Chapter 4 (Bosses)

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Bosses
Chapter 1 Chapter 2 Chapter 3 Chapter 4 Added in  Afterbirth  Blue Womb Chapter 5 Chapter 6 Added in Afterbirth †  The Void
Universal Devil and Angel Room Seven Deadly Sins Added in  Afterbirth  Greed Mode All Mini-Bosses All Bosses

The Womb[edit | edit source]

Boss Blastocyst.png
Boss The Bloat.png
Boss Daddy Long Legs.png
Boss Lokii.png
Blastocyst The Bloat Daddy Long Legs Lokii
Boss Mama Gurdy.png
Boss Mr. Fred.png
Boss Scolex.png
Boss Teratoma.png
Mama Gurdy Mr. Fred Scolex Teratoma
Boss The Fallen.png
Boss Conquest.png
Boss Death.png
Boss The Headless Horseman.png
The Fallen Requires previous entry into a devil room Conquest Needs to be unlocked Death Needs to be unlocked The Headless Horseman Needs to be unlocked
Boss Triachnid.png
Boss The Matriarch.png
Boss Sisters Vis.png
Triachnid Needs to be unlocked The Matriarch Added in Afterbirth † Needs to be unlocked Sisters Vis Added in Afterbirth † Needs to be unlocked

Double Trouble[edit | edit source]

Double Trouble Bosses
Boss Dingle.png
Boss The Cage.png
Boss The Fallen.png
Boss The Gate.png
(Double Trouble)
Dingle
(Double Trouble)
The Cage
(Double Trouble)
The Fallen
(Double Trouble)
The Gate
Boss Gurdy.png
Boss Dangle.png
Boss Little Horn.png
(Double Trouble)
Gurdy
(Double Trouble)
Dangle Added in  Afterbirth Needs to be unlocked
(Double Trouble)
Little Horn Added in  Afterbirth Needs to be unlocked

Utero[edit | edit source]

Boss Blastocyst.png
Boss The Bloat.png
Boss Daddy Long Legs.png
Boss Lokii.png
Blastocyst The Bloat Daddy Long Legs Lokii
Boss Mama Gurdy.png
Boss Mr. Fred.png
Boss Teratoma.png
Boss The Fallen.png
Mama Gurdy Mr. Fred Teratoma The Fallen Requires previous entry into a devil room
Boss Conquest.png
Boss Death.png
Boss The Headless Horseman.png
Conquest Needs to be unlocked Death Needs to be unlocked The Headless Horseman Needs to be unlocked
Boss Triachnid.png
Boss The Matriarch.png
Boss Sisters Vis.png
Triachnid Needs to be unlocked The Matriarch Added in Afterbirth † Needs to be unlocked Sisters Vis Added in Afterbirth † Needs to be unlocked

Double Trouble[edit | edit source]

Double Trouble Bosses
Boss The Cage.png
Boss The Fallen.png
Boss The Gate.png
(Double Trouble)
The Cage
(Double Trouble)
The Fallen
(Double Trouble)
The Gate
Boss Gurdy.png
Boss Loki.png
Boss Little Horn.png
(Double Trouble)
Gurdy
(Double Trouble)
Loki
(Double Trouble)
Little Horn Added in  Afterbirth Needs to be unlocked

Scarred Womb Added in  Afterbirth[edit | edit source]

Boss Blastocyst.png
Boss The Bloat.png
Boss Daddy Long Legs.png
Boss Mama Gurdy.png
Blastocyst The Bloat Daddy Long Legs Mama Gurdy
Boss Scolex.png
Boss Teratoma.png
Boss The Fallen.png
Scolex Teratoma The Fallen Requires previous entry into a devil room
Boss Conquest.png
Boss Death.png
Boss The Headless Horseman.png
Conquest Needs to be unlocked Death Needs to be unlocked The Headless Horseman Needs to be unlocked
Boss Triachnid.png
Boss The Matriarch.png
Boss Sisters Vis.png
Triachnid Needs to be unlocked The Matriarch Added in Afterbirth † Needs to be unlocked Sisters Vis Added in Afterbirth † Needs to be unlocked

Double Trouble[edit | edit source]

Double Trouble Bosses
Boss Gurdy.png
(Double Trouble)
Gurdy

Final Boss[edit | edit source]

Mom's Heart will always appear in the second floor of this chapter or in the last boss room if Curse of the Labyrinth is active. Once It Lives is unlocked, it will appear instead of Mom's Heart.

Boss Mom's Heart.png
Boss It Lives.png
Mom's Heart It Lives Needs to be unlocked


Bosses Boss Monstro.png
Chapter 1
Stage The Basement icon.pngStage The Cellar icon.pngStage Burning Basement icon.png
Blighted OvumDingleThe Duke of FliesFamineFistulaGeminiGurglingsThe HauntLarry Jr.MonstroPinStevenWidowThe FallenThe Headless Horseman
Added in  Afterbirth DangleLittle HornRag ManTurdlings
Chapter 2
Stage The Caves icon.pngStage The Catacombs icon.pngStage Flooded Caves icon.png
Carrion QueenC.H.A.D.ChubDark OneGurdyGurdy Jr.The HollowThe HuskMega FattyMega MawPeepPestilencePolycephalusThe WretchedThe FallenThe Headless Horseman
Added in  Afterbirth The ForsakenThe FrailThe Stain
Added in Afterbirth † Big HornRag Mega
Chapter 3
Stage The Depths icon.pngStage Necropolis icon.pngStage Dank Depths icon.png
The AdversaryThe BloatThe CageThe GateGishLokiMask Of InfamyMonstro IIWarThe FallenThe Headless HorsemanMom
Added in  Afterbirth Brownie
Added in Afterbirth † Sisters Vis
Chapter 4
Stage The Womb icon.pngStage Utero icon.pngStage Scarred Womb icon.png
BlastocystThe BloatConquestDaddy Long LegsDeathLokiiMama GurdyMr. FredScolexTeratomaTriachnidThe FallenThe Headless HorsemanMom's HeartIt Lives
Added in Afterbirth † Sisters VisThe Matriarch
Added in  Afterbirth Blue Womb
???
Added in  Afterbirth Hush
Chapter 5
Stage Sheol icon.pngStage Cathedral icon.png
SatanIsaac
Chapter 6
Stage Dark Room icon.pngStage The Chest icon.png
???The LambMega Satan
Added in Afterbirth † The Void
Stage The Void icon.png
Added in Afterbirth † Delirium
Added in  Afterbirth Greed Mode
Ultra Greed
Added in  Afterbirth Ultra Greed
Added in Afterbirth † Ultra Greedier
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