Challenges

From Binding of Isaac: Rebirth Wiki
Jump to: navigation, search

Challenges are unique runs in the game. Isaac typically starts each challenge with one or more specific items which make normal play more difficult. With few exceptions, Treasure Rooms are not available during challenges. Each challenge unlocks new content for the game, such as Runes when completed.

General Strategy

Most challenges are designed to increase the difficulty of the game in a unique fashion. This doesn't mean all challenges are difficult, however; challenges like Computer Savvy are quite easy to beat. Some challenges do compensate for this by being especially punishing; Solar System is a good example of this. Each challenge has certain strategies that can be employed to make the run easier. However, there are a few strategies that can apply to all challenges.

  • Challenges can be played in co-op, allowing a second player to contribute to the run without being hindered in the same way Isaac is. This is especially useful in any challenge where Isaac is Blindfolded, as the second player will be allowed to fire tears normally.
  • Due to the lack of Treasure Rooms, Devil Rooms become much more valuable. Some challenges can be made much easier by making just one deal, but it is worth noting that other challenges reduce Isaac's health to the extent that Devil Deals become too risky.
    • Some rooms (including Crawl Spaces) may have Treasure Room items by default. Since these items are random, results can vary from run to run.
    • Because locked Treasure Rooms won't spawn, keys can be used far more liberally. Also, Trinkets and Items that generate more coins, along with upgraded shops, can help Isaac acquire a greater range of powerful items.
  • The Bible The Bible instantly kills Mom and Mom's Heart / It Lives. All challenges require defeating Mom, and most require defeating Mom's Heart or It Lives, making this an extremely powerful item, especially in challenges where Mom or Mom's Heart / It Lives is the final boss.
    • Pandora's Box Pandora's Box will spawn The Bible if used in Womb II, Utero II, or Added in Afterbirth Scarred Womb II, making it a reliable way to acquire The Bible.
  • Curse Rooms can spawn items, making them valuable.
  • Removed in Afterbirth In some challenges, Dice Rooms and the D4 D4 are very useful, allowing that challenge's starting items to be rerolled, thus removing most of the difficulty. NOTE: This changes depending on the challenge. Most challenge pages contain details on the results of rerolling.
    • Added in Afterbirth †Butter! Butter!Trinket Butter! icon.pngUsing an active item will drop it onto a pedestal on the ground. Taking damage may result in dropping a passive item. can also remove starter items.
  • Blindfolded challenges are arguably the most difficult challenges due to Isaac's inability to fire tears. There are several methods to work around this.
    • Familiars can provide an alternative method of dealing damage. Powerful familiars like Daddy Longlegs Daddy Longlegs, Lil Brimstone Lil Brimstone, and Added in AfterbirthIncubus Incubus are therefore highly useful items.
    • The Boomerang The Boomerang, The Candle The Candle, and Red Candle Red Candle are also useful for blindfolded challenges, since they recharge based on a timer, rather than an amount of cleared rooms.
    • Added in Afterbirth †Clicker Clicker can allow Isaac to change into Lilith, whose Added in AfterbirthIncubus Incubus overrides the Blindfolded effect by default.
    • Some spacebar items like Tammy's Head Tammy's Head can be really helpful, providing an alternative method of dealing damage.
  • Added in AfterbirthChaos Chaos is a powerful item in challenges, as it can allow powerful items to be found more commonly, such as in the Shop or after defeating Bosses.
  • Defeating a boss beyond the specified end of the challenge (e.g. defeating Mom's Heart when the goal is to defeat Mom) will still spawn the trophy.
    • Added in Afterbirth In some longer challenges (e.g. XXXXXXXXL), using a Sacrifice Room until it teleports Isaac to the Dark Room is a viable strategy. Once in the Dark Room, the trophy can be spawned by defeating The Lamb.

Notes

  • Apart from the achievement related to beating the challenge, all achievements are locked. Also, no Donation Machines will appear in any challenge.
  • The Challenge reward will not be unlocked unless the trophy is picked up. If a Devil Room or Angel Room appears allowing Isaac to go to Sheol or the Cathedral, the unlock will be forfeited.
  • Isaac will not start any challenge with The D6 The D6.

Challenges List

Name Conditions Goal Unlocked by Unlocks


1. Pitch Black
IsaacIsaac
Full red heartFull red heartFull red heart
Curse of Darkness
Curse of the Unknown
Item Pool Treasure Room.png: yes
Item Pool Shop.png: no
Boss Mom.png Default Rune of Hagalaz Rune of HagalazRune of HagalazComplete challenge #1
2. High Brow
IsaacIsaac
Full red heartFull red heartFull red heart
Starts with:
Number One Number One
E Coli E Coli
Butt Bombs Butt Bombs
Flush! Flush!
Petrified Poop Petrified PoopTrinket Petrified Poop icon.pngGreatly increases the chances of a pickup dropping when destroying poop.
Item Pool Treasure Room.png: no
Item Pool Shop.png: yes
Boss Mom.png Default Rune of Jera Rune of JeraRune of JeraComplete challenge #2
3. Head Trauma
IsaacIsaac
Full red heartFull red heartFull red heart
Starts with:
Tiny Planet Tiny Planet
Soy Milk Soy Milk
The Small Rock The Small Rock
Iron Bar Iron Bar
Item Pool Treasure Room.png: no
Item Pool Shop.png: yes
Boss Mom.png Default Rune of Ehwaz Rune of EhwazRune of EhwazComplete challenge #3
4. Darkness Falls
EveEve
Full red heartFull red heart
Starts with:
Pentagram Pentagram
Dead Bird Dead Bird
Whore of Babylon Whore of Babylon
Razor Blade Razor Blade
Sacrificial Dagger Sacrificial Dagger
Dark Matter Dark Matter
Item Pool Treasure Room.png: no
Item Pool Shop.png: yes
Boss Satan.png Darkness Falls Defeat Mom's Heart 11 timesDarkness FallsDarkness Falls Rune of Dagaz Rune of DagazRune of DagazComplete challenge #4
5. The Tank
MagdaleneMagdalene
Full red heartFull red heartFull red heartFull red heart
Starts with:
Infamy Infamy
Bucket of Lard Bucket of Lard
Thunder Thighs Thunder Thighs
Yum Heart Yum Heart
Item Pool Treasure Room.png: no
Item Pool Shop.png: yes
Boss Mom.png The Tank Have 7 or more heart containers at one timeThe TankThe Tank Rune of Ansuz Rune of AnsuzRune of AnsuzComplete challenge #5
6. Solar System
IsaacIsaac
Full red heartFull red heartFull red heart
Blindfolded.png Blindfolded
Starts with:
Distant Admiration Distant Admiration
Forever Alone Forever Alone
Halo of Flies Halo of Flies
Transcendence Transcendence
Item Pool Treasure Room.png: no
Item Pool Shop.png: yes
Boss Mom's Heart.png / Boss It Lives.png Solar System Defeat Mom's Heart 3 timesSolar SystemSolar System Rune of Perthro Rune of PerthroRune of PerthroComplete challenge #6
7. Suicide King
LazarusLazarus
Full red heartFull red heartFull red heart
Starts with:
Ipecac Ipecac
Mr. Mega Mr. Mega
My Reflection My Reflection
1 random pill
Item Pool Treasure Room.png: no
Item Pool Shop.png: yes
Isaac Suicide King Defeat Mom's Heart 11 timesSuicide KingSuicide King Suicide King Suicide KingSuicide KingComplete challenge #7
8. Cat Got Your Tongue
IsaacIsaac
Full black heartFull black heartFull black heartFull soul heartFull soul heartFull soul heart
Blindfolded.png Blindfolded
Starts with:
Guppy's Hair Ball Guppy's Hair Ball
Guppy's Head Guppy's Head
Guppy's Tail Guppy's Tail
Item Pool Treasure Room.png: no
Item Pool Shop.png: yes
Boss Mom.png Cat Got Your Tongue Become Guppy (Collect 3 Guppy Items)Cat Got Your TongueCat Got Your Tongue Rune of Algiz Rune of AlgizRune of AlgizComplete challenge #8
9. Demo Man
IsaacIsaac
Full red heartFull red heartFull red heart
Starts with:
Dr. Fetus Dr. Fetus
Remote Detonator Remote Detonator
Match Stick Match StickTrinket Match Stick icon.pngIncreases the chance of Bombs dropping after clearing a room, and the chance of finding Bombs when opening a Chest.
Item Pool Treasure Room.png: no
Item Pool Shop.png: yes
Boss Mom's Heart.png / Boss It Lives.png Demo Man Defeat Mom's Heart 9 timesDemo ManDemo Man Chaos Card Chaos CardChaos CardComplete challenge #9
10. Cursed!
MagdaleneMagdalene
Full red heartFull red heartFull red heartFull red heart
Starts with:
Blue Map Blue Map
The Compass The Compass
Raw Liver Raw Liver
Treasure Map Treasure Map
Yum Heart Yum Heart
Child's Heart Child's HeartTrinket Child's Heart icon.pngIncreases the chance of a heart pickup dropping after clearing a room, and the chance of finding a heart when opening a Chest.
Curse of the Cursed
Item Pool Treasure Room.png: yes
Item Pool Shop.png: yes
Boss Mom.png Cursed! Have 7 or more heart containers at one timeCursed!Cursed! Credit Card Credit CardCredit CardComplete challenge #10
11. Glass Cannon
JudasJudas
Full red heart
Starts with:
Epic Fetus Epic Fetus
Loki's Horns Loki's Horns
Item Pool Treasure Room.png: no
Item Pool Shop.png: yes
Boss Satan.png Glass Cannon Beat challenge #19 and defeat Lokii for the 1st timeGlass CannonGlass Cannon Rules Card Rules CardRules CardComplete challenge #11
12. When Life Gives You Lemons
IsaacIsaac
Full red heartFull red heartFull red heart
Starts with:
9 Volt 9 Volt
Habit Habit
Lemon Mishap Lemon Mishap
1 Lemon Party pill
Item Pool Treasure Room.png: no
Item Pool Shop.png: yes
Boss Mom.png Default Card Against Humanity Card Against HumanityCard Against HumanityComplete challenge #12
13. Beans!
IsaacIsaac
Full red heartFull red heartFull red heart
Blindfolded.png Blindfolded
Starts with:
9 Volt 9 Volt
The Bean The Bean
The Black Bean The Black Bean
Butt Bombs Butt Bombs
Pyro Pyro
Item Pool Treasure Room.png: no
Item Pool Shop.png: yes
Boss Mom.png Default Burnt Penny Burnt PennyBurnt PennyComplete challenge #13
14. It's in the Cards
IsaacIsaac
Full red heartFull red heartFull red heart
Starts with:
9 Volt 9 Volt
The Battery The Battery
Deck of Cards Deck of Cards
Starter Deck Starter Deck
2 random tarot cards
Item Pool Treasure Room.png: no
Item Pool Shop.png: yes
Boss Mom.png Default SMB Super Fan SMB Super FanSMB Super FanComplete challenge #14
15. Slow Roll
IsaacIsaac
Full red heartFull red heartFull red heart
Starts with:
Cupid's Arrow Cupid's Arrow
My Reflection My Reflection
Polyphemus Polyphemus
Item Pool Treasure Room.png: no
Item Pool Shop.png: yes
Boss Mom.png Default Swallowed Penny Swallowed PennySwallowed PennyComplete challenge #15
16. Computer Savvy
IsaacIsaac
Full red heartFull red heartFull red heart
Starts with:
Spoon Bender Spoon Bender
Technology Technology
Technology 2 Technology 2
Item Pool Treasure Room.png: no
Item Pool Shop.png: yes
Boss Mom.png Default Robo-Baby 2.0 Robo-Baby 2.0Robo-Baby 2.0Complete challenge #16
17. Waka Waka
IsaacIsaac
Full red heartFull red heartFull red heart
Starts with:
Anti-Gravity Anti-Gravity
Strange Attractor Strange Attractor
Item Pool Treasure Room.png: no
Item Pool Shop.png: yes
Boss Mom.png Default Death's Touch Death's TouchDeath's TouchComplete challenge #17
18. The Host
IsaacIsaac
Full red heartFull red heartFull red heart
Starts with:
The Mulligan The Mulligan
Spider Baby Spider Baby
Tick TickTrinket Tick icon.pngDrains 15% health of each enemy with more than 60 HP (ie. most bosses). It also restores one red heart of Isaac whenever he enters an uncleared boss room. The Tick cannot be swapped out for another trinket.
Item Pool Treasure Room.png: no
Item Pool Shop.png: yes
Boss Mom.png Default Technology .5 Technology .5Technology .5Complete challenge #18
19. The Family Man
IsaacIsaac
Full red heartFull red heartFull red heart
Blindfolded.png Blindfolded
Starts with:
BFFS! BFFS!
Brother Bobby Brother Bobby
Dad's Key Dad's Key
Rotten Baby Rotten Baby
Sister Maggy Sister Maggy
Item Pool Treasure Room.png: no
Item Pool Shop.png: yes
Isaac The Family Man Pick up both Key pieces from the Angels in one runThe Family ManThe Family Man Epic Fetus Epic FetusEpic FetusComplete challenge #19
20. Purist
IsaacIsaac
Full red heartFull red heartFull red heart
Item Pool Treasure Room.png: no
Item Pool Shop.png: yes
Boss Mom's Heart.png / Boss It Lives.png Purist Defeat Mom for the first timePuristPurist Rune of Berkano Rune of BerkanoRune of BerkanoComplete challenge #20
Added in Afterbirth 21. XXXXXXXXL
IsaacIsaac
Full red heartFull red heartFull red heart
Item Pool Treasure Room.png: yes
Item Pool Shop.png: yes
Every floor is the size of an XL Womb floor, but does not combine the floors of each chapter.
Boss Mom's Heart.png / Boss It Lives.png Added in AfterbirthXXXXXXXXL Defeat Mom for the 1st timeXXXXXXXXLXXXXXXXXL Added in AfterbirthGold Heart Gold HeartGold HeartComplete challenge #21
Added in Afterbirth 22. SPEED!
IsaacIsaac
Full red heartFull red heartFull red heart
Item Pool Treasure Room.png: yes
Item Pool Shop.png: yes
Everything is sped up like the Broken Watch effect.
Boss Mom's Heart.png / Boss It Lives.png
within 16 minutes, otherwise under constant periodic damage every 10 seconds.
Added in AfterbirthSPEED! Defeat Mom for the 1st timeSPEED!SPEED! Added in AfterbirthGet out of Jail Free Card Get out of Jail Free CardGet out of Jail Free CardComplete challenge #22
Added in Afterbirth 23. Blue Bomber
??????
Full soul heartFull soul heartFull soul heartFull soul heart
Blindfolded.png Blindfolded
Starts with:
Brother Bobby Brother Bobby
Kamikaze! Kamikaze!
Pyromaniac Pyromaniac
Mr. Mega Mr. Mega
Item Pool Treasure Room.png: no
Item Pool Shop.png: yes
Boss Satan.png Added in AfterbirthBlue Bomber Destroy 10 tinted rocks and defeat Mom's Heart 11 timesBlue BomberBlue Bomber Added in AfterbirthGold Bomb Gold BombGold BombComplete challenge #23
Added in Afterbirth 24. PAY TO PLAY
IsaacIsaac
Full red heartFull red heartFull red heart
Starts with:
Money = Power Money = Power
Sack of Pennies Sack of Pennies
50 coins
Item Pool Treasure Room.png: no
Item Pool Shop.png: yes
Every door costs 1 cent to enter. Isaac drops money when hit. Isaac dies if he run out of money.
Isaac Added in AfterbirthPAY TO PLAY Defeat Isaac as CainPAY TO PLAYPAY TO PLAY Added in Afterbirth2 new pills 2 new pills2 new pillsComplete challenge #24
Added in Afterbirth 25. Have a Heart
IsaacIsaac
Starts with:
Charm of the Vampire Charm of the Vampire
Item Pool Treasure Room.png: yes
Item Pool Shop.png: yes
Pennies drop instead of red hearts. Many items that restore red hearts have no effect.
Boss Mom's Heart.png / Boss It Lives.png Added in AfterbirthHave a Heart Defeat Mom for the 1st timeHave a HeartHave a Heart Added in Afterbirth2 new pills 2 new pills2 new pillsComplete challenge #24
Added in Afterbirth 26. I RULE!
IsaacIsaac
Full red heartFull red heartFull red heart
Starts with:
The Boomerang The Boomerang
Key Piece 1 Key Piece 1
Key Piece 2 Key Piece 2
The Ladder The Ladder
Mom's Knife Mom's Knife
Trinity Shield Trinity Shield
Item Pool Treasure Room.png: no
Item Pool Shop.png: yes
Boss Mega Satan.png Added in AfterbirthI RULE! Defeat ??? or The Lamb for the 1st time, and defeat Satan as IsaacI RULE!I RULE! Added in AfterbirthPoker Chip Poker ChipPoker ChipComplete challenge #26
Added in Afterbirth 27. BRAINS!
??????
Full soul heartFull soul heartFull soul heartFull soul heart
Blindfolded.png Blindfolded
Starts with:
3 Bob's Brain Bob's Brain
Thunder Thighs Thunder Thighs
Item Pool Treasure Room.png: no
Item Pool Shop.png: yes
??? Added in AfterbirthBRAINS! Defeat Isaac 5 timesBRAINS!BRAINS! Added in AfterbirthStud Finder Stud FinderStud FinderComplete challenge #27
Added in Afterbirth 28. PRIDE DAY!
IsaacIsaac
Full red heartFull red heartFull red heart
Starts with:
3 Dollar Bill 3 Dollar Bill
Rainbow Baby Rainbow Baby
Item Pool Treasure Room.png: no
Item Pool Shop.png: yes
Cannot drop or replace Rainbow Worm.
Boss Mom's Heart.png / Boss It Lives.png Added in AfterbirthPRIDE DAY! Defeat Mom for the 1st timePRIDE DAY!PRIDE DAY! Added in AfterbirthD8 D8D8Complete challenge #28
Added in Afterbirth 29. Onan's Streak
JudasJudas
Full red heart
Starts with:
The Book of Belial The Book of Belial
Chocolate Milk Chocolate Milk
Item Pool Treasure Room.png: yes
Item Pool Shop.png: yes
Missing a shot deals damage to Judas.
Isaac Added in AfterbirthOnan's Streak Defeat Mom for the 1st timeOnan's StreakOnan's Streak Added in AfterbirthKidney Stone Kidney StoneKidney StoneComplete challenge #29 (Removed in Afterbirth † The unlock is bugged and actually unlocks Blank Rune)
Added in Afterbirth 30. The Guardian
IsaacIsaac
Full red heartFull red heartFull red heart
Blindfolded.png Blindfolded
Starts with:
Holy Grail Holy Grail
Isaac's Heart Isaac's Heart
Punching Bag Punching Bag
Added in AfterbirthSpear of Destiny Spear of Destiny
Item Pool Treasure Room.png: no
Item Pool Shop.png: yes
Isaac's Heart will follow Punching Bag Punching Bag instead of Isaac.
Boss Mom's Heart.png / Boss It Lives.png Added in AfterbirthThe Guardian Defeat Mom for the 1st timeThe GuardianThe Guardian Added in AfterbirthBlank Rune Blank RuneBlank RuneComplete challenge #30 (Removed in Afterbirth † The unlock is bugged and actually unlocks Kidney Stone)
Added in Afterbirth † 31. Backasswards
IsaacIsaac
Full red heartFull red heartFull red heart
Starts with:
8-10 random items
Item Pool Treasure Room.png: no
Item Pool Shop.png: yes
All Chapters progress in reverse order, losing 1 item and 1 red heart container each floor ascended.
The Basement/The Cellar/Burning Basement I Added in Afterbirth †Backasswards Defeat ??? or The Lamb for the 1st timeBackasswardsBackasswards Added in Afterbirth †Laz Bleeds More! Laz Bleeds More!Laz Bleeds More!Complete challenge #31
Added in Afterbirth † 32. Aprils Fool
IsaacIsaac
Full red heartFull red heartFull red heart
Item Pool Treasure Room.png: yes
Item Pool Shop.png: yes
The minimap displays the floor's layout accurately, but displays Isaac's position inaccurately. Pedestal items and pickups are not what they appear to be. Active items, pills, cards, and rune effects are randomized upon each use, making them very unreliable or deadly (for example Suicide King). Items with no charge time (i.e. How To Jump, IV Bag, etc) can be used repeatedly for random effects. Stoneys have a chance of being replaced by Cross Stoneys. Every boss is The Bloat. Isaac's health is not what it appears to be. Key and bomb numbers are accurate.
Boss Mom's Heart.png / Boss It Lives.png Added in Afterbirth †Aprils fool Defeat Mom for the 1st timeAprils foolAprils fool Added in Afterbirth †Maggy Now Holds a Pill! Maggy Now Holds a Pill!Maggy Now Holds a Pill!Complete challenge #32
Added in Afterbirth † 33. Pokey Mans
IsaacIsaac
Full red heartFull red heartFull red heart
Starts with:
Added in Afterbirth Friendly Ball Friendly Ball
Mom's Eyeshadow Mom's Eyeshadow
Item Pool Treasure Room.png: no
Item Pool Shop.png: yes
Each use of Friendly Ball causes a random monster to be spawned. Friendly Ball instantly charges once the spawned monster is killed.
Isaac Added in Afterbirth †Pokey Mans Defeat Mom's Heart 11 timesPokey MansPokey Mans Added in Afterbirth †Charged Key Charged KeyCharged KeyComplete challenge #33
Added in Afterbirth † 34. Ultra Hard
IsaacIsaac
Full red heartFull red heartFull red heart
Starts with:
Key Piece 1 Key Piece 1
Key Piece 2 Key Piece 2
Curse of the Labyrinth
Curse of the Blind
Curse of the Lost
Curse of the Maze
Item Pool Treasure Room.png: yes
Item Pool Shop.png: yes
All enemies spawn as champions if possible. Boss fights will be double trouble if possible. No heart pickups drop.
Boss Mega Satan.png Added in Afterbirth †Ultra Hard Defeat ??? or The Lamb for the first time. Possession of The Polaroid/The Negative is required, prohibiting getting to Dark Room through a Sacrifice Room.Ultra HardUltra Hard Added in Afterbirth †Samson Feels Healthy! Samson Feels Healthy!Samson Feels Healthy!Complete challenge #34
Added in Afterbirth † 35. Pong
IsaacIsaac
Full red heartFull red heartFull red heart
Starts with:
Cupid's Arrow Cupid's Arrow
Rubber Cement Rubber Cement
Item Pool Treasure Room.png: no
Item Pool Shop.png: yes
Damage fixed at 100, tear delay fixed at 150.
??? Added in Afterbirth †PONG Defeat Isaac 5 timesPONGPONG Added in Afterbirth †Greed's Gullet Greed's GulletGreed's GulletComplete challenge #35


MainPageChallenges.png Challenges MainPageChallenges.png

Rebirth
1. Pitch Black 2. High Brow 3. Head Trauma 4. Darkness Falls 5. The Tank 6. Solar System 7. Suicide King 8. Cat Got Your Tongue
9. Demo Man 10. Cursed! 11. Glass Cannon 12. When Life Gives You Lemons 13. Beans! 14. It's in the Cards 15. Slow Roll 16. Computer Savvy
17. Waka Waka 18. The Host 19. The Family Man 20. Purist
Afterbirth
21. XXXXXXXXL 22. SPEED! 23. Blue Bomber 24. PAY TO PLAY 25. Have a Heart 26. I RULE! 27. BRAINS! 28. PRIDE DAY!
29. Onan's Streak 30. The Guardian
Afterbirth †
31. Backasswards 32. Aprils Fool 33. Pokey Mans 34. Ultra Hard 35. Pong
The Binding of Isaac: Rebirth The Binding of Isaac: Rebirth The Binding of Isaac: Rebirth
Achievements Achievements Attributes Attributes Bosses Bosses TarotCard.png Cards and Runes Challenges Challenges Chapters Chapters
Characters Characters MainPageBabies.png Co-op Items Items Item pools Item pools Monsters Monsters Objects Objects
Pickups Pickups Pills Pills Rooms Rooms Seeds Seeds Transformations Transformations Trinkets Trinkets