Collection Page (Afterbirth †)

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Collection Page
Removed in Afterbirth
Added in Afterbirth
Added in Afterbirth †
Afterbirth †

The table below is a recreation of what each page looks like when Afterbirth † is installed and all 547 items have been obtained.


(Click images to open the corresponding item page)

Page 1

Collectible The Sad Onion icon.png
The Sad Onion
Increases Tears by 0.7.
Collectible The Inner Eye icon.png
The Inner Eye
Grants triple shot but decreases tears.
Spoon Bender Icon.png
Spoon Bender
Grants Isaac homing tears.
Collectible Cricket's Head icon.png
Cricket's Head
Increases damage by 0.5, and multiplies it by 1.5x.
Collectible My Reflection icon.png
My Reflection
Gives Isaac's tears a boomerang effect, and increases range and shot speed.
Collectible Number One icon.png
Number One
+1.5 tears, -17.62 range
Collectible Blood of the Martyr icon.png
Blood of the Martyr
Increases Damage by 1, and turns Isaac's tears into blood tears.
Collectible Brother Bobby icon.png
Brother Bobby
Follows Isaac around shooting normal tears.
Skatole Icon.png
All types of fly except Boom Fly and Red Boom Fly become passive and slowly move towards Isaac. Does not prevent contact damage.
Collectible Halo of Flies icon.png
Halo of Flies
Spawns two pretty fly familiars that block enemy shots and deal contact damage to enemies.
1up! icon.png
Gives an extra life. Upon death, you will respawn in the previous room with full health and lose the 1up!.
Collectible Magic Mushroom icon.png
Magic Mushroom
Increases most stats, enlarges Isaac, grants a heart container and restores all health.
Collectible The Virus icon.png
The Virus
Inflicts poison to enemies who make contact with Isaac. Speed down.
Collectible Roid Rage icon.png
Roid Rage
Increases speed by 0.6, range by 5.25, and tear height by 0.5.
Collectible Less Than Three icon.png
Grants Isaac one red heart container and fully restores Isaac's health.
Collectible Raw Liver icon.png
Raw Liver
Grants 2 Heart Containers and completely restores health.
Skeleton Key Icon.png
Skeleton Key
Sets your key count to the maximum of 99.
Collectible A Dollar icon.png
A Dollar
Gives Isaac 99 coins. Can be found multiple times in a single playthrough.
Collectible Boom! icon.png
Grants 10 bombs.
Collectible Transcendence icon.png
Grants flight.
The Compass Icon.png
The Compass
Reveals all special rooms (except secret rooms of any kind).
Collectible Lunch icon.png
Adds 1 heart container.
Collectible Dinner icon.png
Adds 1 heart container.
Collectible Dessert icon.png
Grants Isaac one full red heart container.
Collectible Breakfast icon.png
Grants Isaac one full red heart container.
Collectible Rotten Meat icon.png
Rotten Meat
Adds one heart container.
Collectible Wooden Spoon icon.png
Wooden Spoon
Increases speed by 0.3.
The Belt Icon.png
The Belt
Increases speed by 0.3.
Collectible Mom's Underwear icon.png
Mom's Underwear
Increases range.
Collectible Mom's Heels icon.png
Mom's Heels
Increases range.
Collectible Mom's Lipstick icon.png
Mom's Lipstick
Increases range and shot height.
Collectible Wire Coat Hanger icon.png
Wire Coat Hanger
Increases Tears by 0.7.
The Bible Icon.png
The Bible
Upon activation, Isaac gains flight, allowing him to pass over all obstacles in the current room. Instantly kills Mom, Mom's Heart, and It Lives when activated, but will kill Isaac when activated while fighting Satan.
The Book of Belial Icon.png
The Book of Belial
Upon use increases damage by 2 for the current room and by a further +50% if the character also has the Blood of the Martyr.
Removed in Afterbirth Guarantees a Devil Room or Angel Room will be open after beating a boss while holding it, or Added in Afterbirth increases the chance by 12.5%.
Collectible The Necronomicon icon.png
The Necronomicon
Damages all enemies in the room significantly.
Collectible The Poop icon.png
The Poop
Spawns a pile of poop where the character is standing and knocks nearby monsters back. May yield pickups like regular poop.
Collectible Mr. Boom icon.png
Mr. Boom
Drops a large bomb.
Tammy's Head Icon.png
Tammy's Head
Shoots 10 tears in a circle around Isaac, which retain the damage, shot speed, and special effects (such as poison) of Isaac's tears.
Collectible Mom's Bra icon.png
Mom's Bra
Upon use, petrifies all enemies in the current room for approximately 4 seconds.
Collectible Kamikaze! icon.png
Creates an explosion in the same area as Isaac, dealing half a heart of damage to him and also damaging all enemies caught in the blast radius.
Collectible Mom's Pad icon.png
Mom's Pad
Upon use, inflicts fear to all enemies in the room for 5 seconds.
Collectible Bob's Rotten Head icon.png
Bob's Rotten Head
Upon use, Isaac holds a poison bomb which can be thrown towards any of the four cardinal points and explodes on impact.
Teleport Icon.png
Teleports you to a random room on the level.
Collectible Yum Heart icon.png
Yum Heart
Restores 1 whole red heart.
Collectible Lucky Foot icon.png
Lucky Foot
+1 Luck. Increases chance of winning Shell Game Beggar. (Independent of luck stat)
Collectible Doctor's Remote icon.png
Doctor's Remote
Sets a big red target on the ground (similar to the Epic Fetus item) which can be controlled with tear controls. After 6 seconds or by pressing space again, a huge explosive missile hits it, which damages all enemies caught in its blast radius.
Collectible Cupid's Arrow icon.png
Cupid's Arrow
Grants Isaac piercing tears that travel through enemies (but not obstacles) instead of breaking on impact with them.
Shoop Da Whoop! Icon.png
Shoop Da Whoop!
Fires a laser from Isaac's mouth.
Steven Icon.png
Increases Damage by 1.
Collectible Pentagram icon.png
Increases damage and increases the chance for a Devil or Angel Room to appear.
Collectible Dr. Fetus icon.png
Dr. Fetus
Tears are replaced by bombs that benefit from bomb-enhancing effects and slide for a fixed time after being fired.
Collectible Magneto icon.png
Pulls pickups towards Isaac.
Collectible Treasure Map icon.png
Treasure Map
Reveals all rooms for every floor. However, it does not reveal icons or secret rooms.
Collectible Mom's Eye icon.png
Mom's Eye
Allows Isaac to fire tears from the back of his head.
Lemon Mishap Icon.png
Lemon Mishap
Creates a small yellow pool of creep, which damages enemies that cross it.
Collectible Distant Admiration icon.png
Distant Admiration
A red attack fly circles further out than the Halo of Flies / Pretty Flies, but closer than Forever Alone. Deals more damage than Forever Alone.
Collectible Book of Shadows icon.png
Book of Shadows
Upon use, creates a protective shield nullifying all types of damage for 10 seconds.
Collectible The Ladder icon.png
The Ladder
Allows Isaac to walk across gaps one square across by automatically placing a ladder between the two walkable sections.
Collectible Charm of the Vampire icon.png
Charm of the Vampire
Heals the character for half of a red heart for every 13 monsters killed.
The Battery Icon.png
The Battery
Activated Items can be "overcharged" to allow for an additional use.
Steam Sale Icon.png
Steam Sale
Reduces all Shop prices by 50%, rounded down to 7 coins for an item, rounded up to 2-3 coins for a pickup.
Collectible Anarchist Cookbook icon.png
Anarchist Cookbook
Spawns six troll bombs around the room.
Collectible The Hourglass icon.png
The Hourglass
Upon activation, enemies and their projectiles are slowed down for a short duration.
Sister Maggy Icon.png
Sister Maggy
A familiar that follows Isaac around shooting blood tears.
Technology Icon.png
Replaces tears with a piercing laser with unlimited range.
Collectible Chocolate Milk icon.png
Chocolate Milk
Grants charged tears that deal greater damage when fully charged.
Collectible Growth Hormones icon.png
Growth Hormones
Increases damage by 1 and speed by 0.4.
Collectible Mini Mush icon.png
Mini Mush
Increases Speed and Shot Height and decreases Isaac's size, but lowers Range.
Collectible Rosary icon.png
Adds 3 Soul Hearts and increases the chance for The Bible to appear in any item pool.
Collectible Cube of Meat icon.png
Cube of Meat
Orbiting familiar that blocks enemy shots and deals damage to enemies. If collected while already having one, makes the familiar evolve. Only drops from Horsemen. Similar to Ball of Bandages.
Collectible A Quarter icon.png
A Quarter
Adds 25 to Isaac's coin count, capping at 99.
Collectible PHD icon.png
Converts all bad pills into good pills, spawns one pill pickup and restores health. Identifies all pills upon pickup.
Collectible X-Ray Vision icon.png
X-Ray Vision
Reveals and opens all Secret Room and Super Secret Room entrances.
Collectible My Little Unicorn icon.png
My Little Unicorn
Upon use, grants invulnerability and increased speed for five seconds, removing the ability to shoot tears and replacing it with the ability to deal contact damage to enemies.
Collectible Book of Revelations icon.png
Book of Revelations
Adds 1 soul heart, increases the chance for a Devil or Angel Room to appear, and increases the chance for the next boss to be a Horseman (except on XL floors and floors with fixed bosses such as Mom).
Collectible The Mark icon.png
The Mark
Increases Damage and Speed, plus adds one Soul Heart.
Collectible The Pact icon.png
The Pact
Increases damage by 0.5, tears by 0.7 and grants two soul hearts upon pickup.
Collectible Dead Cat icon.png
Dead Cat
Sets the amount of red heart containers to 1, but gives Isaac 9 extra lives. After dying, Isaac is teleported to the last safe room. New heart containers can be obtained after picking up this item, but after each death, the number of heart containers is set to 1 again.
Collectible Lord of the Pit icon.png
Lord of the Pit
Grants flight and increases speed.
Collectible The Nail icon.png
The Nail
Adds one soul heart and allows the breaking of rocks and damaging enemies by simply walking over them. Increases damage and decreases speed. All effects except for the Soul Heart wear off upon leaving the room.
Collectible We Need to Go Deeper! icon.png
We Need to Go Deeper!
Creates a trapdoor to go to the next floor. If used in The Womb The Womb, it will create a trapdoor to Sheol Sheol, even if the player hasn't unlocked it.
Collectible Deck of Cards icon.png
Deck of Cards
Gives Isaac a random tarot card.
Collectible Monstro's Tooth icon.png
Monstro's Tooth
Monstro jumps onto a random enemy, doing area damage. Can damage/kill the player if summoned in an room without enemies.
Collectible Loki's Horns icon.png
Loki's Horns
Gives a random chance for projectiles to fire in all 4 cardinal directions.
Collectible Little Chubby icon.png
Little Chubby
A familiar that charges forward and deals touch damage to any enemies in its path.
Spider Bite Icon.png
Spider Bite
Adds a chance to shoot slowing tears, reducing speed of enemy movement and any projectile fired by them.
Collectible The Small Rock icon.png
The Small Rock
Increases damage by 1, increases tears by 0.2, and decreases speed by 0.1.
Spelunker Hat Icon.png
Spelunker Hat
Reveals type of adjacent rooms, including location for secret rooms and super secret rooms.
Super Bandage Icon.png
Super Bandage
Grants one Heart Container and gives 2 Soul Hearts.
Collectible The Gamekid icon.png
The Gamekid
Upon use, turns the character into a into a Pac-Man-like creature for 5 seconds, granting invulnerability, inflicting fear on all enemies, and replenishing half a red heart container for every two enemies killed.
Collectible Sack of Pennies icon.png
Sack of Pennies
Isaac is followed by a small bag that drops a coin every 2 rooms.
Collectible Robo-Baby icon.png
Follows Isaac around, shooting enemies with an eye laser similar to Technology.
Collectible Little C.H.A.D. icon.png
Little C.H.A.D.
A familiar who will drop a half red heart every 2 rooms.
The Book of Sin Icon.png
The Book of Sin
Spawns a random pickup, pill, card, or trinket.
Collectible The Relic icon.png
The Relic
Isaac is followed by a small blue cross that will drop a Soul Heart every 4 rooms.
Collectible Little Gish icon.png
Little Gish
Spawns a familiar that follows Isaac around and fires slowing tears, impeding enemies' speed.
Collectible Little Steven icon.png
Little Steven
Spawns a familiar that follows Isaac around and fires homing tears.
Collectible The Halo icon.png
The Halo
Grants one Heart Container, +0.3 Damage, +0.2 Tears, +0.25 Range, +0.3 Speed, and +0.5 Tear Height.
Collectible Mom's Bottle of Pills icon.png
Mom's Bottle of Pills
Gives Isaac a random pill, and will cause him to drop any held Q-slot item (If any). The player will only receive six different pill types in one playthrough.
The Common Cold Icon.png
The Common Cold
Adds a chance to shoot poison tears, dealing damage over time when inflicted.
Collectible The Parasite icon.png
The Parasite
Isaac's tears split in two when they hit something.
The D6 Icon.png
The D6
Allows Isaac to re-roll collectible items in the current room into other items, depending on the current room's Item Pool.
Collectible Mr. Mega icon.png
Mr. Mega
Gives Isaac 5 bombs, and makes all dropped bombs larger, which have an increased blast radius and increased damage.
Collectible The Pinking Shears icon.png
The Pinking Shears
Separates Isaac's head and body for the current room. Isaac's head, which now has flight, will be under the player's control, while his body will seek out enemies to attack by contact damage.
Collectible The Wafer icon.png
The Wafer
All sources of damage that would cause more than one half heart of damage are reduced to one half heart instead.
Collectible Money = Power icon.png
Money = Power
Increases damage by 0.04 for every coin Isaac has, up to +3.96 damage at 99 coins.
Collectible Mom's Contacts icon.png
Mom's Contacts
Adds a chance to shoot petrifying tears, which stop enemies in place and prevent them from moving or attacking. Range up.
The Bean Icon.png
The Bean
Isaac releases bad gas, poisoning any enemy in close vicinity.
Collectible Guardian Angel icon.png
Guardian Angel
Spawns an orbital familiar that blocks enemy projectiles, deals contact damage to enemies, and increases the speed of all orbital familiars.
Collectible Demon Baby icon.png
Demon Baby
Follows Isaac and automatically fires at enemies in its reach.
Collectible Mom's Knife icon.png
Mom's Knife
Isaac's tears are replaced by a knife that pierces enemies, can travel through obstacles, and can hurt enemies while Isaac is holding it. Holding down the fire button before firing increases its range and power.
Collectible Ouija Board icon.png
Ouija Board
Grants spectral tears that travel through obstacles (but not enemies) instead of breaking on impact with them.
Collectible 9 Volt icon.png
9 Volt
Reduces the charge of any Activated Items by 1. Any 1 charge items instead have timed recharges.
Collectible Dead Bird icon.png
Dead Bird
Spawns a flying familiar for the current room that chases enemies whenever Isaac takes damage.
Collectible Brimstone icon.png
Tears are replaced by a laser beam that pierces through all enemies and obstacles in its path and deals high damage. Can only be fired after a short charge-up period.
Collectible Blood Bag icon.png
Blood Bag
Grants one red heart container, restores 5 red hearts, and increases speed by 0.3.
Collectible Odd Mushroom (Thin) icon.png
Odd Mushroom
+1.7 tears, +0.3 speed, reduces damage.
Collectible Odd Mushroom (Large) icon.png
Odd Mushroom
Grants an empty heart container. Increases damage, range and shot height while reducing speed.
Collectible Whore of Babylon icon.png
Whore of Babylon
Increases damage and speed whenever Isaac has half a red heart or less (one red heart for Eve), ignoring any soul or black hearts.
Collectible Monster Manual icon.png
Monster Manual
Summons a random familiar for the current room. Can summon familiars not yet unlocked.

Page 2

Collectible Dead Sea Scrolls icon.png
Dead Sea Scrolls
Triggers the effect of a random activated item from a list of possible options (not every activated item is included).
Collectible Bobby-Bomb icon.png
Gives Isaac 5 Bombs, and causes all dropped bombs to home towards the closest enemy.
Collectible Razor Blade icon.png
Razor Blade
Upon use, deals one heart of damage to Isaac and grants +1.2 damage for the current room.
Collectible Forget Me Now icon.png
Forget Me Now
When activated, the level ends and is freshly regenerated with new rooms, monsters, and items. Disappears after use.
Collectible Forever Alone icon.png
Forever Alone
Spawns a blue attack fly that orbits a long distance from Isaac.
Collectible Bucket of Lard icon.png
Bucket of Lard
Grants two empty heart containers and heals Isaac by half a heart, but decreases speed by 0.2.
Collectible A Pony icon.png
A Pony
Passively grants flight and increased speed. Upon use, Isaac charges in the direction the pony is facing, becoming invulnerable during the charge and damaging enemies.
Collectible Bomb Bag icon.png
Bomb Bag
Isaac is followed by a small bag that drops a Bomb, 1+1 Free, or a Troll Bomb every 3 rooms.
Collectible A Lump of Coal icon.png
A Lump of Coal
The more distance tears travel, the more damage they will do.
Collectible Guppy's Paw icon.png
Guppy's Paw
Removes one red heart container in exchange for gaining 3 Soul Hearts.
Collectible Guppy's Tail icon.png
Guppy's Tail
Increases chance of finding gold chests and normal chests, but reduces chance of finding pickups.
Collectible IV Bag icon.png
IV Bag
Upon activation, Isaac loses a half-heart (one whole heart in The Womb onwards) for a random amount of coins, similar to the blood donation machine.
Collectible Best Friend icon.png
Best Friend
Deploys a decoy Isaac that eventually explodes with an increased blast radius.
Remote Detonator Icon.png
Remote Detonator
Bombs you place explode only when you use this item. Gives 5 bombs.
Stigmata Icon.png
Increases damage, and adds 1 heart container.
Collectible Mom's Purse icon.png
Mom's Purse
Allows Isaac to hold 1 additional trinket.
Collectible Bob's Curse icon.png
Bob's Curse
Gives 5 bombs and grants all bombs poison effect.
Collectible Pageant Boy icon.png
Pageant Boy
Spawns several coins around Isaac.
Collectible Scapular icon.png
Once per room, when Isaac is reduced to his last half red Heart, the aura around his head temporarily vanishes and he is granted one Soul Heart.
Speed Ball Icon.png
Speed Ball
Increases speed by 0.3 and shot speed by 20%.
Collectible Bum Friend icon.png
Bum Friend
A portable beggar who follows Isaac, picks up coins for himself, and occasionally drops a pickup after collecting a coin. Does not spawn collectibles.
Collectible Guppy's Head icon.png
Guppy's Head
Spawns 2-4 blue flies to damage enemies.
Collectible Prayer Card icon.png
Prayer Card
Grants an eternal heart per use.
Collectible Notched Axe icon.png
Notched Axe
Isaac holds the axe above his head for as long as the spacebar button is held (or until he leaves the room). While holding the axe, Isaac can break any rock he touches, but cannot attack or pick up other items.
Collectible Infestation icon.png
1-3 blue flies randomly spawn every time Isaac gets hit.
Collectible Ipecac icon.png
Replaces tears with explosive and poisoning projectiles fired in an arc from the mouth.
Collectible Tough Love icon.png
Tough Love
Adds a chance to shoot a tooth instead of a tear, which deals greater damage than regular tears.
Collectible The Mulligan icon.png
The Mulligan
Tears have a 1/6 chance of spawning allied blue flies when they hit an enemy.
Technology 2 Icon.png
Technology 2
Decreases damage and replaces right eye tears with a unlimited range, piercing laser which fires continuously.
Collectible Mutant Spider icon.png
Mutant Spider
Grants quadruple shot but decreases tears.
Collectible Chemical Peel icon.png
Chemical Peel
Tears fired from left eye do increased damage.
Collectible The Peeper icon.png
The Peeper
Spawns a familiar that floats slowly around the room on a zig-zag pattern similar to Boom Flies damaging enemies it passes through.
Collectible Habit icon.png
When Isaac is hit, 1 point of an item's charge is filled.
Collectible Bloody Lust icon.png
Bloody Lust
Increases damage as Isaac receives damage. Damage increase stays for the whole floor.
Collectible Crystal Ball icon.png
Crystal Ball
Reveals the map (except the Super Secret Room) and drops a random Tarot Card or soul heart.
Spirit of the Night Icon.png
Spirit of the Night
Grants spectral tears and flight.
Collectible Crack the Sky icon.png
Crack the Sky
Summons multiple beams of light in random locations around the room, dealing a large amount of damage to any enemy that touches them.
Collectible Ankh icon.png
Upon death, the player will respawn as ??? with 3 soul hearts.
Collectible Celtic Cross icon.png
Celtic Cross
Grants a chance to trigger the Book of Shadows effect upon taking damage, creating a shield that nullifies all types of damage for 7 seconds.
Collectible Ghost Baby icon.png
Ghost Baby
Spawns a familiar that follows Isaac around and fires spectral tears.
The Candle Icon.png
The Candle
Throws out a blue flame that can pass over gaps (but not through rocks). The flame damages anything in its path.
Collectible Cat-O-Nine-Tails icon.png
Increases Shot Speed and damage.
Collectible D20 icon.png
Rerolls all pickups in the current room.
Collectible Harlequin Baby icon.png
Harlequin Baby
Spawns a familiar that follows Isaac around and fires two tears at once in a V-pattern.
Collectible Epic Fetus icon.png
Epic Fetus
Isaac's tears are replaced with guided missiles, like those used by the Doctor's Remote.
Collectible Polyphemus icon.png
Makes Isaac shoot one huge tear. Also reduces Tears to minimum. Damage increased . If tear does more damage than an enemy's life, the tear continues to travel with the extra remaining damage.
Collectible Daddy Longlegs icon.png
Daddy Longlegs
Daddy Long Legs' shadow follows Isaac and stomps on enemies.
Spider Butt Icon.png
Spider Butt
Damages all enemies in the room and slows them and their projectiles down.
Collectible Sacrificial Dagger icon.png
Sacrificial Dagger
Dagger orbits Isaac, dealing very high damage.
Collectible Mitre icon.png
Grants a chance of converting any red hearts pickups into soul hearts instead.
Collectible Rainbow Baby icon.png
Rainbow Baby
Spawns a familiar that follows Isaac around and fires tears with random effects.
Collectible Dad's Key icon.png
Dad's Key
Opens all doors in the current room when activated, including doors which require a key to open and entrances to secret rooms. Opens the big doors in the first room of both The Chest and the Dark Room.
Stem Cells Icon.png
Stem Cells
Adds one filled heart container and increases Shot Speed.
Collectible Portable Slot icon.png
Portable Slot
Upon activation, 1 coin will be consumed, and a random pickup may drop, similar to the slot machine.
Collectible Holy Water icon.png
Holy Water
When Isaac receives damage, the bottle breaks and a puddle of blue creep forms, which damages non-flying enemies, similar to Lemon Mishap. The bottle is reformed upon entering a different room.
Collectible Fate icon.png
Grants flight and one eternal heart.
The Black Bean Icon.png
The Black Bean
When taking damage, Isaac farts, causing poison damage to all enemies in range.
Collectible White Pony icon.png
White Pony
Passively grants flight and increased speed. Upon use, Isaac charges in the direction the pony is facing, becoming invulnerable during the charge and damaging enemies while also casting the effect of Crack the Sky.
Collectible Sacred Heart icon.png
Sacred Heart
Increases damage and range while reducing shot speed and grants homing tears. Grants a Heart Container and replenishes all Red Hearts.
Collectible Toothpicks icon.png
+0.7 tears, +16% shot speed.
Collectible Holy Grail icon.png
Holy Grail
Grants flight and one heart container.
Collectible Dead Dove icon.png
Dead Dove
Grants spectral tears and flight.
Collectible Blood Rights icon.png
Blood Rights
Damages all enemies in the room, but deals a heart of damage to Isaac with each use.
Collectible Guppy's Hair Ball icon.png
Guppy's Hair Ball
Loosely follows behind Isaac. Can be swung like a flail by rapidly spinning Isaac in a circle. Grows bigger by killing enemies.
Collectible Abel icon.png
A familiar that mirrors the player's movements and shoots in the opposite direction.
Collectible SMB Super Fan icon.png
SMB Super Fan
Increases all stats.
Collectible Pyro icon.png
Adds 99 bombs.
3 Dollar Bill Icon.png
3 Dollar Bill
Gives Isaac a random tear effect every room.
Removed in Afterbirth The effect given changes upon entering a room.
Added in Afterbirth The effect changes every 3 seconds.
Telepathy for Dummies Icon.png
Telepathy for Dummies
Upon activation, grants homing tears for the current room.
Collectible MEAT! icon.png
Adds a heart container and increases damage.
Collectible Magic 8 Ball icon.png
Magic 8 Ball
Increases Shot Speed, and drops a tarot card when picked up.
Collectible Mom's Coin Purse icon.png
Mom's Coin Purse
Spawns 4 random pills around Isaac.
Squeezy Icon.png
Increases tears by 0.4, and spawns 2 Soul Hearts pickups.
Collectible Jesus Juice icon.png
Jesus Juice
Increases Damage and Range.
Collectible Box icon.png
Spawns 1 of each (non-collectible) item: 1 coin, 1 key, 1 bomb, 1 heart, 1 card, 1 pill, 1 trinket.
Collectible Mom's Key icon.png
Mom's Key
Spawns 2 keys. Generates additional pickups from chests.
Collectible Mom's Eyeshadow icon.png
Mom's Eyeshadow
Tears have a chance to charm enemies.
Collectible Iron Bar icon.png
Iron Bar
Increases damage by 0.3 and adds a chance to shoot concussive tears, causing enemies to walk around randomly.
Collectible Midas' Touch icon.png
Midas' Touch
Enemies that touch you are stunned and turn gold. Any enemy killed while in this state will drop a coin.
Collectible Humbling Bundle icon.png
Humbling Bundle
Gives one extra pickup (1+1 Free version) of Red Hearts, pennies, bombs, and keys. Does not work with blue, black, and half red hearts, nickels, and dimes.
Collectible Fanny Pack icon.png
Fanny Pack
Has a chance to drop a random pickup when Isaac takes damage.
Sharp Plug Icon.png
Sharp Plug
Using an activated item while it's not charged will charge it and Sharp Plug does 2 full heart damage to Isaac.
Collectible Guillotine icon.png
Isaac's head is removed from his body and floats around him. Increases Damage by 1 and grants -1 Tear Delay.
Collectible Ball of Bandages icon.png
Ball of Bandages
Orbiting familiar that deals damage to enemies. If collected while already having one, makes the familiar evolve. Only drops from Horsemen. Similar to Cube of Meat.
Champion Belt Icon.png
Champion Belt
Increases damage, but also increases the chance of champion enemies appearing.
Collectible Butt Bombs icon.png
Butt Bombs
Gives +5 bombs and makes all bombs Butt Bombs that fill the room with gas, damaging and confusing all enemies.
Collectible Gnawed Leaf icon.png
Gnawed Leaf
After standing still and not shooting for a short time, Isaac turns invincible until he moves or shoots.
Spider Baby Icon.png
Spider Baby
When hit, spawns up to 2 blue spiders.
Collectible Guppy's Collar icon.png
Guppy's Collar
Grants Isaac a permanent 50% chance to respawn with 1/2 of a red heart after death.
Collectible Lost Contact icon.png
Lost Contact
Every tear has a small shield which will allow it to block one enemy projectile.
Collectible Anemic icon.png
+5 range. After Isaac is damaged, a trail of red creep will be left behind Isaac until he leaves the current room.
Collectible Goat Head icon.png
Goat Head
A Devil Room / Angel Room Door will always spawn after every boss fight, excluding the first floor and floors after Utero II/Womb II.
Collectible Ceremonial Robes icon.png
Ceremonial Robes
Adds 3 black hearts and increases Damage by 1.
Collectible Mom's Wig icon.png
Mom's Wig
Adds a chance to spawn blue spiders when firing tears. Restores 1 red heart.
Collectible Placenta icon.png
Grants a full heart container, and a chance to regenerate a half-heart of health every minute of gameplay.
Collectible Old Bandage icon.png
Old Bandage
Adds one empty heart container. Whenever Isaac takes damage there's a chance that a Red Heart may drop.
Collectible Sad Bombs icon.png
Sad Bombs
+5 Bombs. Upon exploding, bombs shoot 8 tears off in every direction, similar to Tammy's Head. The tears are affected by any tear modifiers Isaac has on his own tears.
Collectible Rubber Cement icon.png
Rubber Cement
Tears bounce off walls, enemies, and environmental objects.
Collectible Anti-Gravity icon.png
-2 Tear Delay. Tears float in position until firing ceases, after which they will fly off in the direction they were shot in.
Collectible Pyromaniac icon.png
Isaac heals 1 heart instead of taking damage from an explosive source. Adds 5 bombs.
Collectible Cricket's Body icon.png
Cricket's Body
Grants -1 Tear Delay and reduces Range. When tears hit an object or deplete their range, they spawn 4 smaller tears, whose Range and Damage scale with Isaac's.
Collectible Gimpy icon.png
Has a chance of spawning a soul heart or black heart when taking damage. Enemies have a chance to drop a Half Red Heart after being killed.
Collectible Black Lotus icon.png
Black Lotus
Grants the player one red heart container, one soul heart, and one black heart.
Collectible Piggy Bank icon.png
Piggy Bank
Gives 3 pennies on pick-up. Every time Isaac is damaged, he will drop one additional penny.
Collectible Mom's Perfume icon.png
Mom's Perfume
Adds a chance to shoot fear tears and decreases tear delay by 1.
Collectible Monstro's Lung icon.png
Monstro's Lung
Increases damage and grants a charged shot that fires multiple tears in the same fashion as Monstro.
Collectible Abaddon icon.png
Increases damage and speed, removes all red heart containers, grants six black hearts, and adds a chance to shoot fear tears.
Collectible Ball of Tar icon.png
Ball of Tar
Adds a chance to shoot slowing tears and the character leaves a trail of slowing creep behind as he moves, impeding enemies' speed.
Stop Watch Icon.png
Stop Watch
Removed in Afterbirth Automatically inflicts slow to all enemies in every room.
Added in Afterbirth Upon taking damage, inflicts slow to all enemies for the current room.
Collectible Tiny Planet icon.png
Tiny Planet
Range up and makes shot tears revolve around Isaac until they drop.
Collectible Infestation 2 icon.png
Infestation 2
Spawns allied blue spiders from killed enemies.
Collectible E Coli icon.png
E Coli
Gives "Turdy Touch" Effect. Enemies that touch Isaac are changed into poop.
Collectible Death's Touch icon.png
Death's Touch
Increases Damage by 1.5, reduces Tears by 0.3 and increases tear size. Grants piercing tears. Tears are replaced by Death's scythes, which is a cosmetic effect only.
Collectible Key Piece 1 icon.png
Key Piece 1
Combined with Key Piece 2, unlocks the golden gate in the starting room of The Chest and Dark Room to fight Mega Satan.
Collectible Key Piece 2 icon.png
Key Piece 2
Combined with Key Piece 1, unlocks the golden gate in the starting room of The Chest and Dark Room to fight Mega Satan.
Collectible Experimental Treatment icon.png
Experimental Treatment
Randomly increases and decreases some of the character's stats.
Collectible Contract From Below icon.png
Contract From Below
Doubles the number of pickups and chests spawned after clearing a room or performing some other triggering action (such as using a blood donation machine), but reduces the chance for any pickups to spawn at all.
Collectible Infamy icon.png
Chance to block projectiles coming from any direction.
Collectible Trinity Shield icon.png
Trinity Shield
Isaac gains a shield that protects him from enemy shots.
Tech.5 Icon.png
Grants a unlimited range piercing laser with random rate of fire that does not replace tears. The laser might occasionally fire with the effect of a random item or trinket, such as Hook Worm, Spoon Bender or Tiny Planet.

Page 3

20 20 Icon.png
Grants double shot.
Collectible Blue Map icon.png
Blue Map
Shows secret and super secret room locations on the map.
Collectible BFFS! icon.png
Increases the size and damage of familiars.
Collectible Hive Mind icon.png
Hive Mind
Increases the size of blue spiders and blue flies and doubles the amount of damage they deal.
Collectible There's Options icon.png
There's Options
There will be 2 items available to choose from after defeating a boss. Choosing 1 item causes the other to disappear.
Collectible Bogo Bombs icon.png
Bogo Bombs
All standard bomb pickups become 1+1 bomb pickups.
Starter Deck Icon.png
Starter Deck
Isaac can hold 2 cards at once and all pills are replaced by cards.
Collectible Little Baggy icon.png
Little Baggy
Isaac can hold 2 pills at once and all cards are replaced by pills.
Collectible Magic Scab icon.png
Magic Scab
Increases luck and HP by 1.
Collectible Blood Clot icon.png
Blood Clot
Increases damage by 1 and range by 5 for tears fired from the left eye.
Screw Icon.png
+0.5 tears up, +0.2 shot speed up.
Collectible Hot Bombs icon.png
Hot Bombs
Grants 5 bombs. Isaac's bombs leave behind fire that damages enemies upon contact.
Collectible Fire Mind icon.png
Fire Mind
Grants flaming tears that deal burning damage over time. Tears have a chance to explode on impact with an enemy, which creates a fire at the location of the explosion.
Collectible Missing No. icon.png
Missing No.
Randomizes all passive items upon pickup and at the start of each succeeding floor.
Collectible Dark Matter icon.png
Dark Matter
Increases Damage by 1 and adds a chance to shoot fear tears.
Collectible Black Candle icon.png
Black Candle
Prevents curses. Grants one black heart. Increases the chance for a Devil or angel room to appear.
Collectible Proptosis icon.png
Tears start out massive with high damage, and then shrink down and become weaker over a short range.
Collectible Missing Page 2 icon.png
Missing Page 2
Gives 1 black heart. Upon taking damage that reduces Isaac's health to one heart or less, activates The Necronomicon effect, dealing 40 damage to all enemies in the room.
Smart Fly Icon.png
Smart Fly
After Isaac takes damage, this fly will deal continuous touch damage to whatever enemy caused the damage until it is dead. The fly will then systematically attack 1 enemy at a time until the room is cleared.
Collectible Dry Baby icon.png
Dry Baby
Spawns a familiar that follows Isaac around and blocks enemy projectiles. Upon blocking a shot, it has a chance of triggering The Necronomicon effect.
Collectible Juicy Sack icon.png
Juicy Sack
A familiar that follows behind Isaac. It drips a trail of creep, which slows enemies, and spawns 1-2 blue spiders after each room.
Collectible Robo-Baby 2.0 icon.png
Robo-Baby 2.0
Fires lasers at any enemy in its line of sight and moves based on the direction Isaac is firing tears.
Collectible Rotten Baby icon.png
Rotten Baby
A familiar that spawns blue flies.
Collectible Headless Baby icon.png
Headless Baby
Familiar that follows Isaac, leaving blood creep on the ground.
Leech Icon.png
Spawns a friendly familiar leech on the ground that hunts down enemies and heals you for half a heart each time it eats one.
Collectible Mystery Sack icon.png
Mystery Sack
Spawns a familiar that follows Isaac around and has a chance to drop a heart, coin, bomb, or key after clearing a room.
Collectible BBF icon.png
Spawns a familiar that flies around the room in a manner similar to the Boom Fly and explodes on contact with an enemy. Respawns after ten seconds.
Collectible Bob's Brain icon.png
Bob's Brain
Spawns a familiar that charges forward when shooting tears and explodes upon contact with an enemy, damaging and poisoning them. The familiar respawns after a few seconds.
Collectible Best Bud icon.png
Best Bud
When hit, summons a white attack fly similar to Distant Admiration for the current room.
Collectible Lil Brimstone icon.png
Lil Brimstone
A Familiar that shoots a thin Brimstone beam. Must charge like Brimstone before shooting.
Collectible Isaac's Heart icon.png
Isaac's Heart
Isaac himself is now immune to all damage, and a heart familiar appears and follows Isaac. If the heart is hurt, Isaac is hurt.
Collectible Lil Haunt icon.png
Lil Haunt
A familiar that damages enemies by chasing them as well as inducing the fear effect.
Collectible Dark Bum icon.png
Dark Bum
Spawns a familiar that follows Isaac around and collects red hearts. For every one-and-a-half red hearts collected, Dark Bum will generate one soul heart, one hostile Spider or one friendly blue spider.
Collectible Big Fan icon.png
Big Fan
Spawns a large orbital familiar that blocks enemy projectiles and deals slight contact damage to enemies.
Sissy Longlegs Icon.png
Sissy Longlegs
Wanders about the room, occasionally spawning blue spiders.
Collectible Punching Bag icon.png
Punching Bag
Spawns a Mulligan Familiar that will wander the room randomly. Enemies will attack the Mulligan if it's closer.
Collectible How to Jump icon.png
How to Jump
Gives Isaac the ability to jump (over gaps, spikes, etc.).
Collectible D100 icon.png
Upon use, rerolls all passive items on Isaac like the D4, every pedestal item in the room like The D6, and every pickup like the D20.
Collectible D4 icon.png
Rerolls all of Isaac's items.
Collectible D10 icon.png
Rerolls the enemies in a room. Only rerolls enemies that are still alive (does not spawn new enemies).
Collectible Blank Card icon.png
Blank Card
Has the same effect as the card or rune currently held by Isaac.
Collectible Book of Secrets icon.png
Book of Secrets
Upon use, gives the effect of Treasure Map, The Compass, or Blue Map for the duration of the current floor.
Collectible Box of Spiders icon.png
Box of Spiders
Summons 2-4 blue spiders.
Collectible Red Candle icon.png
Red Candle
Throws a persistent flame that deals high damage and diminishes as it damages enemies or blocks shots.
Collectible The Jar icon.png
The Jar
When at full health, up to 4 extra hearts can be stored in the jar.
Collectible Flush! icon.png
Changes all enemies in the room into poop. Does not work on all enemies (Knights and bosses are immune). Instantly kills Dingle, Dangle, and Brownie.
Collectible Satanic Bible icon.png
Satanic Bible
Upon activation, Isaac gains a black heart.
Collectible Head of Krampus icon.png
Head of Krampus
Fires a cross-patterned brimstone shot, just like The Fallen and Krampus shoot.
Collectible Butter Bean icon.png
Butter Bean
Isaac farts and pushes back nearby enemies.
Collectible Magic Fingers icon.png
Magic Fingers
For 1 coin, damages all enemies in the room.
Collectible Converter icon.png
When used, converts two soul hearts into a heart container.
Collectible Pandora's Box icon.png
Pandora's Box
Upon use, spawns certain pickups or items depending on the floor it is used on. Single-use.
Collectible Unicorn Stump icon.png
Unicorn Stump
Upon use, grants invulnerability and increased speed for five seconds, but removes the ability to shoot tears.
Taurus Icon.png
Speed down; gains speed while in a room with enemies until gaining My Little Unicorn effect for a few seconds.
Collectible Aries icon.png
+0.25 Speed. Running into enemies while at a high speed will deal 18 points of damage. Does not prevent contact damage.
Collectible Cancer icon.png
Adds 3 soul hearts. Grants The Wafer effect for the current room upon taking damage.
Collectible Leo icon.png
Allows you to crush rocks when you walk over them.
Collectible Virgo icon.png
Grants a chance to trigger the Book of Shadows effect upon taking damage, creating a shield that nullifies all types of damage for 10 seconds. Also converts "bad pills" into "good pills".
Collectible Libra icon.png
Gives 6 coins, 6 bombs, and 6 keys and balances out all attributes.
Scorpio Icon.png
Grants poison tears, which deal damage over time when inflicted.
Collectible Sagittarius icon.png
Increases speed by +0.2 and grants piercing tears.
Collectible Capricorn icon.png
All stats up.
Collectible Aquarius icon.png
A trail of blue creep is left behind Isaac, which damages enemies.
Collectible Pisces icon.png
-1 Tear Delay, adds knock-back shots and increases tear size.
Collectible Eve's Mascara icon.png
Eve's Mascara
Doubles damage, halves tears stat, and greatly reduces shot speed.
Collectible Judas' Shadow icon.png
Judas' Shadow
Adds an extra life; upon death, it respawns Isaac as Black Judas with only two black hearts.
Collectible Maggy's Bow icon.png
Maggy's Bow
Gives one heart container and doubles the healing provided by red hearts.
Collectible Holy Mantle icon.png
Holy Mantle
Automatically negates first taken damage in every room.
Collectible Thunder Thighs icon.png
Thunder Thighs
Destroys rocks upon contact with Isaac. Adds one heart container and lowers Speed.
Strange Attractor Icon.png
Strange Attractor
Pickups, trinkets, and monsters are magnetically attracted to Isaac's tears.
Collectible Cursed Eye icon.png
Cursed Eye
Grants charged tears that can be fired in a tight burst of four. Getting hit while charging will teleport Isaac into another room.
Collectible Mysterious Liquid icon.png
Mysterious Liquid
Tears leave a small, short lasting pool of creep on impact or when their range is depleted.
Collectible Gemini icon.png
Suture becomes attached to Isaac, and does touch damage to enemies within its attacking range.
Collectible Cain's Other Eye icon.png
Cain's Other Eye
Spawns a familiar that floats slowly around the room on a zig-zag pattern similar to The Peeper and shoots normal tears in the same direction as Isaac.
Collectible Blue Baby's Only Friend icon.png
???'s Only Friend
Summons a big attack fly that can be controlled with the shooting direction-keys.
Collectible Samson's Chains icon.png
Samson's Chains
Pull a chain and ball behind you that will damage enemies on contact and is able to break stones.
Collectible Mongo Baby icon.png
Mongo Baby
Summons a familiar that copies the tears of Isaac's other familiars.
Collectible Isaac's Tears icon.png
Isaac's Tears
Shoots 8 tears around Isaac, which retain the damage, shot speed, and special effects of his tears. Each tear shot by Isaac increases item charge by one.
Collectible Undefined icon.png
Teleports Isaac to either the Secret Room, Super Secret Room, Treasure Room, or I AM ERROR.
Collectible Scissors icon.png
Upon use, turns Isaac's head into a stationary familiar for the current room which fires normal tears that deal 3.5 damage.
Collectible Breath of Life icon.png
Breath of Life
Grants a brief moment of invincibility when the charge bar hits zero. If spacebar is held for an additional second after hitting zero, Isaac will take damage.
Collectible The Polaroid icon.png
The Polaroid
If the character has half a red heart or no red hearts after taking damage, it triggers the Book of Shadows effect, creating a shield that nullifies all types of damage for 5 seconds. Also allows entrance into The Chest.
Collectible The Negative icon.png
The Negative
If the character has half a red heart or no red hearts after taking damage, it triggers The Necronomicon effect, damaging all enemies in the room. Also allows entrance into the Dark Room.
Collectible The Ludovico Technique icon.png
The Ludovico Technique
Instead of firing tears, Isaac controls one floating tear that hover over obstacles. This tear deals constant damage when held in place over an enemy.
Soy Milk Icon.png
Soy Milk
Tears shrink and do much less damage, but fire in very rapid succession.
Collectible Godhead icon.png
Increases damage and range while reducing tears and shot speed. Grants homing tears and tears gain a damaging halo.
Collectible Lazarus' Rags icon.png
Lazarus' Rags
Upon dying, resurrect as Revived Lazarus with one heart container and Anemic item.
Collectible The Mind icon.png
The Mind
Grants the combined effects of the Blue Map, Treasure Map, and The Compass, revealing the floor layout and all special rooms, including Secret Rooms and Super Secret Rooms.
The Body Icon.png
The Body
Adds 3 heart containers.
Collectible The Soul icon.png
The Soul
Grants two soul hearts. Isaac now repels enemy projectiles.
Collectible Dead Onion icon.png
Dead Onion
Grants piercing and spectral tears. Increases tear size (without increasing damage) while greatly reducing range and shot speed.
Collectible Broken Watch icon.png
Broken Watch
Chance upon entering a room to slow down or speed up every enemy and their attacks. The chance to slow enemies is quite higher than the chance to speed them up.
The Boomerang Icon.png
The Boomerang
Throws a short-range boomerang which does a bit of damage and has a high chance to stun the enemy for 2 seconds. Can also be used to grab pickups.
Collectible Safety Pin icon.png
Safety Pin
Increases range and shot speed, while adding 1 Black Heart.
Collectible Caffeine Pill icon.png
Caffeine Pill
Increases speed and reduces character size. Also gives a random pill.
Collectible Torn Photo icon.png
Torn Photo
Tears + Shot speed up.
Collectible Blue Cap icon.png
Blue Cap
Grants 1 heart container and increases tears, but decreases shot speed.
Collectible Latch Key icon.png
Latch Key
Increases Luck by 1, grants 1 Soul Heart and spawns 2 Keys.
Collectible Match Book icon.png
Match Book
Grants Isaac 1 Black Heart and 3 bombs. Can also give troll bombs.
Synthoil Icon.png
Increases damage by 1, range by 5.25, and tear height by 0.5.
Collectible A Snack icon.png
A Snack
Grants one full red heart container.
Collectible Diplopia icon.png
Duplicates all pickups and item pedestals in the room.
Collectible Placebo icon.png
When used, copies the effect of the pill Isaac is currently holding without consuming it. Does not copy the effects of cards or runes.
Collectible Wooden Nickel icon.png
Wooden Nickel
When used, has a 50% chance to drop one random type of coin (penny, nickel, or dime).
Collectible Toxic Shock icon.png
Toxic Shock
Upon entering a room, poisons all enemies, dealing double Isaac's tear damage. Killing enemies leaves a small, short lasting pool of green creep on the ground.
Collectible Mega Bean icon.png
Mega Bean
When used, the Mega Bean will freeze all enemies in the current room for a couple of seconds, deal 5 damage and poison any enemies near Isaac, and send a wave of spikes that deals 10 damage across the room in the direction Isaac is facing.
Collectible Glass Cannon icon.png
Glass Cannon
When used, reduces Isaac's health to half a heart (including soul and black hearts) and fires one large piercing spectral tear that does a lot of damage. The damage done by Glass Cannon scales with Isaac's damage (at base damage it does 45 damage).
Collectible Bomber Boy icon.png
Bomber Boy
+5 bombs. Isaac's bombs will now explode in a large cross-shaped pattern (roughly 5 bombs explosions wide). This also affects player-spawned troll bombs.
Collectible Crack Jacks icon.png
Crack Jacks
Adds one heart container and drops a random trinket.
Collectible Mom's Pearls icon.png
Mom's Pearls
+1.25 Range Up. +0.5 Tear Height. +1 Luck Up.
Collectible Car Battery icon.png
Car Battery
Causes Isaac's activated item to activate twice on each use.
Collectible Box of Friends icon.png
Box of Friends
Upon use, duplicates all of Isaac's familiars for the current room.
Collectible The Wiz icon.png
The Wiz
Tears simultaneously fire out of both eyes diagonally, similar to the effect of the R U A Wizard? pill. Isaac's tears also travel above all obstacles.
8 Inch Nails Afterbirth † icon.png
8 Inch Nails
+1.5 Damage Up. Replaces Isaac's tears with nails, which have increased knockback.
Collectible Incubus icon.png
A demonic familiar that follows Isaac and shoots tears identical to Isaac's in terms of damage, range, fire rate, and effects.
Collectible Fate's Reward icon.png
Fate's Reward
A blue head familiar that will follow Isaac and fire tears copying his tear effects and damage.
Collectible Lil Chest icon.png
Lil Chest
Spawns a chest familiar that follows Isaac and drops a random pickup every few rooms.
Sworn Protector Icon.png
Sworn Protector
An orbital angel which does 7 contact damage per tick and blocks enemy shots. Upon blocking 10 shots in a room it drops an eternal heart.
Collectible Friend Zone icon.png
Friend Zone
A white orbiting fly which deals 3 contact damage per tick to enemies. This familiar orbits Isaac at a middle length distance somewhere between Distant Admiration and Forever Alone.
Collectible Lost Fly icon.png
Lost Fly
A familiar fly that moves in a straight line and attaches itself to the first obstacle or wall it comes into contact with in each room. If any enemies walk into its path, it will deal 7 contact damage per tick. If the obstacle it is attached to is destroyed then it will continue rolling in the direction it was previously travelling until it meets another wall or obstacle.

Page 4

Collectible Scatter Bombs icon.png
Scatter Bombs
Adds 5 bombs. Isaac's bombs explode into 2-4 tiny bombs.
Sticky Bombs Icon.png
Sticky Bombs
+5 bombs. Bombs stick to enemies and spawn 2-4 blue spiders if they kill an enemy.
Collectible Epiphora icon.png
Shooting in one direction increases Isaac's rate of fire until the cap is reached. As soon as Isaac changes direction or stops shooting, rate of fire is reset to its normal amount.
Collectible Continuum icon.png
+2.25 Range Up. +1.5 Tear Height. Isaac's tears travel through walls and appear out of the opposite wall. Isaac's tears also travel over rocks and objects.
Collectible Mr. Dolly icon.png
Mr. Dolly
Tears and Range up. Spawns 3 random types of hearts on the floor when picked up.
Collectible Curse of the Tower icon.png
Curse of the Tower
Causes Isaac to spawn 6 troll bombs on the floor every time he gets hit, similar to the Anarchist Cookbook mechanic.
Collectible Charged Baby icon.png
Charged Baby
A familiar that drops a Little Battery every 4 rooms. Has a small chance to freeze all enemies in the room when hit.
Collectible Dead Eye icon.png
Dead Eye
Isaac's damage increases each time an enemy is hit. Damage is reset upon missing a shot.
Collectible Holy Light icon.png
Holy Light
Isaac has a random chance to fire a Holy tear, which, when it hits an enemy, will spawn a Crack the Sky-style light beam on the same enemy, dealing damage.
Collectible Host Hat icon.png
Host Hat
A host familiar that sits on Isaac's head and has a random chance to block enemy shots and retaliate with 3 tears. Grants immunity to explosions.
Collectible Restock icon.png
Causes shops to instantly restock their items when they are bought. Granted by default for every character in Greed Mode.
Collectible Bursting Sack icon.png
Bursting Sack
Spider enemies no longer target or deal contact damage to Isaac.
Collectible No. 2 icon.png
No. 2
Continuously firing tears for several seconds causes Isaac to drop a Butt Bomb. Butt Bombs explode for 60 damage like normal bombs, but also deal 10 damage to all enemies in the room and daze them for a short period of time.
Collectible Pupula Duplex icon.png
Pupula Duplex
Transforms Isaac's tears into a wide arc shape which gives them a much larger hitbox. Gives Isaac spectral tears which allows them to travel through objects in the environment (i.e. rocks).
Collectible Pay to Play icon.png
Pay to Play
This item turns all doors that require a single key into doors which need a coin to enter instead. This affects shops, item rooms and libraries.
Collectible Eden's Blessing icon.png
Eden's Blessing
+0.7 tears up. Grants a random item at the start of the next run.
Collectible Friendly Ball icon.png
Friendly Ball
Throwing the ball at an enemy instantly kills it and captures it. The captured enemy can later be released and will be friendly, fighting for Isaac and persisting between rooms.
Tear Detonator Icon.png
Tear Detonator
When used, will detonate any tears currently on the screen and cause each one to split into 6 more tears which will fire in a circle, similar to Tammy's Head.
Collectible Lil Gurdy icon.png
Lil Gurdy
Gives Isaac a Gurdy familiar that will charge around the room dealing contact damage to enemies. Lil Gurdy is charged by holding down a fire button and letting go. The longer the button is held, the faster Lil Gurdy will fling itself across the screen. Lil Gurdy can pass over objects and obstacles in the room.
Collectible Bumbo icon.png
Spawns a beggar familiar which floats around the room and picks up any nearby coins, leveling up after collecting several coins. At level 2, Bumbo gains a body. At level 3, it begins to fire tears. At level 4, Bumbo chases enemies slowly, dealing contact damage.
Collectible D12 icon.png
Re-rolls all rocks in the current room into other random objects, such as bomb rocks, metal blocks, TNT, or poops.
Collectible Censer icon.png
Gives Isaac a golden censer familiar which creates a huge aura of light that slows down any enemies and enemy shots inside it.
Collectible Key Bum icon.png
Key Bum
Spawns a portable key master that follows Isaac and collects keys, giving random chests in return.
Collectible Rune Bag icon.png
Rune Bag
A bag that follows Isaac and drops a random rune every 3 rooms.
Seraphim Icon.png
An angel familiar which follows Isaac and fires homing tears which deal 10 damage at -25% shot speed and a reduced fire rate.
Collectible Betrayal icon.png
Every time Isaac takes damage, a charm effect is applied to every enemy in the room, causing them to attack each other rather than Isaac.
Collectible Zodiac icon.png
Zodiac will give Isaac a random zodiac item effect that changes after every floor.
Serpent's Kiss Icon.png
Serpent's Kiss
Tears now have a random chance to apply a poison effect, causing 4 or 6 damage per tick to enemies (Similar to The Common Cold item). Isaac now deals poison damage on contact with enemies similar to The Virus item (Damage over time 4 or 6 per tick). Enemies that were poisoned have a chance to drop a black heart when killed.
Collectible Marked icon.png
Isaac will now fire tears automatically directed at a red target on the ground which is controlled by the player. This allows for a full 360 degree tear firing radius. Can be overridden by other tear modifiers such as Mom's Knife or Brimstone.
Tech X Icon.png
Tech X
Tears are replaced with laser rings that pierce through enemies and deal damage to enemies within them. Can be charged to increase the size of the ring.
Collectible Ventricle Razor icon.png
Ventricle Razor
Can be used to place an orange portal and a blue portal. Upon entering a portal, Isaac is teleported to the other portal.
Collectible Tractor Beam icon.png
Tractor Beam
Isaac emits a beam from his face. Isaac's tears travel in the path of the beam.
Collectible God's Flesh icon.png
God's Flesh
Tears now have a random chance to apply a shrinking effect, causing enemies to shrink in size and also run away from Isaac. Shrunk enemies can be crushed and killed by walking over them.
Collectible Maw of the Void icon.png
Maw of the Void
+1.0 Damage Up. After continuously firing tears for 2.5 seconds, a red cross appears on Isaac's head that, upon releasing the fire button, creates a black ring that rapidly deals damage equal to Isaac's tear damage to any enemies in contact with it.
Spear of Destiny Icon.png
Spear of Destiny
In addition to tears, Isaac now holds a spear in front of him which deals damage equal to 2 times his tear damage, and occasionally inflicts fear. The spear cannot be thrown, but deals damage while it is in contact with an enemy.
Collectible Explosivo icon.png
Isaac's tears have a chance to stick to enemies and explode.
Collectible Chaos icon.png
Chaos causes items to be chosen from random item pools. When picked up, drops between 1-6 random pickups on the floor.
Spider Mod Icon.png
Spider Mod
Displays Isaac's tear damage and enemy health bars. Spawns a gray spider familiar that wanders around and inflicts a random status effect on any enemies it comes into contact with. Occasionally spawns a blue spider upon clearing a room.
Collectible Farting Baby icon.png
Farting Baby
A familiar that follows Isaac and blocks tears. If a tear hits Farting Baby, there is a high chance for it to fart, which will either knock back, poison, or charm all nearby enemies.
Collectible GB Bug icon.png
GB Bug
A glitch familiar that bounces around the room and applies a random status effect to any enemies it comes into contact with and has a chance to re-roll pickups that it passes over.
Collectible D8 icon.png
Re-rolls Isaac's speed, range, tears, and damage.
Collectible Purity icon.png
This item will boost one of Isaac's stats depending on the color of the aura around him. The aura will disappear upon taking damage and will reappear with a random color upon entering a new room. A red aura boosts damage, a blue aura boosts rate of fire, a yellow aura boosts speed, and an orange aura boosts range.
Collectible Athame icon.png
Whenever Isaac takes damage, a black ring briefly appears around Isaac, dealing damage to all nearby enemies.
Collectible Empty Vessel icon.png
Empty Vessel
While Isaac has no red hearts, this item grants flight and a random chance to activate an invincibility shield for a few seconds. If Isaac gains any red hearts, these benefits will disappear.
Collectible Evil Eye icon.png
Evil Eye
While firing tears, Isaac has a chance to fire an eye across the screen with a very slow shot speed, which will fire tears of its own in the same direction as Isaac. The eye will be destroyed if it comes into contact with an enemy or obstacle.
Collectible Lusty Blood icon.png
Lusty Blood
Each time Isaac kills an enemy, Isaac's damage increases for the current room.
Collectible Cambion Conception icon.png
Cambion Conception
After taking damage a certain amount of times, a permanent demonic familiar spawns.
Collectible Immaculate Conception icon.png
Immaculate Conception
Upon picking up a certain amount of health, spawn a permanent angelic familiar.
Collectible More Options icon.png
More Options
Two items spawn in every Treasure Room. Only one can be taken; the other will disappear.
Collectible Crown of Light icon.png
Crown of Light
Gives Isaac a crown that glows blue when active, and turns gray when inactive. While Isaac has no empty red heart containers, Isaac's tears are replaced with blue diamond tears that deal double damage. Regardless of health, the crown will deactivate for the current room when Isaac takes damage.
Collectible Deep Pockets icon.png
Deep Pockets
Allows Isaac to carry two cards or pills (or a combination of both) at the same time.
Succubus Icon.png
Spawns a flying familiar that bounces around the room with a black aura, dealing rapid damage to any enemies inside it. While standing in the aura, Isaac gains a 1.5x tear damage multiplier.
Collectible Fruit Cake icon.png
Fruit Cake
Isaac's tears gain a random effect that changes every shot.
Teleport 2.0 Icon.png
Teleport 2.0
When used, teleports Isaac to a random room that has not been explored yet. If all rooms are explored, including secret rooms, it will teleport Isaac to the Devil or Angel room. If all rooms are explored, including the Devil or Angel room, it will teleport Isaac to the I AM ERROR room. If used in a room with enemies, it will teleport Isaac out and back into the exact same room.
Collectible Black Powder icon.png
Black Powder
Isaac leaves a trail of black powder on the floor. Walking in a circle will spawn a pentagram symbol on the floor, which deals 10 damage per tick to any enemies inside it.
Collectible Kidney Bean icon.png
Kidney Bean
Upon use, Isaac farts, charming all nearby enemies.
Collectible Glowing Hour Glass icon.png
Glowing Hour Glass
When used, this item will rewind time, put Isaac back in the previous room, and undo anything that happened in the current room. Any health, pickups, or items gained or lost will be reset back to the previous state.
Collectible Circle of Protection icon.png
Circle of Protection
Surrounds Isaac with a large white halo. Once per second, the halo deals Isaac's tear damage to enemies inside it. It may also convert enemy shots entering the halo into friendly purple homing tears.
Collectible Sack Head icon.png
Sack Head
Greatly increases the chance to find sacks.
Collectible Night Light icon.png
Night Light
A cone of light shines in the direction Isaac is moving that slows enemies and enemy shots.
Collectible Obsessed Fan icon.png
Obsessed Fan
A purple fly familiar that follows Isaac's movements on a 3 second delay and deals contact damage to enemies.
Collectible Mine Crafter icon.png
Mine Crafter
When used, places an explosive TNT barrel that can be pushed and used to destroy rocks or damage enemies. If used a second time in the same room while the previous TNT barrel is still intact, it will remotely explode the TNT.
Collectible PJs icon.png
Grants four soul hearts and fully restores Isaac's red health.
Collectible Head of the Keeper icon.png
Head of the Keeper
Isaac's tears become coins and now have a chance to drop pennies on the floor upon successfully hitting an enemy.
Collectible Papa Fly icon.png
Papa Fly
A blue fly familiar follows Isaac's movements on a 3 second delay. Papa Fly will fire tears at nearby enemies.
Collectible Multidimensional Baby icon.png
Multidimensional Baby
Spawns a familiar that will follow Isaac's movements on a 2.5 second delay. Tears that pass through the baby will be doubled and increase in speed.
Collectible Glitter Bombs icon.png
Glitter Bombs
Gives Isaac 5 bombs, and makes Isaac's bombs have a chance to drop random pickups or charm enemies when they explode.
Collectible My Shadow icon.png
My Shadow
Each time Isaac takes damage, inflicts fear on all enemies in the room and spawns a black friendly Charger that will attack enemies. The Charger will be killed if it is damaged too much.
Collectible Jar of Flies icon.png
Jar of Flies
Every time Isaac kills an enemy, a fly will be added to the jar, up to a maximum of 20. Using the Jar of Flies will release all the flies that are currently in the jar as friendly blue flies that will damage enemies.
Collectible Lil' Loki icon.png
Lil' Loki
A Loki familiar that follows Isaac and shoots 4 tears in a cross pattern.
Collectible Milk! icon.png
A glass of milk follows Isaac and spills on the floor upon taking damage. After the milk spills, Isaac's tear delay is decreased by 2 for the rest of the room.
Collectible D7 icon.png
Restarts the current room and brings back all enemies, allowing more rewards to be acquired by completing the room.
Collectible Binky icon.png
Tears up, adds 1 soul heart, and decreases Isaac's size.
Collectible Mom's Box icon.png
Mom's Box
When used, Mom's Box will drop a random trinket on the ground. While held, increases luck by 1 and doubles the effects of trinkets.
Collectible Kidney Stone icon.png
Kidney Stone
Randomly while firing tears, Isaac will stop firing and turn red, where he will charge and release a lot of 'tears' in one go. In the burst of tears is a kidney stone which deals a lot of damage.
Collectible Mega Blast icon.png
Mega Blast
Upon use, Isaac fires a laser similar to the one used by Mega Satan. This laser deals massive damage, lasts for approximately 15 seconds, and persists between rooms. Isaac is pushed backwards by the force of the laser while it is active.
Collectible Dark Prince's Crown icon.png
Dark Prince's Crown
Increases range, tears, and shot speed when at exactly one red heart.
Collectible Apple! icon.png
Increases tears. Adds a chance to fire a high-damage razor blade.
Collectible Lead Pencil icon.png
Lead Pencil
After every 15 tears fired, Isaac will fire a high-damage cluster of tears.
Collectible Dog Tooth icon.png
Dog Tooth
Increases damage and speed. Upon entering a room adjacent to a secret room, a howl sound effect will play.
Collectible Dead Tooth icon.png
Dead Tooth
While firing, Isaac gains a green aura that poisons nearby enemies.
Collectible Linger Bean icon.png
Linger Bean
Adds a chance to fire a gas cloud that damages nearby enemies.
Shard of Glass Icon.png
Shard of Glass
Upon taking damage, Isaac has a chance to drop a full red heart, gain 5 range, and leave a trail of damaging red creep for the current room.
Collectible Metal Plate icon.png
Metal Plate
Adds a chance to reflect enemy shots. Grants one soul heart.
Collectible Eye of Greed icon.png
Eye of Greed
Adds a chance to fire tears that temporarily stun enemies and turn them into gold. Any enemy killed while in this state will drop coins.
Tarot Cloth Icon.png
Tarot Cloth
Drops a random card or rune. Doubles the effects of cards and runes.
Collectible Varicose Veins icon.png
Varicose Veins
Taking damage releases a ring of 10 high damage tears.
Collectible Compound Fracture icon.png
Compound Fracture
Increases range. Tears turn into bones, which shatter into 1-3 bone shards upon hitting an enemy or obstacle.
Collectible Polydactyly icon.png
Allows Isaac to carry two cards, pills, or any combination of both at the same time. Drops a random card or pill.
Collectible Dad's Lost Coin icon.png
Dad's Lost Coin
Increases range by 1.5. Drops a lucky penny.
Collectible Moldy Bread icon.png
Moldy Bread
Grants one full red heart container.
Collectible Cone Head icon.png
Cone Head
Grants a soul heart. Adds a chance to block enemy shots.
Collectible Belly Button icon.png
Belly Button
Drops a random trinket. Grants a second trinket slot.
Sinus Infection Icon.png
Sinus Infection
Adds a chance to fire a booger which sticks to enemies and poisons them.
Collectible Glaucoma icon.png
Adds a chance to shoot concussive tears, causing enemies to walk around randomly.
Collectible Parasitoid icon.png
Adds a chance to fire an egg sack which spawns slowing creep and spawns a blue fly or spider upon hitting an enemy.
Collectible Eye of Belial icon.png
Eye of Belial
Grants piercing tears. After piercing one enemy, tears start homing and deal double damage.
Sulfuric Acid Icon.png
Sulfuric Acid
Increases damage. Adds a chance to fire acidic tears which can destroy obstacles.
Collectible Glyph of Balance icon.png
Glyph of Balance
Grants 2 soul hearts and modifies drops from Champion Monsters based on certain conditions.
Trinket Analog Stick icon.png
Analog Stick
+0.3 tears up. Allows Isaac to fire tears diagonally.
Collectible Contagion icon.png
The first enemy killed in a room explodes and poisons nearby enemies. Poisoned enemies will also explode upon death.
Collectible Finger! icon.png
Spawns a finger familiar that points at enemies, dealing constant damage.
Shade Icon.png
Spawns a shadow familiar that follows Isaac's movements on a 1 second delay and deals contact damage to enemies.
Collectible Depression icon.png
Spawns a cloud familiar that leaves a trail of tears that damages enemies. Has a chance to spawn damaging beams of light onto enemies that touch the cloud.
Hushy Icon.png
Spawns a Hush familiar that bounces around the room and deals contact damage. While firing tears, it stops moving.
Collectible Lil Monstro icon.png
Lil Monstro
Spawns a familiar that fires clusters of tears. Must be charged before shooting.
Collectible King Baby icon.png
King Baby
Spawns a familiar that follows Isaac and makes other familiars follow it. While firing tears, it stops moving.
Collectible Big Chubby icon.png
Big Chubby
Spawns a familiar that slowly charges forward and damages enemies in its path.
Trinket Tonsil icon.png
Grants a familiar that can block enemy shots.
Collectible Plan C icon.png
Plan C
Kills all enemies in the room, then kills Isaac three seconds later.
Collectible D1 icon.png
Duplicates a random pickup in the room.
Collectible Void icon.png
Consumes all pedestal items in the room. Active items will have their effects added to Void, and passive items will grant stat upgrades.
Collectible Pause icon.png
Freezes all enemies until a fire button is pressed.
Smelter Icon.png
Consumes Isaac's currently held trinket and applies its effect permanently.
Collectible Compost icon.png
Spawns a blue spider or fly. Turns pickups in the room into blue spiders or flies.
Collectible Dataminer icon.png
Displaces enemy sprites for the current room, randomly increases one stat and decreases another.
Collectible Clicker icon.png
Transforms Isaac into another random character.
Collectible Mama Mega! icon.png
Mama Mega!
Damages all enemies and destroys all obstacles. The effect occurs every time a new room is entered for the rest of the floor. Opens doors to the floor's secret and super secret rooms.
Collectible Wait What icon.png
Wait What?
Isaac farts, sending out rock waves.
Collectible Crooked Penny icon.png
Crooked Penny
Spawns a penny and has a 50% chance to double all items and pickups in the room. If the effect fails, the items and pickups disappear.

Page 5

Collectible Dull Razor icon.png
Dull Razor
Hurts Isaac without depleting health, activating any items that trigger upon taking damage.
Collectible Potato Peeler icon.png
Potato Peeler
Removes a heart container, increases damage and range, and grants a Cube of Meat.
Collectible Metronome icon.png
Grants a random item effect for the current room.
Collectible D Infinity icon.png
D Infinity
Grants a random dice item that changes each use.
Collectible Eden's Soul icon.png
Eden's Soul
Spawns two item pedestals.
Collectible Acid Baby icon.png
Acid Baby
Spawns a familiar that drops random pills every 2 rooms cleared. Upon using a pill, all enemies in the room are poisoned.
YO LISTEN! Icon.png
+1 luck. Spawns a fairy familiar that points out secret room entrances and tinted rocks.
Collectible Adrenaline icon.png
Increases damage based on how many empty heart containers Isaac has.
Collectible Jacob's Ladder icon.png
Jacob's Ladder
Tears fire sparks of electricity in random directions upon hitting an obstacle or enemy.
Collectible Ghost Pepper icon.png
Ghost Pepper
Adds a chance to shoot a fire that damages enemies and remains in place until it deals enough damage or the room is left.
Collectible Euthanasia icon.png
Adds a chance to fire needles. If a needle kills an enemy, it bursts into more needles.
Collectible Camo Undies icon.png
Camo Undies
Isaac becomes camouflaged at the beginning of each room. Enemies will not attack Isaac until he starts firing tears.
Collectible Duality icon.png
Whenever a Devil or Angel Room would spawn after defeating a boss, both rooms spawn. Only one can be entered.
Collectible Eucharist icon.png
An Angel Room door will always spawn after every boss fight, excluding the first floor and floors after Utero II/Womb II.
Collectible Sack of Sacks icon.png
Sack of Sacks
Spawns a sack familiar that has a chance to drop a sack upon clearing a room.
Collectible Greed's Gullet icon.png
Greed's Gullet
Grants a heart container for every 25 coins Isaac has.
Collectible Large Zit icon.png
Large Zit
Adds a chance to fire a creep shot that deals double damage and leaves a trail of slowing white creep.
Collectible Little Horn icon.png
Little Horn
Adds a chance to fire a piercing tear that instantly kills any enemy that it touches.
Collectible Brown Nugget icon.png
Brown Nugget
Spawns a stationary fly familiar that fires tears at nearby enemies.
Collectible Poke Go icon.png
Poke Go
Upon entering a room with enemies in it, has a chance to spawn a random friendly enemy that persists across rooms.
Collectible Backstabber icon.png
Has a chance to fire tears that inflict bleeding on enemies, causing them to slowly take damage over time.
Sharp Straw Icon.png
Sharp Straw
Damages all enemies in the room.
Collectible Mom's Razor icon.png
Mom's Razor
Spawns an orbiting razor that damages enemies it touches and inflicts bleeding on enemies, causing them to slowly take damage over time.
Bloodshot Eye Icon.png
Bloodshot Eye
Spawns an orbiting eye familiar that fires tears every 2 seconds.
Collectible Delirious icon.png
Spawns a random charmed boss.
Collectible Angry Fly icon.png
Angry Fly
Spawns a fly familiar that orbits around a random enemy and deals 5 damage per tick to enemies it comes in contact with.
Collectible Black Hole icon.png
Black Hole
Throws a black hole on the ground which sucks in and damages enemies.
Collectible Bozo icon.png
Increases damage by a flat 0.1 and grants a soul heart. Enemies can randomly become briefly charmed or feared. Taking damage has a chance to spawn a rainbow poop.
Collectible Broken Modem icon.png
Broken Modem
Enemies, enemy shots, tears, and pickups will briefly freeze in place at random intervals.
Collectible Mystery Gift icon.png
Mystery Gift
Upon use, spawns a random item from the current room's item pool, with a chance to spawn A Lump of Coal or The Poop instead.
Sprinkler Icon.png
Upon use, spawns a sprinkler that rotates and fires tears.
Collectible Fast Bombs icon.png
Fast Bombs
Grants 7 bombs and allows bombs to be placed rapidly.
Collectible Buddy in a Box icon.png
Buddy in a Box
Grants a familiar with a random tear effect. The familiar is randomized at the start of each floor.
Collectible Lil Delirium icon.png
Lil Delirium
Grants a familiar that transforms into another random familiar every 10 seconds.
Collectible Jumper Cables icon.png
Jumper Cables
Grants an active item charge every 15 enemies killed.
Collectible Coupon icon.png
Upon use, makes a random item from a shop, devil deal, or black market free.
Telekinesis Icon.png
Upon use, for the next two seconds, any enemy shots that come near Isaac are held in place. After the charge is depleted, they are fired back as tears.
Collectible Moving Box icon.png
Moving Box
If the box is empty, picks up all items and pickups in a room and stores them. If the box is not empty, places all stored items and pickups in the current room.
Technology Zero Icon.png
Technology Zero
Connects Isaac's tears with electricity that can damage enemies.
Collectible Leprosy icon.png
Upon taking damage, grants a body part as an orbital, which blocks enemy shots and deals 7 damage per tick to enemies it comes in contact with. The orbitals will be destroyed if they take enough damage from enemies or enemy shots.
7 Seals icon.png
7 Seals
Grants a random Harbinger familiar that changes every 10 seconds.
Collectible Mr. ME! icon.png
Mr. ME!
Summons a controllable ghost that can perform various tasks depending on what it targets.
Collectible Angelic Prism icon.png
Angelic Prism
Grants a prism orbital with a large orbital radius. Tears that pass through the prism split into four multi-colored tears.
Collectible Pop! icon.png
Replaces Isaac's tears with eyeballs that can bounce off of each other. The eyeballs are not limited by range, and will instead dissipate when they stop moving or when hitting an enemy or obstacle.
Collectible Death's List icon.png
Death's List
Grants a reward if all enemies in a room are killed in the order they are marked.
Collectible Haemolacria icon.png
Tears are now fired in an arc. Upon hitting the floor, an obstacle, or an enemy, they burst into many smaller tears in all directions. Increases tear delay.
Collectible Lachryphagy icon.png
Isaac's tears decelerate as they travel. Upon stopping or hitting an obstacle, they burst into 8 tears in all directions. Tears can be fired into other tears to feed them, increasing their damage.
Collectible Trisagion icon.png
Tears are replaced with piercing white blasts of light.
Collectible Schoolbag icon.png
Allows Isaac to hold two active items.
Collectible Blanket icon.png
Grants one soul heart. Upon entering a boss room, grants a shield that blocks one hit, then disappears.
Collectible Sacrificial Altar icon.png
Sacrificial Altar
Upon use, sacrifices up to 2 familiars and spawns an item from the Devil Room Pool for each familiar sacrificed.
Collectible Lil Spewer icon.png
Lil Spewer
Spawns a random pill, and grants a small Spewer familiar that charges up and fires different types of creep.
Collectible Marbles icon.png
Spawns 3 random trinkets. Taking damage has a small chance to swallow Isaac's currently held trinket, gaining its effect permanently.
Collectible Mystery Egg icon.png
Mystery Egg
Spawns an egg familiar, which cracks and turns into a random friendly enemy when Isaac is hurt. The egg regenerates upon entering a different room.
Collectible Flat Stone icon.png
Flat Stone
Tears bounce off the floor. Tears that hit an enemy after bouncing deal splash damage to all nearby enemies for 25% of Isaac's tear damage.
Collectible Marrow icon.png
Grants one bone heart and spawns three red heart pickups.
Slipped Rib Icon.png
Slipped Rib
Spawns a bone familiar that circles around Isaac and reflects enemy shots.
Collectible Hallowed Ground icon.png
Hallowed Ground
Spawns a white poop familiar, which turns into a white poop when Isaac is hurt.
Collectible Pointy Rib icon.png
Pointy Rib
Spawns a bone familiar that can be aimed with the fire buttons and does contact damage.
Collectible Book of the Dead icon.png
Book of the Dead
Upon use, spawns a friendly Bony or an orbital bone for each enemy killed in the current room.
Collectible Dad's Ring icon.png
Dad's Ring
Creates a ring of light around Isaac that petrifies enemies in contact.
Collectible Divorce Papers icon.png
Divorce Papers
Spawns a Mysterious Paper, increases tears, and grants a bone heart.
Collectible Jaw Bone icon.png
Jaw Bone
Spawns a familiar that flies the room while firing, dealing a flat 7 damage to enemies that come in contact and retrieving pickups.
Collectible Brittle Bones icon.png
Brittle Bones
Replaces all red hearts with 6 empty bone hearts. Upon losing a bone heart, Isaac fires bones in 8 directions and permanently gains a tears up.
Collectible Broken Shovel 1 icon.png
Broken Shovel
While held, causes multiple Mom's Foots to come down and stomp on Isaac. One of two parts necessary to create Mom's Shovel.
Collectible Broken Shovel 2 icon.png
Broken Shovel
One of two parts necessary to create Mom's Shovel.
Collectible Mom's Shovel icon.png
Mom's Shovel
Spawns a trapdoor that leads to the next floor upon activation. Unlocks The Forgotten when used on a mound of dirt that appears in Dark Room Dark Room.


  • The item order is based on The Binding of Isaac and its expansion up to item 198.

The Binding of Isaac: Rebirth The Binding of Isaac: Rebirth The Binding of Isaac: Rebirth
Achievements Achievements Attributes Attributes Bosses Bosses TarotCard.png Cards and Runes Challenges Challenges Chapters Chapters
Characters Characters MainPageBabies.png Co-op Items Items Item pools Item pools Monsters Monsters Objects Objects
Pickups Pickups Pills Pills Rooms Rooms Seeds Seeds Transformations Transformations Trinkets Trinkets