A Devil Room door can't appear on the first floor, unless Joker is used. A Devil Room door can also appear in a boss room on the first floor if the floor is spawned with the Curse of the Labyrinth, in which the Devil Room door will appear after defeating the second boss.
Upon defeating Mom's Heart, a Devil Room containing a trapdoor or an Angel Room containing a beam of light may appear. This allows Isaac to visit Sheol or Cathedral respectively even if It Lives has not yet been unlocked. If one of these paths is taken instead of touching the large chest, the next Mom's Heart ending will not play but will be unlocked and it will count as a victory against Mom's Heart.
Devil Rooms and Angel Rooms no longer contain a trapdoor or a beam after defeating It Lives. They instead have their normal contents.
This page was last edited on 8 June 2020, at 13:36.
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