Book of the Dead is an active item added in Booster Pack #5.
- When used, spawns one of the following things for each enemy already killed in the current room:
- An orbital bone familiar (very common).
- A charmed Bony (uncommon).
- A charmed Black Bony (rare).
- Orbital bones deal contact damage equal to Isaac's damage at the time it was spawned, repel enemies that touch it, and will block 3 shots or deal 2 ticks of contact damage before being destroyed.
- Bonys deal 8.3 contact damage and 5 damage with thrown bones.
- Black Bonys will explode on death, dealing 40 damage to enemies it hits. The explosion will also hurt Isaac if he is in range.
- Using the book in a room that had no enemies or was re-entered does nothing and expends the charge.
- Enemy remains can be animated only once, so using the book multiple times in the same room requires more enemies to have died for it to have an effect.
- Destroying Black Poop will damage charmed Bonys acquired from this item.
- Baby-BenderGrants Isaac's familiars homing shots.: No effect.
- Car BatteryCauses Isaac's activated item to activate twice on each use.: Since dead enemies can be animated only once, Car Battery does nothing.
- Duct TapeStops Isaac's familiars from moving.: Only affects orbitals.
- Spawn three charmed enemies in the same room.
- The Book of the Dead is a collection of ancient Egyptian funerary texts made out of papyrus, consisting of magic spells intended to assist a soul's journey through the Duat (underworld) and into the afterlife.
- The quote "Rise from the Grave" is a reference to the beginning screen of the video game "Altered Beast".
- Anarchist CookbookSpawns six troll bombs around the room.
- The BibleUpon activation, Isaac gains flight, allowing him to pass over all obstacles in the current room. Instantly kills Mom, Mom's Heart, and It Lives when activated, but will kill Isaac when activated while fighting Satan.
- The Book of BelialUpon use increases damage by 2 for the current room and by a further +50% if the character also has the Blood of the Martyr.
Guarantees a Devil Room or Angel Room will be open after beating a boss while holding it, or increases the chance by 12.5%.
- Book of the DeadUpon use, spawns a charmed Bony or an orbital bone for each enemy killed in the current room.
- Book of RevelationsAdds 1 soul heart, increases the chance for a Devil or Angel Room to appear, and increases the chance for the next boss to be a Horseman (except on XL floors and floors with fixed bosses such as Mom).
- Book of SecretsUpon use, gives the effect of Treasure Map, The Compass, or Blue Map for the duration of the current floor.
- Book of ShadowsUpon use, creates a protective shield nullifying all types of damage for 10 seconds.
- The Book of SinSpawns a random pickup, pill, card, or trinket.
- How to JumpGives Isaac the ability to jump (over gaps, spikes, etc.).
- Monster ManualSummons a random familiar for the current room. Can summon familiars not yet unlocked.
- The NecronomiconDamages all enemies in the room significantly.
- Satanic BibleUpon activation, Isaac gains a black heart.
- Telepathy for DummiesUpon activation, grants homing tears for the current room.