|| This article is about the conditions that will kill Isaac. For the Death tarot card, see Cards and Runes. For the boss, see Death (Boss).
Death occurs when Isaac runs out of health. There are multiple ways to cause this.
As long as Isaac has health of any type (red, black, or soul) left, they will not be killed, except if Isaac only has an eternal heart.
Typically, when Isaac dies, the game over screen appears; however, there are certain items, characters, and abilities that can revive Isaac after death. It is possible to obtain extra lives throughout a run by picking up various items. When Isaac dies, they will be revived in the previous room under the new life. Below is a list of these items and special death / extra life conditions that they bestow.
grants Isaac a 50% chance to be revived in the previous room
, with one heart container
half-filled. This life activates immediately upon death, before other items
. If the collar fails, other items will then activate.
grants Isaac an extra life. Upon death of the previous life, Isaac will be revived with three heart containers
unless they are ???
(four soul hearts
) or Azazel
, where they will be revived instead with one soul heart
. This life activates before Dead Cat
, but after Guppy's Collar
revives Isaac in the previous room
upon death. This life activates after Dead Cat
and Guppy's Collar
When held, Broken Ankh
has a chance to resurrect Isaac as ???
When Isaac dies, he will respawn as Black Judas and any character unlockables and boss kills will be treated as Judas.
grants Isaac nine extra lives. Upon death in the previous life, Isaac will be revived in the previous room
with one heart container
unless they are ???
, where they will be revived with one soul heart
. These lives activate after Lazarus' Rags
, Guppy's Collar
and the 1up!
, but before the Ankh
and Judas' Shadow
After dying as Lazarus
, Isaac will be revived with only 1 heart container
and will gain Anemic
, leaving a trail of creep
after taking damage. This resets when he exits the room
. Note that unlike other items
that cause Isaac to be revived, when Lazarus
is revived, he will be revived on the spot, as opposed to in the previous room.
While holding this trinket
, when Isaac dies, he will be revived as The Lost
and Missing Poster
will be removed. If playing as The Lost
, Isaac will respawn as normal in the previous room
Quitting the game before the death animation is completed does not allow the player to continue the run, but does not add a death on the stats screen.