Collection Page (Rebirth)

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Collection Page
Removed in Afterbirth
Added in Afterbirth
Added in Afterbirth †
Afterbirth †

The table below is a recreation of what each page looks like without any DLC installed and all 341 items have been obtained.

Pages[edit | edit source]

(Click images to open the corresponding item page)

Page 1

Collectible The Sad Onion icon.png
The Sad Onion
Increases Tears by 0.7.
Collectible The Inner Eye icon.png
The Inner Eye
Grants triple shot but decreases tears.
Spoon Bender Icon.png
Spoon Bender
Grants Isaac homing tears.
Collectible Cricket's Head Rebirth icon.png
Cricket's Head
Increases damage by 0.5, and multiplies it by 1.5x.
Collectible My Reflection icon.png
My Reflection
Gives Isaac's tears a boomerang effect, and increases range and shot speed.
Collectible Number One icon.png
Number One
+1.5 tears, -17.62 range
Collectible Blood of the Martyr icon.png
Blood of the Martyr
Increases Damage by 1, and turns Isaac's tears into blood tears.
Collectible Brother Bobby Rebirth icon.png
Brother Bobby
Follows Isaac around shooting normal tears.
Skatole Icon.png
All types of fly except Boom Fly and Red Boom Fly become passive and slowly move towards Isaac. Does not prevent contact damage.
Collectible Halo of Flies icon.png
Halo of Flies
Spawns two pretty fly familiars that block enemy shots and deal contact damage to enemies.
1up! icon.png
Gives an extra life. Upon death, you will respawn in the previous room with full health and lose the 1up!.
Collectible Magic Mushroom icon.png
Magic Mushroom
Increases most stats, enlarges Isaac, grants a heart container and restores all health.
Collectible The Virus icon.png
The Virus
Inflicts poison to enemies who make contact with Isaac. Speed down.
Collectible Roid Rage icon.png
Roid Rage
Increases speed by 0.6, range by 5.25, and tear height by 0.5.
Collectible Less Than Three Rebirth icon.png
Grants Isaac one red heart container and fully restores Isaac's health.
Collectible Raw Liver icon.png
Raw Liver
Grants 2 Heart Containers and completely restores health.
Skeleton Key Rebirth Icon.png
Skeleton Key
Sets your key count to the maximum of 99.
Collectible A Dollar icon.png
A Dollar
Gives Isaac 99 coins. Can be found multiple times in a single playthrough.
Collectible Boom! icon.png
Grants 10 bombs.
Collectible Transcendence icon.png
Grants flight.
The Compass Rebirth Icon.png
The Compass
Reveals all special rooms (except secret rooms of any kind).
Collectible Lunch icon.png
Adds 1 heart container.
Collectible Dinner icon.png
Adds 1 heart container.
Collectible Dessert icon.png
Grants Isaac one full red heart container.
Collectible Breakfast icon.png
Grants Isaac one full red heart container.
Collectible Rotten Meat icon.png
Rotten Meat
Adds one heart container.
Collectible Wooden Spoon icon.png
Wooden Spoon
Increases speed by 0.3.
The Belt Rebirth Icon.png
The Belt
Increases speed by 0.3.
Collectible Mom's Underwear icon.png
Mom's Underwear
Increases range.
Collectible Mom's Heels icon.png
Mom's Heels
Increases range.
Collectible Mom's Lipstick icon.png
Mom's Lipstick
Increases range and shot height.
Collectible Wire Coat Hanger icon.png
Wire Coat Hanger
Increases Tears by 0.7.
The Bible Icon.png
The Bible
Upon activation, Isaac gains flight, allowing him to pass over all obstacles in the current room. Instantly kills Mom, Mom's Heart, and It Lives when activated, but will kill Isaac when activated while fighting Satan.
The Book of Belial Icon.png
The Book of Belial
Upon use increases damage by 2 for the current room and by a further +50% if the character also has the Blood of the Martyr.
Removed in Afterbirth Guarantees a Devil Room or Angel Room will be open after beating a boss while holding it, or Added in Afterbirth increases the chance by 12.5%.
Collectible The Necronomicon icon.png
The Necronomicon
Damages all enemies in the room significantly.
Collectible The Poop icon.png
The Poop
Spawns a pile of poop where the character is standing and knocks nearby monsters back. May yield pickups like regular poop.
Collectible Mr. Boom icon.png
Mr. Boom
Drops a large bomb.
Tammy's Head Icon.png
Tammy's Head
Shoots 10 tears in a circle around Isaac, which retain the damage, shot speed, and special effects (such as poison) of Isaac's tears.
Collectible Mom's Bra icon.png
Mom's Bra
Upon use, petrifies all enemies in the current room for approximately 4 seconds.
Collectible Kamikaze! icon.png
Creates an explosion in the same area as Isaac, dealing half a heart of damage to him and also damaging all enemies caught in the blast radius.
Collectible Mom's Pad icon.png
Mom's Pad
Upon use, inflicts fear to all enemies in the room for 5 seconds.
Collectible Bob's Rotten Head icon.png
Bob's Rotten Head
Upon use, Isaac holds a poison bomb which can be thrown towards any of the four cardinal points and explodes on impact.
Teleport Icon.png
Teleports you to a random room on the level.
Collectible Yum Heart icon.png
Yum Heart
Restores 1 whole red heart.
Collectible Lucky Foot Rebirth icon.png
Lucky Foot
+1 Luck. Increases chance of winning Shell Game Beggar. (Independent of luck stat)
Collectible Doctor's Remote icon.png
Doctor's Remote
Sets a big red target on the ground (similar to the Epic Fetus item) which can be controlled with tear controls. After 6 seconds or by pressing space again, a huge explosive missile hits it, which damages all enemies caught in its blast radius.
Collectible Cupid's Arrow Rebirth icon.png
Cupid's Arrow
Grants Isaac piercing tears that travel through enemies (but not obstacles) instead of breaking on impact with them.
Shoop Da Whoop! Icon.png
Shoop Da Whoop!
Fires a laser from Isaac's mouth.
Steven Icon.png
Increases Damage by 1.
Collectible Pentagram Rebirth icon.png
Increases damage and increases the chance for a Devil or Angel Room to appear.
Collectible Dr. Fetus icon.png
Dr. Fetus
Tears are replaced by bombs that benefit from bomb-enhancing effects and slide for a fixed time after being fired.
Trinket Magneto Rebirth icon.png
Pulls pickups towards Isaac.
Collectible Treasure Map icon.png
Treasure Map
Reveals all rooms for every floor. However, it does not reveal icons or secret rooms.
Collectible Mom's Eye Rebirth icon.png
Mom's Eye
Allows Isaac to fire tears from the back of his head.
Lemon Mishap Icon.png
Lemon Mishap
Creates a small yellow pool of creep, which damages enemies that cross it.
Collectible Distant Admiration Rebirth icon.png
Distant Admiration
A red attack fly circles further out than the Halo of Flies / Pretty Flies, but closer than Forever Alone. Deals more damage than Forever Alone.
Collectible Book of Shadows icon.png
Book of Shadows
Upon use, creates a protective shield nullifying all types of damage for 10 seconds.
Collectible The Ladder icon.png
The Ladder
Allows Isaac to walk across gaps one square across by automatically placing a ladder between the two walkable sections.
Collectible Charm of the Vampire icon.png
Charm of the Vampire
Heals the character for half of a red heart for every 13 monsters killed.
The Battery Icon.png
The Battery
Activated Items can be "overcharged" to allow for an additional use.
Steam Sale Icon.png
Steam Sale
Reduces all Shop prices by 50%, rounded down to 7 coins for an item, rounded up to 2-3 coins for a pickup.
Collectible Anarchist Cookbook icon.png
Anarchist Cookbook
Spawns six troll bombs around the room.
Collectible The Hourglass icon.png
The Hourglass
Upon activation, enemies and their projectiles are slowed down for a short duration.
Sister Maggy Rebirth Icon.png
Sister Maggy
A familiar that follows Isaac around shooting blood tears.
Technology Icon.png
Replaces tears with a piercing laser with unlimited range.
Collectible Chocolate Milk icon.png
Chocolate Milk
Grants charged tears that deal greater damage when fully charged.
Collectible Growth Hormones icon.png
Growth Hormones
Increases damage by 1 and speed by 0.4.
Collectible Mini Mush icon.png
Mini Mush
Increases Speed and Shot Height and decreases Isaac's size, but lowers Range.
Collectible Rosary icon.png
Adds 3 Soul Hearts and increases the chance for The Bible to appear in any item pool.
Collectible Cube of Meat icon.png
Cube of Meat
Orbiting familiar that blocks enemy shots and deals damage to enemies. If collected while already having one, makes the familiar evolve. Only drops from Horsemen. Similar to Ball of Bandages.
Collectible A Quarter icon.png
A Quarter
Adds 25 to Isaac's coin count, capping at 99.
Collectible PHD icon.png
Converts all bad pills into good pills, spawns one pill pickup and restores health. Identifies all pills upon pickup.
Collectible X-Ray Vision icon.png
X-Ray Vision
Reveals and opens all Secret Room and Super Secret Room entrances.
Collectible My Little Unicorn icon.png
My Little Unicorn
Upon use, grants invulnerability and increased speed for five seconds, removing the ability to shoot tears and replacing it with the ability to deal contact damage to enemies.
Collectible Book of Revelations icon.png
Book of Revelations
Adds 1 soul heart, increases the chance for a Devil or Angel Room to appear, and increases the chance for the next boss to be a Horseman (except on XL floors and floors with fixed bosses such as Mom).
Collectible The Mark icon.png
The Mark
Increases Damage and Speed, plus adds one Soul Heart.
Collectible The Pact icon.png
The Pact
Increases damage by 0.5, tears by 0.7 and grants two soul hearts upon pickup.
Collectible Dead Cat icon.png
Dead Cat
Sets the amount of red heart containers to 1, but gives Isaac 9 extra lives. After dying, Isaac is teleported to the last safe room. New heart containers can be obtained after picking up this item, but after each death, the number of heart containers is set to 1 again.
Collectible Lord of the Pit Rebirth icon.png
Lord of the Pit
Grants flight and increases speed.
Collectible The Nail icon.png
The Nail
Adds one soul heart and allows the breaking of rocks and damaging enemies by simply walking over them. Increases damage and decreases speed. All effects except for the Soul Heart wear off upon leaving the room.
Collectible We Need to Go Deeper! Rebirth icon.png
We Need to Go Deeper!
Creates a trapdoor to go to the next floor. If used in The Womb The Womb, it will create a trapdoor to Sheol Sheol, even if the player hasn't unlocked it.
Collectible Deck of Cards icon.png
Deck of Cards
Gives Isaac a random tarot card.
Collectible Monstro's Tooth icon.png
Monstro's Tooth
Monstro jumps onto a random enemy, doing area damage. Can damage/kill the player if summoned in an room without enemies.
Collectible Loki's Horns icon.png
Loki's Horns
Gives a random chance for projectiles to fire in all 4 cardinal directions.
Collectible Little Chubby icon.png
Little Chubby
A familiar that charges forward and deals touch damage to any enemies in its path.
Spider Bite Icon.png
Spider Bite
Adds a chance to shoot slowing tears, reducing speed of enemy movement and any projectile fired by them.
Collectible The Small Rock icon.png
The Small Rock
Increases damage by 1, increases tears by 0.2, and decreases speed by 0.1.
Spelunker Hat Icon.png
Spelunker Hat
Reveals type of adjacent rooms, including location for secret rooms and super secret rooms.
Super Bandage Icon.png
Super Bandage
Grants one Heart Container and gives 2 Soul Hearts.
Collectible The Gamekid icon.png
The Gamekid
Upon use, turns the character into a into a Pac-Man-like creature for 5 seconds, granting invulnerability, inflicting fear on all enemies, and replenishing half a red heart container for every two enemies killed.
Collectible Sack of Pennies icon.png
Sack of Pennies
Isaac is followed by a small bag that drops a coin every 2 rooms.
Collectible Robo-Baby Rebirth icon.png
Follows Isaac around, shooting enemies with an eye laser similar to Technology.
Collectible Little C.H.A.D. icon.png
Little C.H.A.D.
A familiar who will drop a half red heart every 2 rooms.
The Book of Sin Icon.png
The Book of Sin
Spawns a random pickup, pill, card, or trinket.
Collectible The Relic icon.png
The Relic
Isaac is followed by a small blue cross that will drop a Soul Heart every 4 rooms.
Collectible Little Gish icon.png
Little Gish
Spawns a familiar that follows Isaac around and fires slowing tears, impeding enemies' speed.
Collectible Little Steven icon.png
Little Steven
Spawns a familiar that follows Isaac around and fires homing tears.
Collectible The Halo icon.png
The Halo
Grants one Heart Container, +0.3 Damage, +0.2 Tears, +0.25 Range, +0.3 Speed, and +0.5 Tear Height.
Collectible Mom's Bottle of Pills icon.png
Mom's Bottle of Pills
Gives Isaac a random pill, and will cause him to drop any held Q-slot item (If any). The player will only receive six different pill types in one playthrough.
The Common Cold Icon.png
The Common Cold
Adds a chance to shoot poison tears, dealing damage over time when inflicted.

Page 2

Collectible The Parasite icon.png
The Parasite
Isaac's tears split in two when they hit something.
The D6 Icon.png
The D6
Allows Isaac to re-roll collectible items in the current room into other items, depending on the current room's Item Pool.
Collectible Mr. Mega icon.png
Mr. Mega
Gives Isaac 5 bombs, and makes all dropped bombs larger, which have an increased blast radius and increased damage.
Collectible The Pinking Shears icon.png
The Pinking Shears
Separates Isaac's head and body for the current room. Isaac's head, which now has flight, will be under the player's control, while his body will seek out enemies to attack by contact damage.
Collectible The Wafer icon.png
The Wafer
All sources of damage that would cause more than one half heart of damage are reduced to one half heart instead.
Collectible Money = Power Rebirth icon.png
Money = Power
Increases damage by 0.04 for every coin Isaac has, up to +3.96 damage at 99 coins.
Collectible Mom's Contacts Rebirth icon.png
Mom's Contacts
Adds a chance to shoot petrifying tears, which stop enemies in place and prevent them from moving or attacking. Range up.
The Bean Icon.png
The Bean
Isaac releases bad gas, poisoning any enemy in close vicinity.
Collectible Guardian Angel icon.png
Guardian Angel
Spawns an orbital familiar that blocks enemy projectiles, deals contact damage to enemies, and increases the speed of all orbital familiars.
Collectible Demon Baby Rebirth icon.png
Demon Baby
Follows Isaac and automatically fires at enemies in its reach.
Collectible Mom's Knife Rebirth icon.png
Mom's Knife
Isaac's tears are replaced by a knife that pierces enemies, can travel through obstacles, and can hurt enemies while Isaac is holding it. Holding down the fire button before firing increases its range and power.
Collectible Ouija Board icon.png
Ouija Board
Grants spectral tears that travel through obstacles (but not enemies) instead of breaking on impact with them.
Collectible 9 Volt icon.png
9 Volt
Reduces the charge of any Activated Items by 1. Any 1 charge items instead have timed recharges.
Collectible Dead Bird icon.png
Dead Bird
Spawns a flying familiar for the current room that chases enemies whenever Isaac takes damage.
Collectible Brimstone Rebirth icon.png
Tears are replaced by a laser beam that pierces through all enemies and obstacles in its path and deals high damage. Can only be fired after a short charge-up period.
Collectible Blood Bag icon.png
Blood Bag
Grants one red heart container, restores 5 red hearts, and increases speed by 0.3.
Collectible Odd Mushroom (Thin) icon.png
Odd Mushroom
+1.7 tears, +0.3 speed, reduces damage.
Collectible Odd Mushroom (Large) icon.png
Odd Mushroom
Grants an empty heart container. Increases damage, range and shot height while reducing speed.
Collectible Whore of Babylon Rebirth icon.png
Whore of Babylon
Increases damage and speed whenever Isaac has half a red heart or less (one red heart for Eve), ignoring any soul or black hearts.
Collectible Monster Manual icon.png
Monster Manual
Summons a random familiar for the current room. Can summon familiars not yet unlocked.
Collectible Dead Sea Scrolls icon.png
Dead Sea Scrolls
Triggers the effect of a random activated item from a list of possible options (not every activated item is included).
Collectible Bobby-Bomb icon.png
Gives Isaac 5 Bombs, and causes all dropped bombs to home towards the closest enemy.
Collectible Razor Blade icon.png
Razor Blade
Upon use, deals one heart of damage to Isaac and grants +1.2 damage for the current room.
Collectible Forget Me Now icon.png
Forget Me Now
When activated, the level ends and is freshly regenerated with new rooms, monsters, and items. Disappears after use.
Collectible Forever Alone Rebirth icon.png
Forever Alone
Spawns a blue attack fly that orbits a long distance from Isaac.
Collectible Bucket of Lard icon.png
Bucket of Lard
Grants two empty heart containers and heals Isaac by half a heart, but decreases speed by 0.2.
Collectible A Pony icon.png
A Pony
Passively grants flight and increased speed. Upon use, Isaac charges in the direction the pony is facing, becoming invulnerable during the charge and damaging enemies.
Collectible Bomb Bag icon.png
Bomb Bag
Isaac is followed by a small bag that drops a Bomb, 1+1 Free, or a Troll Bomb every 3 rooms.
Collectible A Lump of Coal icon.png
A Lump of Coal
The more distance tears travel, the more damage they will do.
Collectible Guppy's Paw icon.png
Guppy's Paw
Removes one red heart container in exchange for gaining 3 Soul Hearts.
Collectible Guppy's Tail icon.png
Guppy's Tail
Increases chance of finding gold chests and normal chests, but reduces chance of finding pickups.
Collectible IV Bag icon.png
IV Bag
Upon activation, Isaac loses a half-heart (one whole heart in The Womb onwards) for a random amount of coins, similar to the blood donation machine.
Collectible Best Friend icon.png
Best Friend
Deploys a decoy Isaac that eventually explodes with an increased blast radius.
Remote Detonator Icon.png
Remote Detonator
Bombs you place explode only when you use this item. Gives 5 bombs.
Stigmata Icon.png
Increases damage, and adds 1 heart container.
Collectible Mom's Purse icon.png
Mom's Purse
Allows Isaac to hold 1 additional trinket.
Collectible Bob's Curse Rebirth icon.png
Bob's Curse
Gives 5 bombs and grants all bombs poison effect.
Collectible Pageant Boy icon.png
Pageant Boy
Spawns several coins around Isaac.
Collectible Scapular icon.png
Once per room, when Isaac is reduced to his last half red Heart, the aura around his head temporarily vanishes and he is granted one Soul Heart.
Speed Ball Rebirth Icon.png
Speed Ball
Increases speed by 0.3 and shot speed by 20%.
Collectible Bum Friend Rebirth icon.png
Bum Friend
A portable beggar who follows Isaac, picks up coins for himself, and occasionally drops a pickup after collecting a coin. Does not spawn collectibles.
Collectible Guppy's Head icon.png
Guppy's Head
Spawns 2-4 blue flies to damage enemies.
Collectible Prayer Card icon.png
Prayer Card
Grants an eternal heart per use.
Collectible Notched Axe icon.png
Notched Axe
Isaac holds the axe above his head for as long as the spacebar button is held (or until he leaves the room). While holding the axe, Isaac can break any rock he touches, but cannot attack or pick up other items.
Collectible Infestation Rebirth icon.png
1-3 blue flies randomly spawn every time Isaac gets hit.
Collectible Ipecac icon.png
Replaces tears with explosive and poisoning projectiles fired in an arc from the mouth.
Collectible Tough Love Rebirth icon.png
Tough Love
Adds a chance to shoot a tooth instead of a tear, which deals greater damage than regular tears.
Collectible The Mulligan Rebirth icon.png
The Mulligan
Tears have a 1/6 chance of spawning allied blue flies when they hit an enemy.
Technology 2 Icon.png
Technology 2
Decreases damage and replaces right eye tears with a unlimited range, piercing laser which fires continuously.
Collectible Mutant Spider icon.png
Mutant Spider
Grants quadruple shot but decreases tears.
Collectible Chemical Peel icon.png
Chemical Peel
Tears fired from left eye do increased damage.
Collectible The Peeper Rebirth icon.png
The Peeper
Spawns a familiar that floats slowly around the room on a zig-zag pattern similar to Boom Flies damaging enemies it passes through.
Collectible Habit Rebirth icon.png
When Isaac is hit, 1 point of an item's charge is filled.
Collectible Bloody Lust icon.png
Bloody Lust
Increases damage as Isaac receives damage. Damage increase stays for the whole floor.
Collectible Crystal Ball icon.png
Crystal Ball
Reveals the map (except the Super Secret Room) and drops a random Tarot Card or soul heart.
Spirit of the Night Rebirth Icon.png
Spirit of the Night
Grants spectral tears and flight.
Collectible Crack the Sky icon.png
Crack the Sky
Summons multiple beams of light in random locations around the room, dealing a large amount of damage to any enemy that touches them.
Collectible Ankh icon.png
Upon death, the player will respawn as ??? with 3 soul hearts.
Collectible Celtic Cross Rebirth icon.png
Celtic Cross
Grants a chance to trigger the Book of Shadows effect upon taking damage, creating a shield that nullifies all types of damage for 7 seconds.
Collectible Ghost Baby Rebirth icon.png
Ghost Baby
Spawns a familiar that follows Isaac around and fires spectral tears.
The Candle Icon.png
The Candle
Throws out a blue flame that can pass over gaps (but not through rocks). The flame damages anything in its path.
Collectible Cat-O-Nine-Tails icon.png
Increases Shot Speed and damage.
Collectible D20 Rebirth icon.png
Rerolls all pickups in the current room.
Collectible Harlequin Baby Rebirth icon.png
Harlequin Baby
Spawns a familiar that follows Isaac around and fires two tears at once in a V-pattern.
Collectible Epic Fetus icon.png
Epic Fetus
Isaac's tears are replaced with guided missiles, like those used by the Doctor's Remote.
Collectible Polyphemus Rebirth icon.png
Makes Isaac shoot one huge tear. Also reduces Tears to minimum. Damage increased . If tear does more damage than an enemy's life, the tear continues to travel with the extra remaining damage.
Collectible Daddy Longlegs Rebirth icon.png
Daddy Longlegs
Daddy Long Legs' shadow follows Isaac and stomps on enemies.
Spider Butt Icon.png
Spider Butt
Damages all enemies in the room and slows them and their projectiles down.
Collectible Sacrificial Dagger Rebirth icon.png
Sacrificial Dagger
Dagger orbits Isaac, dealing very high damage.
Collectible Mitre Rebirth icon.png
Grants a chance of converting any red hearts pickups into soul hearts instead.
Collectible Rainbow Baby Rebirth icon.png
Rainbow Baby
Spawns a familiar that follows Isaac around and fires tears with random effects.
Collectible Dad's Key icon.png
Dad's Key
Opens all doors in the current room when activated, including doors which require a key to open and entrances to secret rooms. Opens the big doors in the first room of both The Chest and the Dark Room.
Stem Cells Icon.png
Stem Cells
Adds one filled heart container and increases Shot Speed.
Collectible Portable Slot icon.png
Portable Slot
Upon activation, 1 coin will be consumed, and a random pickup may drop, similar to the slot machine.
Collectible Holy Water Rebirth icon.png
Holy Water
When Isaac receives damage, the bottle breaks and a puddle of blue creep forms, which damages non-flying enemies, similar to Lemon Mishap. The bottle is reformed upon entering a different room.
Collectible Fate icon.png
Grants flight and one eternal heart.
The Black Bean Icon.png
The Black Bean
When taking damage, Isaac farts, causing poison damage to all enemies in range.
Collectible White Pony icon.png
White Pony
Passively grants flight and increased speed. Upon use, Isaac charges in the direction the pony is facing, becoming invulnerable during the charge and damaging enemies while also casting the effect of Crack the Sky.
Collectible Sacred Heart icon.png
Sacred Heart
Increases damage and range while reducing shot speed and grants homing tears. Grants a Heart Container and replenishes all Red Hearts.
Collectible Toothpicks icon.png
+0.7 tears, +16% shot speed.
Collectible Holy Grail icon.png
Holy Grail
Grants flight and one heart container.
Collectible Dead Dove icon.png
Dead Dove
Grants spectral tears and flight.
Collectible Blood Rights icon.png
Blood Rights
Damages all enemies in the room, but deals a heart of damage to Isaac with each use.
Collectible Guppy's Hair Ball Rebirth icon.png
Guppy's Hair Ball
Loosely follows behind Isaac. Can be swung like a flail by rapidly spinning Isaac in a circle. Grows bigger by killing enemies.
Collectible Abel icon.png
A familiar that mirrors the player's movements and shoots in the opposite direction.
Collectible SMB Super Fan Rebirth icon.png
SMB Super Fan
Increases all stats.
Collectible Pyro Rebirth icon.png
Adds 99 bombs.
3 Dollar Bill Icon.png
3 Dollar Bill
Gives Isaac a random tear effect every room.
Removed in Afterbirth The effect given changes upon entering a room.
Added in Afterbirth The effect changes every 3 seconds.
Telepathy for Dummies Icon.png
Telepathy for Dummies
Upon activation, grants homing tears for the current room.
Collectible MEAT! icon.png
Adds a heart container and increases damage.
Collectible Magic 8 Ball Rebirth icon.png
Magic 8 Ball
Increases Shot Speed, and drops a tarot card when picked up.
Collectible Mom's Coin Purse icon.png
Mom's Coin Purse
Spawns 4 random pills around Isaac.
Squeezy Icon.png
Increases tears by 0.4, and spawns 2 Soul Hearts pickups.
Collectible Jesus Juice icon.png
Jesus Juice
Increases Damage and Range.
Collectible Box Rebirth icon.png
Spawns 1 of each (non-collectible) item: 1 coin, 1 key, 1 bomb, 1 heart, 1 card, 1 pill, 1 trinket.
Collectible Mom's Key icon.png
Mom's Key
Spawns 2 keys. Generates additional pickups from chests.
Collectible Mom's Eyeshadow icon.png
Mom's Eyeshadow
Tears have a chance to charm enemies.
Collectible Iron Bar icon.png
Iron Bar
Increases damage by 0.3 and adds a chance to shoot concussive tears, causing enemies to walk around randomly.
Collectible Midas' Touch icon.png
Midas' Touch
Enemies that touch you are stunned and turn gold. Any enemy killed while in this state will drop a coin.
Collectible Humbling Bundle icon.png
Humbling Bundle
Gives one extra pickup (1+1 Free version) of Red Hearts, pennies, bombs, and keys. Does not work with blue, black, and half red hearts, nickels, and dimes.

Page 3

Collectible Fanny Pack icon.png
Fanny Pack
Has a chance to drop a random pickup when Isaac takes damage.
Sharp Plug Icon.png
Sharp Plug
Using an activated item while it's not charged will charge it and Sharp Plug does 2 full heart damage to Isaac.
Collectible Guillotine icon.png
Isaac's head is removed from his body and floats around him. Increases Damage by 1 and grants -1 Tear Delay.
Collectible Ball of Bandages icon.png
Ball of Bandages
Orbiting familiar that deals damage to enemies. If collected while already having one, makes the familiar evolve. Only drops from Horsemen. Similar to Cube of Meat.
Champion Belt Icon.png
Champion Belt
Increases damage, but also increases the chance of champion enemies appearing.
Collectible Butt Bombs icon.png
Butt Bombs
Gives +5 bombs and makes all bombs Butt Bombs that fill the room with gas, damaging and confusing all enemies.
Collectible Gnawed Leaf icon.png
Gnawed Leaf
After standing still and not shooting for a short time, Isaac turns invincible until he moves or shoots.
Spider Baby Icon.png
Spider Baby
When hit, spawns up to 2 blue spiders.
Collectible Guppy's Collar icon.png
Guppy's Collar
Grants Isaac a permanent 50% chance to respawn with 1/2 of a red heart after death.
Collectible Lost Contact icon.png
Lost Contact
Every tear has a small shield which will allow it to block one enemy projectile.
Collectible Anemic Rebirth icon.png
+5 range. After Isaac is damaged, a trail of red creep will be left behind Isaac until he leaves the current room.
Collectible Goat Head Rebirth icon.png
Goat Head
A Devil Room / Angel Room Door will always spawn after every boss fight, excluding the first floor and floors after Utero II/Womb II.
Collectible Ceremonial Robes icon.png
Ceremonial Robes
Adds 3 black hearts and increases Damage by 1.
Collectible Mom's Wig icon.png
Mom's Wig
Adds a chance to spawn blue spiders when firing tears. Restores 1 red heart.
Collectible Placenta icon.png
Grants a full heart container, and a chance to regenerate a half-heart of health every minute of gameplay.
Collectible Old Bandage icon.png
Old Bandage
Adds one empty heart container. Whenever Isaac takes damage there's a chance that a Red Heart may drop.
Collectible Sad Bombs Rebirth icon.png
Sad Bombs
+5 Bombs. Upon exploding, bombs shoot 8 tears off in every direction, similar to Tammy's Head. The tears are affected by any tear modifiers Isaac has on his own tears.
Collectible Rubber Cement icon.png
Rubber Cement
Tears bounce off walls, enemies, and environmental objects.
Collectible Anti-Gravity icon.png
-2 Tear Delay. Tears float in position until firing ceases, after which they will fly off in the direction they were shot in.
Collectible Pyromaniac icon.png
Isaac heals 1 heart instead of taking damage from an explosive source. Adds 5 bombs.
Collectible Cricket's Body icon.png
Cricket's Body
Grants -1 Tear Delay and reduces Range. When tears hit an object or deplete their range, they spawn 4 smaller tears, whose Range and Damage scale with Isaac's.
Collectible Gimpy icon.png
Has a chance of spawning a soul heart or black heart when taking damage. Enemies have a chance to drop a Half Red Heart after being killed.
Collectible Black Lotus Rebirth icon.png
Black Lotus
Grants the player one red heart container, one soul heart, and one black heart.
Collectible Piggy Bank Rebirth icon.png
Piggy Bank
Gives 3 pennies on pick-up. Every time Isaac is damaged, he will drop one additional penny.
Collectible Mom's Perfume icon.png
Mom's Perfume
Adds a chance to shoot fear tears and decreases tear delay by 1.
Collectible Monstro's Lung icon.png
Monstro's Lung
Increases damage and grants a charged shot that fires multiple tears in the same fashion as Monstro.
Collectible Abaddon Rebirth icon.png
Increases damage and speed, removes all red heart containers, grants six black hearts, and adds a chance to shoot fear tears.
Collectible Ball of Tar icon.png
Ball of Tar
Adds a chance to shoot slowing tears and the character leaves a trail of slowing creep behind as he moves, impeding enemies' speed.
Stop Watch Icon.png
Stop Watch
Removed in Afterbirth Automatically inflicts slow to all enemies in every room.
Added in Afterbirth Upon taking damage, inflicts slow to all enemies for the current room.
Collectible Tiny Planet icon.png
Tiny Planet
Range up and makes shot tears revolve around Isaac until they drop.
Collectible Infestation 2 icon.png
Infestation 2
Spawns allied blue spiders from killed enemies.
Collectible E Coli icon.png
E Coli
Gives "Turdy Touch" Effect. Enemies that touch Isaac are changed into poop.
Collectible Death's Touch icon.png
Death's Touch
Increases Damage by 1.5, reduces Tears by 0.3 and increases tear size. Grants piercing tears. Tears are replaced by Death's scythes, which is a cosmetic effect only.
Collectible Key Piece 1 icon.png
Key Piece 1
Combined with Key Piece 2, unlocks the golden gate in the starting room of The Chest and Dark Room to fight Mega Satan.
Collectible Key Piece 2 Rebirth icon.png
Key Piece 2
Combined with Key Piece 1, unlocks the golden gate in the starting room of The Chest and Dark Room to fight Mega Satan.
Collectible Experimental Treatment icon.png
Experimental Treatment
Randomly increases and decreases some of the character's stats.
Collectible Contract From Below icon.png
Contract From Below
Doubles the number of pickups and chests spawned after clearing a room or performing some other triggering action (such as using a blood donation machine), but reduces the chance for any pickups to spawn at all.
Collectible Infamy icon.png
Chance to block projectiles coming from any direction.
Collectible Trinity Shield icon.png
Trinity Shield
Isaac gains a shield that protects him from enemy shots.
Tech.5 Rebirth Icon.png
Grants a unlimited range piercing laser with random rate of fire that does not replace tears. The laser might occasionally fire with the effect of a random item or trinket, such as Hook Worm, Spoon Bender or Tiny Planet.
20 20 Rebirth Icon.png
Grants double shot.
Collectible Blue Map icon.png
Blue Map
Shows secret and super secret room locations on the map.
Collectible BFFS! icon.png
Increases the size and damage of familiars.
Collectible Hive Mind icon.png
Hive Mind
Increases the size of blue spiders and blue flies and doubles the amount of damage they deal.
Collectible There's Options icon.png
There's Options
There will be 2 items available to choose from after defeating a boss. Choosing 1 item causes the other to disappear.
Collectible Bogo Bombs icon.png
Bogo Bombs
All standard bomb pickups become 1+1 bomb pickups.
Starter Deck Icon.png
Starter Deck
Isaac can hold 2 cards at once and all pills are replaced by cards.
Collectible Little Baggy icon.png
Little Baggy
Isaac can hold 2 pills at once and all cards are replaced by pills.
Collectible Magic Scab icon.png
Magic Scab
Increases luck and HP by 1.
Collectible Blood Clot icon.png
Blood Clot
Increases damage by 1 and range by 5 for tears fired from the left eye.
Screw Icon.png
+0.5 tears up, +0.2 shot speed up.
Collectible Hot Bombs icon.png
Hot Bombs
Grants 5 bombs. Isaac's bombs leave behind fire that damages enemies upon contact.
Collectible Fire Mind icon.png
Fire Mind
Grants flaming tears that deal burning damage over time. Tears have a chance to explode on impact with an enemy, which creates a fire at the location of the explosion.
Collectible Missing No. icon.png
Missing No.
Randomizes all passive items upon pickup and at the start of each succeeding floor.
Collectible Dark Matter icon.png
Dark Matter
Increases Damage by 1 and adds a chance to shoot fear tears.
Collectible Black Candle icon.png
Black Candle
Prevents curses. Grants one black heart. Increases the chance for a Devil or angel room to appear.
Collectible Proptosis Rebirth icon.png
Tears start out massive with high damage, and then shrink down and become weaker over a short range.
Collectible Missing Page 2 icon.png
Missing Page 2
Gives 1 black heart. Upon taking damage that reduces Isaac's health to one heart or less, activates The Necronomicon effect, dealing 40 damage to all enemies in the room.
Smart Fly Icon.png
Smart Fly
After Isaac takes damage, this fly will deal continuous touch damage to whatever enemy caused the damage until it is dead. The fly will then systematically attack 1 enemy at a time until the room is cleared.
Collectible Dry Baby icon.png
Dry Baby
Spawns a familiar that follows Isaac around and blocks enemy projectiles. Upon blocking a shot, it has a chance of triggering The Necronomicon effect.
Collectible Juicy Sack icon.png
Juicy Sack
A familiar that follows behind Isaac. It drips a trail of creep, which slows enemies, and spawns 1-2 blue spiders after each room.
Collectible Robo-Baby 2.0 Rebirth icon.png
Robo-Baby 2.0
Fires lasers at any enemy in its line of sight and moves based on the direction Isaac is firing tears.
Collectible Rotten Baby icon.png
Rotten Baby
A familiar that spawns blue flies.
Collectible Headless Baby icon.png
Headless Baby
Familiar that follows Isaac, leaving blood creep on the ground.
Leech Icon.png
Spawns a friendly familiar leech on the ground that hunts down enemies and heals you for half a heart each time it eats one.
Collectible Mystery Sack icon.png
Mystery Sack
Spawns a familiar that follows Isaac around and has a chance to drop a heart, coin, bomb, or key after clearing a room.
Collectible BBF icon.png
Spawns a familiar that flies around the room in a manner similar to the Boom Fly and explodes on contact with an enemy. Respawns after ten seconds.
Collectible Bob's Brain icon.png
Bob's Brain
Spawns a familiar that charges forward when shooting tears and explodes upon contact with an enemy, damaging and poisoning them. The familiar respawns after a few seconds.
Collectible Best Bud Rebirth icon.png
Best Bud
When hit, summons a white attack fly similar to Distant Admiration for the current room.
Collectible Lil Brimstone Rebirth icon.png
Lil' Brimstone
A Familiar that shoots a thin Brimstone beam. Must charge like Brimstone before shooting.
Collectible Isaac's Heart icon.png
Isaac's Heart
Isaac himself is now immune to all damage, and a heart familiar appears and follows Isaac. If the heart is hurt, Isaac is hurt.
Collectible Lil Haunt icon.png
Lil Haunt
A familiar that damages enemies by chasing them as well as inducing the fear effect.
Collectible Dark Bum Rebirth icon.png
Dark Bum
Spawns a familiar that follows Isaac around and collects red hearts. For every one-and-a-half red hearts collected, Dark Bum will generate one soul heart, one hostile Spider or one friendly blue spider.
Collectible Big Fan icon.png
Big Fan
Spawns a large orbital familiar that blocks enemy projectiles and deals slight contact damage to enemies.
Sissy Longlegs Icon.png
Sissy Longlegs
Wanders about the room, occasionally spawning blue spiders.
Collectible Punching Bag icon.png
Punching Bag
Spawns a Mulligan Familiar that will wander the room randomly. Enemies will attack the Mulligan if it's closer.
Collectible How to Jump icon.png
How to Jump
Gives Isaac the ability to jump (over gaps, spikes, etc.).
Collectible D100 icon.png
Upon use, rerolls all passive items on Isaac like the D4, every pedestal item in the room like The D6, and every pickup like the D20.
Collectible D4 icon.png
Rerolls all of Isaac's items.
Collectible D10 icon.png
Rerolls the enemies in a room. Only rerolls enemies that are still alive (does not spawn new enemies).
Collectible Blank Card icon.png
Blank Card
Has the same effect as the card or rune currently held by Isaac.
Collectible Book of Secrets icon.png
Book of Secrets
Upon use, gives the effect of Treasure Map, The Compass, or Blue Map for the duration of the current floor.
Collectible Box of Spiders Rebirth icon.png
Box of Spiders
Summons 2-4 blue spiders.
Collectible Red Candle icon.png
Red Candle
Throws a persistent flame that deals high damage and diminishes as it damages enemies or blocks shots.
Collectible The Jar Rebirth icon.png
The Jar
When at full health, up to 4 extra hearts can be stored in the jar.
Collectible Flush! icon.png
Changes all enemies in the room into poop. Does not work on all enemies (Knights and bosses are immune). Instantly kills Dingle, Dangle, and Brownie.
Collectible Satanic Bible icon.png
Satanic Bible
Upon activation, Isaac gains a black heart.
Collectible Head of Krampus icon.png
Head of Krampus
Fires a cross-patterned brimstone shot, just like The Fallen and Krampus shoot.
Collectible Butter Bean icon.png
Butter Bean
Isaac farts and pushes back nearby enemies.
Collectible Magic Fingers icon.png
Magic Fingers
For 1 coin, damages all enemies in the room.
Collectible Converter icon.png
When used, converts two soul hearts into a heart container.
Collectible Pandora's Box icon.png
Pandora's Box
Upon use, spawns certain pickups or items depending on the floor it is used on. Single-use.
Collectible Unicorn Stump icon.png
Unicorn Stump
Upon use, grants invulnerability and increased speed for five seconds, but removes the ability to shoot tears.
Taurus Rebirth Icon.png
Speed down; gains speed while in a room with enemies until gaining My Little Unicorn effect for a few seconds.
Collectible Aries icon.png
+0.25 Speed. Running into enemies while at a high speed will deal 18 points of damage. Does not prevent contact damage.
Collectible Cancer Rebirth icon.png
Adds 3 soul hearts. Grants The Wafer effect for the current room upon taking damage.
Collectible Leo icon.png
Allows you to crush rocks when you walk over them.
Collectible Virgo icon.png
Grants a chance to trigger the Book of Shadows effect upon taking damage, creating a shield that nullifies all types of damage for 10 seconds. Also converts "bad pills" into "good pills".
Collectible Libra icon.png
Gives 6 coins, 6 bombs, and 6 keys and balances out all attributes.
Scorpio Icon.png
Grants poison tears, which deal damage over time when inflicted.

Page 4

Collectible Sagittarius Rebirth icon.png
Increases speed by +0.2 and grants piercing tears.
Collectible Capricorn icon.png
All stats up.
Collectible Aquarius Rebirth icon.png
A trail of blue creep is left behind Isaac, which damages enemies.
Collectible Pisces icon.png
-1 Tear Delay, adds knock-back shots and increases tear size.
Collectible Eve's Mascara icon.png
Eve's Mascara
Doubles damage, halves tears stat, and greatly reduces shot speed.
Collectible Judas' Shadow icon.png
Judas' Shadow
Adds an extra life; upon death, it respawns Isaac as Black Judas with only two black hearts.
Collectible Maggy's Bow icon.png
Maggy's Bow
Gives one heart container and doubles the healing provided by red hearts.
Collectible Holy Mantle icon.png
Holy Mantle
Automatically negates first taken damage in every room.
Collectible Thunder Thighs icon.png
Thunder Thighs
Destroys rocks upon contact with Isaac. Adds one heart container and lowers Speed.
Strange Attractor Rebirth Icon.png
Strange Attractor
Pickups, trinkets, and monsters are magnetically attracted to Isaac's tears.
Collectible Cursed Eye icon.png
Cursed Eye
Grants charged tears that can be fired in a tight burst of four. Getting hit while charging will teleport Isaac into another room.
Collectible Mysterious Liquid icon.png
Mysterious Liquid
Tears leave a small, short lasting pool of creep on impact or when their range is depleted.
Collectible Gemini Rebirth icon.png
Suture becomes attached to Isaac, and does touch damage to enemies within its attacking range.
Collectible Cain's Other Eye icon.png
Cain's Other Eye
Spawns a familiar that floats slowly around the room on a zig-zag pattern similar to The Peeper and shoots normal tears in the same direction as Isaac.
Collectible Blue Baby's Only Friend icon.png
???'s Only Friend
Summons a big attack fly that can be controlled with the shooting direction-keys.
Collectible Samson's Chains icon.png
Samson's Chains
Pull a chain and ball behind you that will damage enemies on contact and is able to break stones.
Collectible Mongo Baby icon.png
Mongo Baby
Summons a familiar that copies the tears of Isaac's other familiars.
Collectible Isaac's Tears Rebirth icon.png
Isaac's Tears
Shoots 8 tears around Isaac, which retain the damage, shot speed, and special effects of his tears. Each tear shot by Isaac increases item charge by one.
Collectible Undefined icon.png
Teleports Isaac to either the Secret Room, Super Secret Room, Treasure Room, or I AM ERROR.
Collectible Scissors icon.png
Upon use, turns Isaac's head into a stationary familiar for the current room which fires normal tears that deal 3.5 damage.
Collectible Breath of Life icon.png
Breath of Life
Grants a brief moment of invincibility when the charge bar hits zero. If spacebar is held for an additional second after hitting zero, Isaac will take damage.
Collectible The Polaroid icon.png
The Polaroid
If the character has half a red heart or no red hearts after taking damage, it triggers the Book of Shadows effect, creating a shield that nullifies all types of damage for 5 seconds. Also allows entrance into The Chest.
Collectible The Negative icon.png
The Negative
If the character has half a red heart or no red hearts after taking damage, it triggers The Necronomicon effect, damaging all enemies in the room. Also allows entrance into the Dark Room.
Collectible The Ludovico Technique icon.png
The Ludovico Technique
Instead of firing tears, Isaac controls one floating tear that hover over obstacles. This tear deals constant damage when held in place over an enemy.
Soy Milk Icon.png
Soy Milk
Tears shrink and do much less damage, but fire in very rapid succession.
Collectible Godhead icon.png
Increases damage and range while reducing tears and shot speed. Grants homing tears and tears gain a damaging halo.
Collectible Lazarus' Rags icon.png
Lazarus' Rags
Upon dying, resurrect as Revived Lazarus with one heart container and Anemic item.
Collectible The Mind icon.png
The Mind
Grants the combined effects of the Blue Map, Treasure Map, and The Compass, revealing the floor layout and all special rooms, including Secret Rooms and Super Secret Rooms.
The Body Icon.png
The Body
Adds 3 heart containers.
Collectible The Soul icon.png
The Soul
Grants two soul hearts. Isaac now repels enemy projectiles.
Collectible Dead Onion icon.png
Dead Onion
Grants piercing and spectral tears. Increases tear size (without increasing damage) while greatly reducing range and shot speed.
Collectible Broken Watch icon.png
Broken Watch
Chance upon entering a room to slow down or speed up every enemy and their attacks. The chance to slow enemies is quite higher than the chance to speed them up.
The Boomerang Rebirth Icon.png
The Boomerang
Throws a short-range boomerang which does a bit of damage and has a high chance to stun the enemy for 2 seconds. Can also be used to grab pickups.
Collectible Safety Pin icon.png
Safety Pin
Increases range and shot speed, while adding 1 Black Heart.
Collectible Caffeine Pill Rebirth icon.png
Caffeine Pill
Increases speed and reduces character size. Also gives a random pill.
Collectible Torn Photo icon.png
Torn Photo
Tears + Shot speed up.
Collectible Blue Cap icon.png
Blue Cap
Grants 1 heart container and increases tears, but decreases shot speed.
Collectible Latch Key icon.png
Latch Key
Increases Luck by 1, grants 1 Soul Heart and spawns 2 Keys.
Collectible Match Book icon.png
Match Book
Grants Isaac 1 Black Heart and 3 bombs. Can also give troll bombs.
Synthoil Icon.png
Increases damage by 1, range by 5.25, and tear height by 0.5.
Collectible A Snack icon.png
A Snack
Grants one full red heart container.

The Binding of Isaac: Rebirth The Binding of Isaac: Rebirth The Binding of Isaac: Rebirth
Achievements Achievements Attributes Attributes Bosses Bosses TarotCard.png Cards and Runes Challenges Challenges Chapters Chapters
Characters Characters MainPageBabies.png Co-op Items Items Item pools Item pools Monsters Monsters Objects Objects
Pickups Pickups Pills Pills Rooms Rooms Seeds Seeds Transformations Transformations Trinkets Trinkets