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Item icon
Item altar

Character appearance
Tear appearance
Item Pool Devil Room.png Devil Room
Added in Afterbirth (page 1, column 15, line 6)
Removed in Afterbirth (page 2, column 5, line 2)

Brimstone is a special passive item.


  • Isaac's tears are replaced with a charged blood laser beam that pierces through all enemies and obstacles in its path.
    • The laser deals damage equal to Isaac's damage each tick, and ticks a total of 13 times.
  • Added in Afterbirth This item belongs to the Leviathan set. Collecting three items from the set will transform Isaac into a Lovecraftian horror.


  • Azazel starts the game with a short-ranged, slower charging version of Brimstone. Picking up Brimstone with him will give him the long ranged version. Without the long ranged version, his mini-brimstone won't have enough length to use any homing items. Added in Afterbirth His mini-brimstone's range can be increased with range up items or pills.
  • If multiple Brimstones are picked up (via Added in Afterbirth Diplopia Diplopia
    Diplopia Icon.pngOne time useDuplicates all pickups and item pedestals in the room.
    , Added in Afterbirth † Crooked Penny Crooked Penny
    Crooked Penny Icon.png4 roomsSpawns a penny and has a 50% chance to double all items and pickups in the room. If the effect fails, the items and pickups disappear.
    or on a victory lap), then another beam is added.


  • 20/20 20/20
    20 20 Icon.pngGrants double shot.
    - Overridden by Brimstone.
    • Added in Afterbirth Shoots two Brimstone lasers simultaneously without increasing charge time.
  • Added in Afterbirth 8 Inch Nails 8 Inch Nails
    8 Inch Nails Icon.png+1.5 Damage Up. Replaces Isaac's tears with nails, which have increased knockback.
    - Brimstone pushes enemies away in the direction the beam is travelling, but not out of the path of the beam.
  • A Lump of Coal A Lump of Coal
    A Lump of Coal Icon.pngThe more distance tears travel, the more damage they will do.
    - Changes the color, but does not have an effect on damage.
    • Added in Afterbirth Beam will gradually increase in size but rapidly increase damage the farther it travels, on a multiplier that is roughly +20% per tile of distance. This allows for a huge damage increase from longer distances.
  • Chocolate Milk Chocolate Milk
    Chocolate Milk Icon.pngGrants charged tears that deal greater damage when fully charged.
    - Decreases charge time slightly, but does not increase damage.
  • Added in Afterbirth Continuum Continuum
    Continuum Icon.png+2.25 Range Up. +1.5 Tear Height. Isaac's tears travel through walls and appear out of the opposite wall. Isaac's tears also travel over rocks and objects.
    - Overridden by Brimstone.
  • Cricket's Body Cricket's Body
    Cricket's Body Icon.pngGrants -1 Tear Delay and reduces Range. When tears hit an object or deplete their range, they spawn 4 smaller tears, whose Range and Damage scale with Isaac's.
    /Added in Afterbirth † Compound Fracture Compound Fracture
    Compound Fracture Icon.pngIncreases range. Tears turn into bones, which shatter into 1-3 bone shards upon hitting an enemy or obstacle.
    : Overridden by Brimstone except for stat effects which are applied.
  • Cursed Eye Cursed Eye
    Cursed Eye Icon.pngGrants charged tears that can be fired in a tight burst of four. Getting hit while charging will teleport Isaac into another room.
    - Overridden by Brimstone.
  • Dr. Fetus Dr. Fetus
    Dr. Fetus Icon.pngTears are replaced by bombs that benefit from bomb-enhancing effects and slide a fixed range after being fired.
    - Overrides Brimstone.
    • Added in Afterbirth Isaac shoots bombs while charging Brimstone.
  • Epic Fetus Epic Fetus
    Epic Fetus Icon.pngIsaac's tears are replaced with guided missiles, like those used by the Doctor's Remote.
    - Overrides Brimstone.
    • Added in Afterbirth After the missile hits the ground, it spawns 10 Brimstone beams similar to the effect given by Sad Bombs. Azazel's mini-brimstone does not give the Sad Bombs effect.
  • Added in Afterbirth Evil Eye Evil Eye
    Evil Eye Icon.pngWhile firing tears, Isaac has a chance to fire an eye across the screen with a very slow shot speed, which will fire tears of its own in the same direction as Isaac. The eye will be destroyed if it comes into contact with an enemy or obstacle.
    - Overridden by Brimstone.
  • Fire Mind Fire Mind
    Fire Mind Icon.pngGrants flaming tears that deal burning damage over time. Tears have a chance to explode on impact with an enemy, which creates a fire at the location of the explosion.
    - Beam inflicts burning, but cannot cause explosions or leave fires on the ground.
  • Added in Afterbirth † Flat Stone Flat Stone
    Flat Stone Icon.pngTears bounce off the floor. Tears that hit an enemy after bouncing deal splash damage to all nearby enemies for 25% of Isaac's tear damage.
    : Overridden by Brimstone.
  • Flat Worm Flat Worm
    Flat Worm Icon.pngIsaac's tears take on an oblong appearance. They also push enemies back.
    - No effect.
  • Added in Afterbirth Holy Light Holy Light
    Holy Light Icon.pngIsaac has a random chance to fire a Holy tear, which, when it hits an enemy, will spawn a Crack the Sky-style light beam on the same enemy, dealing damage.
    - Overridden by Brimstone.
  • Hook Worm Hook Worm
    Hook Worm Icon.pngTears move shifting left to right forming a path of right angles. +10 to Range (effective range remains about the same).
    - Beam changes angles while firing straight, but also effectively increases the width of the beam.
  • Ipecac Ipecac
    Ipecac Icon.pngReplaces tears with explosive and poisoning projectiles fired in an arc from the mouth.
    - The character gains neither the increased damage nor the decreased tears of Ipecac. They only gain the minor poison effect.
    • Added in Afterbirth † Isaac shoots Ipecac tears while charging Brimstone. Both Brimstone and Ipecac shots modify Isaac's damage and tear delay stat, meaning that Ipecac fires slower and Brimstone charges slower, but Brimstone does an extra 40*13 damage. Take care to pre-charge Brimstone so that the Ipecac shot is on cooldown as Isaac enters a room.
  • Isaac's Tears Isaac's Tears
    Isaac's Tears Icon.png6 roomsShoots 8 tears around Isaac, which retain the damage, shot speed, and special effects of his tears. Each tear shot by Isaac increases item charge by one.
    - Fires normal tears, but nearly instantly charges when charging Brimstone.
  • Added in Afterbirth † Jacob's Ladder Jacob's Ladder
    Jacob's Ladder Icon.pngTears fire sparks of electricity in random directions upon hitting an obstacle or enemy.
    - Overridden by Brimstone.
  • Added in Afterbirth Kidney Stone Kidney Stone
    Kidney Stone Icon.pngRandomly while firing tears, Isaac will stop firing and turn red, where he will charge and release a lot of 'tears' in one go. In the burst of tears is a kidney stone which deals a lot of damage.
    : Overridden by Brimstone.
  • Added in Afterbirth † Lachryphagy Lachryphagy
    Lachryphagy Icon.pngIsaac's tears decelerate as they travel. Upon stopping or hitting an obstacle, they burst into 8 tears in all directions. Tears can be fired into other tears to feed them, increasing their damage.
    : Overridden by Brimstone.
  • Added in Afterbirth † Lead Pencil Lead Pencil
    Lead Pencil Icon.pngAfter every 15 tears fired, Isaac will fire a high-damage cluster of tears.
    : Overridden by Brimstone.
  • Added in Afterbirth Marked Marked
    Marked Icon.pngIsaac will now fire tears automatically directed at a red target on the ground which is controlled by the player. This allows for a full 360 degree tear firing radius. Can be overridden by other tear modifiers such as Mom's Knife or Brimstone.
    : Overridden by Brimstone.
  • Monstro's Lung Monstro's Lung
    Monstro's Lung Icon.pngIncreases damage and grants a charged shot that fires multiple tears in the same fashion as Monstro.
    - Overridden by Brimstone.
    • Added in Afterbirth Fires 3-5 additional Brimstone lasers in random directions around Isaac. Does not increase charge time. Charging a new Brimstone laser removes the original from in front of the player, but not the additional ones added by Monstro's Lung. This effectively increases fire rate.
  • My Reflection My Reflection
    My Reflection Icon.pngGives Isaac's tears a boomerang effect, and increases range and shot speed.
    - Overridden by Brimstone.
    • Added in Afterbirth Makes the beam curve when moving. Has the same effect on Azazel's mini-brimstone but doubles the range.
  • Mysterious Liquid Mysterious Liquid
    Mysterious Liquid Icon.pngTears leave a small, short lasting pool of creep on impact or when their range is depleted.
    - Overridden by Brimstone.
    • Added in Afterbirth When Brimstone hits enemies or walls it leaves creep based on how long it hits.
  • Ouija Board Ouija Board
    Ouija Board Icon.pngGrants spectral tears that travel through obstacles (but not enemies) instead of breaking on impact with them.
    - Overridden by Brimstone.
  • The Parasite The Parasite
    The Parasite Icon.pngIsaac's tears split in two when they hit something.
    - Overridden by Brimstone.
  • Added in Afterbirth † Pop! Pop!
    Pop! Icon.pngReplaces Isaac's tears with eyeballs that can bounce off of each other. The eyeballs are not limited by range, and will instead dissipate when they stop moving or when hitting an enemy or obstacle.
    : Overridden by Brimstone.
  • Added in Afterbirth Pupula Duplex Pupula Duplex
    Pupula Duplex Icon.pngTransforms Isaac's tears into a wide arc shape which gives them a much larger hitbox. Gives Isaac spectral tears which allows them to travel through objects in the environment (i.e. rocks).}
    - Overridden by Brimstone.
  • Rubber Cement Rubber Cement
    Rubber Cement Icon.pngTears bounce off walls, enemies, and environmental objects.
    - Lasers ricochet off walls.
  • Soy Milk Soy Milk
    Soy Milk Icon.pngTears shrink and do much less damage, but fire in very rapid succession.
    - Greatly reduces Brimstone charge time and damage.
  • Technology Technology
    Technology Icon.pngReplaces tears with a piercing laser with unlimited range.
    - Overridden by Brimstone.
    • Added in Afterbirth Brimstone beams become surrounded with swiveling Technology laser beams, granting a 1.5x damage multiplier.
  • Technology 2 Technology 2
    Technology 2 Icon.pngDecreases damage and replaces right eye tears with a unlimited range, piercing laser which fires continuously.
    - Laser fires while Brimstone is charging.
  • Added in Afterbirth † Technology Zero Technology Zero
    Technology Zero Icon.pngConnects Isaac's tears with electricity that can damage enemies.
    : Overridden by Brimstone.
  • Added in Afterbirth † Trisagion Trisagion
    Trisagion Icon.pngTears are replaced with piercing white blasts of light.
    : Overridden by Brimstone.
  • Wiggle Worm Wiggle Worm
    Wiggle Worm Icon.pngGives Isaac's shots a wave-like trajectory.
    - Makes the beam wavy.


  • Added in Afterbirth † Apple! Apple!
    Apple! Icon.pngIncreases tears. Adds a chance to fire a high-damage razor blade.
    / Added in Afterbirth † Euthanasia Euthanasia
    Euthanasia Icon.pngAdds a chance to fire needles. If a needle kills an enemy, it bursts into more needles.
    / Tough Love Tough Love
    Tough Love Icon.pngAdds a chance to shoot a tooth instead of a tear, which deals greater damage than regular tears.
    - The beam can gain the damage multiplier from each of the items, although there is no visual difference. The bonus applies for the whole beam and not on a per-tick basis. Euthanasia loses its instant kill ability, however.
  • Anti-Gravity Anti-Gravity
    Anti-Gravity Icon.png-2 Tear Delay. Tears float in position until firing ceases, after which they will fly off in the direction they were shot in.
    - An orb of energy expands, then shrinks while firing the beam after a delay. The orb still hurts enemies if they touch it. Makes it harder to hit enemies with Azazel as the laser does not increase in range. Effectively allows a faster firing rate, since Isaac can start charging a new shot immediately after releasing the fire key without cancelling the first shot and is a great combo with soy milk
    • Added in Afterbirth Incubus Incubus
      Incubus Icon.pngA demonic familiar that follows Isaac and shoots tears identical to Isaac's in terms of damage, range, fire rate, and effects.
      won't fire delayed Brimstone shots and will fire regular Brimstone shots instead.
  • Dark Matter Dark Matter
    Dark Matter Icon.pngIncreases Damage by 1 and adds a chance to shoot fear tears.
    - Beam will have a chance to cause fear.
  • Added in Afterbirth Diplopia Diplopia
    Diplopia Icon.pngOne time useDuplicates all pickups and item pedestals in the room.
    - Picking up two Brimstones will make Isaac simultaneously fire two lasers, similar to the 20/20 effect.
  • Added in Afterbirth God's Flesh God's Flesh
    God's Flesh Icon.pngTears now have a random chance to apply a shrinking effect, causing enemies to shrink in size and also run away from Isaac. Shrunk enemies can be crushed and killed by walking over them.
    - Chance to shrink enemies and turns the beam indigo.
  • Guppy: Flies are spawned at a rate of approximately one fly per tick of damage for each enemy it hits. This causes a lot of flies to spawn very quickly. The spawned flies will also move to attack the targeted enemy immediately.
  • Added in Afterbirth † Haemolacria Haemolacria
    Haemolacria Icon.pngTears are now fired in an arc. Upon hitting the floor, an obstacle, or an enemy, they burst into many smaller tears in all directions. Increases tear delay.
    : Increased tear delay and damage, and blood tears burst into several lasers fired in random directions.
  • Loki's Horns Loki's Horns
    Loki's Horns Icon.pngGives a random chance for projectiles to fire in all 4 cardinal directions.
    - Occasionally causes Isaac to fire the beam in all four cardinal directions, similarly to Head of Krampus Head of Krampus
    Head of Krampus Icon.png6 roomsFires a cross-patterned brimstone shot, just like The Fallen and Krampus shoot.
    's effect.
  • The Ludovico Technique The Ludovico Technique
    The Ludovico Technique Icon.pngInstead of firing tears, Isaac controls one floating tear that hover over obstacles. This tear deals constant damage when held in place over an enemy.
    - The laser becomes a large ring that is controllable and does not need to be charged. Enemies inside the ring without touching it are not hurt. Shot speed is ignored. The Tears stat is ignored and damage is dealt very rapidly at a rate equivalent to 2 tear delay.
  • The Mulligan The Mulligan
    The Mulligan Icon.pngTears have a 1/6 chance of spawning allied blue flies when they hit an enemy.
    - Spawns blue flies constantly when hitting an enemy.
  • Mom's Eye Mom's Eye
    Mom's Eye Icon.pngAllows Isaac to fire tears from the back of his head.
    - Sometimes shoots a laser from the back of Isaac's head.
  • Mom's Knife Mom's Knife
    Mom's Knife Icon.pngIsaac's tears are replaced by a knife that pierces enemies, can travel through obstacles, and can hurt enemies while Isaac is holding it. Holding down the fire button before firing increases its range and power.
    - Adds a small barrage of knives after the main knife is fired, with each knife doing 80% of Isaac's base damage. The barrage of knives goes all the way across the screen and increases in quantity the longer the charge.
  • Mom's Wig Mom's Wig
    Mom's Wig Icon.pngAdds a chance to spawn blue spiders when firing tears. Restores 1 red heart.
    - Holding down a fire button to charge the attack very rapidly rolls the probability to spawn blue spiders, releasing to fire the beam however, does not.
  • Monstro's Lung Monstro's Lung
    Monstro's Lung Icon.pngIncreases damage and grants a charged shot that fires multiple tears in the same fashion as Monstro.
    - Causes Isaac to fire multiple beams in random directions.
  • Mutant Spider Mutant Spider
    Mutant Spider Icon.pngGrants quadruple shot but decreases tears.
    - Increases charge time but fires four separate Brimstone beams instead of one. Azazel's beams overlay each other instead of spreading out, causing additional damage.
  • Number One Number One
    Number One Icon.png+1.5 tears, -15.77 range
    - Greatly decreases charge time and turns beam yellow.
  • Polyphemus Polyphemus
    Polyphemus Icon.pngMakes Isaac shoot one huge tear. Also reduces Tears to minimum. Damage increased . If tear does more damage than an enemy's life, the tear continues to travel with the extra remaining damage.
    - Significantly increases damage and increases charge duration.
  • Proptosis Proptosis
    Proptosis Icon.pngTears start out massive with high damage, and then shrink down and become weaker over a short range.
    - Damage is doubled with no drop-off at range.
    • Added in Afterbirth Range is unchanged, but damage quickly drops further along the beam. This also affects the beams produced by Tammy's Head.
  • Sacred Heart Sacred Heart
    Sacred Heart Icon.pngIncreases damage and range while reducing shot speed and grants homing tears. Grants a Heart Container and replenishes all Red Hearts.
    - Increases damage and makes laser home in on enemies.
  • Sad Bombs Sad Bombs
    Sad Bombs Icon.png+5 Bombs. Upon exploding, bombs shoot 8 tears off in every direction, similar to Tammy's Head. The tears are affected by any tear modifiers Isaac has on his own tears.
    - Changes the tears fired by bombs upon their explosions to Brimstone beams, in a manner identical to its synergy with Tammy's Head.
  • Spider Bite Spider Bite
    Spider Bite Icon.pngAdds a chance to shoot slowing tears, reducing speed of enemy movement and any projectile fired by them.
    - Slow effect persists and turns the beam color to light pink.
  • Spoon Bender Spoon Bender
    Spoon Bender Icon.pngGrants Isaac homing tears.
    - Turns beam purple and makes it curve towards enemies similar to The Gate's. Azazel's mini-brimstone charge will become purple, but will not home.
  • Strange Attractor Strange Attractor
    Strange Attractor Icon.pngPickups, trinkets, and monsters are magnetically attracted to Isaac's tears.
    - Enemies are sucked towards the beam, increasing damage significantly. Consumables will also be moved by the beam.
  • Tammy's Head Tammy's Head
    Tammy's Head Icon.png1 roomsShoots 10 tears in a circle around Isaac, which retain the damage, shot speed, and special effects (such as poison) of Isaac's tears.
    - Fires Brimstone beams in every direction.
  • Added in Afterbirth Tech X Tech X
    Tech X Icon.pngTears are replaced with laser rings that pierce through enemies and deal damage to enemies within them. Can be charged to increase the size of the ring.
    - Brimstone now becomes a large ring that varies in size depending on how long it is charged before firing.
    • Tech X + A Lump of Coal A Lump of Coal
      A Lump of Coal Icon.pngThe more distance tears travel, the more damage they will do.
      - The Brimstone ring now increases in size and damage the further it travels.
    • Tech X + Mom's Knife Mom's Knife
      Mom's Knife Icon.pngIsaac's tears are replaced by a knife that pierces enemies, can travel through obstacles, and can hurt enemies while Isaac is holding it. Holding down the fire button before firing increases its range and power.
      - Mom's Knife and a Mom's Knife+Brimstone barrage are shot alongside the rings.
  • The Common Cold The Common Cold
    The Common Cold Icon.pngAdds a chance to shoot poison tears, dealing damage over time when inflicted.
    - Beam turns green and poisons enemies.
  • The Inner Eye The Inner Eye
    The Inner Eye Icon.pngGrants triple shot but decreases tears.
    - Produces 3 beams and greatly increases charge time.
  • Tiny Planet Tiny Planet
    Tiny Planet Icon.pngRange up and makes shot tears revolve around Isaac until they drop.
    - The beam will wrap around the character and shoot straight forward.
  • Added in Afterbirth † Varicose Veins Varicose Veins
    Varicose Veins Icon.pngTaking damage releases a ring of 10 high damage tears.
    : Fires 10 Brimstone beams in a circle around Isaac upon taking damage.

In-game Footage


  • The term brimstone (burn stone) comes from the King James Bible in reference to burning sulfur. It is used in the phrase "fire and brimstone" to describe the torments of hell.
  • Brimstone's item icon originally comes from the alchemical symbol for sulfur, referred to as the Leviathan Cross. It was later adopted by Anton LaVey in The Satanic Bible to represent hell, and is now often associated with Satanism.
  • The ram horns gained from picking up Brimstone were added as a cosmetic item to Team Fortress 2 to promote The Binding of Isaac: Rebirth. If the game was purchased before the 10th of December, players were awarded the item in genuine quality.



 PC  Hard mode only DQY7 QK7M (Basement XL: Second boss's devil room)

 PC  HM12 QGTW (Curse room adjacent to spawn teleports to devil room)

 PC  Added in Afterbirth Normal and hard modes only QW44 N10D (Second floor devil room; Isaac may proceed normally, but all other characters must not enter the first floor treasure room)

 PC  Added in Afterbirth Normal and hard modes only B8TK KNEP (Second floor devil room)

 Vita  LHVK 9NTS (Second floor devil room)

 PS4  SSH7 STDS (Second Floor Devil Room)

 Switch  Added in Afterbirth † Hard mode only DBDR SJGV (First Floor Devil Room)

Mac Added in Afterbirth Normal and hard modes only CE2R R2BZ (Second floor devil room)

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