Challenges

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Challenges are unique runs in the game. Challenges typically start the player off with one or more specific items which make normal play more difficult. You will not find Treasure Rooms (with the exception of a select few challenges). Completing one of the thirty five challenges unlocks new content for the game, such as Runes.

General Strategy[edit | edit source]

Most challenges are geared to make a run difficult in some form. Sometimes, these challenges are easy, like Computer Savvy. Other times, they can be vicious, like Solar System. Each challenge has a certain strategy that can make the run easier. However, there are a few strategies that can apply to all challenges.

  • You can play in co-op for every challenge, making it easier for the ones where you cannot fire tears - especially for Cat Got Your Tongue, since it will spawn flies.
  • Because of the lack of Treasure Rooms, Devil Rooms become much more valuable. Some challenges can be made much easier by making just one deal.
  • You can also be more liberal with your use of keys for the same reason. Trinkets and Items that generate more coins, along with upgraded shops, can help reduce the difficulty in many challenge runs.
  • The Bible The Bible
    The Bible Icon.png6 roomsUpon activation, Isaac gains flight, allowing him to pass over all obstacles in the current room. Instantly kills Mom, Mom's Heart, and It Lives when activated, but will kill Isaac when activated while fighting Satan.
    can make the end of some runs extremely easy. Because of how some challenges operate, the run may only require defeating Mom or Mom's Heart / It Lives. Since The Bible The Bible
    The Bible Icon.png6 roomsUpon activation, Isaac gains flight, allowing him to pass over all obstacles in the current room. Instantly kills Mom, Mom's Heart, and It Lives when activated, but will kill Isaac when activated while fighting Satan.
    is a one-hit kill against these, getting it when you have the chance is usually a good investment for these runs.
    • Pandora's Box Pandora's Box
      Pandora's Box Icon.pngOne time useUpon use, spawns certain pickups or items depending on the floor it is used on. Single-use.
      will spawn The Bible The Bible
      The Bible Icon.png6 roomsUpon activation, Isaac gains flight, allowing him to pass over all obstacles in the current room. Instantly kills Mom, Mom's Heart, and It Lives when activated, but will kill Isaac when activated while fighting Satan.
      if used in Womb II, Utero II, or Added in Afterbirth Scarred Womb II, which may then be used against Mom's Heart / It Lives.
  • Curse Rooms gain value since they can spawn items. You may wish to restart on the first floor until your Curse Room spawns an item worth 1 heart of damage.
  • Dice Rooms and the D4 D4
    D4 Icon.png6 roomsRerolls all of Isaac's items.
    are very useful, as in some cases you can reroll your entire build and remove (or add) difficulty.
    • Added in Afterbirth Dice rooms do not re-roll starter challenge items or remove Blindfolded.
    • Added in Afterbirth † Butter! Butter!
      Butter! Icon.pngUsing an active item will drop it onto a pedestal on the ground. Taking damage may result in dropping a passive item.
      can remove starter items.
  • In Blindfolded challenges, familiars can make the run easier, as they are your only source of conventional damage. Powerful familiars like Daddy Longlegs Daddy Longlegs
    Daddy Longlegs Icon.pngDaddy Long Legs' shadow follows Isaac and stomps on enemies.
    , Lil Brimstone Lil Brimstone
    Lil Brimstone Icon.pngA Familiar that shoots a thin Brimstone beam. Must charge like Brimstone before shooting.
    , and Added in Afterbirth Incubus Incubus
    Incubus Icon.pngA demonic familiar that follows Isaac and shoots tears identical to Isaac's in terms of damage, range, fire rate, and effects.
    are very good items to pick up. Some of the strongest familiars need to be unlocked first, so it may be wise to take the time to unlock them beforehand.
    • The Boomerang The Boomerang
      The Boomerang Icon.png4 secondsThrows a short-range boomerang which does a bit of damage and has a high chance to stun the enemy for 2 seconds. Can also be used to grab pickups.
      , The Candle The Candle
      The Candle Icon.png4 secondsThrows out a blue flame that can pass over gaps (but not through rocks). The flame damages anything in its path.
      , and Red Candle Red Candle
      Red Candle Icon.png4 secondsThrows a persistent flame that deals high damage and diminishes as it damages enemies or blocks shots.
      are also useful for blindfolded challenges, since they deal damage and recharge based on a timer.
      • Added in Afterbirth In Blindfolded challenges, if possible finding and using the Added in Afterbirth † Clicker Clicker
        Clicker Icon.png6 roomsTransforms Isaac into another random character.
        , change yourself into the character Lilith, will make these challenges incredibly easy with access to tears through her Added in Afterbirth Incubus Incubus
        Incubus Icon.pngA demonic familiar that follows Isaac and shoots tears identical to Isaac's in terms of damage, range, fire rate, and effects.
        you gain.
  • Added in Afterbirth In challenges that remove Treasure Rooms, Added in Afterbirth Chaos Chaos
    Chaos Icon.pngChaos causes items to be chosen from random item pools. When picked up, drops between 1-6 random pickups on the floor.
    has more potential to be useful by potentially making Treasure Room (among other rare items) items purchasable from the shop. On the downside, it may replace the Devil/Angel Room items with something less valuable.
  • Defeating a boss beyond the specified end of the challenge (e.g. defeating Mom's Heart when the goal is to defeat Mom) will still cause them to drop the trophy.
    • Added in Afterbirth This means a legitimate tactic for some of the longer challenges (e.g. XXXXXXXXL) is to use the Sacrifice Room until it teleports you to the Dark Room, then going through and defeating The Lamb, completing the challenge regardless of what floor you were teleported from.

Notes[edit | edit source]

  • New content, other than the Challenge Reward, cannot be unlocked. Likewise, you will not find a Donation Machine anywhere.
  • The Challenge reward will not be unlocked unless you pick up the trophy, meaning that if a Devil Room or Angel Room appears and allows you to go to Sheol or the Cathedral, you will be forfeiting the unlock if you fail to complete the floor.
  • Any challenge featuring Isaac will not start with The D6 The D6
    The D6 Icon.png6 roomsAllows Isaac to re-roll collectible items in the current room into other items, depending on the current room's Item Pool.
    .

Challenge list[edit | edit source]

Name Conditions Goal Unlocked by Unlocks
1. Pitch Black
Isaac App.png
HUD Red Heart.pngHUD Red Heart.pngHUD Red Heart.png
Curse of Darkness
Curse of the Unknown
Item Pool Treasure Room.png: yes
Item Pool Shop.png: no
Boss Mom.png Default Rune of Hagalaz
2. High Brow
Isaac App.png
HUD Red Heart.pngHUD Red Heart.pngHUD Red Heart.png
Starts with:
Number One Number One
Number One Icon.png+1.5 tears, -15.77 range

E Coli E Coli
E Coli Icon.pngGives "Turdy Touch" Effect. Enemies that touch Isaac are changed into poop.

Butt Bombs Butt Bombs
Butt Bombs Icon.pngGives +5 bombs and makes all bombs Butt Bombs that fill the room with gas, damaging and confusing all enemies.

Flush! Flush!
Flush! Icon.png6 roomsChanges all enemies in the room into poop. Does not work on all enemies (Knights and bosses are immune). Instantly kills Dingle, Dangle, and Brownie.

Petrified Poop Petrified Poop
Petrified Poop Icon.pngGreatly increases the chances of a pickup dropping when destroying poop.

Item Pool Treasure Room.png: no
Item Pool Shop.png: yes
Boss Mom.png Default Rune of Jera
3. Head Trauma
Isaac App.png
HUD Red Heart.pngHUD Red Heart.pngHUD Red Heart.png
Starts with:
Tiny Planet Tiny Planet
Tiny Planet Icon.pngRange up and makes shot tears revolve around Isaac until they drop.

Soy Milk Soy Milk
Soy Milk Icon.pngTears shrink and do much less damage, but fire in very rapid succession.

The Small Rock The Small Rock
The Small Rock Icon.pngIncreases damage by 1, increases tears by 0.2, and decreases speed by 0.1.

Iron Bar Iron Bar
Iron Bar Icon.pngIncreases damage by 0.3 and adds a chance to shoot concussive tears, causing enemies to walk around randomly.

Item Pool Treasure Room.png: no
Item Pool Shop.png: yes
Boss Mom.png Default Rune of Ehwaz
4. Darkness Falls
Eve App.png
HUD Red Heart.pngHUD Red Heart.png
Starts with:
Pentagram Pentagram
Pentagram Icon.pngIncreases damage and increases the chance for a Devil or Angel Room to appear.

Dead Bird Dead Bird
Dead Bird Icon.pngSpawns a flying familiar for the current room that chases enemies whenever Isaac takes damage.

Whore of Babylon Whore of Babylon
Whore of Babylon Icon.pngIncreases damage and speed whenever Isaac has half a red heart or less (one red heart for Eve), ignoring any soul or black hearts.

Razor Blade Razor Blade
Razor Blade Icon.pngUnlimitedUpon use, deals one heart of damage to Isaac and grants +1.2 damage for the current room.

Sacrificial Dagger Sacrificial Dagger
Sacrificial Dagger Icon.pngDagger orbits Isaac, dealing very high damage.

Dark Matter Dark Matter
Dark Matter Icon.pngIncreases Damage by 1 and adds a chance to shoot fear tears.

Item Pool Treasure Room.png: no
Item Pool Shop.png: yes
Boss Satan.png Darkness Falls Defeat Mom's Heart 11 times
Darkness FallsDarkness Falls
Rune of Dagaz
5. The Tank
Magdalene App.png
HUD Red Heart.pngHUD Red Heart.pngHUD Red Heart.pngHUD Red Heart.png
Starts with:
Infamy Infamy
Infamy Icon.pngChance to block projectiles coming from any direction.

Bucket of Lard Bucket of Lard
Bucket of Lard Icon.pngGrants two empty heart containers and heals Isaac by half a heart, but decreases speed by 0.2.

Thunder Thighs Thunder Thighs
Thunder Thighs Icon.pngDestroys rocks upon contact with Isaac. Adds one heart container and lowers Speed.

Yum Heart Yum Heart
Yum Heart Icon.png4 roomsRestores 1 whole red heart.

Item Pool Treasure Room.png: no
Item Pool Shop.png: yes
Boss Mom.png The Tank Have 7 or more heart containers at one time
The TankThe Tank
Rune of Ansuz
6. Solar System
Isaac App.png
HUD Red Heart.pngHUD Red Heart.pngHUD Red Heart.png
Blindfolded App.png Blindfolded
Starts with:
Distant Admiration Distant Admiration
Distant Admiration Icon.pngA red attack fly circles further out than the Halo of Flies / Pretty Flies, but closer than Forever Alone. Deals more damage than Forever Alone.

Forever Alone Forever Alone
Forever Alone Icon.pngSpawns a blue attack fly that orbits a long distance from Isaac.

Halo of Flies Halo of Flies
Halo of Flies Icon.pngSpawns two pretty fly familiars that block enemy shots and deal contact damage to enemies.

Transcendence Transcendence
Transcendence Icon.pngGrants flight.

Item Pool Treasure Room.png: no
Item Pool Shop.png: yes
Boss Mom's Heart.png / Boss It Lives.png Solar System Defeat Mom's Heart 3 times
Solar SystemSolar System
Rune of Perthro
7. Suicide King
Lazarus App.png
HUD Red Heart.pngHUD Red Heart.pngHUD Red Heart.png
Starts with:
Ipecac Ipecac
Ipecac Icon.pngReplaces tears with explosive and poisoning projectiles fired in an arc from the mouth.

Mr. Mega Mr. Mega
Mr. Mega Icon.pngGives Isaac 5 bombs, and makes all dropped bombs larger, which have an increased blast radius and increased damage.

My Reflection My Reflection
My Reflection Icon.pngGives Isaac's tears a boomerang effect, and increases range and shot speed.

1 random Pill
Item Pool Treasure Room.png: no
Item Pool Shop.png: yes
Isaac Suicide King Defeat Mom's Heart 11 times
Suicide KingSuicide King
Suicide King
8. Cat Got Your Tongue
Isaac App.png
Soul HeartSoul HeartSoul HeartBlack HeartBlack HeartBlack Heart
Blindfolded App.png Blindfolded
Starts with:
Guppy's Hair Ball Guppy's Hair Ball
Guppy's Hair Ball Icon.pngLoosely follows behind Isaac. Can be swung like a flail by rapidly spinning Isaac in a circle. Grows bigger by killing enemies.

Guppy's Head Guppy's Head
Guppy's Head Icon.png1 roomsSpawns 2-4 blue flies to damage enemies.

Guppy's Tail Guppy's Tail
Guppy's Tail Icon.pngIncreases chance of finding gold chests and normal chests, but reduces chance of finding pickups.

Item Pool Treasure Room.png: no
Item Pool Shop.png: yes
Boss Mom.png Cat Got Your Tongue Become Guppy (Collect 3 Guppy Items)
Cat Got Your TongueCat Got Your Tongue
Rune of Algiz
9. Demo Man
Isaac App.png
HUD Red Heart.pngHUD Red Heart.pngHUD Red Heart.png
Starts with:
Dr. Fetus Dr. Fetus
Dr. Fetus Icon.pngTears are replaced by bombs that benefit from bomb-enhancing effects and slide a fixed range after being fired.

Remote Detonator Remote Detonator
Remote Detonator Icon.pngUnlimitedBombs you place explode only when you use this item. Gives 5 bombs.

Match Stick Match Stick
Match Stick Icon.pngIncreases the chance of Bombs dropping after clearing a room, and the chance of finding Bombs when opening a Chest.

Item Pool Treasure Room.png: no
Item Pool Shop.png: yes
Boss Mom's Heart.png / Boss It Lives.png Demo Man Defeat Mom's Heart 9 times
Demo ManDemo Man
Chaos Card
10. Cursed!
Magdalene App.png
HUD Red Heart.pngHUD Red Heart.pngHUD Red Heart.pngHUD Red Heart.png
Starts with:
Blue Map Blue Map
Blue Map Icon.pngShows secret and super secret room locations on the map.

The Compass The Compass
The Compass Icon.pngReveals all special rooms (except secret rooms of any kind).

Raw Liver Raw Liver
Raw Liver Icon.pngGrants 2 Heart Containers and completely restores health.

Treasure Map Treasure Map
Treasure Map Icon.pngReveals all rooms for every floor. However, it does not reveal icons or secret rooms.

Yum Heart Yum Heart
Yum Heart Icon.png4 roomsRestores 1 whole red heart.

Child's Heart Child's Heart
Child's Heart Icon.pngIncreases the chance of a Heart dropping after clearing a room, and the chance of finding a Heart when opening a Chest.

Curse of the Cursed
Item Pool Treasure Room.png: yes
Item Pool Shop.png: yes
Boss Mom.png Cursed! Have 7 or more heart containers at one time
Cursed!Cursed!
Credit Card
11. Glass Cannon
Judas App.png
HUD Red Heart.png
Starts with:
Epic Fetus Epic Fetus
Epic Fetus Icon.pngIsaac's tears are replaced with guided missiles, like those used by the Doctor's Remote.

Loki's Horns Loki's Horns
Loki's Horns Icon.pngGives a random chance for projectiles to fire in all 4 cardinal directions.

Item Pool Treasure Room.png: no
Item Pool Shop.png: yes
Boss Satan.png Glass Cannon Beat challenge #19 and defeat Lokii for the 1st time
Glass CannonGlass Cannon
Rules Card
12. When Life Gives You Lemons
Isaac App.png
HUD Red Heart.pngHUD Red Heart.pngHUD Red Heart.png
Starts with:
9 Volt 9 Volt
9 Volt Icon.pngReduces the charge of any Activated Items by 1. Any 1 charge items instead have timed recharges.

Habit Habit
Habit Icon.pngWhen Isaac is hit, 1 point of an item's charge is filled.

Lemon Mishap Lemon Mishap
Lemon Mishap Icon.png2 roomsCreates a small yellow pool of creep, which damages enemies that cross it.

1 Lemon Party pill
Item Pool Treasure Room.png: no
Item Pool Shop.png: yes
Boss Mom.png Default Card Against Humanity
13. Beans!
Isaac App.png
HUD Red Heart.pngHUD Red Heart.pngHUD Red Heart.png
Blindfolded App.png Blindfolded
Starts with:
9 Volt 9 Volt
9 Volt Icon.pngReduces the charge of any Activated Items by 1. Any 1 charge items instead have timed recharges.

The Bean The Bean
The Bean Icon.png1 roomsIsaac releases bad gas, poisoning any enemy in close vicinity.

The Black Bean The Black Bean
The Black Bean Icon.pngWhen taking damage, Isaac farts, causing poison damage to all enemies in range.

Butt Bombs Butt Bombs
Butt Bombs Icon.pngGives +5 bombs and makes all bombs Butt Bombs that fill the room with gas, damaging and confusing all enemies.

Pyro Pyro
Pyro Icon.pngAdds 99 bombs.

Item Pool Treasure Room.png: no
Item Pool Shop.png: yes
Boss Mom.png Default Burnt Penny
14. It's in the Cards
Isaac App.png
HUD Red Heart.pngHUD Red Heart.pngHUD Red Heart.png
Starts with:
9 Volt 9 Volt
9 Volt Icon.pngReduces the charge of any Activated Items by 1. Any 1 charge items instead have timed recharges.

The Battery The Battery
The Battery Icon.pngActivated Items can be "overcharged" to allow for an additional use.

Deck of Cards Deck of Cards
Deck of Cards Icon.png6 roomsGives Isaac a random Tarot Card.

Starter Deck Starter Deck
Starter Deck Icon.pngIsaac can hold 2 cards at once and all pills are replaced by cards.

2 random tarot cards
Item Pool Treasure Room.png: no
Item Pool Shop.png: yes
Boss Mom.png Default SMB Super Fan
15. Slow Roll
Isaac App.png
HUD Red Heart.pngHUD Red Heart.pngHUD Red Heart.png
Starts with:
Cupid's Arrow Cupid's Arrow
Cupid's Arrow Icon.pngGrants Isaac piercing tears that travel through enemies (but not obstacles) instead of breaking on impact with them.

My Reflection My Reflection
My Reflection Icon.pngGives Isaac's tears a boomerang effect, and increases range and shot speed.

Polyphemus Polyphemus
Polyphemus Icon.pngMakes Isaac shoot one huge tear. Also reduces Tears to minimum. Damage increased . If tear does more damage than an enemy's life, the tear continues to travel with the extra remaining damage.

Item Pool Treasure Room.png: no
Item Pool Shop.png: yes
Boss Mom.png Default Swallowed Penny
16. Computer Savvy
Isaac App.png
HUD Red Heart.pngHUD Red Heart.pngHUD Red Heart.png
Starts with:
Spoon Bender Spoon Bender
Spoon Bender Icon.pngGrants Isaac homing tears.

Technology Technology
Technology Icon.pngReplaces tears with a piercing laser with unlimited range.

Technology 2 Technology 2
Technology 2 Icon.pngDecreases damage and replaces right eye tears with a unlimited range, piercing laser which fires continuously.

Item Pool Treasure Room.png: no
Item Pool Shop.png: yes
Boss Mom.png Default Robo-Baby 2.0
17. Waka Waka
Isaac App.png
HUD Red Heart.pngHUD Red Heart.pngHUD Red Heart.png
Starts with:
Anti-Gravity Anti-Gravity
Anti-Gravity Icon.png-2 Tear Delay. Tears float in position until firing ceases, after which they will fly off in the direction they were shot in.

Strange Attractor Strange Attractor
Strange Attractor Icon.pngPickups, trinkets, and monsters are magnetically attracted to Isaac's tears.

Item Pool Treasure Room.png: no
Item Pool Shop.png: yes
Boss Mom.png Default Death's Touch
18. The Host
Isaac App.png
HUD Red Heart.pngHUD Red Heart.pngHUD Red Heart.png
Starts with:
The Mulligan The Mulligan
The Mulligan Icon.pngTears have a 1/6 chance of spawning allied blue flies when they hit an enemy.

Spider Baby Spider Baby
Spider Baby Icon.pngWhen hit, spawns up to 2 blue spiders.

Tick Tick
Tick Icon.pngDrain 15% health of each enemy with more than 60 HP (ie. most bosses). Also restores one red heart of Isaac whenever he enters an uncleared boss room. The Tick cannot be swapped out for another trinket.

Item Pool Treasure Room.png: no
Item Pool Shop.png: yes
Boss Mom.png Default Technology .5
19. The Family Man
Isaac App.png
HUD Red Heart.pngHUD Red Heart.pngHUD Red Heart.png
Blindfolded App.png Blindfolded
Starts with:
BFFS! BFFS!
BFFS! Icon.pngIncreases the size and damage of familiars.

Brother Bobby Brother Bobby
Brother Bobby Icon.pngFollows Isaac around shooting normal tears.

Dad's Key Dad's Key
Dad's Key Icon.png2 roomsOpens all doors in the current room when activated, including doors which require a key to open and entrances to secret rooms. Opens the big doors in the first room of both The Chest and the Dark Room.

Rotten Baby Rotten Baby
Rotten Baby Icon.pngA familiar that spawns blue flies.

Sister Maggy Sister Maggy
Sister Maggy Icon.pngA familiar that follows Isaac around shooting blood tears.

Item Pool Treasure Room.png: no
Item Pool Shop.png: yes
Isaac The Family Man Pick up both Key pieces from the Angels in one run
The Family ManThe Family Man
Epic Fetus
20. Purist
Isaac App.png
HUD Red Heart.pngHUD Red Heart.pngHUD Red Heart.png
Item Pool Treasure Room.png: no
Item Pool Shop.png: yes
Boss Mom's Heart.png / Boss It Lives.png Purist Defeat Mom for the first time
PuristPurist
Rune of Berkano
Added in Afterbirth
21. XXXXXXXXL
Isaac App.png
HUD Red Heart.pngHUD Red Heart.pngHUD Red Heart.png
Item Pool Treasure Room.png: yes
Item Pool Shop.png: yes
Every floor is the size of an XL Womb floor, but does not combine the floors of each chapter.
Boss Mom's Heart.png / Boss It Lives.png Added in Afterbirth XXXXXXXXL Defeat Mom for the 1st time
XXXXXXXXLXXXXXXXXL
Gold Heart
Added in Afterbirth
22. SPEED!
Isaac App.png
HUD Red Heart.pngHUD Red Heart.pngHUD Red Heart.png
Item Pool Treasure Room.png: yes
Item Pool Shop.png: yes
Everything is sped up like the Broken Watch effect.
Boss Mom's Heart.png / Boss It Lives.png
within 16 minutes, otherwise under
constant periodic damage every 10 seconds.
Added in Afterbirth SPEED! Defeat Mom for the 1st time
SPEED!SPEED!
Get out of Jail Free Card
Added in Afterbirth
23. Blue Bomber
???
HUD Soul Heart.pngHUD Soul Heart.pngHUD Soul Heart.png
Blindfolded App.png Blindfolded
Starts with:
Brother Bobby Brother Bobby
Brother Bobby Icon.pngFollows Isaac around shooting normal tears.

Kamikaze! Kamikaze!
Kamikaze! Icon.pngUnlimitedCreates an explosion in the same area as Isaac, dealing half a heart of damage to him and also damaging all enemies caught in the blast radius.

Pyromaniac Pyromaniac
Pyromaniac Icon.pngIsaac heals 1 heart instead of taking damage from an explosive source. Adds 5 bombs.

Mr. Mega Mr. Mega
Mr. Mega Icon.pngGives Isaac 5 bombs, and makes all dropped bombs larger, which have an increased blast radius and increased damage.

Item Pool Treasure Room.png: no
Item Pool Shop.png: yes
Boss Satan.png Added in Afterbirth Blue Bomber Destroy 10 tinted rocks and defeat Mom's Heart 11 times
Blue BomberBlue Bomber
Gold Bomb
Added in Afterbirth
24. PAY TO PLAY
Isaac App.png
HUD Red Heart.pngHUD Red Heart.pngHUD Red Heart.png
Starts with:
Money = Power Money = Power
Money = Power Icon.pngIncreases damage by 0.04 for every coin Isaac has, up to +3.96 damage at 99 coins.

Sack of Pennies Sack of Pennies
Sack of Pennies Icon.pngIsaac is followed by a small bag that drops a coin every 2 rooms.

50 coins
Item Pool Treasure Room.png: no
Item Pool Shop.png: yes
Every door costs 1 cent to enter. Isaac drops money when hit. Isaac dies if you run out of money.
Isaac Added in Afterbirth PAY TO PLAY Defeat Isaac as Cain
PAY TO PLAYPAY TO PLAY
2 new pills
Added in Afterbirth
25. Have a Heart
Isaac App.png
Red HeartEmpty Red HeartEmpty Red HeartEmpty Red HeartEmpty Red HeartEmpty Red Heart
Empty Red HeartEmpty Red HeartEmpty Red HeartEmpty Red HeartEmpty Red HeartEmpty Red Heart
Starts with:
Charm of the Vampire Charm of the Vampire
Charm of the Vampire Icon.pngHeals the character for half of a red heart for every 13 monsters killed.

Item Pool Treasure Room.png: yes
Item Pool Shop.png: yes
Pennies drop instead of red hearts. Many items that restore red hearts have no effect.
Boss Mom's Heart.png / Boss It Lives.png Added in Afterbirth Have a Heart Defeat Mom for the 1st time
Have a HeartHave a Heart
2 new pills
Added in Afterbirth
26. I RULE!
Isaac App.png
HUD Red Heart.pngHUD Red Heart.pngHUD Red Heart.png
Starts with:
The Boomerang The Boomerang
The Boomerang Icon.png4 secondsThrows a short-range boomerang which does a bit of damage and has a high chance to stun the enemy for 2 seconds. Can also be used to grab pickups.

Key Piece 1 Key Piece 1
Key Piece 1 Icon.pngCombined with Key Piece 2, unlocks the golden gate in the starting room of The Chest and Dark Room to fight Mega Satan.

Key Piece 2 Key Piece 2
Key Piece 2 Icon.pngCombined with Key Piece 1, unlocks the golden gate in the starting room of The Chest and Dark Room to fight Mega Satan.

The Ladder The Ladder
The Ladder Icon.pngAllows Isaac to walk across gaps one square across by automatically placing a ladder between the two walkable sections.

Mom's Knife Mom's Knife
Mom's Knife Icon.pngIsaac's tears are replaced by a knife that pierces enemies, can travel through obstacles, and can hurt enemies while Isaac is holding it. Holding down the fire button before firing increases its range and power.

Trinity Shield Trinity Shield
Trinity Shield Icon.pngIsaac gains a shield that protects him from enemy shots.

Item Pool Treasure Room.png: no
Item Pool Shop.png: yes
Boss Mega Satan.png Added in Afterbirth I RULE! Defeat ??? or The Lamb for the 1st time, and defeat Satan as Isaac
I RULE!I RULE!
Poker Chip
Added in Afterbirth
27. BRAINS!
???
HUD Soul Heart.pngHUD Soul Heart.pngHUD Soul Heart.png
Blindfolded App.png Blindfolded
Starts with:
3 Bob's Brain Bob's Brain
Bob's Brain Icon.pngSpawns a familiar that charges forward when shooting tears and explodes upon contact with an enemy, damaging and poisoning them. The familiar respawns after a few seconds.

Thunder Thighs Thunder Thighs
Thunder Thighs Icon.pngDestroys rocks upon contact with Isaac. Adds one heart container and lowers Speed.

Item Pool Treasure Room.png: no
Item Pool Shop.png: yes
??? Added in Afterbirth BRAINS! Defeat Isaac 5 times
BRAINS!BRAINS!
Stud Finder
Added in Afterbirth
28. PRIDE DAY!
Isaac App.png
HUD Red Heart.pngHUD Red Heart.pngHUD Red Heart.png
Starts with:
3 Dollar Bill 3 Dollar Bill
3 Dollar Bill Icon.pngGives Isaac a random tear effect every room.
Removed in Afterbirth The effect given changes upon entering a room.
Added in Afterbirth The effect changes every 3 seconds.

Rainbow Baby Rainbow Baby
Rainbow Baby Icon.pngSpawns a familiar that follows Isaac around and fires tears with random effects.

Added in Afterbirth Rainbow Worm Rainbow Worm
Rainbow Worm Icon.pngIsaac's tears gain a worm effect that changes every 3 seconds.

Item Pool Treasure Room.png: no
Item Pool Shop.png: yes
Cannot drop or replace Rainbow Worm.
Boss Mom's Heart.png / Boss It Lives.png Added in Afterbirth PRIDE DAY! Defeat Mom for the 1st time
PRIDE DAY!PRIDE DAY!
D8
Added in Afterbirth
29. Onan's Streak
Judas App.png
HUD Red Heart.png
Starts with:
The Book of Belial The Book of Belial
The Book of Belial Icon.png3 roomsUpon use increases damage by 2 for the current room and by a further +50% if the character also has the Blood of the Martyr.
Removed in Afterbirth Guarantees a Devil Room or Angel Room will be open after beating a boss while holding it.
Added in Afterbirth Increases the chance for a Devil or Angel Room to appear by 12.5%.

Chocolate Milk Chocolate Milk
Chocolate Milk Icon.pngGrants charged tears that deal greater damage when fully charged.

Item Pool Treasure Room.png: yes
Item Pool Shop.png: yes
Missing a shot deals damage to Judas.
Isaac Added in Afterbirth Onan's Streak Defeat Mom for the 1st time
Onan's StreakOnan's Streak
Kidney Stone
Added in Afterbirth
30. The Guardian
Isaac App.png
HUD Red Heart.pngHUD Red Heart.pngHUD Red Heart.png
Blindfolded App.png Blindfolded
Starts with:
Holy Grail Holy Grail
Holy Grail Icon.pngGrants flight and one heart container.

Isaac's Heart Isaac's Heart
Isaac's Heart Icon.pngIsaac himself is now immune to all damage, and a heart familiar appears and follows Isaac. If the heart is hurt, Isaac is hurt.

Punching Bag Punching Bag
Punching Bag Icon.pngSpawns a Mulligan Familiar that will wander the room randomly. Enemies will attack the Mulligan if it's closer.

Spear of Destiny Spear of Destiny
Spear of Destiny Icon.pngIn addition to tears, Isaac now holds a spear in front of him which deals damage equal to 2 times his tear damage, and occasionally inflicts fear. The spear cannot be thrown, but deals damage while it is in contact with an enemy.

Item Pool Treasure Room.png: no
Item Pool Shop.png: yes
Isaac's Heart will follow the Punching Bag instead of Isaac.
Boss Mom's Heart.png / Boss It Lives.png Added in Afterbirth The Guardian Defeat Mom for the 1st time
The GuardianThe Guardian
Blank Rune
Added in Afterbirth †
31. Backasswards
Isaac App.png
HUD Red Heart.pngHUD Red Heart.pngHUD Red Heart.png
Starts with:
8-10 random items
Item Pool Treasure Room.png: no
Item Pool Shop.png: yes
All Chapters progress in reverse order, losing 1 item and 1 red heart container each floor you ascend.
The Basement/The Cellar/Burning Basement I Added in Afterbirth † Backasswards Defeat ??? or The Lamb for the 1st time
BackasswardsBackasswards
Laz Bleeds More!
Added in Afterbirth †
32. Aprils Fool
Isaac App.png
HUD Red Heart.pngHUD Red Heart.pngHUD Red Heart.png
Item Pool Treasure Room.png: yes
Item Pool Shop.png: yes
The minimap displays the floor's layout accurately, but displays Isaac's position inaccurately.

Pedestal items and pickups are not what they appear to be. Active item, pill, card, and rune effects are randomized upon each use, making them very unreliable or deadly (for example Suicide King). Items with no charge time (i.e. How To Jump, IV Bag, etc) can be used repeatedly for random effects. Stoneys have a chance of being replaced by Cross Stoneys. Every boss is The Bloat. Isaac's health is not what it appears to be. Key and bomb numbers are accurate.

Boss Mom's Heart.png / Boss It Lives.png Added in Afterbirth † Aprils fool Defeat Mom for the 1st time
Aprils foolAprils fool
Maggy Now Holds a Pill!
Added in Afterbirth †
33. Pokey Mans
Isaac App.png
HUD Red Heart.pngHUD Red Heart.pngHUD Red Heart.png
Starts with:
Added in Afterbirth Friendly Ball Friendly Ball
Friendly Ball Icon.png3 roomsThrowing the ball at an enemy instantly kills it and captures it. The captured enemy can later be released and will be charmed until it dies, persisting between floors.

Mom's Eyeshadow Mom's Eyeshadow
Mom's Eyeshadow Icon.pngTears have a chance to charm enemies.

Item Pool Treasure Room.png: no
Item Pool Shop.png: yes
Each use of Friendly Ball causes a random monster to be spawned. Friendly Ball instantly charges once the spawned monster is killed.
Isaac Added in Afterbirth † Pokey Mans Defeat Mom's Heart 11 times
Pokey MansPokey Mans
Charged Key
Added in Afterbirth †
34. Ultra Hard
Isaac App.png
HUD Red Heart.pngHUD Red Heart.pngHUD Red Heart.png
Starts with:
Key Piece 1 Key Piece 1
Key Piece 1 Icon.pngCombined with Key Piece 2, unlocks the golden gate in the starting room of The Chest and Dark Room to fight Mega Satan.

Key Piece 2 Key Piece 2
Key Piece 2 Icon.pngCombined with Key Piece 1, unlocks the golden gate in the starting room of The Chest and Dark Room to fight Mega Satan.

Curse of the Labyrinth
Curse of the Blind
Curse of the Lost
Curse of the Maze
Item Pool Treasure Room.png: yes
Item Pool Shop.png: yes
All enemies spawn as champions if possible. Boss fights will be double trouble if possible. No heart pickups drop.
Boss Mega Satan.png Added in Afterbirth † Ultra Hard Defeat ??? or The Lamb for the first time
Ultra HardUltra Hard
Samson Feels Healthy!
Added in Afterbirth †
35. Pong
Isaac App.png
HUD Red Heart.pngHUD Red Heart.pngHUD Red Heart.png
Starts with:
Cupid's Arrow Cupid's Arrow
Cupid's Arrow Icon.pngGrants Isaac piercing tears that travel through enemies (but not obstacles) instead of breaking on impact with them.

Rubber Cement Rubber Cement
Rubber Cement Icon.pngTears bounce off walls, enemies, and environmental objects.

Item Pool Treasure Room.png: no
Item Pool Shop.png: yes
Damage fixed at 100, tear delay fixed at 150.
??? Added in Afterbirth † PONG Defeat Isaac 5 times
PONGPONG
Greed's Gullet



The Binding of Isaac: Rebirth The Binding of Isaac: Rebirth The Binding of Isaac: Rebirth
MainPageAchievements.png Achievements MainPageAttributes.png Attributes MainPageBosses.png Bosses TarotCard.png Cards and Runes MainPageChallenges.png Challenges MainPageChapters.png Chapters
Isaac App.png Characters MainPageBabies.png Co-op MainPageItems Small.png Items Item Pools Item Pools MainPageMonsters.png Monsters MainPageObjects.png Objects
Red heart.png Pickups BlueBlue.png Pills MainPageRooms.png Rooms MainPageSeeds2.png Seeds Guppy App.png Transformations The Left Hand Icon.png Trinkets
Promotional Content