Chapters

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Chapters are sets of floors which contain similar enemies, themes, bosses, and difficulties. Earlier chapters are divided into two floors, while later chapters contain one floor. Each chapter has different environments which, while retaining the same feel, have slightly different themes, enemies, bosses, and difficulties. Each environment also has its own music.

Chapter 1

Basement.png Cellar.png Burning Basement.png
The Basement The Cellar Added in Afterbirth Burning Basement

Chapter 2

Caves.png Catacombs.png Flooded Caves.png
The Caves The Catacombs Added in Afterbirth Flooded Caves

Chapter 3

Depths.png Necropolis.png Dank Depths.png
The Depths Necropolis Added in Afterbirth Dank Depths

Chapter 4

Womb.png Utero.png Scarred Womb.png
The Womb Utero Added in Afterbirth Scarred Womb

Chapter 4.5 (Optional)

Blue Womb.png
Added in Afterbirth ??? (Blue Womb)


Chapter 5

Cathedral.png Sheol.png
Cathedral Sheol

Chapter 6

The Chest.png Dark Room.png
The Chest Dark Room

Endgame (Optional)

The Void.png
Added in Afterbirth † The Void
SmallIsaac.pngChaptersSmallIsaac.png
Chapter 1 Chapter 2 Chapter 3 Chapter 4 Optional Chapter 5 Chapter 6 Endgame
Normal mode only
Hard mode only 		Stage basement.png Stage caves.png Stage depths.png Stage womb.png Stage sheol.png
Sheol


Stage cathedral.png
Cathedral 		Stage dark room.png
Dark Room


Stage chest.png
The Chest
The Basement The Caves The Depths The Womb
Added in Afterbirth Added in Afterbirth †
Stage cellar.png Stage catacombs.png Stage necropolis.png Stage utero.png ??? Stage the void.png
The Cellar The Catacombs Necropolis Utero ??? The Void
Added in Afterbirth Added in Afterbirth Added in Afterbirth Added in Afterbirth
Stage burning basement.png Stage flooded caves.png Stage dank depths.png Stage scarred womb.png
Burning Basement Flooded Caves Dank Depths Scarred Womb
Added in Afterbirth Greed mode only
Added in Afterbirth † Greedier mode only 		Added in Afterbirth Added in Afterbirth
Stage basement.png Stage caves.png Stage depths.png Stage womb.png Stage sheol.png The Shop Ultra Greed
The Basement The Caves The Depths The Womb Sheol The Shop Ultra Greed


The Binding of Isaac: Rebirth The Binding of Isaac: Rebirth The Binding of Isaac: Rebirth
Achievements Achievements Attributes Attributes Bosses Bosses TarotCard.png Cards and Runes Challenges Challenges Chapters Chapters
Characters Characters MainPageBabies.png Co-op Items Items Item Pools Item Pools Monsters Monsters Objects Objects
Pickups Pickups Pills Pills Rooms Rooms Seeds Seeds Transformations Transformations Trinkets Trinkets
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