Items in this pool can spawn in the
Curse Room. This does not apply to Red Chests.
Curse immunity + evil up
Prevents curses. Grants one Black Heart. Increases the chance for a Devil or Angel Room to appear.
Adds 3 Black Hearts and increases damage by 1.
Contract From Below
Wealth... but at what cost?
Doubles the number of pickups and chests spawned after clearing a room or performing some other triggering action (such as using a Blood Donation Machine), but reduces the chance for any pickups to spawn at all.
Sets Isaac's Red Heart containers to 1, but gives Isaac 9 extra lives. After dying, Isaac respawns with 1 Red Heart in the last safe room.
Has a chance of spawning a Soul Heart or Black Heart when taking damage. Enemies have a chance to drop a Half Red Heart after being killed.
He accepts your offering
A Devil Room / Angel Room Door will always spawn after every boss fight, excluding the first floor and floors after Utero II/Womb II.
Grants Isaac a permanent 50% chance to respawn with 1/2 of a Red Heart after death.
Increases chance of finding Locked Chests and normal Chests, but reduces chance of finding pickups.
Increases Damage and Speed, plus adds one Soul Heart.
DMG + Tears UP
Increases damage by 0.5, tears by 0.7 and grants two soul hearts upon pickup.
Increases damage and increases the chance for a Devil or Angel Room to appear.
Call to the void
Whenever Isaac takes damage, a black ring briefly appears around Isaac, dealing damage to all nearby enemies.
Curse of the Tower
You feel cursed...
Causes Isaac to spawn 6 Troll Bombs on the floor every time he gets hit, similar to the mechanic.
Dark Prince's Crown
Loss is power
Increases range, tears, and shot speed when at exactly one red heart.
Adds a chance to fire needles that instantly kill basic enemies and deal triple damage to bosses. If a needle kills an enemy, it bursts into more tears/needles.
Adds a chance to fire a piercing tear that instantly kills any enemy that it touches.
Spawns an orbiting razor that damages enemies it touches and inflicts bleeding on enemies, causing them to slowly take damage over time.
Spawns a shadow familiar that follows Isaac's movements on a 1 second delay and deals contact damage to enemies. After dealing enough damage, it is absorbed by Isaac and spawns friendly Chargers.
I see the future
Drops a random card or rune. Doubles the effects of cards and runes.