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Font TeamMeat C.pngFont TeamMeat a.pngFont TeamMeat n.pngFont TeamMeat c.pngFont TeamMeat e.pngFont TeamMeat r.png
Item icon
Item altar

Character appearance
Item Pool Treasure Room.png Treasure Room
Added in AfterbirthGreed mode onlyItem Pool Treasure Room.png Treasure Room
Added in Afterbirth (page 3, column 16, line 3)
Removed in Afterbirth (page 3, column 6, line 10)
Disambig.png This article is about the item. For the trinket, see Cancer (Trinket).

Cancer is a passive Zodiac item.

Effects[edit | edit source]

  • Grants three soul hearts.
  • Upon taking damage, grants The Wafer The Wafer
    The Wafer Icon.pngAll sources of damage that would cause more than one half heart of damage are reduced to one half heart instead.
    effect of damage reduction for the current room.

In-game Footage[edit | edit source]

Trivia[edit | edit source]

Gallery[edit | edit source]

Seeds[edit | edit source]

 PC  9TPQ J2AM (Treasure room adjacent to spawn)

 PC  Q8GC 7GQQ (Treasure room, second floor)

 PC  G4AZ K1EK (Treasure room adjacent to spawn)

 3DS  F9GW K1Q0 (Treasure room adjacent to spawn)

 Switch  Greedier mode only WLHZ P736 (First Golden Treasure Room)

Zodiac Signs

Aries Aries
Aries Icon.png+0.25 Speed. Running into enemies while at a high speed will deal 18 points of damage. Does not prevent contact damage.
Taurus Taurus
Taurus Icon.pngSpeed down; gains speed while in a room with enemies until gaining My Little Unicorn effect for a few seconds.
Gemini Gemini
Gemini (Item) Icon.pngSuture becomes attached to Isaac, and does touch damage to enemies within its attacking range.
Cancer Cancer
Cancer Icon.pngAdds 3 soul hearts. Grants The Wafer effect for the current room upon taking damage.
Leo Leo
Leo Icon.pngAllows you to crush rocks when you walk over them.
Virgo Virgo
Virgo Icon.pngGrants a chance to trigger the Book of Shadows effect upon taking damage, creating a shield that nullifies all types of damage for 10 seconds. Also converts "bad pills" into "good pills".
Libra Libra
Libra Icon.pngGives 6 coins, 6 bombs, and 6 keys and balances out all attributes.
Scorpio Scorpio
Scorpio Icon.pngGrants poison tears, which deal damage over time when inflicted.
Sagittarius Sagittarius
Sagittarius Icon.pngIncreases speed by +0.2 and grants piercing tears.
Capricorn Capricorn
Capricorn Icon.pngAll stats up.
Aquarius Aquarius
Aquarius Icon.pngA trail of blue creep is left behind Isaac, which damages enemies.
Pisces Pisces
Pisces Icon.png-1 Tear Delay, adds knock-back shots and increases tear size.
Added in Afterbirth Zodiac Zodiac
Zodiac Icon.pngZodiac will give Isaac a random zodiac item effect that changes after every floor.

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