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Challenges

From Binding of Isaac: Rebirth Wiki
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Challenges are unique runs in the game. Isaac typically starts each challenge with one or more specific items which make normal play more difficult. With few exceptions, Treasure Rooms are not available during challenges. Each challenge unlocks new content for the game, such as Runes, when completed.

General Strategy[edit | edit source]

Most challenges are designed to increase the difficulty of the game in a unique fashion. This doesn't mean all challenges are difficult, however; challenges like Computer Savvy are quite easy to beat. Some challenges do compensate for this by being especially punishing; Solar System is a good example of this. Each challenge has certain strategies that can be employed to make the run easier. However, there are a few strategies that can apply to all challenges.

  • Challenges can be played in co-op, allowing a second player to contribute to the run without being hindered in the same way Isaac is. This is especially useful in any challenge where Isaac is Blindfolded, as the second player will be allowed to fire tears normally.
  • Due to the lack of Treasure Rooms, Devil Rooms become much more valuable. Some challenges can be made much easier by making just one deal, but it is worth noting that other challenges reduce Isaac's health to an extent that Devil Deals become too risky.
    • Some rooms (including Crawl Spaces) may have Treasure Room items by default. Since these items are random, results can vary from run to run.
    • Because locked Treasure Rooms won't spawn, keys can be used far more liberally. In addition, Trinkets and Items that generate more coins, along with upgraded shops, can help Isaac acquire a greater range of powerful items.
  • The Bible The BibleThe Bible Icon.png6 roomsUpon activation, Isaac gains flight, allowing him to pass over all obstacles in the current room. Instantly kills Mom, Mom's Heart, and It Lives when activated, but will kill Isaac when activated while fighting Satan. instantly kills Mom and Mom's Heart / It Lives. All challenges require defeating Mom, and most require defeating Mom's Heart or It Lives, making this an extremely powerful item, especially in challenges where Mom or Mom's Heart / It Lives is the final boss.
    • Pandora's Box Pandora's BoxPandora's Box Icon.pngOne time useUpon use, spawns certain pickups or items depending on the floor it is used on. Single-use. will spawn The Bible if used in Womb II, Utero II, or Added in  Afterbirth Scarred Womb II, making it a reliable way to acquire The Bible.
  • Curse Rooms can spawn items, making them valuable.
  • Removed in Afterbirth In some challenges, Dice Rooms and the D4 D4D4 Icon.png6 roomsRerolls all of Isaac's items. are very useful, allowing that challenge's starting items to be rerolled, thus removing most of the difficulty. NOTE: This changes depending on the challenge. Most challenge pages contain details on the results of rerolling.
    • Added in Afterbirth †Butter! Butter!Butter! Icon.pngUsing an active item will drop it onto a pedestal on the ground. Taking damage may result in dropping a passive item. can also remove starter items.
  • Blindfolded challenges are arguably the most difficult challenges due to Isaac's inability to fire tears. There are several methods to work around this.
    • Familiars can provide an alternative method of dealing damage. Powerful familiars like Daddy Longlegs Daddy LonglegsDaddy Longlegs Rebirth Icon.pngDaddy Long Legs' shadow follows Isaac and stomps on enemies., Lil' Brimstone Lil' BrimstoneLil Brimstone Rebirth Icon.pngA Familiar that shoots a thin Brimstone beam. Must charge like Brimstone before shooting., and Added in  AfterbirthIncubus IncubusIncubus Icon.pngA demonic familiar that follows Isaac and shoots tears identical to Isaac's in terms of damage, range, fire rate, and effects. are therefore highly useful items.
    • The Boomerang The BoomerangThe Boomerang Rebirth Icon.png4 secondsThrows a short-range boomerang which does a bit of damage and has a high chance to stun the enemy for 2 seconds. Can also be used to grab pickups., The Candle The CandleThe Candle Icon.png4 secondsThrows out a blue flame that can pass over gaps (but not through rocks). The flame damages anything in its path., and Red Candle Red CandleRed Candle Icon.png4 secondsThrows a persistent flame that deals high damage and diminishes as it damages enemies or blocks shots. are also useful for blindfolded challenges, since they recharge based on a timer, rather than an amount of cleared rooms.
    • Added in Afterbirth †Clicker ClickerClicker Icon.png6 roomsTransforms Isaac into another random character. can allow Isaac to change into Lilith, whose Added in  AfterbirthIncubus IncubusIncubus Icon.pngA demonic familiar that follows Isaac and shoots tears identical to Isaac's in terms of damage, range, fire rate, and effects. overrides the Blindfolded effect by default.
  • Added in  AfterbirthChaos ChaosChaos Icon.pngChaos causes items to be chosen from random item pools. When picked up, drops between 1-6 random pickups on the floor. is a powerful item in challenges, as it can allow powerful items to be found more commonly, such as in the Shop or after defeating Bosses.
  • Defeating a boss beyond the specified end of the challenge (e.g. defeating Mom's Heart when the goal is to defeat Mom) will still spawn the trophy.
    • Added in  Afterbirth In some longer challenges (e.g. XXXXXXXXL), using a Sacrifice Room until it teleports Isaac to the Dark Room is a viable strategy. Once in the Dark Room, the trophy can be spawned by defeating The Lamb.

Notes[edit | edit source]

  • Apart from the achievement related to beating the challenge, all achievements are locked. Also, no Donation Machines will appear in any challenge.
  • The Challenge reward will not be unlocked unless the trophy is picked up. If a Devil Room or Angel Room appears allowing Isaac to go to Sheol or the Cathedral, the unlock will be forfeited.
  • Isaac will not start any challenge with The D6 The D6The D6 Icon.png6 roomsAllows Isaac to re-roll collectible items in the current room into other items, depending on the current room's Item Pool..

Challenges List[edit | edit source]

Name Conditions Goal Unlocked by Unlocks
1. Pitch Black
Isaac App.png
Full red heartFull red heartFull red heart
Curse of Darkness
Curse of the Unknown
Item Pool Treasure Room.png: yes
Item Pool Shop.png: no
Boss Mom.png Default Rune of Hagalaz Rune of HagalazRune of HagalazComplete challenge #1
2. High Brow
Isaac App.png
Full red heartFull red heartFull red heart
Starts with:
Number One Number OneNumber One Icon.png+1.5 tears, -17.62 range
E Coli E ColiE Coli Icon.pngGives "Turdy Touch" Effect. Enemies that touch Isaac are changed into poop.
Butt Bombs Butt BombsButt Bombs Icon.pngGives +5 bombs and makes all bombs Butt Bombs that fill the room with gas, damaging and confusing all enemies.
Flush! Flush!Flush! Icon.png6 roomsChanges all enemies in the room into poop. Does not work on all enemies (Knights and bosses are immune). Instantly kills Dingle, Dangle, and Brownie.
Petrified Poop Petrified PoopPetrified Poop Icon.pngGreatly increases the chances of a pickup dropping when destroying poop.
Item Pool Treasure Room.png: no
Item Pool Shop.png: yes
Boss Mom.png Default Rune of Jera Rune of JeraRune of JeraComplete challenge #2
3. Head Trauma
Isaac App.png
Full red heartFull red heartFull red heart
Starts with:
Tiny Planet Tiny PlanetTiny Planet Icon.pngRange up and makes shot tears revolve around Isaac until they drop.
Soy Milk Soy MilkSoy Milk Icon.pngTears shrink and do much less damage, but fire in very rapid succession.
The Small Rock The Small RockThe Small Rock Icon.pngIncreases damage by 1, increases tears by 0.2, and decreases speed by 0.1.
Iron Bar Iron BarIron Bar Icon.pngIncreases damage by 0.3 and adds a chance to shoot concussive tears, causing enemies to walk around randomly.
Item Pool Treasure Room.png: no
Item Pool Shop.png: yes
Boss Mom.png Default Rune of Ehwaz Rune of EhwazRune of EhwazComplete challenge #3
4. Darkness Falls
Eve App.png
Full red heartFull red heart
Starts with:
Pentagram PentagramPentagram Icon.pngIncreases damage and increases the chance for a Devil or Angel Room to appear.
Dead Bird Dead BirdDead Bird Icon.pngSpawns a flying familiar for the current room that chases enemies whenever Isaac takes damage.
Whore of Babylon Whore of BabylonWhore of Babylon Icon.pngIncreases damage and speed whenever Isaac has half a red heart or less (one red heart for Eve), ignoring any soul or black hearts.
Razor Blade Razor BladeRazor Blade Icon.pngUnlimitedUpon use, deals one heart of damage to Isaac and grants +1.2 damage for the current room.
Sacrificial Dagger Sacrificial DaggerSacrificial Dagger Icon.pngDagger orbits Isaac, dealing very high damage.
Dark Matter Dark MatterDark Matter Icon.pngIncreases Damage by 1 and adds a chance to shoot fear tears.
Item Pool Treasure Room.png: no
Item Pool Shop.png: yes
Boss Satan.png Darkness Falls Defeat Mom's Heart 11 timesDarkness FallsDarkness Falls Rune of Dagaz Rune of DagazRune of DagazComplete challenge #4
5. The Tank
Magdalene App.png
Full red heartFull red heartFull red heartFull red heart
Starts with:
Infamy InfamyInfamy Icon.pngChance to block projectiles coming from any direction.
Bucket of Lard Bucket of LardBucket of Lard Icon.pngGrants two empty heart containers and heals Isaac by half a heart, but decreases speed by 0.2.
Thunder Thighs Thunder ThighsThunder Thighs Icon.pngDestroys rocks upon contact with Isaac. Adds one heart container and lowers Speed.
Yum Heart Yum HeartYum Heart Icon.png4 roomsRestores 1 whole red heart.
Item Pool Treasure Room.png: no
Item Pool Shop.png: yes
Boss Mom.png The Tank Have 7 or more heart containers at one timeThe TankThe Tank Rune of Ansuz Rune of AnsuzRune of AnsuzComplete challenge #5
6. Solar System
Isaac App.png
Full red heartFull red heartFull red heart
Blindfolded.png Blindfolded
Starts with:
Distant Admiration Distant AdmirationDistant Admiration Rebirth Icon.pngA red attack fly circles further out than the Halo of Flies / Pretty Flies, but closer than Forever Alone. Deals more damage than Forever Alone.
Forever Alone Forever AloneForever Alone Rebirth Icon.pngSpawns a blue attack fly that orbits a long distance from Isaac.
Halo of Flies Halo of FliesHalo of Flies Icon.pngSpawns two pretty fly familiars that block enemy shots and deal contact damage to enemies.
Transcendence TranscendenceTranscendence Icon.pngGrants flight.
Item Pool Treasure Room.png: no
Item Pool Shop.png: yes
Boss Mom's Heart.png / Boss It Lives.png Solar System Defeat Mom's Heart 3 timesSolar SystemSolar System Rune of Perthro Rune of PerthroRune of PerthroComplete challenge #6
7. Suicide King
Lazarus App.png
Full red heartFull red heartFull red heart
Starts with:
Ipecac IpecacIpecac Icon.pngReplaces tears with explosive and poisoning projectiles fired in an arc from the mouth.
Mr. Mega Mr. MegaMr. Mega Icon.pngGives Isaac 5 bombs, and makes all dropped bombs larger, which have an increased blast radius and increased damage.
My Reflection My ReflectionMy Reflection Icon.pngGives Isaac's tears a boomerang effect, and increases range and shot speed.
1 random pill
Item Pool Treasure Room.png: no
Item Pool Shop.png: yes
Isaac Suicide King Defeat Mom's Heart 11 timesSuicide KingSuicide King Suicide King Suicide KingSuicide KingComplete challenge #7
8. Cat Got Your Tongue
Isaac App.png
Full black heartFull black heartFull black heartFull soul heartFull soul heartFull soul heart
Blindfolded.png Blindfolded
Starts with:
Guppy's Hair Ball Guppy's Hair BallGuppy's Hair Ball Rebirth Icon.pngLoosely follows behind Isaac. Can be swung like a flail by rapidly spinning Isaac in a circle. Grows bigger by killing enemies.
Guppy's Head Guppy's HeadGuppy's Head Icon.png1 roomsSpawns 2-4 blue flies to damage enemies.
Guppy's Tail Guppy's TailGuppy's Tail Icon.pngIncreases chance of finding gold chests and normal chests, but reduces chance of finding pickups.
Item Pool Treasure Room.png: no
Item Pool Shop.png: yes
Boss Mom.png Cat Got Your Tongue Become Guppy (Collect 3 Guppy Items)Cat Got Your TongueCat Got Your Tongue Rune of Algiz Rune of AlgizRune of AlgizComplete challenge #8
9. Demo Man
Isaac App.png
Full red heartFull red heartFull red heart
Starts with:
Dr. Fetus Dr. FetusDr. Fetus Icon.pngTears are replaced by bombs that benefit from bomb-enhancing effects and slide for a fixed time after being fired.
Remote Detonator Remote DetonatorRemote Detonator Icon.pngUnlimitedBombs you place explode only when you use this item. Gives 5 bombs.
Match Stick Match StickMatch Stick Icon.pngIncreases the chance of Bombs dropping after clearing a room, and the chance of finding Bombs when opening a Chest.
Item Pool Treasure Room.png: no
Item Pool Shop.png: yes
Boss Mom's Heart.png / Boss It Lives.png Demo Man Defeat Mom's Heart 9 timesDemo ManDemo Man Chaos Card Chaos CardChaos CardComplete challenge #9
10. Cursed!
Magdalene App.png
Full red heartFull red heartFull red heartFull red heart
Starts with:
Blue Map Blue MapBlue Map Icon.pngShows secret and super secret room locations on the map.
The Compass The CompassThe Compass Rebirth Icon.pngReveals all special rooms (except secret rooms of any kind).
Raw Liver Raw LiverRaw Liver Icon.pngGrants 2 Heart Containers and completely restores health.
Treasure Map Treasure MapTreasure Map Icon.pngReveals all rooms for every floor. However, it does not reveal icons or secret rooms.
Yum Heart Yum HeartYum Heart Icon.png4 roomsRestores 1 whole red heart.
Child's Heart Child's HeartChild's Heart Icon.pngIncreases the chance of a Heart dropping after clearing a room, and the chance of finding a Heart when opening a Chest.
Curse of the Cursed
Item Pool Treasure Room.png: yes
Item Pool Shop.png: yes
Boss Mom.png Cursed! Have 7 or more heart containers at one timeCursed!Cursed! Credit Card Credit CardCredit CardComplete challenge #10
11. Glass Cannon
Judas App.png
Full red heart
Starts with:
Epic Fetus Epic FetusEpic Fetus Icon.pngIsaac's tears are replaced with guided missiles, like those used by the Doctor's Remote.
Loki's Horns Loki's HornsLoki's Horns Icon.pngGives a random chance for projectiles to fire in all 4 cardinal directions.
Item Pool Treasure Room.png: no
Item Pool Shop.png: yes
Boss Satan.png Glass Cannon Beat challenge #19 and defeat Lokii for the 1st timeGlass CannonGlass Cannon Rules Card Rules CardRules CardComplete challenge #11
12. When Life Gives You Lemons
Isaac App.png
Full red heartFull red heartFull red heart
Starts with:
9 Volt 9 Volt9 Volt Icon.pngReduces the charge of any Activated Items by 1. Any 1 charge items instead have timed recharges.
Habit HabitHabit Icon.pngWhen Isaac is hit, 1 point of an item's charge is filled.
Lemon Mishap Lemon MishapLemon Mishap Icon.png2 roomsCreates a small yellow pool of creep, which damages enemies that cross it.
1 Lemon Party pill
Item Pool Treasure Room.png: no
Item Pool Shop.png: yes
Boss Mom.png Default Card Against Humanity Card Against HumanityCard Against HumanityComplete challenge #12
13. Beans!
Isaac App.png
Full red heartFull red heartFull red heart
Blindfolded.png Blindfolded
Starts with:
9 Volt 9 Volt9 Volt Icon.pngReduces the charge of any Activated Items by 1. Any 1 charge items instead have timed recharges.
The Bean The BeanThe Bean Icon.png1 roomsIsaac releases bad gas, poisoning any enemy in close vicinity.
The Black Bean The Black BeanThe Black Bean Icon.pngWhen taking damage, Isaac farts, causing poison damage to all enemies in range.
Butt Bombs Butt BombsButt Bombs Icon.pngGives +5 bombs and makes all bombs Butt Bombs that fill the room with gas, damaging and confusing all enemies.
Pyro PyroPyro Rebirth Icon.pngAdds 99 bombs.
Item Pool Treasure Room.png: no
Item Pool Shop.png: yes
Boss Mom.png Default Burnt Penny Burnt PennyBurnt PennyComplete challenge #13
14. It's in the Cards
Isaac App.png
Full red heartFull red heartFull red heart
Starts with:
9 Volt 9 Volt9 Volt Icon.pngReduces the charge of any Activated Items by 1. Any 1 charge items instead have timed recharges.
The Battery The BatteryThe Battery Icon.pngActivated Items can be "overcharged" to allow for an additional use.
Deck of Cards Deck of CardsDeck of Cards Icon.png6 roomsGives Isaac a random Tarot Card.
Starter Deck Starter DeckStarter Deck Icon.pngIsaac can hold 2 cards at once and all pills are replaced by cards.
2 random tarot cards
Item Pool Treasure Room.png: no
Item Pool Shop.png: yes
Boss Mom.png Default SMB Super Fan SMB Super FanSMB Super FanComplete challenge #14
15. Slow Roll
Isaac App.png
Full red heartFull red heartFull red heart
Starts with:
Cupid's Arrow Cupid's ArrowCupid's Arrow Rebirth Icon.pngGrants Isaac piercing tears that travel through enemies (but not obstacles) instead of breaking on impact with them.
My Reflection My ReflectionMy Reflection Icon.pngGives Isaac's tears a boomerang effect, and increases range and shot speed.
Polyphemus PolyphemusPolyphemus Rebirth Icon.pngMakes Isaac shoot one huge tear. Also reduces Tears to minimum. Damage increased . If tear does more damage than an enemy's life, the tear continues to travel with the extra remaining damage.
Item Pool Treasure Room.png: no
Item Pool Shop.png: yes
Boss Mom.png Default Swallowed Penny Swallowed PennySwallowed PennyComplete challenge #15
16. Computer Savvy
Isaac App.png
Full red heartFull red heartFull red heart
Starts with:
Spoon Bender Spoon BenderSpoon Bender Icon.pngGrants Isaac homing tears.
Technology TechnologyTechnology Icon.pngReplaces tears with a piercing laser with unlimited range.
Technology 2 Technology 2Technology 2 Icon.pngDecreases damage and replaces right eye tears with a unlimited range, piercing laser which fires continuously.
Item Pool Treasure Room.png: no
Item Pool Shop.png: yes
Boss Mom.png Default Robo-Baby 2.0 Robo-Baby 2.0Robo-Baby 2.0Complete challenge #16
17. Waka Waka
Isaac App.png
Full red heartFull red heartFull red heart
Starts with:
Anti-Gravity Anti-GravityAnti-Gravity Icon.png-2 Tear Delay. Tears float in position until firing ceases, after which they will fly off in the direction they were shot in.
Strange Attractor Strange AttractorStrange Attractor Rebirth Icon.pngPickups, trinkets, and monsters are magnetically attracted to Isaac's tears.
Item Pool Treasure Room.png: no
Item Pool Shop.png: yes
Boss Mom.png Default Death's Touch Death's TouchDeath's TouchComplete challenge #17
18. The Host
Isaac App.png
Full red heartFull red heartFull red heart
Starts with:
The Mulligan The MulliganThe Mulligan Rebirth Icon.pngTears have a 1/6 chance of spawning allied blue flies when they hit an enemy.
Spider Baby Spider BabySpider Baby Icon.pngWhen hit, spawns up to 2 blue spiders.
Tick TickTick Icon.pngDrain 15% health of each enemy with more than 60 HP (ie. most bosses). Also restores one red heart of Isaac whenever he enters an uncleared boss room. The Tick cannot be swapped out for another trinket.
Item Pool Treasure Room.png: no
Item Pool Shop.png: yes
Boss Mom.png Default Technology .5 Technology .5Technology .5Complete challenge #18
19. The Family Man
Isaac App.png
Full red heartFull red heartFull red heart
Blindfolded.png Blindfolded
Starts with:
BFFS! BFFS!BFFS! Icon.pngIncreases the size and damage of familiars.
Brother Bobby Brother BobbyBrother Bobby Rebirth Icon.pngFollows Isaac around shooting normal tears.
Dad's Key Dad's KeyDad's Key Icon.png2 roomsOpens all doors in the current room when activated, including doors which require a key to open and entrances to secret rooms. Opens the big doors in the first room of both The Chest and the Dark Room.
Rotten Baby Rotten BabyRotten Baby Icon.pngA familiar that spawns blue flies.
Sister Maggy Sister MaggySister Maggy Icon.pngA familiar that follows Isaac around shooting blood tears.
Item Pool Treasure Room.png: no
Item Pool Shop.png: yes
Isaac The Family Man Pick up both Key pieces from the Angels in one runThe Family ManThe Family Man Epic Fetus Epic FetusEpic FetusComplete challenge #19
20. Purist
Isaac App.png
Full red heartFull red heartFull red heart
Item Pool Treasure Room.png: no
Item Pool Shop.png: yes
Boss Mom's Heart.png / Boss It Lives.png Purist Defeat Mom for the first timePuristPurist Rune of Berkano Rune of BerkanoRune of BerkanoComplete challenge #20
Added in  Afterbirth 21. XXXXXXXXL
Isaac App.png
Full red heartFull red heartFull red heart
Item Pool Treasure Room.png: yes
Item Pool Shop.png: yes
Every floor is the size of an XL Womb floor, but does not combine the floors of each chapter.
Boss Mom's Heart.png / Boss It Lives.png Added in  AfterbirthXXXXXXXXL Defeat Mom for the 1st timeXXXXXXXXLXXXXXXXXL Added in  AfterbirthGold Heart Gold HeartGold HeartComplete challenge #21
Added in  Afterbirth 22. SPEED!
Isaac App.png
Full red heartFull red heartFull red heart
Item Pool Treasure Room.png: yes
Item Pool Shop.png: yes
Everything is sped up like the Broken Watch effect.
Boss Mom's Heart.png / Boss It Lives.png
within 16 minutes, otherwise under constant periodic damage every 10 seconds.
Added in  AfterbirthSPEED! Defeat Mom for the 1st timeSPEED!SPEED! Added in  AfterbirthGet out of Jail Free Card Get out of Jail Free CardGet out of Jail Free CardComplete challenge #22
Added in  Afterbirth 23. Blue Bomber
???
Full soul heartFull soul heartFull soul heartFull soul heart
Blindfolded.png Blindfolded
Starts with:
Brother Bobby Brother BobbyBrother Bobby Rebirth Icon.pngFollows Isaac around shooting normal tears.
Kamikaze! Kamikaze!Kamikaze! Icon.pngUnlimitedCreates an explosion in the same area as Isaac, dealing half a heart of damage to him and also damaging all enemies caught in the blast radius.
Pyromaniac PyromaniacPyromaniac Icon.pngIsaac heals 1 heart instead of taking damage from an explosive source. Adds 5 bombs.
Mr. Mega Mr. MegaMr. Mega Icon.pngGives Isaac 5 bombs, and makes all dropped bombs larger, which have an increased blast radius and increased damage.
Item Pool Treasure Room.png: no
Item Pool Shop.png: yes
Boss Satan.png Added in  AfterbirthBlue Bomber Destroy 10 tinted rocks and defeat Mom's Heart 11 timesBlue BomberBlue Bomber Added in  AfterbirthGold Bomb Gold BombGold BombComplete challenge #23
Added in  Afterbirth 24. PAY TO PLAY
Isaac App.png
Full red heartFull red heartFull red heart
Starts with:
Money = Power Money = PowerMoney = Power Icon.pngIncreases damage by 0.04 for every coin Isaac has, up to +3.96 damage at 99 coins.
Sack of Pennies Sack of PenniesSack of Pennies Icon.pngIsaac is followed by a small bag that drops a coin every 2 rooms.
50 coins
Item Pool Treasure Room.png: no
Item Pool Shop.png: yes
Every door costs 1 cent to enter. Isaac drops money when hit. Isaac dies if he run out of money.
Isaac Added in  AfterbirthPAY TO PLAY Defeat Isaac as CainPAY TO PLAYPAY TO PLAY Added in  Afterbirth2 new pills 2 new pills2 new pillsComplete challenge #24
Added in  Afterbirth 25. Have a Heart
Isaac App.png
Starts with:
Charm of the Vampire Charm of the VampireCharm of the Vampire Icon.pngHeals the character for half of a red heart for every 13 monsters killed.
Item Pool Treasure Room.png: yes
Item Pool Shop.png: yes
Pennies drop instead of red hearts. Many items that restore red hearts have no effect.
Boss Mom's Heart.png / Boss It Lives.png Added in  AfterbirthHave a Heart Defeat Mom for the 1st timeHave a HeartHave a Heart Added in  Afterbirth2 new pills 2 new pills2 new pillsComplete challenge #24
Added in  Afterbirth 26. I RULE!
Isaac App.png
Full red heartFull red heartFull red heart
Starts with:
The Boomerang The BoomerangThe Boomerang Rebirth Icon.png4 secondsThrows a short-range boomerang which does a bit of damage and has a high chance to stun the enemy for 2 seconds. Can also be used to grab pickups.
Key Piece 1 Key Piece 1Key Piece 1 Icon.pngCombined with Key Piece 2, unlocks the golden gate in the starting room of The Chest and Dark Room to fight Mega Satan.
Key Piece 2 Key Piece 2Key Piece 2 Icon.pngCombined with Key Piece 1, unlocks the golden gate in the starting room of The Chest and Dark Room to fight Mega Satan.
The Ladder The LadderThe Ladder Icon.pngAllows Isaac to walk across gaps one square across by automatically placing a ladder between the two walkable sections.
Mom's Knife Mom's KnifeMom's Knife Icon.pngIsaac's tears are replaced by a knife that pierces enemies, can travel through obstacles, and can hurt enemies while Isaac is holding it. Holding down the fire button before firing increases its range and power.
Trinity Shield Trinity ShieldTrinity Shield Icon.pngIsaac gains a shield that protects him from enemy shots.
Item Pool Treasure Room.png: no
Item Pool Shop.png: yes
Boss Mega Satan.png Added in  AfterbirthI RULE! Defeat ??? or The Lamb for the 1st time, and defeat Satan as IsaacI RULE!I RULE! Added in  AfterbirthPoker Chip Poker ChipPoker ChipComplete challenge #26
Added in  Afterbirth 27. BRAINS!
???
Full soul heartFull soul heartFull soul heartFull soul heart
Blindfolded.png Blindfolded
Starts with:
3 Bob's Brain Bob's BrainBob's Brain Icon.pngSpawns a familiar that charges forward when shooting tears and explodes upon contact with an enemy, damaging and poisoning them. The familiar respawns after a few seconds.
Thunder Thighs Thunder ThighsThunder Thighs Icon.pngDestroys rocks upon contact with Isaac. Adds one heart container and lowers Speed.
Item Pool Treasure Room.png: no
Item Pool Shop.png: yes
??? Added in  AfterbirthBRAINS! Defeat Isaac 5 timesBRAINS!BRAINS! Added in  AfterbirthStud Finder Stud FinderStud FinderComplete challenge #27
Added in  Afterbirth 28. PRIDE DAY!
Isaac App.png
Full red heartFull red heartFull red heart
Starts with:
3 Dollar Bill 3 Dollar Bill3 Dollar Bill Icon.pngGives Isaac a random tear effect every room.
Removed in Afterbirth The effect given changes upon entering a room.
Added in Afterbirth The effect changes every 3 seconds.

Rainbow Baby Rainbow BabyRainbow Baby Rebirth Icon.pngSpawns a familiar that follows Isaac around and fires tears with random effects.
Item Pool Treasure Room.png: no
Item Pool Shop.png: yes
Cannot drop or replace Rainbow Worm.
Boss Mom's Heart.png / Boss It Lives.png Added in  AfterbirthPRIDE DAY! Defeat Mom for the 1st timePRIDE DAY!PRIDE DAY! Added in  AfterbirthD8 D8D8Complete challenge #28
Added in  Afterbirth 29. Onan's Streak
Judas App.png
Full red heart
Starts with:
The Book of Belial The Book of BelialThe Book of Belial Icon.png3 roomsUpon use increases damage by 2 for the current room and by a further +50% if the character also has the Blood of the Martyr.
Removed in Afterbirth Guarantees a Devil Room or Angel Room will be open after beating a boss while holding it, or Added in  Afterbirth increases the chance by 12.5%.

Chocolate Milk Chocolate MilkChocolate Milk Icon.pngGrants charged tears that deal greater damage when fully charged.
Item Pool Treasure Room.png: yes
Item Pool Shop.png: yes
Missing a shot deals damage to Judas.
Isaac Added in  AfterbirthOnan's Streak Defeat Mom for the 1st timeOnan's StreakOnan's Streak Added in  AfterbirthKidney Stone Kidney StoneKidney StoneComplete challenge #29 (Removed in Afterbirth † The unlock is bugged and actually unlocks Blank Rune)
Added in  Afterbirth 30. The Guardian
Isaac App.png
Full red heartFull red heartFull red heart
Blindfolded.png Blindfolded
Starts with:
Holy Grail Holy GrailHoly Grail Icon.pngGrants flight and one heart container.
Isaac's Heart Isaac's HeartIsaac's Heart Icon.pngIsaac himself is now immune to all damage, and a heart familiar appears and follows Isaac. If the heart is hurt, Isaac is hurt.
Punching Bag Punching BagPunching Bag Icon.pngSpawns a Mulligan Familiar that will wander the room randomly. Enemies will attack the Mulligan if it's closer.

Item Pool Treasure Room.png: no
Item Pool Shop.png: yes
Isaac's Heart will follow Punching Bag Punching BagPunching Bag Icon.pngSpawns a Mulligan Familiar that will wander the room randomly. Enemies will attack the Mulligan if it's closer. instead of Isaac.
Boss Mom's Heart.png / Boss It Lives.png Added in  AfterbirthThe Guardian Defeat Mom for the 1st timeThe GuardianThe Guardian Added in  AfterbirthBlank Rune Blank RuneBlank RuneComplete challenge #30 (Removed in Afterbirth † The unlock is bugged and actually unlocks Kidney Stone)
Added in Afterbirth † 31. Backasswards
Isaac App.png
Full red heartFull red heartFull red heart
Starts with:
8-10 random items
Item Pool Treasure Room.png: no
Item Pool Shop.png: yes
All Chapters progress in reverse order, losing 1 item and 1 red heart container each floor ascended.
The Basement/The Cellar/Burning Basement I Added in Afterbirth †Backasswards Defeat ??? or The Lamb for the 1st timeBackasswardsBackasswards Added in Afterbirth †Laz Bleeds More! Laz Bleeds More!Laz Bleeds More!Complete challenge #31
Added in Afterbirth † 32. Aprils Fool
Isaac App.png
Full red heartFull red heartFull red heart
Item Pool Treasure Room.png: yes
Item Pool Shop.png: yes
The minimap displays the floor's layout accurately, but displays Isaac's position inaccurately. Pedestal items and pickups are not what they appear to be. Active item, pill, card, and rune effects are randomized upon each use, making them very unreliable or deadly (for example Suicide King). Items with no charge time (i.e. How To Jump, IV Bag, etc) can be used repeatedly for random effects. Stoneys have a chance of being replaced by Cross Stoneys. Every boss is The Bloat. Isaac's health is not what it appears to be. Key and bomb numbers are accurate.
Boss Mom's Heart.png / Boss It Lives.png Added in Afterbirth †Aprils fool Defeat Mom for the 1st timeAprils foolAprils fool Added in Afterbirth †Maggy Now Holds a Pill! Maggy Now Holds a Pill!Maggy Now Holds a Pill!Complete challenge #32
Added in Afterbirth † 33. Pokey Mans
Isaac App.png
Full red heartFull red heartFull red heart
Starts with:

Mom's Eyeshadow Mom's EyeshadowMom's Eyeshadow Icon.pngTears have a chance to charm enemies.
Item Pool Treasure Room.png: no
Item Pool Shop.png: yes
Each use of Friendly Ball causes a random monster to be spawned. Friendly Ball instantly charges once the spawned monster is killed.
Isaac Added in Afterbirth †Pokey Mans Defeat Mom's Heart 11 timesPokey MansPokey Mans Added in Afterbirth †Charged Key Charged KeyCharged KeyComplete challenge #33
Added in Afterbirth † 34. Ultra Hard
Isaac App.png
Full red heartFull red heartFull red heart
Starts with:
Key Piece 1 Key Piece 1Key Piece 1 Icon.pngCombined with Key Piece 2, unlocks the golden gate in the starting room of The Chest and Dark Room to fight Mega Satan.
Key Piece 2 Key Piece 2Key Piece 2 Rebirth Icon.pngCombined with Key Piece 1, unlocks the golden gate in the starting room of The Chest and Dark Room to fight Mega Satan.
Curse of the Labyrinth
Curse of the Blind
Curse of the Lost
Curse of the Maze
Item Pool Treasure Room.png: yes
Item Pool Shop.png: yes
All enemies spawn as champions if possible. Boss fights will be double trouble if possible. No heart pickups drop.
Boss Mega Satan.png Added in Afterbirth †Ultra Hard Defeat ??? or The Lamb for the first timeUltra HardUltra Hard Added in Afterbirth †Samson Feels Healthy! Samson Feels Healthy!Samson Feels Healthy!Complete challenge #34
Added in Afterbirth † 35. Pong
Isaac App.png
Full red heartFull red heartFull red heart
Starts with:
Cupid's Arrow Cupid's ArrowCupid's Arrow Rebirth Icon.pngGrants Isaac piercing tears that travel through enemies (but not obstacles) instead of breaking on impact with them.
Rubber Cement Rubber CementRubber Cement Icon.pngTears bounce off walls, enemies, and environmental objects.
Item Pool Treasure Room.png: no
Item Pool Shop.png: yes
Damage fixed at 100, tear delay fixed at 150.
??? Added in Afterbirth †PONG Defeat Isaac 5 timesPONGPONG Added in Afterbirth †Greed's Gullet Greed's GulletGreed's GulletComplete challenge #35


MainPageChallenges.png Challenges MainPageChallenges.png

Rebirth
1. Pitch Black 2. High Brow 3. Head Trauma 4. Darkness Falls 5. The Tank 6. Solar System 7. Suicide King 8. Cat Got Your Tongue
9. Demo Man 10. Cursed! 11. Glass Cannon 12. When Life Gives You Lemons 13. Beans! 14. It's in the Cards 15. Slow Roll 16. Computer Savvy
17. Waka Waka 18. The Host 19. The Family Man 20. Purist
Afterbirth
21. XXXXXXXXL 22. SPEED! 23. Blue Bomber 24. PAY TO PLAY 25. Have a Heart 26. I RULE! 27. BRAINS! 28. PRIDE DAY!
29. Onan's Streak 30. The Guardian
Afterbirth †
31. Backasswards 32. Aprils Fool 33. Pokey Mans 34. Ultra Hard 35. Pong
The Binding of Isaac: Rebirth The Binding of Isaac: Rebirth The Binding of Isaac: Rebirth
Achievements Achievements Attributes Attributes Bosses Bosses TarotCard.png Cards and Runes Challenges Challenges Chapters Chapters
Characters Characters MainPageBabies.png Co-op Items Items Item Pools Item Pools Monsters Monsters Objects Objects
Pickups Pickups Pills Pills Rooms Rooms Seeds Seeds Transformations Transformations Trinkets Trinkets