Contagion

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Item icon
Item altar

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Character appearance
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Added in Afterbirth †

Contagion is a passive item added in Afterbirth †.

Effects[edit | edit source]

  • In each room, the first enemy killed will release a gas explosion and poison nearby enemies.
    • Poisoned enemies will also release gas upon death, spreading the effect.
      • Poisoned enemies do not need to die while the poison is still active to spread the effect.

Notes[edit | edit source]

  • The initial gas explosion deals 5 damage, and the poison deals Isaac's tear damage per tick, for 7 ticks.

Interactions[edit | edit source]

  • Dr. Fetus Dr. FetusDr. Fetus Icon.pngTears are replaced by bombs that benefit from bomb-enhancing effects and slide a fixed range after being fired.: Bomb damage does not apply to poison damage.
  • Epic Fetus Epic FetusEpic Fetus Icon.pngIsaac's tears are replaced with guided missiles, like those used by the Doctor's Remote.: Missile damage does not apply to poison damage.
  • Ipecac IpecacIpecac Icon.pngReplaces tears with explosive and poisoning projectiles fired in an arc from the mouth.: Ipecac only applies a 2x multiplier as opposed to +40 to poison damage.
  • Poison tears: No effect.

In-game Footage[edit | edit source]

Trivia[edit | edit source]

  • Its sprite is a recolor of Toxic Shock Toxic ShockToxic Shock Icon.pngUpon entering a room, poisons all enemies, dealing double Isaac's tear damage. Killing enemies leaves a small, short lasting pool of green creep on the ground..
  • This item may be a reference to the movies Contagion and Outbreak, or the game Plague Inc..
    • A contagion is a disease spread by close contact.


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