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Chapter 3 (Bosses)

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Bosses
Chapter 1 Chapter 2 Chapter 3 Chapter 4 Added in Afterbirth  Blue Womb Chapter 5 Chapter 6 Added in Afterbirth †  The Void
Universal Devil and Angel Room Seven Deadly Sins Added in Afterbirth  Greed Mode All Mini-Bosses All Bosses

The Depths[edit | edit source]

Boss The Adversary.png
Boss The Cage.png
Boss The Gate.png
Boss Loki.png
The Adversary The Cage The Gate Loki
Boss Monstro II.png
Boss The Fallen.png
Boss Gish.png
Boss The Headless Horseman.png
Monstro II The Fallen Requires previous entry into a devil room Gish Needs to be unlocked The Headless Horseman Needs to be unlocked
Boss War.png
Boss Brownie.png
Boss Sisters Vis.png
War Needs to be unlocked Brownie Added in Afterbirth Needs to be unlocked Sisters Vis Added in Afterbirth † Needs to be unlocked

Double Trouble[edit | edit source]

Double Trouble Bosses
Boss Chub.png
Boss Gurdy Jr..png
The Haunt
(Double Trouble)
Chub 		(Double Trouble)
Gurdy Jr. 		(Double Trouble)
The Haunt
Boss The Hollow.png
Boss The Husk.png
Boss Larry Jr..png
(Double Trouble)
The Hollow 		(Double Trouble)
The Husk 		(Double Trouble)
Larry Jr.
Boss The Wretched.png
Boss Little Horn.png
Boss Rag Man.png
(Double Trouble)
The Wretched 		(Double Trouble)
Little Horn Added in Afterbirth Needs to be unlocked 		(Double Trouble)
Rag Man Added in Afterbirth Needs to be unlocked

Necropolis[edit | edit source]

Boss The Adversary.png
Boss The Bloat.png
Boss The Gate.png
Boss Loki.png
The Adversary The Bloat The Gate Loki
Boss Mask Of Infamy.png
Boss The Fallen.png
Boss The Headless Horseman.png
Mask of Infamy The Fallen Requires previous entry into a devil room The Headless Horseman Needs to be unlocked
Boss War.png
Boss Brownie.png
Boss Sisters Vis.png
War Needs to be unlocked Brownie Added in Afterbirth Needs to be unlocked Sisters Vis Added in Afterbirth † Needs to be unlocked

Double Trouble[edit | edit source]

Double Trouble Bosses
Boss Blighted Ovum.png
The Haunt
Boss The Husk.png
Boss Larry Jr..png
(Double Trouble)
Blighted Ovum 		(Double Trouble)
The Haunt 		(Double Trouble)
The Husk 		(Double Trouble)
Larry Jr.
Boss Dangle.png
Boss Little Horn.png
Boss Rag Man.png
(Double Trouble)
Dangle Added in Afterbirth Needs to be unlocked 		(Double Trouble)
Little Horn Added in Afterbirth Needs to be unlocked 		(Double Trouble)
Rag Man Added in Afterbirth Needs to be unlocked

Dank Depths Added in Afterbirth[edit | edit source]

Boss The Adversary.png
Boss Loki.png
Boss Monstro II.png
The Adversary Loki Monstro II
Boss The Fallen.png
Boss Gish.png
Boss The Headless Horseman.png
The Fallen Requires previous entry into a devil room Gish Needs to be unlocked The Headless Horseman Needs to be unlocked
Boss War.png
Boss Brownie.png
Boss Sisters Vis.png
War Needs to be unlocked Brownie Added in Afterbirth Needs to be unlocked Sisters Vis Added in Afterbirth † Needs to be unlocked

Double Trouble[edit | edit source]

Double Trouble Bosses
The Haunt
Boss Little Horn.png
(Double Trouble)
The Haunt 		(Double Trouble)
Little Horn Added in Afterbirth Needs to be unlocked

Final Boss[edit | edit source]

Mom will always appear in the second floor of this chapter or in the last boss room if Curse of the Labyrinth is active.

Boss Mom.png
Mom


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