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Depression is a passive item added in Afterbirth †.
- Spawns a rain cloud familiar that follows Isaac and leaves behind a trail of damaging blue creep.
- The creep deals 2 damage per tick or 6 damage per second to non-flying enemies.
- If the cloud touches an enemy, it has a small chance to spawn a damaging Holy Light beam onto the enemy.
- The light beams deal 20 + Isaac's base damage per tick and may strike an enemy up to 8 times.
- The creep will not deal damage to Isaac.
- BFFS!Increases the size and damage of familiars.: Increase cloud size but does not increase damage.
- Depression is the emotional state of low mood and aversion to activity.
Item concept arts for AB+, including Depression
PC VZ7K 0GXN (Adjacent to spawn) (Normal mode only)