Chapters

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Chapters are sets of floors which contain similar enemies, themes, bosses, and difficulties. Earlier chapters are divided into two floors, while later chapters contain one floor. Each chapter has different environments which, while retaining the same feel, have slightly different themes, enemies, bosses, and difficulties. Each environment also has its own music.

Chapter 1

The BasementStage The Basement icon.pngThe Basement The CellarStage The Cellar icon.pngThe Cellar Burning BasementStage Burning Basement icon.pngBurning Basement
The Basement The Cellar Added in Afterbirth Burning Basement

Chapter 2

The CavesStage The Caves icon.pngThe Caves The CatacombsStage The Catacombs icon.pngThe Catacombs Flooded CavesStage Flooded Caves icon.pngFlooded Caves
The Caves The Catacombs Added in Afterbirth Flooded Caves

Chapter 3

The DepthsStage The Depths icon.pngThe Depths NecropolisStage Necropolis icon.pngNecropolis Dank DepthsStage Dank Depths icon.pngDank Depths
The Depths Necropolis Added in Afterbirth Dank Depths

Chapter 4

The WombStage The Womb icon.pngThe Womb UteroStage Utero icon.pngUtero Scarred WombStage Scarred Womb icon.pngScarred Womb
The Womb Utero Added in Afterbirth Scarred Womb

Chapter 4.5 (Optional)

???Stage Blue Womb icon.png???
Added in Afterbirth ???


Chapter 5

CathedralStage Cathedral icon.pngCathedral SheolStage Sheol icon.pngSheol
Cathedral Sheol

Chapter 6

The ChestStage The Chest icon.pngThe Chest Dark RoomStage Dark Room icon.pngDark Room
The Chest Dark Room

Endgame (Optional)

The VoidStage The Void icon.pngThe Void
Added in Afterbirth † The Void


SmallIsaac.pngChaptersSmallIsaac.png
Chapter 1 Chapter 2 Chapter 3 Chapter 4 Optional Chapter 5 Chapter 6 Endgame
Normal mode only
Hard mode only
Stage The Basement icon.png Stage The Caves icon.png Stage The Depths icon.png Stage The Womb icon.png Stage Sheol icon.png
Sheol


Stage Cathedral icon.png
Cathedral
Stage Dark Room icon.png
Dark Room


Stage The Chest icon.png
The Chest
The Basement The Caves The Depths The Womb
Added in Afterbirth Added in Afterbirth †
Stage The Cellar icon.png Stage The Catacombs icon.png Stage Necropolis icon.png Stage Utero icon.png ??? Stage The Void icon.png
The Cellar The Catacombs Necropolis Utero ??? The Void
Added in Afterbirth Added in Afterbirth Added in Afterbirth Added in Afterbirth
Stage Burning Basement icon.png Stage Flooded Caves icon.png Stage Dank Depths icon.png Stage Scarred Womb icon.png
Burning Basement Flooded Caves Dank Depths Scarred Womb
Added in Afterbirth Greed mode only
Added in Afterbirth † Greedier mode only
Added in Afterbirth Added in Afterbirth
Stage The Basement icon.png Stage The Caves icon.png Stage The Depths icon.png Stage The Womb icon.png Stage Sheol icon.png The Shop Ultra Greed
The Basement The Caves The Depths The Womb Sheol The Shop Ultra Greed
The Binding of Isaac: Rebirth The Binding of Isaac: Rebirth The Binding of Isaac: Rebirth
Achievements Achievements Attributes Attributes Bosses Bosses TarotCard.png Cards and Runes Challenges Challenges Chapters Chapters
Characters Characters MainPageBabies.png Co-op Items Items Item Pools Item Pools Monsters Monsters Objects Objects
Pickups Pickups Pills Pills Rooms Rooms Seeds Seeds Transformations Transformations Trinkets Trinkets