While regular boils can be touched without taking damage, champion forms do inflict one heart of damage on touch (like all champions).
- Champion boils grow significantly slower, but take more hits to deflate. The exception to this is gray champions, which grow faster and take fewer hits to deflate.
 The Binding of Isaac: Rebirth
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