Brains move around the room slowly, leaving a trail of Creep that does one full heart of damage to Isaac. They are relatively weak on their own, but can quickly corner Isaac when fought in groups. Brains can also be spawned by Oobs.
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 Defeat The Lamb for the 1st time The gate is open! |
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Poison Minds behave like regular Brains, but crawl diagonally and leave a trail of green creep.
The MemBrain is a much larger Brain that slowly moves around the room and occasionally hops to fire blood shots in 8 directions. It has a large amount of health, and will split into two Brains upon death.
If Poison Minds aren't unlocked yet, they are replaced by Brains.
- MemBrains, along with Dingas and Mama Guts, have the second-highest base health of all non-boss enemies, second to Oobs.
- A MemBrain is a pun on the word membrane, which means a thin, flexible layer of body tissue.
The Binding of Isaac: Rebirth 
Achievements
Attributes
Bosses
Cards and Runes
Challenges
Chapters
Characters
Co-op
Items
Item Pools
Monsters
Objects
Pickups
Pills
Rooms
Seeds
Transformations
Trinkets
