The first and second familiars will each spawn after taking damage 15 times. The third and fourth familiars will each spawn after taking damage 30 more times. No further familiars will spawn. As a result, after taking damage 90 times, four out of six possible familiars will have spawned.
Isaac will look progressively more pregnant as he takes damage.
Familiars spawned by the item do not affect item pools, so multiple copies of one familiar can be obtained. For example, a second Incubus can be purchased after Cambion Conception spawns one.
If a familiar obtained is a copy of another one you've already obtained, using Box of Friends will only clone one of that familiar, similarly to the Box of Friends's effects on cloned familiars that it spawns.
This page was last edited on 1 October 2020, at 23:35.
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