D12

3 rooms

None

(page 4, column 1, row 2)(page 4, column 1, row 2)

Defeat Hush as CainD12

D12 is an unlockable activated item added in Afterbirth.

Effect

• Re-rolls most obstacles in the current room into others.
  • Poops of any type and TNT cannot be rerolled, although other obstacles may be rerolled into them.

Notes

• Urns, mushrooms, skulls, and polyps can be re-rolled. Depending on the current chapter, rocks can also be re-rolled into them.
• The D12 is the only way in the game to remove metal blocks.
• The D12 can re-roll obstacles into rainbow poop, golden poop and tinted rocks, although the chance is low.
• The D12 will not re-roll key blocks.
• The D12 will not re-roll Fireplaces, Stone Grimaces, or other obstacles that the game classifies as enemies.
• The Satan and angel statues found in Devil Rooms/Angel Rooms are unaffected by the D12.

Strategies

• The D12 can be used in big rooms with lots of obstacles to maximize the chance of obtaining helpful obstacles such as rainbow poop, golden poop, and tinted rocks.
• The D12 can be used to access otherwise unreachable spots or items (for instance, when they are surrounded by metal blocks).

Seeds

 PC  YL6N 8KK4 (Treasure room above spawn)

Dice

D1Duplicates a random pickup in the room.	D4Rerolls all of Isaac's items.	The D6Allows Isaac to re-roll collectible items in the current room into other items, depending on the current room's Item Pool.	D7Restarts the current room and brings back all enemies, allowing more rewards to be acquired by completing the room.	D8Re-rolls Isaac's speed, range, tears, and damage.	D10Rerolls the enemies in a room. Only rerolls enemies that are still alive (does not spawn new enemies).	D12Re-rolls all rocks in the current room into other random objects, such as bomb rocks, metal blocks, TNT, or poops.	D20Rerolls all pickups in the current room.	D100Upon use, rerolls all passive items on Isaac like the D4, every pedestal item in the room like The D6, and every pickup like the D20.	D InfinityGrants a random dice item that changes each use.
Pickups (Duplicates)	Isaac's Items	Room's Items	Room	Stats	Enemies	Rocks	Pickups (Randomizes)	Items Pickups	Random Dice

Cain Unlocks
A Bag of PenniesDefeat Isaac as CainA Bag of BombsDefeat Satan as CainAbelDefeat The Lamb as CainCain's EyeDefeat ??? as CainCain's Other EyeComplete the Boss Rush as CainGlass BabyDefeat Mom's Heart on hard mode as Cain	D12Defeat Hush as CainEvil EyeDefeat Ultra Greed as CainGreen BabyDefeat Mega Satan as CainPicky BabyEarn all hard mode completion marks as CainPAY TO PLAYDefeat Isaac as Cain	Silver DollarDefeat Delirium as CainSack of SacksDefeat Ultra Greedier as Cain