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Bosses are very strong monsters found in Boss Rooms at the end of a floor. The boss at the end of the floor must be defeated to advance to the next floor. In later chapters, many of these non-final bosses can spawn as degraded bosses, or normal enemies. The same can go for mini-bosses, which can spawn on later floors as degraded mini-bosses. However, some bosses and mini-bosses may not appear as degraded bosses at all. The boss for a particular floor is chosen from the pool of bosses for the chapters of the floor. After defeating Satan for the first time, bosses may also spawn as champions, which can change various attributes such as health, damage, and attack pattern. Upon defeat, most bosses will drop an item from the Boss item pool.

Bosses boast additional resistances to status effects. For example, fear occurs less often and the Added in AfterbirthNight Light Night Light is unable to slow them down.

Additionally, some floors may spawn a room with a mini-boss.

In total, there are 72 bosses and 18 mini-bosses. 10 bosses were added in The Binding of Isaac: Afterbirth and 6 were added in The Binding of Isaac: Afterbirth †.

Trivia

  • Originally, every boss and enemy in Isaac was going to resemble Isaac in some way. [1] This is still the case for some.
  • Double Trouble boss pools can have bosses from previous chapters and can be the same for both versions of that chapter's floor. This means that, for example, Double Trouble boss fights in The Caves can feature bosses from The Cellar or The Basement, and every Double Trouble fight in The Caves can also be encountered in The Catacombs.
  • Bosses often come in three versions: normal (for example, Monstro), posthumous (Monstro II), and alternate (Gish). Usually, the posthumous boss looks like the original with some horrible mutilation; for example, Monstro and Chub had most of their skin ripped off.
    • Most bosses and their alternate/posthumous forms either share similar death animations or share the fact that they lack death animations.
  • Some bosses appear as evolved or larger versions of enemies (for example, Chub looks like a bigger Charger). Some even act as larger versions of other bosses (Little Horn   and Big Horn  ).


Bosses  
Chapter 1
   
GeminiStevenBlighted OvumDingleThe Duke of FliesFamineFistulaGurglingsThe HauntLarry Jr.MonstroPinWidowThe FallenThe Headless Horseman
DangleLittle HornRag ManTurdlings
Chapter 2
   
ChubC.H.A.D.Carrion QueenDark OneGurdyGurdy Jr.The HollowThe HuskMega FattyMega MawPeepPestilencePolycephalusThe WretchedThe FallenThe Headless Horseman
The ForsakenThe FrailThe Stain
Big HornRag Mega
Chapter 3
   
The AdversaryThe BloatThe CageThe GateMonstro IIGishLokiMask of InfamyWarThe FallenThe Headless HorsemanMom
Brownie
Sisters Vis
Chapter 4
   
BlastocystThe BloatConquestDaddy Long LegsTriachnidDeathLokiiMama GurdyMr. FredScolexTeratomaThe FallenThe Headless HorsemanMom's HeartIt Lives
Sisters VisThe Matriarch
Blue Womb
 
Hush
Chapter 5
  
SatanIsaac
Chapter 6
  
???The LambMega Satan
The Void
 
Delirium
Greed Mode
 
Ultra Greed
Ultra Greedier
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