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Font TeamMeat D.pngFont TeamMeat 4.png
Item icon
Item altar
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Table dividing line 2.png
6 rooms 6  rooms
Treasure Room Treasure Room
Greed mode only Shop Shop
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Added in Afterbirth(page 3, column 19, row 2)
Removed in Afterbirth(page 3, column 9, row 8)
The D4 Blow up 30 arcade machinesThe D4The D4

The D4 is an unlockable activated item.

Effect[edit | edit source]

  • Upon use, re-rolls each of Isaac's passive items into new ones.
    • Removed in Afterbirth † The new items will be drawn from the Treasure Room item pool.
    • Added in Afterbirth † Each new item will be drawn from the specific item pool where the item it replaces was acquired.
      • If the item has no pool (gained as a starting item, fixed drops such as a Blood Bag Blood BagCollectible Blood Bag icon.pngGrants one red heart container, restores 5 red hearts, and increases speed by 0.3. from a Blood Donation Machine or The Virus The VirusCollectible The Virus icon.pngInflicts poison to enemies who make contact with Isaac. Speed down. from Lust, or gained via the debug console), the Treasure Room pool is used.
      • Sometimes the reroll will change an item's pool to something else Isaac has, possibly resulting in proliferation of a certain pool.

Notes[edit | edit source]

  • The D4 does not re-roll Dead Cat Dead CatCollectible Dead Cat icon.pngSets the amount of red heart containers to 1, but gives Isaac 9 extra lives. After dying, Isaac is teleported to the last safe room. New heart containers can be obtained after picking up this item, but after each death, the number of heart containers is set to 1 again., Halo of Flies Halo of FliesCollectible Halo of Flies icon.pngSpawns two pretty fly familiars that block enemy shots and deal contact damage to enemies., Key Piece 1 Key Piece 1Collectible Key Piece 1 icon.pngCombined with Key Piece 2, unlocks the golden gate in the starting room of The Chest and Dark Room to fight Mega Satan., Key Piece 2 Key Piece 2Collectible Key Piece 2 Rebirth icon.pngCombined with Key Piece 1, unlocks the golden gate in the starting room of The Chest and Dark Room to fight Mega Satan., Missing No. Missing No.Collectible Missing No. icon.pngRandomizes all passive items upon pickup and at the start of each succeeding floor., The Polaroid The PolaroidCollectible The Polaroid icon.pngIf the character has half a red heart or no red hearts after taking damage, it triggers the Book of Shadows effect, creating a shield that nullifies all types of damage for 5 seconds. Also allows entrance into The Chest., The Negative The NegativeCollectible The Negative icon.pngIf the character has half a red heart or no red hearts after taking damage, it triggers The Necronomicon effect, damaging all enemies in the room. Also allows entrance into the Dark Room., or Added in Afterbirth †Tonsil TonsilTrinket Tonsil icon.pngWhen hit, there is a small chance a removed tonsil familiar starts following Isaac, blocking enemy shots..
  • The D4 does not remove Azazel's Brimstone laser.
  • Added in Afterbirth The D4 does not remove Lilith's startingIncubus IncubusCollectible Incubus icon.pngA demonic familiar that follows Isaac and shoots tears identical to Isaac's in terms of damage, range, fire rate, and effects..
  • Items that grant pickups (like Pyro PyroCollectible Pyro Rebirth icon.pngAdds 99 bombs. or A Dollar A DollarCollectible A Dollar icon.pngGives Isaac 99 coins. Can be found multiple times in a single playthrough.) do not remove their bonuses when rerolled.
  • Sometimes using the D4 will grant several items from the Devil/Angel pool, despite the fact that the player didn't have any Devil/Angel items previously.
  • The D4 does not remove gained hearts from health up items.
  • If Isaac has a transformation, its effects will not be lost upon re-rolling.
  • The D4 can grant items that have not yet been unlocked.
  • The items gained by the D4 count towards the Collection Page.
  • Added in Afterbirth If it is unlocked, The Lost starts with this item along with Spectral Tears. Using it will reroll Holy Mantle Holy MantleCollectible Holy Mantle icon.pngAutomatically negates first taken damage in every room. but will not reroll the Spectral Tears.
  • Every Cube of Meat Cube of MeatCollectible Cube of Meat icon.pngOrbiting familiar that blocks enemy shots and deals damage to enemies. If collected while already having one, makes the familiar evolve. Only drops from Horsemen. Similar to Ball of Bandages. produced using Added in Afterbirth †Potato Peeler Potato PeelerCollectible Potato Peeler icon.pngUnlimitedRemoves a heart container, increases damage and range, and grants a Cube of Meat. count as an item for reroll to the D4. Because health usually is not removed in rerolling items this is useful to increase the number of items at the expense of the item pool.
  • Multiple copies of the same item (as generated by Added in AfterbirthDiplopia DiplopiaCollectible Diplopia icon.pngOne time useDuplicates all pickups and item pedestals in the room., cheating, or gathering them from multiple item pools (e.g. Steam Sale Steam SaleSteam Sale Icon.pngReduces all Shop prices by 50%, rounded down to 7 coins for an item, rounded up to 2-3 coins for a pickup. from both the Shop and Greed), while not present in duplicate on the pause screen, will each be rerolled into a different item.

In-game Footage[edit | edit source]

Trivia[edit | edit source]

  • The image of the D4 that appears on activation is incorrect; it shows the numbers 9, 7, and 8 on the right face of the dice, when it should depict numbers consistent with the left face (i.e. 1 at the top, 3 at the front, and 4 at the right).

Gallery[edit | edit source]

Bugs[edit | edit source]

  • Previously held passive items are not removed, just disabled. As such, using the D4 too often will exhaust every single passive item in the Treasure Room item pool, causing items rerolled by D4 to become Breakfast. Treasure Rooms themselves may still contain active items, however.
  • Previously held items are not removed from the pause menu, which makes it difficult to determine which items Isaac currently has.
    • Added in Afterbirth This bug was fixed in Afterbirth.
  • When D4 is used with a co-op baby present, the baby's sprite will turn into a glitched sprite of Isaac.
  • When the D4 has rerolled through all items it will eventually remove all of them upon use.
  • If Tech.5 is fired while D4 is used, the laser will appear to continue firing for the rest of the room.
  • If you reroll Schoolbag you will keep both active items but if you pick up a new active item it will swap with the one currently selected and the other will disappear.

Seeds[edit | edit source]

 PC  F4BR 0P86 (Treasure room adjacent to spawn) (Hard mode only)

 PC  Added in Afterbirth † DMM6 TWQV (normal mode only)

 PS4  89EX S9KG (Treasure room south of spawn)

 Vita  7VC9 TRMS (Treasure room adjacent to spawn)

 Switch  ZDA0 CMV4 (First Treasure Room)

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