Cain

	3.5 (*1.20)
	+0
	1
	17.75
	1.3
	0
	1 key Paper Clip
	Lucky Foot
Hold 55 coins at one time

Cain is unlocked when the player owns 55 or more coins at once in a run. He starts with two Red Heart containers, the Lucky Foot, and one key.

Cain will also start with the Paper Clip trinket if 68 coins have been donated to the Greed Donation Machine.

Notes

• Cain can only shoot tears from his right eye. This affects certain items: Blood Clot and Chemical Peel have a 50% chance to do increased damage and Technology 2 will prevent him from firing normal tears, even tear-changing effects like Brimstone. Also, the R U a Wizard? pill will cause Cain to fire tears to his right exclusively.

Unlockable Items

• 

  Cain's Other Eye - Complete the Boss Rush as Cain.

• 

  Glass Baby - Defeat Mom's Heart on Hard mode as Cain.

• 

  A Bag of Bombs - Defeat Satan as Cain.

• 

  A Bag of Pennies - Defeat Isaac as Cain.

• 

  Abel - Defeat The Lamb as Cain.

• 

  Cain's Eye - Defeat ??? as Cain.

• 

  Evil Eye - Defeat Ultra Greed as Cain.

• 

  Sack of Sacks - Defeat Ultra Greedier as Cain.

• 

  D12 - Defeat Hush as Cain.

• 

  Green Baby - Defeat Mega Satan as Cain.

• 

  Silver Dollar - Defeat Delirium as Cain.

• 

  Picky Baby - Earn all Hard mode completion marks as Cain.

Trivia

• Cain appeared in the original Binding of Isaac and required the same coin count to unlock.
• Cain is a reference to the Biblical story of Cain and Abel, in which Cain commits the first murder by killing Abel.
  • Abel also appears as an item in Rebirth.
• Glass Baby could be a reference to Cain having a glass eye.

Characters
Rebirth	Afterbirth	Afterbirth †