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Font TeamMeat D.pngFont TeamMeat e.pngFont TeamMeat p.pngFont TeamMeat r.pngFont TeamMeat e.pngFont TeamMeat s.pngFont TeamMeat s.pngFont TeamMeat i.pngFont TeamMeat o.pngFont TeamMeat n.png
Item icon
Item altar

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Item Pool Treasure Room.png Treasure Room
Greed mode onlyItem Pool Treasure Room.png Treasure Room
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(page 4, column 4, line 6)
Added in Afterbirth †

Depression is a passive item added in Afterbirth †.

Effect[edit | edit source]

  • Spawns a rain cloud familiar that follows Isaac and leaves behind a trail of damaging blue creep.
    • The creep deals 2 damage per tick or 6 damage per second to non-flying enemies.
  • If the cloud touches an enemy, it has a small chance to spawn a damaging Holy Light beam onto the enemy.
    • The light beams deal 20 + Isaac's base damage per tick and may strike an enemy up to 8 times.
    • The creep will not deal damage to Isaac.

Interactions[edit | edit source]

  • BFFS! BFFS!BFFS! Icon.pngIncreases the size and damage of familiars.: Increase cloud size but does not increase damage.

In-game Footage[edit | edit source]

Trivia[edit | edit source]

  • Depression is the emotional state of low mood and aversion to activity.

Gallery[edit | edit source]

Seeds[edit | edit source]

 PC  VZ7K 0GXN (Adjacent to spawn) (Normal mode only)

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