Name
|
ID
|
Icon
|
Quote
|
Description
|
1 Heart Cost
|
7 Seals
|
526
|
|
Lil harbingers!
|
Grants a random Harbinger familiar that changes every 10 seconds.
|
Athame
|
408
|
|
Call to the void
|
Whenever Isaac takes damage, a black ring briefly appears around Isaac, dealing damage to all nearby enemies.
|
Betrayal
|
391
|
|
Turn your enemy
|
Every time Isaac takes damage, a charm effect is applied to every enemy in the room, causing them to attack each other rather than Isaac.
|
Black Powder
|
420
|
|
Spin the black circle!
|
Isaac leaves a trail of black powder on the floor. Walking in a circle will spawn a pentagram symbol on the floor, which deals 10 damage per tick to any enemies inside it.
|
Brother Bobby
|
8
|
|
Friends 'till the end
|
Follows Isaac around shooting normal tears.
|
Cambion Conception
|
412
|
|
Feed them hate
|
After taking damage a certain amount of times, a permanent demonic familiar spawns.
|
Ceremonial Robes
|
216
|
|
Sin up
|
Adds 3 black hearts and increases Damage by 1.
|
Contract From Below
|
241
|
|
Wealth... but at what cost?
|
Doubles the number of pickups and chests spawned after clearing a room or performing some other triggering action (such as using a blood donation machine), but reduces the chance for any pickups to spawn at all.
|
Dark Bum
|
278
|
|
He wants to take your life
|
Spawns a familiar that follows Isaac around and collects red hearts. For every one-and-a-half red hearts collected, Dark Bum will generate one soul heart, one hostile Spider or one friendly blue spider.
|
Dark Matter
|
259
|
|
Fear shot
|
Increases Damage by 1 and adds a chance to shoot fear tears.
|
Dead Cat
|
81
|
|
9 lives
|
Sets the amount of red heart containers to 1, but gives Isaac 9 extra lives. After dying, Isaac is teleported to the last safe room. New heart containers can be obtained after picking up this item, but after each death, the number of heart containers is set to 1 again.
|
Death's List
|
530
|
|
Just hope you're not next...
|
Grants a reward if all enemies in a room are killed in the order they are marked.
|
Demon Baby
|
113
|
|
Auto-turret friend
|
Follows Isaac and automatically fires at enemies in its reach.
|
Duality
|
498
|
|
You feel very balanced
|
Whenever a Devil or Angel Room would spawn after defeating a boss, both rooms spawn. Only one can be entered.
|
Empty Vessel
|
409
|
|
I reward an empty vessel
|
While Isaac has no red hearts, this item grants flight and a random chance to activate an invincibility shield for a few seconds. If Isaac gains any red hearts, these benefits will disappear.
|
Ghost Baby
|
163
|
|
Spectral buddy
|
Spawns a familiar that follows Isaac around and fires spectral tears.
|
Gimpy
|
225
|
|
Sweet Suffering
|
Has a chance of spawning a soul heart or black heart when taking damage. Enemies have a chance to drop a Half Red Heart after being killed.
|
Goat Head
|
215
|
|
He accepts your offering
|
A Devil Room / Angel Room Door will always spawn after every boss fight, excluding the first floor and floors after Utero II/Womb II.
|
Guppy's Collar
|
212
|
|
Eternal Life?
|
Grants Isaac a permanent 50% chance to respawn with 1/2 of a red heart after death.
|
Guppy's Hair Ball
|
187
|
|
Swing it
|
Loosely follows behind Isaac. Can be swung like a flail by rapidly spinning Isaac in a circle. Grows bigger by killing enemies.
|
Guppy's Tail
|
134
|
|
Cursed?
|
Increases chance of finding gold chests and normal chests, but reduces chance of finding pickups.
|
Headless Baby
|
269
|
|
Bloody Friend
|
Familiar that follows Isaac, leaving blood creep on the ground.
|
Lil Delirium
|
519
|
|
Delirious friend
|
Grants a familiar that transforms into another random familiar every 10 seconds.
|
The Mark
|
79
|
|
DMG up
|
Increases Damage and Speed, plus adds one Soul Heart.
|
Missing Page 2
|
262
|
|
Evil up. Your enemies will pay!
|
Gives 1 black heart. Upon taking damage that reduces Isaac's health to one heart or less, activates The Necronomicon effect, dealing 40 damage to all enemies in the room.
|
Multidimensional Baby
|
431
|
|
ydduB Buddy
|
Spawns a familiar that will follow Isaac's movements on a 2.5 second delay. Tears that pass through the baby will be doubled and increase in speed.
|
My Shadow
|
433
|
|
Me! And my shaaaadow!
|
Each time Isaac takes damage, inflicts fear on all enemies in the room and spawns a black Charger familiar that will attack enemies. The Charger will be killed if it is damaged too much.
|
Pentagram
|
51
|
|
DMG up
|
Increases damage and increases the chance for a Devil or Angel Room to appear.
|
Rotten Baby
|
268
|
|
Infested friend
|
A familiar that spawns blue flies.
|
Sacrificial Dagger
|
172
|
|
My fate protects me
|
Dagger orbits Isaac, dealing very high damage.
|
Shade
|
468
|
|
It follows
|
Spawns a shadow familiar that follows Isaac's movements on a 1 second delay and deals contact damage to enemies.
|
Sister Maggy
|
67
|
|
Friends 'till the end
|
A familiar that follows Isaac around shooting blood tears.
|
Succubus
|
417
|
|
Damage booster
|
Spawns a flying familiar that bounces around the room with a black aura, dealing rapid damage to any enemies inside it. While standing in the aura, Isaac gains a 1.5x tear damage multiplier.
|
Whore of Babylon
|
122
|
|
Curse up
|
Increases damage and speed whenever Isaac has half a red heart or less (one red heart for Eve), ignoring any soul or black hearts.
|
 2 Hearts Cost
|
Abaddon
|
230
|
|
Evil + DMG up + fear shot
|
Increases damage and speed, removes all red heart containers, grants six black hearts, and adds a chance to shoot fear tears.
|
Brimstone
|
118
|
|
Blood laser barrage
|
Tears are replaced by a laser beam that pierces through all enemies and obstacles in its path and deals high damage. Can only be fired after a short charge-up period.
|
Dark Prince's Crown
|
442
|
|
Loss is power
|
Increases range, tears, and shot speed when at exactly one red heart.
|
Death's Touch
|
237
|
|
Penetrative shot + damage up
|
Increases Damage by 1.5, reduces Tears by 0.3 and increases tear size. Grants piercing tears. Tears are replaced by Death's scythes, which is a cosmetic effect only.
|
Eye of Belial
|
462
|
|
Possessed tears!
|
Grants piercing tears. After piercing one enemy, tears start homing and deal double damage.
|
Incubus
|
360
|
|
Dark friend
|
A demonic familiar that follows Isaac and shoots tears identical to Isaac's in terms of damage, range, fire rate, and effects.
|
Judas' Shadow
|
311
|
|
Sweet revenge
|
Adds an extra life; upon death, it respawns Isaac as Black Judas with only two black hearts.
|
Lil Brimstone
|
275
|
|
Evil Friend
|
A Familiar that shoots a thin Brimstone beam. Must charge like Brimstone before shooting.
|
Lord of the Pit
|
82
|
|
Demon wings
|
Grants flight and increases speed.
|
Maw of the Void
|
399
|
|
Consume thy enemy!
|
+1.0 Damage Up. After continuously firing tears for 2.5 seconds, a red cross appears on Isaac's head that, upon releasing the fire button, creates a black ring that rapidly deals damage equal to Isaac's tear damage to any enemies in contact with it.
|
Mom's Knife
|
114
|
|
Stab stab stab
|
Isaac's tears are replaced by a knife that pierces enemies, can travel through obstacles, and can hurt enemies while Isaac is holding it. Holding down the fire button before firing increases its range and power.
|
The Pact
|
80
|
|
DMG + Tears UP
|
Increases damage by 0.5, tears by 0.7 and grants two soul hearts upon pickup.
|
Spirit of the Night
|
159
|
|
Scary
|
Grants spectral tears and flight.
|