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Item icon
Item altar
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(page 4, column 4, row 6)
Added in Afterbirth †

Depression is a passive item added in The Binding of Isaac: Afterbirth †.

Effects[edit | edit source]

  • Spawns a rain cloud familiar that follows Isaac and leaves behind a trail of damaging blue creep.
    • The creep deals 2 damage per tick or 6 damage per second to non-flying enemies.
  • If the cloud touches an enemy, it has a small chance to spawn a damaging Holy Light beam onto the enemy.
    • The light beams deal 20 + Isaac's tear damage per tick and may strike an enemy up to 8 times.
    • The creep will not deal damage to Isaac.

Interactions[edit | edit source]

  • BFFS! BFFS!: Increase cloud size but does not increase damage.

In-game Footage[edit | edit source]

Trivia[edit | edit source]

  • Depression is the emotional state of low mood and aversion to activity.

Gallery[edit | edit source]

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