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Chapter 2 (Bosses)

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Bosses
Chapter 1 Chapter 2 Chapter 3 Chapter 4 Added in Afterbirth  Blue Womb Chapter 5 Chapter 6 Added in Afterbirth †  The Void
Universal Devil and Angel Room Seven Deadly Sins Added in Afterbirth  Greed Mode All Mini-Bosses All Bosses

The Caves[edit | edit source]

Boss Chub.png
Boss Dark One.png
Boss Gurdy.png
Boss Gurdy Jr..png
Chub Dark One Gurdy Gurdy Jr.
Boss Mega Fatty.png
Boss Mega Maw.png
Boss Peep.png
Boss The Fallen.png
Mega Fatty Mega Maw Peep The Fallen Requires previous entry into a devil room
Boss C.H.A.D..png
Boss The Headless Horseman.png
Boss Pestilence.png
Boss The Forsaken.png
C.H.A.D. Needs to be unlocked The Headless Horseman Needs to be unlocked Pestilence Needs to be unlocked The Forsaken Added in Afterbirth Needs to be unlocked
Boss The Frail.png
Boss The Stain.png
Boss Big Horn.png
Boss Rag Mega.png
The Frail Added in Afterbirth Needs to be unlocked The Stain Added in Afterbirth Needs to be unlocked Big Horn Added in Afterbirth † Needs to be unlocked Rag Mega Added in Afterbirth † Needs to be unlocked

Double Trouble[edit | edit source]

Double Trouble Bosses
Boss Dingle.png
Boss The Duke of Flies.png
Boss Gemini.png
Boss Larry Jr..png
(Double Trouble)
Dingle
(Double Trouble)
The Duke of Flies
(Double Trouble)
Gemini
(Double Trouble)
Larry Jr.
Boss Monstro.png
Boss Pin.png
Boss Polycephalus.png
(Double Trouble)
Monstro
(Double Trouble)
Pin
(Double Trouble)
Polycephalus

The Catacombs[edit | edit source]

Boss Carrion Queen.png
Boss Dark One.png
Boss Gurdy Jr..png
Boss The Hollow.png
Carrion Queen Dark One Gurdy Jr. The Hollow
Boss The Husk.png
Boss Peep.png
Boss Polycephalus.png
Boss The Wretched.png
The Husk Peep Polycephalus The Wretched
Boss The Fallen.png
Boss The Headless Horseman.png
Boss Pestilence.png
Boss The Forsaken.png
The Fallen Requires previous entry into a devil room The Headless Horseman Needs to be unlocked Pestilence Needs to be unlocked The Forsaken Added in Afterbirth Needs to be unlocked
Boss The Frail.png
Boss The Stain.png
Boss Big Horn.png
Boss Rag Mega.png
The Frail Added in Afterbirth Needs to be unlocked The Stain Added in Afterbirth Needs to be unlocked Big Horn Added in Afterbirth † Needs to be unlocked Rag Mega Added in Afterbirth † Needs to be unlocked

Double Trouble[edit | edit source]

Double Trouble Bosses
Boss Dingle.png
Boss The Duke of Flies.png
Boss Gemini.png
(Double Trouble)
Dingle
(Double Trouble)
The Duke of Flies
(Double Trouble)
Gemini
Boss Larry Jr..png
Boss Monstro.png
Boss Pin.png
(Double Trouble)
Larry Jr.
(Double Trouble)
Monstro
(Double Trouble)
Pin

Flooded Caves Added in Afterbirth[edit | edit source]

Boss Chub.png
Boss Dark One.png
Boss Gurdy.png
Boss Gurdy Jr..png
Chub Dark One Gurdy Gurdy Jr.
Boss Peep.png
Boss Polycephalus.png
Boss The Fallen.png
Boss C.H.A.D..png
Peep Polycephalus The Fallen Requires previous entry into a devil room C.H.A.D. Needs to be unlocked
Boss The Headless Horseman.png
Boss Pestilence.png
Boss The Forsaken.png
Boss The Frail.png
The Headless Horseman Needs to be unlocked Pestilence Needs to be unlocked The Forsaken Added in Afterbirth Needs to be unlocked The Frail Added in Afterbirth Needs to be unlocked
Boss The Stain.png
Boss Big Horn.png
Boss Rag Mega.png
The Stain Added in Afterbirth Needs to be unlocked Big Horn Added in Afterbirth † Needs to be unlocked Rag Mega Added in Afterbirth † Needs to be unlocked

Double Trouble[edit | edit source]

Double Trouble Bosses
Boss Monstro.png
(Double Trouble)
Monstro


Bosses Boss Monstro.png
Chapter 1
Stage The Basement icon.pngStage The Cellar icon.pngStage Burning Basement icon.png
Blighted OvumDingleThe Duke of FliesFamineFistulaGeminiGurglingsThe HauntLarry Jr.MonstroPinStevenWidowThe FallenThe Headless Horseman
Added in Afterbirth DangleLittle HornRag ManTurdlings
Chapter 2
Stage The Caves icon.pngStage The Catacombs icon.pngStage Flooded Caves icon.png
Carrion QueenC.H.A.D.ChubDark OneGurdyGurdy Jr.The HollowThe HuskMega FattyMega MawPeepPestilencePolycephalusThe WretchedThe FallenThe Headless Horseman
Added in Afterbirth The ForsakenThe FrailThe Stain
Added in Afterbirth † Big HornRag Mega
Chapter 3
Stage The Depths icon.pngStage Necropolis icon.pngStage Dank Depths icon.png
The AdversaryThe BloatThe CageThe GateGishLokiMask Of InfamyMonstro IIWarThe FallenThe Headless HorsemanMom
Added in Afterbirth Brownie
Added in Afterbirth † Sisters Vis
Chapter 4
Stage The Womb icon.pngStage Utero icon.pngStage Scarred Womb icon.png
BlastocystThe BloatConquestDaddy Long LegsDeathLokiiMama GurdyMr. FredScolexTeratomaTriachnidThe FallenThe Headless HorsemanMom's HeartIt Lives
Added in Afterbirth † Sisters VisThe Matriarch
Added in Afterbirth Blue Womb
???
Added in Afterbirth Hush
Chapter 5
Stage Sheol icon.pngStage Cathedral icon.png
SatanIsaac
Chapter 6
Stage Dark Room icon.pngStage The Chest icon.png
???The LambMega Satan
Added in Afterbirth † The Void
Stage The Void icon.png
Added in Afterbirth † Delirium
Added in Afterbirth Greed Mode
Ultra Greed
Added in Afterbirth Ultra Greed
Added in Afterbirth † Ultra Greedier
The Binding of Isaac: Rebirth The Binding of Isaac: Rebirth The Binding of Isaac: Rebirth
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