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Item icon
Item altar
Character appearance
Tear appearance
Item Pool Devil Room.pngDevil Room
Added in Afterbirth (page 1, column 15, line 6)
Removed in Afterbirth (page 2, column 5, line 2)

Brimstone is a special passive item.


  • Isaac's tears are replaced with a charged blood laser beam that pierces through all enemies and obstacles in its path.
    • The laser deals damage equal to Isaac's damage each tick, and ticks a total of 13 times.
  • Added in Afterbirth This item belongs to the Leviathan set. Collecting three items from the set will transform Isaac into a Lovecraftian horror.


  • Azazel starts the game with a short-ranged, slower charging version of Brimstone. Picking up Brimstone with him will give him the long ranged version. Without the long ranged version, his mini-brimstone won't have enough length to use any homing items. Added in Afterbirth His mini-brimstone's range can be increased with range up items or pills.
  • If multiple Brimstones are picked up (via Added in Afterbirth Diplopia Diplopia, Added in Afterbirth † Crooked Penny Crooked Penny or on a victory lap), then another beam is added.


  • 20/20 20/20: Overridden by Brimstone.
    • Added in Afterbirth Shoots two Brimstone lasers simultaneously without increasing charge time.
  • Added in Afterbirth 8 Inch Nails 8 Inch Nails: Brimstone pushes enemies away in the direction the beam is travelling, but not out of the path of the beam.
  • A Lump of Coal A Lump of Coal: Changes the color, but does not have an effect on damage.
    • Added in Afterbirth Beam will gradually increase in size but rapidly increase damage the farther it travels, on a multiplier that is roughly +20% per tile of distance. This allows for a huge damage increase from longer distances.
  • Chocolate Milk Chocolate Milk: Decreases charge time slightly, but does not increase damage.
  • Added in Afterbirth Continuum Continuum: Overridden by Brimstone.
  • Cursed Eye Cursed Eye: Overridden by Brimstone.
  • Dr. Fetus Dr. Fetus: Overrides Brimstone.
    • Added in Afterbirth Isaac shoots bombs while charging Brimstone.
  • Epic Fetus Epic Fetus: Overrides Brimstone.
    • Added in Afterbirth After the missile hits the ground, it spawns 10 Brimstone beams similar to the effect given by Sad Bombs. Azazel's mini-brimstone does not give the Sad Bombs effect.
  • Added in Afterbirth Evil Eye Evil Eye: Overridden by Brimstone.
  • Fire Mind Fire Mind: Beam inflicts burning, but cannot cause explosions or leave fires on the ground.
  • Flat Worm Flat Worm: No effect.
  • Added in Afterbirth Holy Light Holy Light: Overridden by Brimstone.
  • Hook Worm Hook Worm: Beam changes angles while firing straight, but also effectively increases the width of the beam.
  • Ipecac Ipecac: The character gains neither the increased damage nor the decreased tears of Ipecac. They only gain the minor poison effect.
    • Added in Afterbirth † Isaac shoots Ipecac tears while charging Brimstone. Both Brimstone and Ipecac shots modify Isaac's damage and tear delay stat, meaning that Ipecac fires slower and Brimstone charges slower, but Brimstone does an extra 40*13 damage. Take care to pre-charge Brimstone so that the Ipecac shot is on cooldown as Isaac enters a room.
  • Isaac's Tears Isaac's Tears: Fires normal tears, but nearly instantly charges when charging Brimstone.
  • Added in Afterbirth † Jacob's Ladder Jacob's Ladder: Overridden by Brimstone.
  • Monstro's Lung Monstro's Lung: Overridden by Brimstone.
    • Added in Afterbirth Fires 3-5 additional Brimstone lasers in random directions around Isaac. Does not increase charge time. Charging a new Brimstone laser removes the original from in front of the player, but not the additional ones added by Monstro's Lung. This effectively increases fire rate.
  • My Reflection My Reflection: Overridden by Brimstone.
    • Added in Afterbirth Makes the beam curve when moving. Has the same effect on Azazel's mini-brimstone but doubles the range.
  • Mysterious Liquid Mysterious Liquid: Overridden by Brimstone.
    • Added in Afterbirth When Brimstone hits enemies or walls it leaves creep based on how long it hits.
  • Ouija Board Ouija Board: Overridden by Brimstone.
  • Added in Afterbirth Pupula Duplex Pupula Duplex: Overridden by Brimstone.
  • Rubber Cement Rubber Cement: Lasers ricochet off walls.
  • Soy Milk Soy Milk: Greatly reduces Brimstone charge time and damage.
  • Technology Technology: Overridden by Brimstone.
    • Added in Afterbirth Brimstone beams become surrounded with swiveling Technology laser beams, granting a 1.5x damage multiplier.
  • Technology 2 Technology 2: Laser fires while Brimstone is charging.
  • The Parasite The Parasite: Overridden by Brimstone.
  • Wiggle Worm Wiggle Worm: Makes the beam wavy.


  • Added in Afterbirth † Apple! Apple! / Added in Afterbirth † Euthanasia Euthanasia / Tough Love Tough Love: The beam can gain the damage multiplier from each of the items, although there is no visual difference. The bonus applies for the whole beam and not on a per-tick basis. Euthanasia loses its instant kill ability, however.
  • Anti-Gravity Anti-Gravity: An orb of energy expands, then shrinks while firing the beam after a delay. The orb still hurts enemies if they touch it. Makes it harder to hit enemies with Azazel as the laser does not increase in range. Effectively allows a faster firing rate, since Isaac can start charging a new shot immediately after releasing the fire key without cancelling the first shot and is a great combo with soy milk
    • Added in Afterbirth Incubus Incubus won't fire delayed Brimstone shots and will fire regular Brimstone shots instead.
  • Dark Matter Dark Matter: Beam will have a chance to cause fear.
  • Added in Afterbirth Diplopia Diplopia: Picking up two Brimstones will make Isaac simultaneously fire two lasers, similar to the 20/20 effect.
  • Added in Afterbirth God's Flesh God's Flesh: Chance to shrink enemies and turns the beam indigo.
  • Guppy: Flies are spawned at a rate of approximately one fly per tick of damage for each enemy it hits. This causes a lot of flies to spawn very quickly. The spawned flies will also move to attack the targeted enemy immediately.
  • Loki's Horns Loki's Horns: Occasionally causes Isaac to fire the beam in all four cardinal directions, similarly to Head of Krampus Head of Krampus's effect.
  • The Ludovico Technique The Ludovico Technique: The laser becomes a large ring that is controllable and does not need to be charged. Enemies inside the ring without touching it are not hurt. Shot speed is ignored. The Tears stat is ignored and damage is dealt very rapidly at a rate equivalent to 2 tear delay.
  • The Mulligan The Mulligan: Spawns blue flies constantly when hitting an enemy.
  • Mom's Eye Mom's Eye: Sometimes shoots a laser from the back of Isaac's head.
  • Mom's Knife Mom's Knife: Adds a small barrage of knives after the main knife is fired, with each knife doing 80% of Isaac's base damage. The barrage of knives goes all the way across the screen and increases in quantity the longer the charge.
  • Mom's Wig Mom's Wig: Holding down a fire button to charge the attack very rapidly rolls the probability to spawn blue spiders, releasing to fire the beam however, does not.
  • Monstro's Lung Monstro's Lung - Causes Isaac to fire multiple beams in random directions.
  • Mutant Spider Mutant Spider: Increases charge time but fires four separate Brimstone beams instead of one. Azazel's beams overlay each other instead of spreading out, causing additional damage.
  • Number One Number One: Greatly decreases charge time and turns beam yellow.
  • Polyphemus Polyphemus: Significantly increases damage and increases charge duration.
  • Proptosis Proptosis: Damage is doubled with no drop-off at range.
    • Added in Afterbirth Range is unchanged, but damage quickly drops further along the beam. This also affects the beams produced by Tammy's Head.
  • Sacred Heart Sacred Heart: Increases damage and makes laser home in on enemies.
  • Sad Bombs Sad Bombs: Changes the tears fired by bombs upon their explosions to Brimstone beams, in a manner identical to its synergy with Tammy's Head.
  • Spider Bite Spider Bite: Slow effect persists and turns the beam color to light pink.
  • Spoon Bender Spoon Bender: Turns beam purple and makes it curve towards enemies similar to The Gate's. Azazel's mini-brimstone charge will become purple, but will not home.
  • Strange Attractor Strange Attractor: Enemies are sucked towards the beam, increasing damage significantly. Consumables will also be moved by the beam.
  • Tammy's Head Tammy's Head: Fires Brimstone beams in every direction.
  • Added in Afterbirth Tech X Tech X: Brimstone now becomes a large ring that varies in size depending on how long it is charged before firing.
    • Added in Afterbirth Tech X Tech X + A Lump of Coal A Lump of Coal: The Brimstone ring now increases in size and damage the further it travels.
    • Added in Afterbirth Tech X Tech X + Mom's Knife Mom's Knife: Mom's Knife and a Mom's Knife+Brimstone barrage are shot alongside the rings.
  • The Common Cold The Common Cold: Beam turns green and poisons enemies.
  • The Inner Eye The Inner Eye: Produces 3 beams and greatly increases charge time.
  • Tiny Planet Tiny Planet: The beam will wrap around the character and shoot straight forward.

In-game Footage


  • The term brimstone (burn stone) comes from the King James Bible in reference to burning sulfur. It is used in the phrase "fire and brimstone" to describe the torments of hell.
  • Brimstone's item icon originally comes from the alchemical symbol for sulfur, referred to as the Leviathan Cross. It was later adopted by Anton LaVey in The Satanic Bible to represent hell, and is now often associated with Satanism.
  • The ram horns gained from picking up Brimstone were added as a cosmetic item to Team Fortress 2 to promote The Binding of Isaac: Rebirth. If the game was purchased before the 10th of December, players were awarded the item in genuine quality


 PC  DQY7 QK7M (Basement XL: Second boss's devil room) (Hard Mode)

 PC  HM12 QGTW (Curse room adjacent to spawn teleports to devil room)

 PC Added in Afterbirth QW44 N10D (Second floor devil room; Isaac may proceed normally, but all other characters must not enter the first floor treasure room) (Normal and hard mode)

 PC Added in Afterbirth B8TK KNEP (Second floor devil room) (Normal and hard mode)

 Vita  LHVK 9NTS (Second floor devil room)

 PS4  SSH7 STDS (Second Floor Devil Room)

 Switch  Added in Afterbirth † DBDR SJGV (First Floor Devil Room) (Hard Mode)

Mac Added in Afterbirth CE2R R2BZ (Second floor devil room) (Normal and hard mode)


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