Devil Room (Afterbirth+ Item Pool)

Item Pool
Rebirth	Treasure Room	Shop	Library	Curse Room	Boss	Secret Room	Devil Room	Angel Room	Golden Chest	Red Chest	Beggar	Devil Beggar	Key Master
Afterbirth	Treasure Room	Shop	Library	Curse Room	Boss	Secret Room	Devil Room	Angel Room	Golden Chest	Red Chest	Beggar	Devil Beggar	Key Master	Bomb Bum
Greed Mode	Treasure Room	Shop	Library	Curse Room	Boss	Secret Room	Devil Room	Angel Room	Golden Chest
Afterbirth †	Treasure Room	Shop	Library	Curse Room	Boss	Secret Room	Devil Room	Angel Room	Golden Chest	Red Chest	Beggar	Devil Beggar	Key Master	Bomb Bum
Greed Mode	Treasure Room	Shop	Library	Curse Room	Boss	Secret Room	Devil Room	Angel Room	Golden Chest

The Devil Room Pool is the pool of items that can be found in the Devil Room. All items can be bought for some number of heart containers. If Isaac has no heart containers, items can be bought for three soul hearts.

Activated Collectibles

Name	ID	Icon	Quote	Description
1 Heart Cost
The Book of Belial	34		Temporary DMG up	Upon use increases damage by 2 for the current room and by a further +50% if the character also has the Blood of the Martyr. Guarantees a Devil Room or Angel Room will be open after beating a boss while holding it. Increases the chance for a Devil or Angel Room to appear by 12.5%.
The Book of Sin	97		Reusable Item Generator	Spawns a random pickup, pill, card, or trinket.
Guppy's Head	145		Reusable fly hive	Spawns 2-4 blue flies to damage enemies.
Guppy's Paw	133		Soul converter	Removes one red heart container in exchange for gaining 3 Soul Hearts.
Mega Blast	441		Laser breath	Upon use, Isaac fires a laser similar to the one used by Mega Satan. This laser deals massive damage, lasts for approximately 15 seconds, and persists between rooms. Isaac is pushed backwards by the force of the laser while it is active.
The Necronomicon	35		Mass room damage	Damages all enemies in the room significantly.
Plan C	475		Use with caution	Kills all enemies in the room, then kills Isaac three seconds later.
Razor Blade	126		Feel my pain	Upon use, deals one heart of damage to Isaac and grants +1.2 damage for the current room.
Void	477		Consume	Consumes all pedestal items in the room. Active items will have their effects added to Void, and passive items will grant stat upgrades.
We Need to Go Deeper!	84		Reusable level skip	Creates a trapdoor to go to the next floor. If used in The Womb, it will create a trapdoor to Sheol, even if the player hasn't unlocked it.
Book of the Dead	545		Rise from the grave	Upon use, spawns a charmed Bony or an orbital bone for each enemy killed in the current room.
2 Hearts Cost
The Nail	83		Temporary demon form	Adds one soul heart and allows the breaking of rocks and damaging enemies by simply walking over them. Increases damage and decreases speed. All effects except for the Soul Heart wear off upon leaving the room.
Sacrificial Altar	536		He demands a sacrifice	Upon use, sacrifices up to 2 familiars and spawns an item from the Devil Room Pool for each familiar sacrificed.
Satanic Bible	292		Reusable Evil	Upon activation, Isaac gains a black heart.

Passive Collectibles

Name	ID	Icon	Quote	Description
1 Heart Cost
7 Seals	526		Lil harbingers!	Grants a random Harbinger familiar that changes every 10 seconds.
Athame	408		Call to the void	Whenever Isaac takes damage, a black ring briefly appears around Isaac, dealing damage to all nearby enemies.
Betrayal	391		Turn your enemy	Every time Isaac takes damage, a charm effect is applied to every enemy in the room, causing them to attack each other rather than Isaac.
Black Powder	420		Spin the black circle!	Isaac leaves a trail of black powder on the floor. Walking in a circle will spawn a pentagram symbol on the floor, which deals 10 damage per tick to any enemies inside it.
Brother Bobby	8		Friends 'till the end	Follows Isaac around shooting normal tears.
Cambion Conception	412		Feed them hate	After taking damage a certain amount of times, a permanent demonic familiar spawns.
Ceremonial Robes	216		Sin up	Adds 3 black hearts and increases Damage by 1.
Contract From Below	241		Wealth... but at what cost?	Doubles the number of pickups and chests spawned after clearing a room or performing some other triggering action (such as using a blood donation machine), but reduces the chance for any pickups to spawn at all.
Dark Bum	278		He wants to take your life	Spawns a familiar that follows Isaac around and collects red hearts. For every one-and-a-half red hearts collected, Dark Bum will generate one soul heart, one hostile Spider or one friendly blue spider.
Dark Matter	259		Fear shot	Increases Damage by 1 and adds a chance to shoot fear tears.
Dead Cat	81		9 lives	Sets the amount of red heart containers to 1, but gives Isaac 9 extra lives. After dying, Isaac is teleported to the last safe room. New heart containers can be obtained after picking up this item, but after each death, the number of heart containers is set to 1 again.
Death's List	530		Just hope you're not next...	Grants a reward if all enemies in a room are killed in the order they are marked.
Demon Baby	113		Auto-turret friend	Follows Isaac and automatically fires at enemies in its reach.
Duality	498		You feel very balanced	Whenever a Devil or Angel Room would spawn after defeating a boss, both rooms spawn. Only one can be entered.
Empty Vessel	409		I reward an empty vessel	While Isaac has no red hearts, this item grants flight and a random chance to activate an invincibility shield for a few seconds. If Isaac gains any red hearts, these benefits will disappear.
Ghost Baby	163		Spectral buddy	Spawns a familiar that follows Isaac around and fires spectral tears.
Gimpy	225		Sweet Suffering	Has a chance of spawning a soul heart or black heart when taking damage. Enemies have a chance to drop a Half Red Heart after being killed.
Goat Head	215		He accepts your offering	A Devil Room / Angel Room Door will always spawn after every boss fight, excluding the first floor and floors after Utero II/Womb II.
Guppy's Collar	212		Eternal Life?	Grants Isaac a permanent 50% chance to respawn with 1/2 of a red heart after death.
Guppy's Hair Ball	187		Swing it	Loosely follows behind Isaac. Can be swung like a flail by rapidly spinning Isaac in a circle. Grows bigger by killing enemies.
Guppy's Tail	134		Cursed?	Increases chance of finding gold chests and normal chests, but reduces chance of finding pickups.
Headless Baby	269		Bloody Friend	Familiar that follows Isaac, leaving blood creep on the ground.
Lil Delirium	519		Delirious friend	Grants a familiar that transforms into another random familiar every 10 seconds.
The Mark	79		DMG up	Increases Damage and Speed, plus adds one Soul Heart.
Missing Page 2	262		Evil up. Your enemies will pay!	Gives 1 black heart. Upon taking damage that reduces Isaac's health to one heart or less, activates The Necronomicon effect, dealing 40 damage to all enemies in the room.
Multidimensional Baby	431		ydduB Buddy	Spawns a familiar that will follow Isaac's movements on a 2.5 second delay. Tears that pass through the baby will be doubled and increase in speed.
My Shadow	433		Me! And my shaaaadow!	Each time Isaac takes damage, inflicts fear on all enemies in the room and spawns a black Charger familiar that will attack enemies. The Charger will be killed if it is damaged too much.
Pentagram	51		DMG up	Increases damage and increases the chance for a Devil or Angel Room to appear.
Rotten Baby	268		Infested friend	A familiar that spawns blue flies.
Sacrificial Dagger	172		My fate protects me	Dagger orbits Isaac, dealing very high damage.
Shade	468		It follows	Spawns a shadow familiar that follows Isaac's movements on a 1 second delay and deals contact damage to enemies.
Sister Maggy	67		Friends 'till the end	A familiar that follows Isaac around shooting blood tears.
Succubus	417		Damage booster	Spawns a flying familiar that bounces around the room with a black aura, dealing rapid damage to any enemies inside it. While standing in the aura, Isaac gains a 1.5x tear damage multiplier.
Whore of Babylon	122		Curse up	Increases damage and speed whenever Isaac has half a red heart or less (one red heart for Eve), ignoring any soul or black hearts.
2 Hearts Cost
Abaddon	230		Evil + DMG up + fear shot	Increases damage and speed, removes all red heart containers, grants six black hearts, and adds a chance to shoot fear tears.
Brimstone	118		Blood laser barrage	Tears are replaced by a laser beam that pierces through all enemies and obstacles in its path and deals high damage. Can only be fired after a short charge-up period.
Dark Prince's Crown	442		Loss is power	Increases range, tears, and shot speed when at exactly one red heart.
Death's Touch	237		Penetrative shot + damage up	Increases Damage by 1.5, reduces Tears by 0.3 and increases tear size. Grants piercing tears. Tears are replaced by Death's scythes, which is a cosmetic effect only.
Eye of Belial	462		Possessed tears!	Grants piercing tears. After piercing one enemy, tears start homing and deal double damage.
Incubus	360		Dark friend	A demonic familiar that follows Isaac and shoots tears identical to Isaac's in terms of damage, range, fire rate, and effects.
Judas' Shadow	311		Sweet revenge	Adds an extra life; upon death, it respawns Isaac as Black Judas with only two black hearts.
Lil Brimstone	275		Evil Friend	A Familiar that shoots a thin Brimstone beam. Must charge like Brimstone before shooting.
Lord of the Pit	82		Demon wings	Grants flight and increases speed.
Maw of the Void	399		Consume thy enemy!	+1.0 Damage Up. After continuously firing tears for 2.5 seconds, a red cross appears on Isaac's head that, upon releasing the fire button, creates a black ring that rapidly deals damage equal to Isaac's tear damage to any enemies in contact with it.
Mom's Knife	114		Stab stab stab	Isaac's tears are replaced by a knife that pierces enemies, can travel through obstacles, and can hurt enemies while Isaac is holding it. Holding down the fire button before firing increases its range and power.
The Pact	80		DMG + Tears UP	Increases damage by 0.5, tears by 0.7 and grants two soul hearts upon pickup.
Spirit of the Night	159		Scary	Grants spectral tears and flight.

Notes

• Mega Blast is 5 times less likely to appear than any other item in the pool.