Challenges

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Challenges are unique runs in the game. Challenges typically start the player off with one or more specific items which make normal play more difficult. You will not find Treasure Rooms (with the exception of a select few challenges). Completing one of the thirty five challenges unlocks new content for the game, such as Runes.

General Strategy[edit | edit source]

Most challenges are geared to make a run difficult in some form. Sometimes, these challenges are easy, like Computer Savvy. Other times, they can be vicious, like Solar System. Each challenge has a certain strategy that can make the run easier. However, there are a few strategies that can apply to all challenges.

  • You can play in co-op for every challenge, making it easier for the ones where you cannot fire tears - especially for Cat Got Your Tongue, since it will spawn flies.
  • Because of the lack of Treasure Rooms, Devil Rooms become much more valuable. Some challenges can be made much easier by making just one deal.
  • You can also be more liberal with your use of keys for the same reason. Trinkets and Items that generate more coins, along with upgraded shops, can help reduce the difficulty in many challenge runs.
  • The Bible The BibleThe Bible Icon.png6 roomsUpon activation, Isaac gains flight, allowing him to pass over all obstacles in the current room. Instantly kills Mom, Mom's Heart, and It Lives when activated, but will kill Isaac when activated while fighting Satan. can make the end of some runs extremely easy. Because of how some challenges operate, the run may only require defeating Mom or Mom's Heart / It Lives. Since The Bible The BibleThe Bible Icon.png6 roomsUpon activation, Isaac gains flight, allowing him to pass over all obstacles in the current room. Instantly kills Mom, Mom's Heart, and It Lives when activated, but will kill Isaac when activated while fighting Satan. is a one-hit kill against these, getting it when you have the chance is usually a good investment for these runs.
    • Pandora's Box Pandora's BoxPandora's Box Icon.pngOne time useUpon use, spawns certain pickups or items depending on the floor it is used on. Single-use. will spawn The Bible The BibleThe Bible Icon.png6 roomsUpon activation, Isaac gains flight, allowing him to pass over all obstacles in the current room. Instantly kills Mom, Mom's Heart, and It Lives when activated, but will kill Isaac when activated while fighting Satan. if used in Womb II, Utero II, or Added in Afterbirth Scarred Womb II, which may then be used against Mom's Heart / It Lives.
  • Curse Rooms gain value since they can spawn items. You may wish to restart on the first floor until your Curse Room spawns an item worth 1 heart of damage.
  • Dice Rooms and the D4 D4D4 Icon.png6 roomsRerolls all of Isaac's items. are very useful, as in some cases you can reroll your entire build and remove (or add) difficulty.
    • Added in Afterbirth Dice rooms do not re-roll starter challenge items or remove Blindfolded.
    • Added in Afterbirth †Butter! Butter!Butter! Icon.pngUsing an active item will drop it onto a pedestal on the ground. Taking damage may result in dropping a passive item. can remove starter items.
  • In Blindfolded challenges, familiars can make the run easier, as they are your only source of conventional damage. Powerful familiars like Daddy Longlegs Daddy LonglegsDaddy Longlegs Icon.pngDaddy Long Legs' shadow follows Isaac and stomps on enemies., Lil Brimstone Lil BrimstoneLil Brimstone Icon.pngA Familiar that shoots a thin Brimstone beam. Must charge like Brimstone before shooting., and Added in AfterbirthIncubus IncubusIncubus Icon.pngA demonic familiar that follows Isaac and shoots tears identical to Isaac's in terms of damage, range, fire rate, and effects. are very good items to pick up. Some of the strongest familiars need to be unlocked first, so it may be wise to take the time to unlock them beforehand.
    • The Boomerang The BoomerangThe Boomerang Icon.png4 secondsThrows a short-range boomerang which does a bit of damage and has a high chance to stun the enemy for 2 seconds. Can also be used to grab pickups., The Candle The CandleThe Candle Icon.png4 secondsThrows out a blue flame that can pass over gaps (but not through rocks). The flame damages anything in its path., and Red Candle Red CandleRed Candle Icon.png4 secondsThrows a persistent flame that deals high damage and diminishes as it damages enemies or blocks shots. are also useful for blindfolded challenges, since they deal damage and recharge based on a timer.
      • Added in Afterbirth In Blindfolded challenges, if possible finding and using the Added in Afterbirth †Clicker ClickerClicker Icon.png6 roomsTransforms Isaac into another random character., change yourself into the character Lilith, will make these challenges incredibly easy with access to tears through her Added in AfterbirthIncubus IncubusIncubus Icon.pngA demonic familiar that follows Isaac and shoots tears identical to Isaac's in terms of damage, range, fire rate, and effects. you gain.
  • Added in Afterbirth In challenges that remove Treasure Rooms, Added in AfterbirthChaos ChaosChaos Icon.pngChaos causes items to be chosen from random item pools. When picked up, drops between 1-6 random pickups on the floor. has more potential to be useful by potentially making Treasure Room (among other rare items) items purchasable from the shop. On the downside, it may replace the Devil/Angel Room items with something less valuable.
  • Defeating a boss beyond the specified end of the challenge (e.g. defeating Mom's Heart when the goal is to defeat Mom) will still cause them to drop the trophy.
    • Added in Afterbirth This means a legitimate tactic for some of the longer challenges (e.g. XXXXXXXXL) is to use the Sacrifice Room until it teleports you to the Dark Room, then going through and defeating The Lamb, completing the challenge regardless of what floor you were teleported from.

Notes[edit | edit source]

  • New content, other than the Challenge Reward, cannot be unlocked. Likewise, you will not find a Donation Machine anywhere.
  • The Challenge reward will not be unlocked unless you pick up the trophy, meaning that if a Devil Room or Angel Room appears and allows you to go to Sheol or the Cathedral, you will be forfeiting the unlock if you fail to complete the floor.
  • Any challenge featuring Isaac will not start with The D6 The D6The D6 Icon.png6 roomsAllows Isaac to re-roll collectible items in the current room into other items, depending on the current room's Item Pool..

Challenge list[edit | edit source]


The Binding of Isaac: Rebirth The Binding of Isaac: Rebirth The Binding of Isaac: Rebirth
MainPageAchievements.png Achievements MainPageAttributes.png Attributes MainPageBosses.png Bosses TarotCard.png Cards and Runes MainPageChallenges.png Challenges MainPageChapters.png Chapters
Isaac App.png Characters MainPageBabies.png Co-op MainPageItems Small.png Items Item Pools Item Pools MainPageMonsters.png Monsters MainPageObjects.png Objects
Red heart.png Pickups BlueBlue.png Pills MainPageRooms.png Rooms MainPageSeeds2.png Seeds Guppy App.png Transformations The Left Hand Icon.png Trinkets