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Bosses

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Bosses are very strong monsters found in boss rooms at the end of a floor. The boss at the end of the floor must be defeated in order to advance to the next floor. In later chapters, bosses are able to spawn as normal enemies. This starts in the caves, where the Gurglings are often encountered. The boss for a particular floor is chosen from the pool of bosses for the environment of the floor. Bosses may also spawn as champions, which can change various attributes such as health, damage, and attack pattern. Upon defeat, most bosses will drop an item from the boss item pool.

Bosses boast additional resistances to status effects. For example, fear occurs less often and the Night Light is unable to slow them down.

Additionally, some floors may spawn a room with a Mini-Boss.

Chapter 1

The Basement

Boss Monstro.png Boss Gemini.png
Boss Larry Jr..png
Monstro Gemini Larry Jr.
Boss Dingle.png
Boss Gurglings.png
Boss Steven.png
Dingle Gurglings Steven

The Cellar

Boss Pin.png
Boss Widow.png
Boss Blighted Ovum.png
Pin Widow Blighted Ovum
Boss Fistula.png
Boss Gurdy Jr..png
Boss The Haunt.png
Fistula Gurdy Jr. The Haunt

The Basement and The Cellar

Boss The Duke of Flies.png
Boss Famine.png
Boss Rag Man.png
The Duke of Flies Famine Rag Man DLC Indicator.png
Boss Little Horn.png
Boss Dangle.png
Boss Turdlings.png
Little Horn DLC Indicator.png Dangle DLC Indicator.png Turdlings DLC Indicator.png

Burning Basement DLC Indicator.png

Boss Rag Man.png
Boss Little Horn.png
Boss Dangle.png
Rag Man DLC Indicator.png Little Horn DLC Indicator.png Dangle DLC Indicator.png
Boss Turdlings.png
Turdlings DLC Indicator.png

Chapter 2

The Caves

Boss Chub.png
Boss Gurdy.png
Boss Mega Maw.png
Chub Gurdy Mega Maw
Boss Mega Fatty.png
Boss C.H.A.D..png
Boss Rag Mega.png
Mega Fatty C.H.A.D. Rag Mega Afterbirth† Indicator.png

The Catacombs

Boss The Hollow.png
Boss The Husk.png
Boss Dark One.png
The Hollow The Husk Dark One
Boss Polycephalus.png
Boss Carrion Queen.png
Boss The Wretched.png
Polycephalus Carrion Queen The Wretched

The Caves and The Catacombs

Boss Peep.png
Boss Gurdy Jr..png
Boss Pestilence.png
Peep Gurdy Jr. Pestilence
Boss The Frail.png
Boss The Stain.png
Boss The Forsaken.png
The Frail DLC Indicator.png The Stain DLC Indicator.png The Forsaken DLC Indicator.png
Boss Big Horn.png
Big Horn Afterbirth† Indicator.png

Double Trouble

Boss Dingle.png
Boss The Duke of Flies.png
Boss Gemini.png
(Double Trouble)

Dingle

(Double Trouble)

The Duke of Flies

(Double Trouble)

Gemini

Boss Widow.png
Boss Pin.png
Boss Polycephalus.png
(Double Trouble)

Widow

(Double Trouble)

Pin

(Double Trouble)

Polycephalus

Boss Larry Jr..png
Boss Blighted Ovum.png
Boss Monstro.png
(Double Trouble)

Larry Jr.

(Double Trouble)

Blighted Ovum

(Double Trouble)

Monstro

Flooded Caves DLC Indicator.png

Boss The Frail.png
Boss The Stain.png
Boss The Forsaken.png
The Frail DLC Indicator.png The Stain DLC Indicator.png The Forsaken DLC Indicator.png
Boss Big Horn.png
Big Horn Afterbirth† Indicator.png

Chapter 3

Floor 1

The Depths

Boss The Cage.png
Boss Monstro II.png
Boss The Gate.png
Boss Gish.png
The Cage Monstro II The Gate Gish

Necropolis

Boss The Adversary.png
Boss The Bloat.png
Boss Mask Of Infamy.png
The Adversary The Bloat Mask of Infamy


The Depths and Necropolis

Boss Loki.png
Boss War.png
Boss Brownie.png
Loki War Brownie DLC Indicator.png
Boss Sisters Vis.png
Sisters Vis Afterbirth† Indicator.png

Double Trouble

Boss Gurdy Jr..png
The Haunt
Boss The Wretched.png
Boss The Husk.png
(Double Trouble)

Gurdy Jr.

(Double Trouble)

The Haunt

(Double Trouble)

The Wretched

(Double Trouble)

The Husk

Boss Peep.png
Boss Mega Fatty.png
Boss Dark One.png
(Double Trouble)

Peep

(Double Trouble)

Mega Fatty

(Double Trouble)

Dark One

Boss Mega Maw.png
Boss Larry Jr..png
Boss Blighted Ovum.png
(Double Trouble)

Mega Maw

(Double Trouble)

Larry Jr.

(Double Trouble)

Blighted Ovum

Dank Depths DLC Indicator.png

Boss Brownie.png
Brownie DLC Indicator.png

Floor 2

The Depths, Necropolis and Dank Depths

Boss Mom.png
Mom

Chapter 4

Floor 1

The Womb

Boss Mr. Fred.png
Boss Scolex.png
Mr. Fred Scolex

Utero

Boss Mama Gurdy.png
Boss Lokii.png
Mama Gurdy Lokii

The Womb and Utero

Boss Blastocyst.png
Boss The Bloat.png
Boss Daddy Long Legs.png
Blastocyst The Bloat Daddy Long Legs
Boss Teratoma.png
Boss Triachnid.png
Boss Death.png
Teratoma Triachnid Death
Boss Conquest.png
Conquest

Double Trouble

Boss The Cage.png
Boss Gurdy.png
Boss The Fallen.png
Boss The Gate.png
Boss Loki.png
(Double Trouble)

The Cage

(Double Trouble)

Gurdy

(Double Trouble)

The Fallen

(Double Trouble)

The Gate

(Double Trouble)

Loki

Scarred Womb

Floor 2

The Womb, Utero and Scarred Womb

Boss Mom's Heart.png
Boss It Lives.png
Mom's Heart It Lives

Blue Womb DLC Indicator.png

Boss Hush.png
Hush DLC Indicator.png


The Void Afterbirth† Indicator.png

Boss Delirium.png
Delirium Afterbirth† Indicator.png

Chapter 5

Sheol

Boss Satan.png
Satan

The Cathedral

Boss Isaac (Boss).png
Isaac

Chapter 6

The Chest

???
???

Dark Room

Boss The Lamb.png
The Lamb

Golden Door Boss

Boss Mega Satan.png
Mega Satan

Universal

Universal Bosses are those which may appear at the end of floors 1-5 and 7, replacing a boss from the pool for that environment.

Boss The Fallen.png
Boss The Headless Horseman.png
The Fallen The Headless Horseman

Devil and Angel Room

Devil Room

Boss Krampus.png
Krampus

Angel Room

Boss Angel.png
Boss Angel2.png
Uriel Gabriel

Seven Deadly Sins and Others

Seven Deadly Sins

The Seven Deadly Sins are mini-bosses that can be encountered on any floor, and will appear on post-Womb/Utero floors as regular enemies. Unlike with regular bosses, there is no special door leading to a mini-boss room, meaning that there is no way to tell whether a room is inhabited by a mini-boss unless the player is in possession of an item that reveals map icons such as Compass or a Map item. Once in a mini-boss room, the player cannot escape through means of bombing the door, as it will be boarded off.

Each of the Sins has specific drops, that are consumables or a pedestal item (less frequently).
In a room containing multiple Sins, only the last one will drop something, allowing you to choose what drop you want by killing a certain mini-boss last.

All them are based on the Seven Deadly Sins.

Boss Envy.png
Boss Gluttony.png
Boss Wrath.png
Envy Gluttony Wrath
Boss Pride.png
Boss Lust.png
Boss Greed.png
Pride Lust Greed
Boss Sloth.png
Sloth

These monsters can also spawn as much stronger alternatives, known as the Seven Super Deadly Sins.

Boss Super Envy.png
Boss Super Gluttony.png
Boss Super Wrath.png
Super Envy Super Gluttony Super Wrath
Boss Super Pride.png
Boss Super Lust.png
Boss Super Greed.png
Super Pride Super Lust Super Greed
Boss Super Sloth.png
Super Sloth

There is also an Ultra variant of both Pride and Greed. Ultra Pride resembles Edmund and Florian, while Ultra Greed serves as the final boss for Greed Mode.

Boss Ultra Pride.png
Ultra Pride

Greed Mode DLC Indicator.png

Boss Ultra Greed.png
Ultra Greed DLC Indicator.png

All Mini-Bosses

The Seven Deadly Sins

Boss Envy.png
Boss Gluttony.png
Boss Wrath.png
Envy Gluttony Wrath
Boss Pride.png
Boss Lust.png
Boss Greed.png
Pride Lust Greed
Boss Sloth.png
Sloth

The Seven Super Deadly Sins

Boss Super Envy.png
Boss Super Gluttony.png
Boss Super Wrath.png
Super Envy Super Gluttony Super Wrath
Boss Super Pride.png
Boss Super Lust.png
Boss Super Greed.png
Super Pride Super Lust Super Greed
Boss Super Sloth.png
Super Sloth

Ultra Pride

Boss Ultra Pride.png
Ultra Pride

Krampus

Boss Krampus.png
Krampus

Angels

Boss Angel.png
Boss Angel2.png
Uriel Gabriel

All Bosses

Boss Monstro.png Boss Gemini.png
Boss Larry Jr..png
Monstro Gemini Larry Jr.
Boss Dingle.png
Boss Gurglings.png
Boss Steven.png
Dingle Gurglings Steven
Boss Pin.png
Boss Widow.png
Boss Blighted Ovum.png
Pin Widow Blighted Ovum
Boss Fistula.png
Boss Gurdy Jr..png
Boss The Haunt.png
Fistula Gurdy Jr. The Haunt
Boss The Duke of Flies.png
Boss Rag Man.png
Boss Little Horn.png
The Duke of Flies Rag Man DLC Indicator.png Little Horn DLC Indicator.png
Boss Dangle.png
Boss Turdlings.png
Boss Chub.png
Dangle DLC Indicator.png Turdlings DLC Indicator.png Chub
Boss Gurdy.png
Boss Mega Maw.png
Boss C.H.A.D..png
Gurdy Mega Maw C.H.A.D.
Boss Mega Fatty.png
Boss The Hollow.png
Boss The Husk.png
Mega Fatty The Hollow The Husk
Boss Dark One.png
Boss Polycephalus.png
Boss The Frail.png
Dark One Polycephalus The Frail DLC Indicator.png
Boss The Stain.png
Boss The Forsaken.png
Boss Carrion Queen.png
The Stain DLC Indicator.png The Forsaken DLC Indicator.png Carrion Queen
Boss The Wretched.png
Boss Peep.png
Boss The Cage.png
The Wretched Peep The Cage
Boss Monstro II.png
Boss The Gate.png
Boss Gish.png
Monstro II The Gate Gish
Boss The Adversary.png
Boss The Bloat.png
Boss Mask Of Infamy.png
The Adversary The Bloat Mask of Infamy
Boss Loki.png
Boss Brownie.png
Boss Mr. Fred.png
Loki Brownie DLC Indicator.png Mr. Fred
Boss Scolex.png
Boss Mama Gurdy.png
Boss Lokii.png
Scolex Mama Gurdy Lokii
Boss Blastocyst.png
Boss Daddy Long Legs.png
Boss Teratoma.png
Blastocyst Daddy Long Legs Teratoma
Boss Triachnid.png
Boss The Fallen.png
Triachnid The Fallen

The Harbingers

Boss Famine.png
Boss Pestilence.png
Boss War.png
Famine Pestilence War
Boss Death.png
Boss Conquest.png
Boss The Headless Horseman.png
Death Conquest The Headless Horseman

Final Bosses

Boss Mom.png
Boss Mom's Heart.png
Boss It Lives.png
Boss Hush.png
Boss Delirium.png
Mom Mom's Heart It Lives Hush DLC Indicator.png Delirium Afterbirth† Indicator.png
Boss Satan.png
Boss The Lamb.png
Boss Isaac (Boss).png
???
Satan The Lamb Isaac ???
Boss Mega Satan.png
Boss Ultra Greed.png
Boss Ultra Greedier.png
Mega Satan Ultra Greed DLC Indicator.png Ultra Greedier Afterbirth† Indicator.png

Trivia

  • "Originally every boss/enemy in Isaac was going to resemble Isaac in some way. this is the case for most."[1]
  • Double Trouble boss pools can have bosses from any of the previous chapters' pools, and are the same for both versions of that chapter's floor. This means that, for example, Double Trouble boss fights in the Caves can feature bosses from the Cellar or the Basement, and every Double Trouble fight in the Caves can also be encountered in the Catacombs.
  • Bosses often come in three versions: normal (For example, Monstro), posthumous (Monstro II), and alternate (Gish). Usually, the posthumous boss looks like the original with some horrible mutilation; for example, Monstro and Chub had most of their skin ripped off.

Bugs

Bug Bug! Defeating a boss quickly enough might cause the boss music to play, even after the boss dies.

SmallIsaac.png The Binding of Isaac: Rebirth SmallIsaac.png

MainPageAchievements.png Achievements MainPageAttributes.png Attributes MainPageBosses.png Bosses TarotCard.png Cards and Runes MainPageChallenges.png Challenges MainPageChapters.png Chapters
Isaac App.png Characters MainPageBabies.png Co-op Magic Mushroom Icon.png Items Isaac's Tears Icon.png Item Pools MainPageMonsters.png Monsters MainPageObjects.png Objects
Red heart.png Pickups BlueBlue.png Pills MainPageRooms.png Rooms MainPageSeeds2.png Seeds Guppy App.png Transformations The Left Hand Icon.png Trinkets
Bosses Boss Monstro.png
Chapter 1 Blighted OvumDingleThe Duke of FliesFamineFistulaGeminiGurdy Jr.GurglingsThe HauntLarry Jr.MonstroPinStevenWidow
DLC Indicator.png DangleLittle HornRag ManTurdlings
Chapter 2 C.H.A.D.ChubDark OneGurdyGurdy Jr.The HollowThe HuskMega FattyMega MawPeepPestilencePolycephalusCarrion QueenThe Wretched
DLC Indicator.png The ForsakenThe FrailThe Stain
Afterbirth† Indicator.png Big HornRag Mega
Chapter 3 The AdversaryThe BloatThe CageCarrion QueenThe GateGishLokiMask of InfamyMonstro IIWarThe WretchedMom
DLC Indicator.png Brownie
Afterbirth† Indicator.png Sisters Vis
Chapter 4 BlastocystThe BloatConquestDaddy Long LegsDeathIt LivesLokiiMama GurdyMom's HeartMr. FredScolexTeratomaTriachnid
DLC Indicator.png Blue Womb DLC Indicator.png Hush
Chapter 5 The FallenIsaacSatan
Chapter 6 ???The LambMega Satan
DLC Indicator.png Greed Mode DLC Indicator.png Ultra Greed
Afterbirth† Indicator.png Ultra Greedier
Afterbirth† Indicator.png The Void Afterbirth† Indicator.png Delirium
Chapters 1-4 The FallenThe Headless Horseman