|This article is about the conditions that will kill Isaac. For the Death tarot card, see Cards and Runes. For the boss, see Death (Boss).|
Death occurs when Isaac runs out of health. There are multiple ways to cause this.
- Damage from monsters
- Damage from bosses
- Damage from obstacles
- Damage from bombs
- Damage from a blood donation machine
- Damage from curse rooms
- Trading your last bit of health when making a deal with the Devil unless that item provides any hearts in return, such as the Ceremonial Robes
- Using The Bible against Satan
- Using the Suicide King card
- ... and more!
Extra Lives[edit | edit source]
Typically, when Isaac dies, the game over screen appears; however, there are certain items, characters, and abilities that can revive Isaac after death. It is possible to obtain extra lives throughout a run by picking up various items. When Isaac dies, they will be revived in the previous room under the new life. Below is a list of these items and special death / extra life conditions that they bestow.
Guppy's Collar grants Isaac a 50% chance to be revived in the previous room, with one heart container half-filled. This life activates immediately upon death, before other items. If the collar fails, other items will then activate.
1up![edit | edit source]
The 1up! grants Isaac an extra life. Upon death of the previous life, Isaac will be revived with three heart containers unless they are ??? (four soul hearts) or Azazel, where they will be revived instead with one soul heart. This life activates before Dead Cat, but after Guppy's Collar.
Ankh[edit | edit source]
When Isaac dies, he will respawn as Black Judas and any character unlockables and boss kills will be treated as Judas.
Dead Cat grants Isaac nine extra lives. Upon death in the previous life, Isaac will be revived in the previous room with one heart container unless they are ???, where they will be revived with one soul heart. These lives activate after Lazarus' Rags, Guppy's Collar and the 1up!, but before the Ankh and Judas' Shadow.
Lazarus and Lazarus' Rags[edit | edit source]
After dying as Lazarus, Isaac will be revived with only 1 heart container and will gain Anemic, leaving a trail of creep behind Lazarus after taking damage. This resets when he exits the room. Note that unlike other items that cause Isaac to be revived, when Lazarus is revived, he will be revived on the spot, as opposed to in the previous room.
Unlockable achievements[edit | edit source]
Bugs[edit | edit source]
|Achievements||Attributes||Bosses||Cards and Runes||Challenges||Chapters|