Creep

Creep is a liquid caused by the attacks of certain monsters and bosses, or may be spawned by Isaac. Creep appears on the ground as a "shiny" puddle or line. There are a few different kinds of creep which can affect enemies or Isaac. Having the ability to fly or the Callus trinket prevents the effects of creep.

Creep that will affect Isaac is shown flickering rapidly. When all enemies inside a room are defeated, the creep they produced will quickly disappear.

Red Creep

Red Creep is the most common type of creep in the game. It can be created by various different enemies, champions, or Isaac himself. When spawned by enemies, it damages Isaac but not other enemies in the room. When spawned by Isaac, it damages walking enemies but not Isaac. It deals 1/2 heart damage to the player, unlike in the original where it did a full heart of damage. Red creep is representative of blood.

Green Creep

Green Creep is spawned by various enemies, Ultra Pride, Pestilence, green champion monsters, and Dangle and Brownie (when they are poisoned). It is functionally equivalent to red creep, and can be spawned by Isaac with the Bob transformation, Bob's Bladder, Toxic Shock, Mysterious Liquid, or 7 Seals (Pestilence). Green creep is representative of acid, or poison.

Yellow Creep

Yellow Creep is spawned only by Peep, Lemon Mishap, or Lemon Party pills. When spawned by Peep, it deals half a heart of damage to the player. When spawned by Isaac, it continuously damages walking enemies and seems to do more damage than any other type of creep that Isaac can create. Yellow creep is representative of urine.

Black Creep

Black Creep is spawned by various enemies, Gish, the Something's Wrong... pill, Ball of Tar, and 7 Seals (Famine). It slows the affected enemy or player down. When spawned by enemies, it affects Isaac but not other enemies. When spawned by Isaac, it affects enemies in the room but not Isaac. Black creep is representative of tar.

White Creep

White Creep is functionally similar to black creep. White creep is spawned by several bosses, including Widow, The Wretched, Triachnid and The Frail, as well as Small Baby Long Legs. Isaac can spawn white creep with Juicy Sack, Large Zit and Parasitoid. White creep is representative of a liquid form of Cobweb.

Blue Creep

Blue creep is spawned by Hush, Depression, or when Isaac is damaged with Holy Water. Aquarius also causes Isaac to leave a trail of blue creep wherever he walks. Blue creep damages enemies that walk over it. Blue creep spawned by Hush makes Isaac slide, and does not affect other enemies. It is representative of water or tears.

Grey Creep

Grey Creep is spawned only by The Cage. It damages Isaac like Red Creep but does not affect other enemies. It may be representative of some type of rotten liquid.

Orange Creep

Orange Creep is spawned only by Mama Gurdy. It slows down Isaac like black creep and deals a full heart of damage to the player but does not affect other enemies. Unlike other types of creep, orange creep does not flicker rapidly, even though it only affects Isaac. Due to its nature, it may be representative of vomit, pus, or some other bodily liquid.

Brown Creep

Brown Creep is spawned only from bosses such as Brownie, Dangle, Turdlings, X-Lax pill and Sisters Vis. It is slippery and will make Isaac slide. Unlike other types of creep, brown creep does not flicker rapidly, even though it only affects Isaac. It is representative of poop (likely to be diarrhea).

Gallery

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  Green Creep, spawned by Mysterious Liquid.

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  Trail of slowing White Creep, spawned by Juicy Sack.

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  Yellow Creep, spawned by Lemon Mishap.

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  Trail of slowing Black Creep, spawned by Ball of Tar.

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  Trail of Blue Creep, spawned by Aquarius.

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  Trail of Red Creep, spawned by Headless Baby.

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  Trail of Brown Creep, spawned by Brownie.