Creep

Creep is a liquid caused by the attacks of certain monsters and bosses, or may be spawned by Isaac. Creep appears on the ground as a "shiny" puddle or line. There are a few different kinds of creep which can affect enemies or Isaac. Having the ability to fly or the CallusPrevents damage from creep and spikes. trinket prevents the effects of creep.

Creep that will affect Isaac is shown flickering rapidly.

Red Creep

Red Creep is the most common type of creep in the game. It can be created by various different enemies, champions, or Isaac himself. When spawned by enemies, it damages Isaac but not other enemies in the room. When spawned by Isaac, it damages walking enemies but not Isaac. It deals 1/2 heart damage to the player, unlike in the original where it did a full heart of damage. Red creep is representative of blood.

Green Creep

Green Creep is spawned by various enemies, Ultra Pride, Pestilence, green champion monsters, and Dangle and Brownie (when they are poisoned). It is functionally equivalent to red creep, and can be spawned by Isaac with the Bob transformation, Bob's BladderLeaves a pool of green creep under all bombs Isaac places, which damages enemies that walk over it., Toxic ShockUpon entering a room, poisons all enemies, dealing double Isaac's tear damage. Killing enemies leaves a small, short lasting pool of green creep on the ground., Mysterious LiquidTears leave a small, short lasting pool of creep on impact or when their range is depleted., or 7 SealsGrants a random Harbinger familiar that changes every 10 seconds. (Pestilence). Green creep is representative of acid, or poison.

Yellow Creep

Yellow Creep is spawned only by Peep, Lemon MishapCreates a small yellow pool of creep, which damages enemies that cross it., or Lemon Party pills. When spawned by Peep, it deals half a heart of damage to the player. When spawned by Isaac, it continuously damages walking enemies and seems to do more damage than any other type of creep that Isaac can create. Yellow creep is representative of urine.

Black Creep

Black Creep is spawned by various enemies, Gish, the Something's Wrong... pill, Ball of TarAdds a chance to shoot slowing tears and the character leaves a trail of slowing creep behind as he moves, impeding enemies' speed., and 7 SealsGrants a random Harbinger familiar that changes every 10 seconds. (Famine). It slows the affected enemy or player down. When spawned by enemies, it affects Isaac but not other enemies. When spawned by Isaac, it affects enemies in the room but not Isaac. Black creep is representative of tar.

White Creep

White Creep is functionally similar to black creep. White creep is spawned by several bosses, including Widow, The Wretched, Triachnid and The Frail, as well as Small Baby Long Legs. Isaac can spawn white creep with Juicy SackA familiar that follows behind Isaac. It drips a trail of creep, which slows enemies, and spawns 1-2 blue spiders after each room., Large ZitAdds a chance to fire a creep shot that deals double damage and leaves a trail of slowing white creep. and ParasitoidAdds a chance to fire an egg sack which spawns slowing creep and spawns a blue fly or spider upon hitting an enemy.. White creep is representative of a liquid form of cobweb.

Blue Creep

Blue creep is spawned by Hush, DepressionSpawns a cloud familiar that leaves a trail of tears that damages enemies. Has a chance to spawn damaging beams of light onto enemies that touch the cloud., or when Isaac is damaged with Holy WaterWhen Isaac receives damage, the bottle breaks and a puddle of blue creep forms, which damages non-flying enemies, similar to Lemon Mishap. The bottle is reformed upon entering a different room.. AquariusA trail of blue creep is left behind Isaac, which damages enemies. also causes Isaac to leave a trail of blue creep wherever he walks. Blue creep damages enemies that walk over it. Blue creep spawned by Hush makes Isaac slide, and does not affect other enemies. It is representative of water or tears.

Grey Creep

Grey Creep is spawned only by The Cage. It damages Isaac like Red Creep but does not affect other enemies. It may be representative of some type of rotten liquid.

Orange Creep

Orange Creep is spawned only by Mama Gurdy. It slows down Isaac like black creep but does not affect other enemies. Unlike other types of creep, orange creep does not flicker rapidly, even though it only affects Isaac. Due to its nature, it may be representative of vomit, or some other bodily liquid.

Brown Creep

Brown Creep is spawned only from bosses such as Brownie, Dangle, Turdlings, X-Lax pill and Sisters Vis. It is slippery and will make Isaac slide. Unlike other types of creep, brown creep does not flicker rapidly, even though it only affects Isaac. It is representative of poop (likely to be diarrhea).

Gallery

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  Green Creep, spawned by Mysterious LiquidTears leave a small, short lasting pool of creep on impact or when their range is depleted..

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  Trail of slowing White Creep, spawned by Juicy SackA familiar that follows behind Isaac. It drips a trail of creep, which slows enemies, and spawns 1-2 blue spiders after each room..

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  Yellow Creep, spawned by Lemon MishapCreates a small yellow pool of creep, which damages enemies that cross it..

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  Trail of slowing Black Creep, spawned by Ball of TarAdds a chance to shoot slowing tears and the character leaves a trail of slowing creep behind as he moves, impeding enemies' speed..

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  Trail of Blue Creep, spawned by AquariusA trail of blue creep is left behind Isaac, which damages enemies..

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  Trail of Red Creep, spawned by Headless BabyFamiliar that follows Isaac, leaving blood creep on the ground..

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  Trail of Brown Creep, spawned by Brownie.