Bosses

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Bosses are very strong monsters found in boss rooms at the end of a floor. The boss at the end of the floor must be defeated in order to advance to the next floor. In later chapters, bosses are able to spawn as normal enemies. This starts in the caves, where the Gurglings are often encountered. The boss for a particular floor is chosen from the pool of bosses for the environment of the floor. Bosses may also spawn as champions, which can change various attributes such as health, damage, and attack pattern. Upon defeat, most bosses will drop an item from the boss item pool.

Bosses boast additional resistances to status effects. For example, fear occurs less often and the Night Light is unable to slow them down.

Additionally, some floors may spawn a room with a Mini-Boss.

In total, there are 72 bosses and 18 mini-bosses. 10 bosses were added in Afterbirth and 6 were added in Afterbirth †.

Chapter 1

The Basement

Boss Monstro.png Boss Gemini.png
Boss Larry Jr..png
Boss Dingle.png
Boss Gurglings.png
Monstro Gemini Larry Jr. Dingle Gurglings
Boss Steven.png
Boss Dangle.png
Boss Turdlings.png
Steven Needs to be unlocked Dangle Added in Afterbirth Needs to be unlocked Turdlings Added in Afterbirth Needs to be unlocked

The Cellar

Boss Pin.png
Boss Widow.png
Boss Blighted Ovum.png
Boss Fistula.png
Boss The Haunt.png
Pin Widow Blighted Ovum Fistula The Haunt

The Basement and The Cellar

Boss The Duke of Flies.png
Boss Famine.png
Boss Rag Man.png
Boss Little Horn.png
The Duke of Flies Famine Needs to be unlocked Rag Man Added in Afterbirth Needs to be unlocked Little Horn Added in Afterbirth Needs to be unlocked

Burning Basement Added in Afterbirth

Boss Monstro.png
Boss Larry Jr..png
Boss The Duke of Flies.png
Boss The Haunt.png
Boss Famine.png
Monstro Larry Jr. The Duke of Flies The Haunt Famine Needs to be unlocked
Boss Rag Man.png
Boss Little Horn.png
Rag Man Added in Afterbirth Needs to be unlocked Little Horn Added in Afterbirth Needs to be unlocked

Chapter 2

The Caves

Boss Chub.png
Boss Gurdy.png
Boss Mega Maw.png
Boss Mega Fatty.png
Boss C.H.A.D..png
Chub Gurdy Mega Maw Mega Fatty C.H.A.D. Needs to be unlocked

The Catacombs

Boss The Hollow.png
Boss The Husk.png
Boss Dark One.png
Boss Polycephalus.png
The Hollow The Husk Dark One Polycephalus
Boss Carrion Queen.png
Boss The Wretched.png
Carrion Queen The Wretched

The Caves and The Catacombs

Boss Gurdy Jr..png
Boss Peep.png
Boss Pestilence.png
Boss The Frail.png
Boss The Stain.png
Gurdy Jr. Peep Pestilence Needs to be unlocked The Frail Added in Afterbirth Needs to be unlocked The Stain Added in Afterbirth Needs to be unlocked
Boss The Forsaken.png
Boss Big Horn.png
Boss Rag Mega.png
The Forsaken Added in Afterbirth Needs to be unlocked Big Horn Added in Afterbirth † Needs to be unlocked Rag Mega Added in Afterbirth † Needs to be unlocked

Double Trouble

Boss Dingle.png
Boss The Duke of Flies.png
Boss Gemini.png
Boss Widow.png
Boss Pin.png
(Double Trouble)

Dingle

(Double Trouble)

The Duke of Flies

(Double Trouble)

Gemini

(Double Trouble)

Widow

(Double Trouble)

Pin

Boss Larry Jr..png
Boss Blighted Ovum.png
Boss Monstro.png
(Double Trouble)

Larry Jr.

(Double Trouble)

Blighted Ovum

(Double Trouble)

Monstro

Flooded Caves Added in Afterbirth

Boss Chub.png
Boss C.H.A.D..png
Boss Gurdy Jr..png
Boss Gurdy.png
Boss Polycephalus.png
Chub C.H.A.D. Needs to be unlocked Gurdy Jr. Gurdy Polycephalus
Boss Pestilence.png
Boss The Stain.png
Boss The Frail.png
Boss The Forsaken.png
Pestilence Needs to be unlocked The Stain Added in Afterbirth Needs to be unlocked The Frail Added in Afterbirth Needs to be unlocked The Forsaken Added in Afterbirth Needs to be unlocked
Boss Big Horn.png
Boss Rag Mega.png
Big Horn Added in Afterbirth † Needs to be unlocked Rag Mega Added in Afterbirth † Needs to be unlocked

Chapter 3

Floor 1

The Depths

Boss The Cage.png
Boss Monstro II.png
Boss Gish.png
The Cage Monstro II Gish Needs to be unlocked

Necropolis

Boss The Bloat.png
Boss Mask Of Infamy.png
The Bloat Mask of Infamy

The Depths and Necropolis

Boss Loki.png
Boss The Gate.png
Boss The Adversary.png
Boss War.png
Loki The Gate The Adversary War Needs to be unlocked
Boss Brownie.png
Boss Sisters Vis.png
Brownie Added in Afterbirth Needs to be unlocked Sisters Vis Added in Afterbirth † Needs to be unlocked

Double Trouble

Boss Gurdy Jr..png
The Haunt
Boss The Wretched.png
Boss The Husk.png
(Double Trouble)

Gurdy Jr.

(Double Trouble)

The Haunt

(Double Trouble)

The Wretched

(Double Trouble)

The Husk

Boss Peep.png
Boss Mega Fatty.png
Boss Dark One.png
(Double Trouble)

Peep

(Double Trouble)

Mega Fatty

(Double Trouble)

Dark One

Boss Mega Maw.png
Boss Larry Jr..png
Boss Blighted Ovum.png
(Double Trouble)

Mega Maw

(Double Trouble)

Larry Jr.

(Double Trouble)

Blighted Ovum

Dank Depths Added in Afterbirth

Boss Monstro II.png
Boss Gish.png
Boss The Adversary.png
Boss Loki.png
Boss War.png
Monstro II Gish Needs to be unlocked The Adversary Loki War Needs to be unlocked
Boss Brownie.png
Boss Sisters Vis.png
Brownie Added in Afterbirth Needs to be unlocked Sisters Vis Added in Afterbirth † Needs to be unlocked

Floor 2

The Depths, Necropolis and Dank Depths

Boss Mom.png
Mom

Chapter 4

Floor 1

The Womb

Boss Scolex.png
Scolex

The Womb and Utero

Boss Teratoma.png
Boss Mr. Fred.png
Boss Blastocyst.png
Boss The Bloat.png
Boss Daddy Long Legs.png
Teratoma Mr. Fred Blastocyst The Bloat Daddy Long Legs
Boss Lokii.png
Boss Mama Gurdy.png
Boss Triachnid.png
Boss Death.png
Boss Conquest.png
Lokii Mama Gurdy Triachnid Needs to be unlocked Death Needs to be unlocked Conquest Needs to be unlocked
Boss Sisters Vis.png
Boss The Matriarch.png
Sisters Vis Added in Afterbirth † Needs to be unlocked The Matriarch Added in Afterbirth † Needs to be unlocked

Double Trouble

Boss The Cage.png
Boss Gurdy.png
Boss The Fallen.png
Boss The Gate.png
Boss Loki.png
(Double Trouble)

The Cage

(Double Trouble)

Gurdy

(Double Trouble)

The Fallen

(Double Trouble)

The Gate

(Double Trouble)

Loki

Scarred Womb

Boss Blastocyst.png
Boss The Bloat.png
Boss Daddy Long Legs.png
Boss Triachnid.png
Boss Mama Gurdy.png
Blastocyst The Bloat Daddy Long Legs Triachnid Needs to be unlocked Mama Gurdy
Boss Teratoma.png
Boss Scolex.png
Boss Death.png
Boss Conquest.png
Teratoma Scolex Death Needs to be unlocked Conquest Needs to be unlocked
Boss Sisters Vis.png
Boss The Matriarch.png
Sisters Vis Added in Afterbirth † Needs to be unlocked The Matriarch Added in Afterbirth † Needs to be unlocked

Floor 2

The Womb, Utero and Scarred Womb

Boss Mom's Heart.png
Boss It Lives.png
Mom's Heart It Lives Needs to be unlocked

Chapter 5

Sheol

Boss Satan.png
Satan

The Cathedral

Boss Isaac (Boss).png
Isaac

Chapter 6

The Chest

???
???

Dark Room

Boss The Lamb.png
The Lamb

Golden Door Boss

Boss Mega Satan.png
Mega Satan

Blue Womb Added in Afterbirth

Boss Hush.png
Hush Added in Afterbirth

The Void Added in Afterbirth †

Boss Delirium.png
Delirium Added in Afterbirth †

Universal

Universal Bosses are those which may appear at the end of floors 1-5 and 7, replacing a boss from the pool for that environment.

Boss The Fallen.png
Boss The Headless Horseman.png
The Fallen The Headless Horseman Needs to be unlocked

Devil and Angel Room Needs to be unlocked

Devil Room

Boss Krampus.png
Krampus

Angel Room

Boss Angel.png
Boss Angel2.png
Uriel Gabriel

Seven Deadly Sins and Others

Seven Deadly Sins

The Seven Deadly Sins are mini-bosses that can be encountered on any floor, and will appear on post-Womb/Utero floors as regular enemies. Unlike with regular bosses, there is no special door leading to a mini-boss room, meaning that there is no way to tell whether a room is inhabited by a mini-boss unless the player is in possession of an item that reveals map icons such as Compass or a Map item. Once in a mini-boss room, the player cannot escape through means of bombing the door, as it will be boarded off.

Each of the Sins has specific drops, that are consumables or a pedestal item (less frequently).
In a room containing multiple Sins, only the last one will drop something, allowing you to choose what drop you want by killing a certain mini-boss last.

All them are based on the Seven Deadly Sins.

Boss Envy.png
Boss Gluttony.png
Boss Wrath.png
Envy Gluttony Wrath
Boss Pride.png
Boss Lust.png
Boss Greed.png
Pride Lust Greed
Boss Sloth.png
Sloth

These monsters can also spawn as much stronger alternatives, known as the Seven Super Deadly Sins.

Boss Super Envy.png
Boss Super Gluttony.png
Boss Super Wrath.png
Super Envy Super Gluttony Super Wrath
Boss Super Pride.png
Boss Super Lust.png
Boss Super Greed.png
Super Pride Super Lust Super Greed
Boss Super Sloth.png
Super Sloth

There is also an Ultra variant of both Pride and Greed. Ultra Pride resembles Edmund and Florian, while Ultra Greed serves as the final boss for Greed Mode.

Boss Ultra Pride.png
Ultra Pride

Greed Mode Added in Afterbirth

Greed Mode

Boss Ultra Greed.png
Ultra Greed Added in Afterbirth

Greedier Mode

Boss Ultra Greedier.png
Ultra Greedier Added in Afterbirth †

All Mini-Bosses

The Seven Deadly Sins

Boss Envy.png
Boss Gluttony.png
Boss Wrath.png
Envy Gluttony Wrath
Boss Pride.png
Boss Lust.png
Boss Greed.png
Pride Lust Greed
Boss Sloth.png
Sloth

The Seven Super Deadly Sins

Boss Super Envy.png
Boss Super Gluttony.png
Boss Super Wrath.png
Super Envy Super Gluttony Super Wrath
Boss Super Pride.png
Boss Super Lust.png
Boss Super Greed.png
Super Pride Super Lust Super Greed
Boss Super Sloth.png
Super Sloth

Ultra Pride

Boss Ultra Pride.png
Ultra Pride

Krampus Needs to be unlocked

Boss Krampus.png
Krampus

Angels Needs to be unlocked

Boss Angel.png
Boss Angel2.png
Uriel Gabriel

All Bosses

Boss Monstro.png Boss Gemini.png
Boss Larry Jr..png
Monstro Gemini Larry Jr.
Boss Dingle.png
Boss Gurglings.png
Boss Steven.png
Dingle Gurglings Steven Needs to be unlocked
Boss Pin.png
Boss Widow.png
Boss Blighted Ovum.png
Pin Widow Blighted Ovum
Boss Fistula.png
Boss The Haunt.png
Fistula The Haunt
Boss The Duke of Flies.png
Boss Rag Man.png
Boss Little Horn.png
The Duke of Flies Rag Man Added in Afterbirth Needs to be unlocked Little Horn Added in Afterbirth Needs to be unlocked
Boss Dangle.png
Boss Turdlings.png
Boss Chub.png
Dangle Added in Afterbirth Needs to be unlocked Turdlings Added in Afterbirth Needs to be unlocked Chub
Boss Gurdy Jr..png
Boss Gurdy.png
Boss Mega Maw.png
Boss C.H.A.D..png
Gurdy Jr. Gurdy Mega Maw C.H.A.D. Needs to be unlocked
Boss Mega Fatty.png
Boss The Hollow.png
Boss The Husk.png
Mega Fatty The Hollow The Husk
Boss Dark One.png
Boss Polycephalus.png
Boss The Frail.png
Dark One Polycephalus The Frail Added in Afterbirth Needs to be unlocked
Boss The Stain.png
Boss The Forsaken.png
Boss Carrion Queen.png
The Stain Added in Afterbirth Needs to be unlocked The Forsaken Added in Afterbirth Needs to be unlocked Carrion Queen
Boss The Wretched.png
Boss Peep.png
Boss Big Horn.png
The Wretched Peep Big Horn Added in Afterbirth † Needs to be unlocked
Boss Rag Mega.png
Boss The Cage.png
Boss Loki.png
Rag Mega Added in Afterbirth † Needs to be unlocked The Cage Loki
Boss Monstro II.png
Boss Gish.png
Boss The Gate.png
Monstro II Gish Needs to be unlocked The Gate
Boss The Adversary.png
Boss The Bloat.png
Boss Mask Of Infamy.png
The Adversary The Bloat Mask of Infamy
Boss Brownie.png
Boss Sisters Vis.png
Boss Mr. Fred.png
Brownie Added in Afterbirth Needs to be unlocked Sisters Vis Added in Afterbirth † Needs to be unlocked Mr. Fred
Boss Scolex.png
Boss Mama Gurdy.png
Boss Lokii.png
Scolex Mama Gurdy Lokii
Boss Blastocyst.png
Boss The Matriarch.png
Boss Teratoma.png
Blastocyst The Matriarch Added in Afterbirth † Needs to be unlocked Teratoma
Boss Daddy Long Legs.png
Boss Triachnid.png
Boss The Fallen.png
Daddy Long Legs Triachnid Needs to be unlocked The Fallen

The Harbingers Needs to be unlocked

Boss Famine.png
Boss Pestilence.png
Boss War.png
Famine Pestilence War
Boss Death.png
Boss Conquest.png
Boss The Headless Horseman.png
Death Conquest The Headless Horseman

Final Bosses

Boss Mom.png
Boss Mom's Heart.png
Boss It Lives.png
Mom Mom's Heart It Lives Needs to be unlocked
Boss Satan.png
Boss Isaac (Boss).png
Satan Isaac
???
Boss The Lamb.png
??? The Lamb
Boss Mega Satan.png
Boss Hush.png
Mega Satan Hush Added in Afterbirth
Boss Ultra Greed.png
Boss Ultra Greedier.png
Ultra Greed Added in Afterbirth Ultra Greedier Added in Afterbirth †
Boss Delirium.png
Delirium Added in Afterbirth †

Trivia

  • "Originally every boss/enemy in Isaac was going to resemble Isaac in some way. this is the case for most."[1]
  • Double Trouble boss pools can have bosses from any of the previous chapters' pools, and are the same for both versions of that chapter's floor. This means that, for example, Double Trouble boss fights in the Caves can feature bosses from the Cellar or the Basement, and every Double Trouble fight in the Caves can also be encountered in the Catacombs.
  • Bosses often come in three versions: normal (For example, Monstro), posthumous (Monstro II), and alternate (Gish). Usually, the posthumous boss looks like the original with some horrible mutilation; for example, Monstro and Chub had most of their skin ripped off.
  • Most bosses and their alternate/posthumous forms either share similar death animations or share the fact that they lack death animations.

Bugs

Bug Bug! Defeating a boss quickly enough might cause the boss music to play, even after the boss dies.


The Binding of Isaac: Rebirth The Binding of Isaac: Rebirth The Binding of Isaac: Rebirth
MainPageAchievements.png Achievements MainPageAttributes.png Attributes MainPageBosses.png Bosses TarotCard.png Cards and Runes MainPageChallenges.png Challenges MainPageChapters.png Chapters
Isaac App.png Characters MainPageBabies.png Co-op MainPageItems Small.png Items Item Pools Item Pools MainPageMonsters.png Monsters MainPageObjects.png Objects
Red heart.png Pickups BlueBlue.png Pills MainPageRooms.png Rooms MainPageSeeds2.png Seeds Guppy App.png Transformations The Left Hand Icon.png Trinkets
Bosses Boss Monstro.png
Chapter 1
Stage basement.png
Stage cellar.png
Stage burning basement.png
Blighted OvumDingleThe Duke of FliesFamineFistulaGeminiGurglingsThe HauntLarry Jr.MonstroPinStevenWidow
Added in Afterbirth DangleLittle HornRag ManTurdlings
Chapter 2
Stage caves.png
Stage catacombs.png
Stage flooded caves.png
Carrion QueenC.H.A.D.ChubDark OneGurdyGurdy Jr.The HollowThe HuskMega FattyMega MawPeepPestilencePolycephalusThe Wretched
Added in Afterbirth The ForsakenThe FrailThe Stain
Added in Afterbirth † Big HornRag Mega
Chapter 3
Stage depths.png
Stage necropolis.png
Stage dank depths.png
The AdversaryThe BloatThe CageThe GateGishLokiMask Of InfamyMonstro IIWarMom
Added in Afterbirth Brownie
Added in Afterbirth † Sisters Vis
Chapter 4
Stage womb.png
Stage utero.png
Stage scarred womb.png
BlastocystThe BloatConquestDaddy Long LegsDeathLokiiMama GurdyMr. FredScolexTeratomaTriachnidMom's HeartIt Lives
Added in Afterbirth † Sisters VisThe Matriarch
Added in Afterbirth Blue Womb
???
Added in Afterbirth Hush
Chapter 5
Stage sheol.png
Stage cathedral.png
SatanIsaac
Chapter 6
Stage dark room.png
Stage chest.png
???The LambMega Satan
Added in Afterbirth Greed Mode
Ultra Greed
Added in Afterbirth Ultra Greed
Added in Afterbirth † Ultra Greedier
Added in Afterbirth † The Void
Stage the void.png
Added in Afterbirth † Delirium
Chapters 1-4 The FallenThe Headless Horseman