Boss (Item Pool)

Item Pool

Treasure Room

Shop

Library

Curse Room

Boss

Secret Room

Devil Room

Angel Room

Golden Chest

Red Chest

Beggar

Devil Beggar

Key Master

Bomb Bum

Treasure Room

Shop

Library

Curse Room

Boss

Secret Room

Devil Room

Angel Room

Golden Chest

The Boss Pool is the pool of items that are dropped by bosses and can be found in the Boss Challenge Room.

Name	ID	Icon	Quote	Description
<3	15		HP up	Grants Isaac one red heart container and fully restores Isaac's health.
The Belt	28		Speed up	Increases speed by 0.3.
Blood Clot	254		DMG + range up	Increases damage by 1 and range by 5 for tears fired from the left eye.
Blue Cap	342		HP + tears up + shot speed down	Grants 1 Red Heart container and increases tears, but decreases shot speed.
Box	198		Stuff	Spawns 1 of each (non-collectible) item: 1 Penny, 1 Key, 1 Bomb, 1 Red Heart, 1 card, 1 pill, 1 trinket.
Breakfast	25		HP up	Grants Isaac one full Red Heart container.
Caffeine Pill	340		Speed up + size down	Increases speed and reduces character size. Also gives a random pill.
Cat-O-Nine-Tails	165		Shot speed + damage up	Increases shot speed and damage.
Dessert	24		HP Up	Grants Isaac one full Red Heart container.
Dinner	23		HP Up	Adds 1 Red Heart container.
Experimental Treatment	240		All stats up, then shuffled	Randomly increases and decreases some of the character's stats.
Growth Hormones	70		Speed + DMG up	Increases damage by 1 and speed by 0.4.
The Halo	101		All stats up	Grants one Heart Container, +0.3 Damage, +0.2 Tears, +0.25 Range, +0.3 Speed, and +0.5 Tear Height.
Jesus Juice	197		Damage + range up	Increases Damage and Range.
Latch Key	343		Luck up	Increases Luck by 1, grants 1 Soul Heart and spawns 2 Keys.
Little C.H.A.D.	96		Gives kisses	A familiar who will drop a half red heart every 3 rooms.
Little Steven	100		Psychic friend	Spawns a familiar that follows Isaac around and fires homing tears.
Lunch	22		HP Up	Adds 1 heart container.
MEAT!	193		DMG + HP up	Adds a heart container and increases damage.
Magic 8 Ball	194		Shot speed up	Increases Shot Speed, and drops a tarot card when picked up.
Magic Mushroom	12		All Stats Up!	Increases most stats, enlarges Isaac, grants a heart container and restores all health.
Magic Scab	253		HP + Luck up	Increases luck and HP by 1.
Match Book	344		Evil up	Grants Isaac 1 Black Heart and 3 bombs. Can also give troll bombs.
Mom's Coin Purse	195		What's all this...?	Spawns 4 random pills around Isaac.
Mom's Heels	30		Range up	Increases range.
Mom's Lipstick	31		Range up	Increases range and shot height.
Mom's Underwear	29		Range up	Increases range.
Old Bandage	219		HP up	Adds one empty heart container. Whenever Isaac takes damage there's a chance that a Red Heart may drop.
Pageant Boy	141		Ultimate grand supreme	Spawns several coins around Isaac.
Pentagram	51		DMG up	Increases damage and increases the chance for a Devil or Angel Room to appear.
Placenta	218		HP up + regen	Grants a full heart container, and a chance to regenerate a half-heart of health every minute of gameplay.
Roid Rage	14		Speed and range up	Increases speed by 0.6, range by 5.25, and tear height by 0.5.
Rotten Meat	26		HP up	Adds one heart container.
Safety Pin	339		Evil + range + shot speed up	Increases range and shot speed, while adding 1 Black Heart.
Screw	255		Tears and shot speed up.	+0.5 tears up, +0.2 shot speed up.
A Snack	346		HP up	Grants one full red heart container.
Speed Ball	143		Speed + shot speed up	Increases speed by 0.3 and shot speed by 20%.
Squeezy	196		Tears up	Increases tears by 0.4, and spawns 2 Soul Hearts pickups.
Stem Cells	176		HP up	Adds one filled heart container and increases Shot Speed.
Super Bandage	92		+2 hearts	Grants one Heart Container and gives 2 Soul Hearts.
Synthoil	345		DMG up + range	Increases damage by 1, range by 5.25, and tear height by 0.5.
Toothpicks	183		Tears + shot speed up	+0.7 tears, +16% shot speed.
Torn Photo	341		Tears + shot speed up	Tears + Shot speed up.
Wire Coat Hanger	32		Tears up	Increases Tears by 0.7.
Wooden Spoon	27		Speed up	Increases speed by 0.3.
Binky	438		Memories...	Tears up, adds 1 Soul Heart, and decreases Isaac's size.
Crack Jacks	354		Don't swallow the prize!	Adds one Red Heart container and drops a random trinket.
Mom's Pearls	355		Range + luck up	+1.25 Range Up. +0.5 Tear Height. +1 Luck Up.
Mr. Dolly	370		Range + tears up	Tears and Range up. Spawns 3 random types of hearts on the floor when picked up.
PJs	428		You feel cozy	Grants four soul hearts and fully restores Isaac's red health.
Belly Button	458		What's in there?	Drops a random trinket. Grants a second trinket slot.
Dad's Lost Coin	455		I remember this...	Increases range by 1.5. Drops a Lucky Penny.
Divorce Papers	547		Tears up + you feel empty	Spawns a Mysterious Paper, increases tears, and grants a bone heart.
Marbles	538		Choking hazard	Spawns 3 random trinkets. Taking damage has a small chance to swallow Isaac's currently held trinket, gaining its effect permanently.
Marrow	541		HP up?	Grants one bone heart and spawns three red heart pickups.
Moldy Bread	456		Midnight snack!	Grants one full red heart container.
Polydactyly	454		Hold me!	Allows Isaac to carry two cards, pills, or any combination of both at the same time. Drops a random card or pill.

Trivia

• Most items in this pool will increase stats, increase health, grant pickups, grant trinkets, or some combination of the four. The ones that don't, Little Steven, Little C.H.A.D., and Little Gish, are familiars that will always drop from the boss they are themed after, respectively Steven, C.H.A.D., and Gish. Said bosses are all references to previous games made by Edmund McMillen, and all of them need to be unlocked by beating the chapter they appear in a certain amount of times.