Boss Rush

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The Boss Rush is an optional room that becomes available by beating Mom within 20 minutes.

In the center of a large room there will be 4 random items to choose from. Picking up an item will cause the other three to disappear and start the Boss Rush. Completing the Boss Rush will also reward 1 more item, separate from the 4 seen when first entering the room.

Added in Afterbirth There is a chance that there will only be 2 items to choose from. Additionally, items may be trapped behind rocks or spikes. Items may appear in the corners of the room instead of the center.

Added in Afterbirth † There is a small chance that there will be 8 items to choose from.

Waves[edit | edit source]

The Boss Rush consists of 15 waves with 2 bosses per wave. The next wave does not spawn until both bosses from the previous wave have been killed, and any lingering monsters from previous waves will not prevent the next wave from spawning.

Occasionally, all the bosses fought in the Boss Rush will be their Champion variants, if they have one.

Rebirth[edit | edit source]

All 15 waves are predetermined.

Afterbirth[edit | edit source]

All 15 waves are randomized. Each wave spawns two random bosses from the list. Each boss can only appear once per Boss Rush.

Layouts[edit | edit source]

Notes[edit | edit source]

  • If Mom is beaten within 20 minutes and Isaac enters the Devil Room, he must return to the boss room before 20 minutes has passed; otherwise, the Boss Rush entrance will be closed.
    • If Isaac is teleported to the Devil Room while inside the Boss Rush room (for example, using a Joker Joker card), exiting the Devil Room will lead him to Mom's Boss Room.
  • If Isaac dies during the Boss Rush, but is able to respawn, the entrance to the Boss Rush room will still be open if the timer is still under 20 minutes. If the Boss Rush entrance has closed, the room can still be re-entered by dying in the Mom boss fight room at the cost of another life.
  • The Boss Rush can only be retried by picking up an item off a pedestal in its room. If the item Isaac originally picked from the room was an activated item, the pedestal and item it was swapped out for will still be there. Swapping the items again will restart the fight. Alternatively, a new pedestal can be created, such as through a XX - Judgement XX - Judgement card, and taking its item will also restart the fight.
  • Added in Afterbirth If a mystery sack spawns for whatever reason, picking it up will start the Boss Rush. The player can still pick up one of the pedestal items.
  • The boss rush does not unlock anything if beaten in a challenge.
  • Added in Afterbirth † Using Void Void or the Black Rune Black Rune will start the Boss Rush.
  • If a chest is opened in the Boss Rush room, it will start the Boss Rush.
  • Added in Afterbirth † If used before defeating Mom, Mama Mega! Mama Mega! will open the Boss Rush room even if the time limit has expired.

Tips[edit | edit source]

  • The player's playtime can be checked at any moment by pressing TAB (or long pressing SELECT on the controller), enabling Extra HUD in the options menu, or by simply looking down to the bottom screen on the 3DS version, where it is shown on the map.
  • Each boss will drop red hearts on normal difficulty. Dark Bum Dark Bum can turn these into soul hearts, providing loads of extra health.
  • Take out Carrion Queen quickly, as its red poops will remain for the rest of the boss rush. They can be advantageous though, as other bosses can also take damage from these poops. In particular, bouncing bosses like The Hollow and The Husk can quickly kill themselves on contact.
  • Wave 9 can be quite difficult as Monstro II (he always spawns on the left side) can catch the player off guard with an offscreen Brimstone Brimstone laser. The black creep left by Gish will remain until he is killed.
  • The Bloat + Mask of Infamy is one of the hardest waves, but The Bloat can be baited into destroying both the heart and the mask itself of the Mask of Infamy with its Brimstone Brimstone lasers.
  • Any Teleport effect (such as cards, activated items, Telepills etc) can be used to leave the Boss Rush. This can be used to gain one item without having to fight any bosses.
  • Added in Afterbirth The Gate's curving brimstone attack targets any enemy on screen, including other bosses. It may be beneficial to focus on the other boss before killing it.

Unlockable Achievements[edit | edit source]

Bugs[edit | edit source]

Bug Bug! Closing the game upon taking an item and reopening it will mark Boss Rush as cleared without having to fight any waves, as well as let Isaac take the item that spawns at the end.
Bug Bug! It is possible for item pedestals to spawn on red poop (which can be spawned by Carrion Queen or red Dingle) or spikes. Attempting to pick up the item will damage Isaac.
Bug Bug! One of the possible layouts for the Boss Rush room will have spikes near the location that an item pedestal spawns after completing the fight. If you possess There's Options, one of the item pedestals can appear in the same place as the spikes, causing you to take damage by picking that item up.
Bug Bug! Entering Boss Rush after the 20 minutes (killing Mom before it, but waiting to enter) and using Glowing Hour Glass will crash the game.

SmallIsaac.png Rooms SmallIsaac.png

Boss Room Icon.png
Boss Room
Mini-Boss Room Icon.png
Mini-Boss Room
Treasure Room Icon.png
Treasure Room
Shop Icon.png
Arcade Icon.png
Challenge Room Icon.png
Challenge Room
Boss Challenge Room Icon.png
Boss Challenge Room
Curse Room Icon.png
Curse Room
Sacrifice Room Icon.png
Sacrifice Room
Secret Room Icon.png
Secret Room
Super Secret Room Icon.png
Super Secret Room
Library Icon.png
Devil Room Icon.png
Devil Room
Angel Room Icon.png
Angel Room
Vault Icon.png
Dice Room Icon.png
Dice Room
Bedroom Icon.png Bedroom2 Icon.png
Super Secret Room Icon.png
Super Secret Room Icon.png
Boss Rush
Super Secret Room Icon.png
Crawl Space
Super Secret Room Icon.png
Black Market

SmallIsaac.png The Binding of Isaac: Rebirth SmallIsaac.png

MainPageAchievements.png Achievements MainPageAttributes.png Attributes MainPageBosses.png Bosses TarotCard.png Cards and Runes MainPageChallenges.png Challenges MainPageChapters.png Chapters
Isaac App.png Characters MainPageBabies.png Co-op Magic Mushroom Icon.png Items Isaac's Tears Icon.png Item Pools MainPageMonsters.png Monsters MainPageObjects.png Objects
Red heart.png Pickups BlueBlue.png Pills MainPageRooms.png Rooms MainPageSeeds2.png Seeds Guppy App.png Transformations The Left Hand Icon.png Trinkets