|Guppy||Beelzebub||Super Bum||Yes Mother?||Bob||Fun Guy||Leviathan|| Conjoined |
|Spun||Seraphim||Oh Crap||Bookworm||Spider Baby||Adult||Stompy|
After picking up three distinct items from the following list, Isaac grows two tumor faces from his cheeks, which fire simultaneously and diagonally similar to the effect of The Wiz. Decreases Isaac's damage by 0.3 and slightly decreases Isaac's tears.
|Brother Bobby||8||Friends 'till the end||Follows Isaac around shooting normal tears.|
|Harlequin Baby||167||Double shot buddy||Spawns a familiar that follows Isaac around and fires two tears at once in a V-pattern.|
|Headless Baby||269||Bloody Friend||Familiar that follows Isaac, leaving blood creep on the ground.|
|Little Steven||100||Psychic friend||Spawns a familiar that follows Isaac around and fires homing tears.|
|Mongo Baby||322||Mongo Friend||Summons a familiar that copies the tears of Isaac's other familiars.|
|Rotten Baby||268||Infested friend||A familiar that spawns blue flies.|
|Sister Maggy||67||Friends 'till the end||A familiar that follows Isaac around shooting blood tears.|
Notes[edit | edit source]
- Isaac starts with this transformation in The Family Man challenge, but due to the challenge's Blindfolded property, it's useless without the Incubus.
|The Binding of Isaac: Rebirth|
|Achievements||Attributes||Bosses||Cards and Runes||Challenges||Chapters|