Challenge Room

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Challenge Rooms are special rooms that allow Isaac to fight enemies for extra rewards. They will only spawn on a floor if, upon entering the floor, Isaac's total health is greater than or equal to his number of heart containers. There are two kinds of challenge rooms: Normal Challenge Rooms, which appear on the first floor of a chapter or on XL floors, and Boss Challenge Rooms, which appear on the second floor of a chapter.

Normal Challenge Room[edit | edit source]

Challenge Room.png

Normal Challenge Rooms can only be entered if Isaac's total health (Red, Black, and Soul Hearts) is greater than or equal to his number of heart containers. Picking up its contents will cause three waves of enemies to spawn. While in chapter 4 (The Womb The Womb/Utero Utero), 3 waves of bosses will be spawned (usually bosses from The Basement The Basement/The Caves The Caves).

Added in Afterbirth † Each wave cleared will charge Isaac's active item by 1.

The enemies that spawn depend on the current chapter, and each chapter has two different possible sets of enemies:

Floor Wave 1 Wave 2 Wave 3
The Basement The Basement 3 Hoppers 3 Horfs 2 Clotties
5 Attack Flies 5 Pooters 4 Gapers
The Cellar The Cellar 3 Fattys 3 Round Worms 5 Dips
3 Gapers 3 Horfs 3 Fatties
The Caves The Caves 5 Chargers 4 Globins 4 Maws
5 Spitties 3 Hives 3 Hosts
The Catacombs The Catacombs 2 Bonies 2 Tumors 3 Wall Creeps
4 Round Worms 3 Nightcrawlers 1 Grub
The Depths The Depths 3 Vis 4 Leapers 4 Globins
4 Babies 5 Hoppers 4 Knights
Necropolis Necropolis 4 Knights 3 Mom's Hands 3 Fat Sacks
4 Bonies 2 Squirts 3 Nulls
The Womb The Womb
Utero Utero
Cathedral Cathedral
Sheol Sheol
3 Larry Jrs Chub and 3 Chargers 2 Monstros
Fistula Loki Chub

Boss Challenge Room[edit | edit source]

Boss Challenge Room Door.png

Boss Challenge Rooms can only be entered if Isaac has one or less Red Heart; soul hearts are ignored in determining his health for this. Picking up its contents will cause two waves of bosses to spawn. Starting on Chapter 4, they use the same waves of bosses as Normal Challenge Rooms.

Added in Afterbirth † Each wave cleared will charge Isaac's active item by 1.

The bosses that spawn depend on the current chapter. Alternate floors have two possible sets of bosses that could spawn:

Floor Wave 1 Wave 2
The Basement The Basement Monstro Larry Jr.
The Cellar The Cellar Pin Gurglings
Dingle Gemini
The Caves The Caves Chub Peep
The Catacombs The Catacombs Mega Fatty Mega Maw
Fistula The Haunt
The Depths The Depths Loki Monstro II
Necropolis Necropolis Mega Maw The Husk
Dark One Loki

Layouts[edit | edit source]

The following room maps were made using Basement Renovator for cleaner viewing; note that both normal and boss challenge rooms use the same layouts.

ID Weight Notes Image preview
0-2 1.0 This room appears three times in the room pool, making it three times more likely to appear than normal. Challenge 0-2.png
3-4 1.0 This room appears twice in the room pool, making it twice as likely to appear than normal. Challenge 3-4.png
5 0.5 The item will be from the Treasure Room pool. Challenge 5.png
6 1.0 Challenge 6.png
7 0.75 Challenge 7.png
8 0.5 Challenge 8.png
9 0.5 Challenge 9.png
10 0.5 Challenge 10.png
11 1.0 Challenge 11.png
12 1.0 Challenge 12.png

Notes[edit | edit source]

  • Added in Afterbirth The waves appear in random orders rather than the orders listed above.
  • If Isaac has some way to teleport out of the room, the contents of the Challenge Room can be taken without fighting the enemies.
    • If a trigger to start a challenge room is left in the room after teleporting out (such as a chest or active item) or an item is spawned in the room and collected (such as rewards from Beggars or Blood Donation Machines), the challenge room will start over when it is picked up/opened.
  • If a Secret Room is next to a Challenge Room, it can be entered by using a bomb in the Secret Room on the wall separating the two rooms. However, the entrance to the Secret Room from the Challenge Room closes itself, meaning Isaac cannot escape through the Secret Room entrance.
  • If Spiders spawn from a Red Chest before or during a wave, the Spiders have to be killed in order for the waves to start/continue.
    • If Spiders spawn from a Red Chest after the challenge room is cleared, the player can leave the room without fighting them.
  • If a Secret Room is next to a Boss Challenge Room, it can be entered by using a bomb in the Secret Room on the wall separating the two rooms. However, the entrance to the Secret Room from the Boss Challenge Room closes itself, meaning Isaac cannot escape through the Secret Room entrance.
  • Because of the health requirements, both types of Challenge Room will always be open for The Lost and ???.

Bugs[edit | edit source]

Bug Bug! Removed in Afterbirth † If the game crashes or you close it before you finish the challenge room it will crash every time you try to continue that run.


SmallIsaac.png Rooms SmallIsaac.png

Unlocked Added in Afterbirth Added in Afterbirth †
Boss Room Icon.png
Boss Room
Mini-Boss Room Icon.png
Mini-Boss Room
Curse Room Icon.png
Curse Room
Sacrifice Room Icon.png
Sacrifice Room
Room 1x1 small.png
Closet
Room 1x1.png
Grave Room
Locked Treasure Room Icon.png
Treasure Room
Shop Icon.png
Shop
Library Icon.png
Library
Slotted Arcade Icon.png
Arcade
Barred Challenge Room Icon.png
Challenge Room
Boss Challenge Room Icon.png
Boss Challenge Room
Double-locked Vault Icon.png
Vault
Dice Room Icon.png
Dice Room
Double-boarded Bedroom Icon.png Bedroom2 Icon.png
Bedroom
Hidden Secret Room Icon.png
Secret Room
Super Secret Room Icon.png
Super Secret Room
Super Secret Room Icon.png
Crawl Space
Super Secret Room Icon.png
Black Market
Super Secret Room Icon.png
I AM ERROR
Post-boss Added in Afterbirth
Devil Room Icon.png
Devil Room
Angel Room Icon.png
Angel Room
Super Secret Room Icon.png
Boss Rush
Super Secret Room Icon.png
Blue Womb Entrance
The Binding of Isaac: Rebirth The Binding of Isaac: Rebirth The Binding of Isaac: Rebirth
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