Chapter 2 (Bosses)

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Bosses
Chapter 1 Chapter 2 Chapter 3 Chapter 4 Added in Afterbirth  Blue Womb Chapter 5 Chapter 6 Added in Afterbirth †  The Void
Universal Devil and Angel Room Seven Deadly Sins Added in Afterbirth  Greed Mode All Mini-Bosses All Bosses

The Caves[edit | edit source]

Boss Chub.png
Boss Dark One.png
Boss Gurdy.png
 Boss Gurdy Jr..png
Chub Dark One Gurdy Gurdy Jr.
Boss Mega Fatty.png
Boss Mega Maw.png
Boss Peep.png
Boss The Fallen.png
Mega Fatty Mega Maw Peep The Fallen Requires previous entry into a devil room
Boss C.H.A.D..png
Boss The Headless Horseman.png
Boss Pestilence.png
Boss The Forsaken.png
C.H.A.D. Needs to be unlocked The Headless Horseman Needs to be unlocked Pestilence Needs to be unlocked The Forsaken Added in Afterbirth Needs to be unlocked
Boss The Frail.png
Boss The Stain.png
Boss Big Horn.png
Boss Rag Mega.png
The Frail Added in Afterbirth Needs to be unlocked The Stain Added in Afterbirth Needs to be unlocked Big Horn Added in Afterbirth † Needs to be unlocked Rag Mega Added in Afterbirth † Needs to be unlocked

Double Trouble[edit | edit source]

Double Trouble Bosses
Boss Dingle.png
Boss The Duke of Flies.png
 Boss Gemini.png
Boss Larry Jr..png
(Double Trouble)
Dingle 		(Double Trouble)
The Duke of Flies 		(Double Trouble)
Gemini 		(Double Trouble)
Larry Jr.
Boss Monstro.png
Boss Pin.png
Boss Polycephalus.png
(Double Trouble)
Monstro 		(Double Trouble)
Pin 		(Double Trouble)
Polycephalus

The Catacombs[edit | edit source]

Boss Carrion Queen.png
Boss Dark One.png
 Boss Gurdy Jr..png
Boss The Hollow.png
Carrion Queen Dark One Gurdy Jr. The Hollow
Boss The Husk.png
Boss Peep.png
Boss Polycephalus.png
Boss The Wretched.png
The Husk Peep Polycephalus The Wretched
Boss The Fallen.png
Boss The Headless Horseman.png
Boss Pestilence.png
Boss The Forsaken.png
The Fallen Requires previous entry into a devil room The Headless Horseman Needs to be unlocked Pestilence Needs to be unlocked The Forsaken Added in Afterbirth Needs to be unlocked
Boss The Frail.png
Boss The Stain.png
Boss Big Horn.png
Boss Rag Mega.png
The Frail Added in Afterbirth Needs to be unlocked The Stain Added in Afterbirth Needs to be unlocked Big Horn Added in Afterbirth † Needs to be unlocked Rag Mega Added in Afterbirth † Needs to be unlocked

Double Trouble[edit | edit source]

Double Trouble Bosses
Boss Dingle.png
Boss The Duke of Flies.png
 Boss Gemini.png
(Double Trouble)
Dingle 		(Double Trouble)
The Duke of Flies 		(Double Trouble)
Gemini
Boss Larry Jr..png
 Boss Monstro.png
Boss Pin.png
(Double Trouble)
Larry Jr. 		(Double Trouble)
Monstro 		(Double Trouble)
Pin

Flooded Caves Added in Afterbirth[edit | edit source]

Boss Chub.png
Boss Dark One.png
Boss Gurdy.png
 Boss Gurdy Jr..png
Chub Dark One Gurdy Gurdy Jr.
Boss Peep.png
Boss Polycephalus.png
Boss The Fallen.png
Boss C.H.A.D..png
Peep Polycephalus The Fallen Requires previous entry into a devil room C.H.A.D. Needs to be unlocked
Boss The Headless Horseman.png
Boss Pestilence.png
Boss The Forsaken.png
Boss The Frail.png
The Headless Horseman Needs to be unlocked Pestilence Needs to be unlocked The Forsaken Added in Afterbirth Needs to be unlocked The Frail Added in Afterbirth Needs to be unlocked
Boss The Stain.png
Boss Big Horn.png
Boss Rag Mega.png
The Stain Added in Afterbirth Needs to be unlocked Big Horn Added in Afterbirth † Needs to be unlocked Rag Mega Added in Afterbirth † Needs to be unlocked

Double Trouble[edit | edit source]

Double Trouble Bosses
Boss Monstro.png
(Double Trouble)
Monstro


Bosses Boss Monstro.png
Chapter 1
Stage The Basement icon.pngStage The Cellar icon.pngStage Burning Basement icon.png 		Blighted Ovum • Dingle • The Duke of Flies • Famine • Fistula • Gemini • Gurglings • The Haunt • Larry Jr. • Monstro • Pin • Steven • Widow • The Fallen • The Headless Horseman
Added in Afterbirth Dangle • Little Horn • Rag Man • Turdlings
Chapter 2
Stage The Caves icon.pngStage The Catacombs icon.pngStage Flooded Caves icon.png 		Carrion Queen • C.H.A.D. • Chub • Dark One • Gurdy • Gurdy Jr. • The Hollow • The Husk • Mega Fatty • Mega Maw • Peep • Pestilence • Polycephalus • The Wretched • The Fallen • The Headless Horseman
Added in Afterbirth The Forsaken • The Frail • The Stain
Added in Afterbirth † Big Horn • Rag Mega
Chapter 3
Stage The Depths icon.pngStage Necropolis icon.pngStage Dank Depths icon.png 		The Adversary • The Bloat • The Cage • The Gate • Gish • Loki • Mask Of Infamy • Monstro II • War • The Fallen • The Headless Horseman • Mom
Added in Afterbirth Brownie
Added in Afterbirth † Sisters Vis
Chapter 4
Stage The Womb icon.pngStage Utero icon.pngStage Scarred Womb icon.png 		Blastocyst • The Bloat • Conquest • Daddy Long Legs • Death • Lokii • Mama Gurdy • Mr. Fred • Scolex • Teratoma • Triachnid • The Fallen • The Headless Horseman • Mom's Heart • It Lives
Added in Afterbirth † Sisters Vis • The Matriarch
Added in Afterbirth Blue Womb
??? 		Added in Afterbirth Hush
Chapter 5
Stage Sheol icon.pngStage Cathedral icon.png 		Satan • Isaac
Chapter 6
Stage Dark Room icon.pngStage The Chest icon.png 		??? • The Lamb • Mega Satan
Added in Afterbirth † The Void
Stage The Void icon.png 		Added in Afterbirth † Delirium
Added in Afterbirth Greed Mode
Ultra Greed 		Added in Afterbirth Ultra Greed
Added in Afterbirth † Ultra Greedier
The Binding of Isaac: Rebirth The Binding of Isaac: Rebirth The Binding of Isaac: Rebirth
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