Name
|
Conditions
|
Goal
|
Unlocked by
|
Unlocks
|
1. Pitch Black
|
|
|
Default
|
Rune of Hagalaz
|
2. High Brow
|
|
|
Default
|
Rune of Jera
|
3. Head Trauma
|
|
|
Default
|
Rune of Ehwaz
|
4. Darkness Falls
|
|
|
Defeat Mom's Heart 11 times
|
Rune of Dagaz
|
5. The Tank
|
|
|
Have 7 or more Red Heart containers at one time
|
Rune of Ansuz
|
6. Solar System
|
|
/
|
Defeat Mom's Heart 3 times
|
Rune of Perthro
|
7. Suicide King
|
|
|
Defeat Mom's Heart 11 times
|
Suicide King
|
8. Cat Got Your Tongue
|
|
|
Become Guppy
|
Rune of Algiz
|
9. Demo Man
|
|
/
|
Defeat Mom's Heart 9 times
|
Chaos Card
|
10. Cursed!
|
|
|
Have 7 or more Red Heart Containers at one time
|
Credit Card
|
11. Glass Cannon
|
|
|
Beat The Family Man (challenge #19) and defeat Lokii
|
Rules Card
|
12. When Life Gives You Lemons
|
|
|
Default
|
Card Against Humanity
|
13. Beans!
|
|
|
Default
|
Burnt Penny
|
14. It's in the Cards
|
|
|
Default
|
SMB Super Fan
|
15. Slow Roll
|
|
|
Default
|
Swallowed Penny
|
16. Computer Savvy
|
|
|
Default
|
Robo-Baby 2.0
|
17. Waka Waka
|
|
|
Default
|
Death's Touch
|
18. The Host
|
|
|
Default
|
Technology .5
|
19. The Family Man
|
|
|
Pick up both Key Pieces from the Angels in one run
|
Epic Fetus
|
20. Purist
|
|
/
|
Defeat Mom
|
Rune of Berkano
|
21. XXXXXXXXL
|

|
: yes
: yes
|
Every floor is the size of an XL Womb floor, but does not combine the floors of each chapter.
|
|
/
|
 Defeat Mom
|
 Gold Heart
|
22. SPEED!
|

|
: yes
: yes
|
Everything is sped up like the Broken Watch effect.
|
|
/  within 16 minutes, otherwise under constant periodic damage every 10 seconds.
|
 Defeat Mom
|
 Get out of Jail Free Card
|
23. Blue Bomber
|
|
|
 Destroy 10 Tinted Rocks and defeat Mom's Heart 11 times
|
 Gold Bomb
|
24. PAY TO PLAY
|
|
|
 Defeat Isaac as Cain
|
 2 new pills
|
25. Have a Heart
|

|
Starts with:
Charm of the Vampire
|
: yes
: yes
|
Pennies drop instead of Red Hearts. Many items that restore Red Hearts have no effect.
|
|
/
|
 Defeat Mom
|
 2 new pills
|
26. I RULE!
|
|
|
 Defeat ??? or The Lamb, and defeat Satan as Isaac
|
 Poker Chip
|
27. BRAINS!
|
|
|
 Defeat Isaac 5 times
|
 Stud Finder
|
28. PRIDE DAY!
|
|
/
|
 Defeat Mom
|
 D8
|
29. Onan's Streak
|
|
|
 Defeat Mom
|
 Kidney Stone
|
30. The Guardian
|
|
/
|
 Defeat Mom
|
 Blank Rune
|
31. Backasswards
|

|
Starts with: 8-10 random items
|
: no
: yes
|
All chapters progress in reverse order, losing 1 item and 1 Red Heart container each floor ascended.
|
|
The Basement/ The Cellar/ Burning Basement I
|
 Defeat ??? or The Lamb
|
 Laz Bleeds More!
|
32. Aprils Fool
|

|
: yes
: yes
|
The minimap displays the floor's layout accurately, but displays Isaac's position inaccurately. Pedestal items and pickups are not what they appear to be. Active items, pills, cards, and rune effects are randomized upon each use, making them very unreliable or deadly (for example Suicide King). Items with no charge time (i.e. How To Jump, IV Bag, etc) can be used repeatedly for random effects. Stoneys have a chance of being replaced by Cross Stonies. Every boss is The Bloat. Isaac's health is not what it appears to be. Key and bomb numbers are accurate.
|
|
/
|
 Defeat Mom
|
 Maggy Now Holds a Pill!
|
33. Pokey Mans
|

|
Starts with:
 Friendly Ball
Mom's Eyeshadow
|
: no
: yes
|
Each use of Friendly Ball causes a random monster to be spawned. Friendly Ball instantly charges once the spawned monster is killed.
|
|
|
 Defeat Mom's Heart 11 times
|
 Charged Key
|
34. Ultra Hard
|
|
|
 Defeat ??? or The Lamb. Possession of The Polaroid/ The Negative is required, barring getting to Dark Room through a Sacrifice Room.
|
 Samson Feels Healthy!
|
35. Pong
|
|
|
 Defeat Isaac 5 times
|
 Greed's Gullet
|