Cursed Skull

Cursed Skull is a trinket.

Effects

• If Isaac has less than one full red heart after taking damage, he will be immediately teleported to a random room.

Notes

• It is not recommended to have this item equipped during a boss fight as the boss's health will be restored to 100% if the player is teleported out of the room and returns, placing the player at a disadvantage unless he has acquired a PlacentaGrants a full heart container, and a chance to regenerate a half-heart of health every minute of gameplay..
• Does not affect The Lost, as being hit with Holy MantleAutomatically negates first taken damage in every room. does not count as taking damage.

In-game Footage

Bones

Items:

• Brittle BonesReplaces all red hearts with 6 empty bone hearts. Upon losing a bone heart, Isaac fires bones in 8 directions and permanently gains a tears up.
• Compound FractureIncreases range. Tears turn into bones, which shatter into 1-3 bone shards upon hitting an enemy or obstacle.
• Dead ToothWhile firing, Isaac gains a green aura that poisons nearby enemies.
• Dog ToothIncreases damage and speed. Upon entering a room adjacent to a secret room, a howl sound effect will play.
• Jaw BoneSpawns a familiar that flies the room while firing, dealing a flat 7 damage to enemies that come in contact and retrieving pickups.
• MarrowGrants one bone heart and spawns three red heart pickups.
• Monstro's ToothMonstro jumps onto a random enemy, doing area damage. Can damage/kill the player if summoned in an room without enemies.
• My Little UnicornUpon use, grants invulnerability and increased speed for five seconds, removing the ability to shoot tears and replacing it with the ability to deal contact damage to enemies.
• Pointy RibSpawns a bone familiar that can be aimed with the fire buttons and does contact damage.
• Slipped RibSpawns a bone familiar that circles around Isaac and reflects enemy shots.
• Unicorn StumpUpon use, grants invulnerability and increased speed for five seconds, but removes the ability to shoot tears.

Trinkets:

• Black ToothAdds a chance to fire a black tooth that poisons enemies.
• Cursed SkullIf Isaac has less than one full red heart after taking damage, he will be immediately teleported to the last cleared room he was in.
• Finger BoneGrants a chance to gain a bone heart upon taking damage.
• Rib of GreedPrevents Greed and Super Greed from appearing in shops and secret rooms.
• Wish BoneTaking damage has a small chance to destroy the trinket and spawn a random item.