Devil Room (Item Pool)

Item Pool

Treasure Room

Shop

Library

Curse Room

Boss

Secret Room

Devil Room

Angel Room

Golden Chest

Red Chest

Beggar

Devil Beggar

Key Master

Bomb Bum

Treasure Room

Shop

Library

Curse Room

Boss

Secret Room

Devil Room

Angel Room

Golden Chest

The Devil Room pool is the pool of items that can be found in the Devil Room. All items can be bought for some number of Red Heart containers. If Isaac has no Red Heart containers, items can be bought for three Soul Hearts / Black Hearts.

Activated Collectibles

Name	ID	Icon	Quote	Description
1 Heart Cost
Guppy's Head	145		Reusable fly hive	Spawns 2-4 Blue Flies to damage enemies.
Guppy's Paw	133		Soul converter	Removes one Red Heart container in exchange for gaining 3 Soul Hearts.
Razor Blade	126		Feel my pain	Upon use, deals one heart of damage to Isaac and grants +1.2 damage for the current room.
The Book of Belial	34		Temporary DMG up	Increases damage by 2 for the current room, also granting a 1.5x damage multiplier if Isaac has Blood of the Martyr. Guarantees a Devil Room or Angel Room will be open after beating a boss while holding it. Increases the chance by 12.5%.
The Book of Sin	97		Reusable Item Generator	Spawns a random pickup, pill, card, or trinket.
The Necronomicon	35		Mass room damage	Damages all enemies in the room significantly.
We Need to Go Deeper!	84		Reusable level skip	Creates a trapdoor to go to the next floor. If used in The Womb, it will create a trapdoor to Sheol, even if the player hasn't unlocked it.
Mega Blast	441		Laser breath	Upon use, Isaac fires a laser similar to the one used by Mega Satan. This laser deals massive damage, lasts for approximately 15 seconds, and persists between rooms. Isaac is pushed backwards by the force of the laser while it is active.
Book of the Dead	545		Rise from the grave	Upon use, spawns a friendly Bony or an orbital bone for each enemy killed in the current room.
Plan C	475		Use with caution	Kills all enemies in the room, then kills Isaac three seconds later.
Void	477		Consume	Consumes all pedestal items in the room. Active items will have their effects added to Void, and passive items will grant stat upgrades.
2 Hearts Cost
Satanic Bible	292		Reusable Evil	Upon activation, Isaac gains a black heart.
The Nail	83		Temporary demon form	Adds one soul heart and allows the breaking of rocks and damaging enemies by simply walking over them. Increases damage and decreases speed. All effects except for the Soul Heart wear off upon leaving the room.
Sacrificial Altar	536		He demands a sacrifice	Upon use, sacrifices up to 2 familiars and spawns an item from the Devil Room Pool for each familiar sacrificed.

Passive Collectibles

Name	ID	Icon	Quote	Description
1 Heart Cost
Brother Bobby	8		Friends 'till the end	Follows Isaac around shooting normal tears.
Ceremonial Robes	216		Sin up	Adds 3 Black Hearts and increases damage by 1.
Contract From Below	241		Wealth... but at what cost?	Doubles the number of pickups and chests spawned after clearing a room or performing some other triggering action (such as using a Blood Donation Machine), but reduces the chance for any pickups to spawn at all.
Dark Bum	278		He wants to take your life	Spawns a familiar that follows Isaac around and collects Red Hearts. For every one-and-a-half Red Hearts collected, Dark Bum will generate one Soul Heart, one hostile Spider or one friendly Blue Spider.
Dark Matter	259		Fear shot	Increases damage by 1 and adds a chance to shoot fear tears.
Dead Bird	117		Protective buddy	Spawns a flying familiar for the current room that chases enemies whenever Isaac takes damage.
Dead Cat	81		9 lives	Sets Isaac's Red Heart containers to 1, but gives Isaac 9 extra lives. After dying, Isaac respawns with 1 Red Heart in the last safe room.
Demon Baby	113		Auto-turret friend	Follows Isaac and automatically fires at enemies in its reach.
Ghost Baby	163		Spectral buddy	Spawns a familiar that follows Isaac around and fires spectral tears.
Gimpy	225		Sweet Suffering	Has a chance of spawning a Soul Heart or Black Heart when taking damage. Enemies have a chance to drop a Half Red Heart after being killed.
Goat Head	215		He accepts your offering	A Devil Room / Angel Room Door will always spawn after every boss fight, excluding the first floor and floors after Utero II/Womb II.
Guppy's Collar	212		Eternal Life?	Grants Isaac a permanent 50% chance to respawn with 1/2 of a Red Heart after death.
Guppy's Hair Ball	187		Swing it	Loosely follows behind Isaac. It can be swung like a flail by rapidly spinning Isaac in a circle. Grows bigger by killing enemies.
Guppy's Tail	134		Cursed?	Increases chance of finding Locked Chests and normal Chests, but reduces chance of finding pickups.
Headless Baby	269		Bloody Friend	Familiar that follows Isaac, leaving blood creep on the ground.
Missing Page 2	262		Evil up. Your enemies will pay!	Gives 1 black heart. Upon taking damage that reduces Isaac's health to one heart or less, activates The Necronomicon effect, dealing 40 damage to all enemies in the room.
Pentagram	51		DMG up	Increases damage and increases the chance for a Devil or Angel Room to appear.
Rotten Baby	268		Infested friend	A familiar that spawns blue flies.
Sacrificial Dagger	172		My fate protects me	A dagger orbits Isaac, dealing very high damage and blocking enemy shots.
Sister Maggy	67		Friends 'till the end	A familiar that follows Isaac around shooting blood tears.
The Mark	79		DMG up	Increases Damage and Speed, plus adds one Soul Heart.
Whore of Babylon	122		Curse up	Increases damage and speed whenever Isaac has half a red heart or less (one red heart for Eve), ignoring any soul or black hearts.
Athame	408		Call to the void	Whenever Isaac takes damage, a black ring briefly appears around Isaac, dealing damage to all nearby enemies.
Betrayal	391		Turn your enemy	Every time Isaac takes damage, a charm effect is applied to every enemy in the room, causing them to attack each other rather than Isaac.
Black Powder	420		Spin the black circle!	Isaac leaves a trail of black powder on the floor. Walking in a circle will spawn a pentagram symbol on the floor, which deals 10 damage per tick to any enemies inside it.
Cambion Conception	412		Feed them hate	After taking damage a certain amount of times, a permanent demonic familiar spawns.
Empty Vessel	409		I reward an empty vessel	While Isaac has no red hearts, this item grants flight and a random chance to activate an invincibility shield for a few seconds. If Isaac gains any Red Hearts, these benefits will disappear.
Multidimensional Baby	431		ydduB Buddy	Spawns a familiar that will follow Isaac's movements on a 2.5-second delay. Tears that pass through the baby will be doubled and increase in speed.
My Shadow	433		Me! And my shaaaadow!	Each time Isaac takes damage, inflicts fear on all enemies in the room and spawns a black friendly Charger that will attack enemies. The Charger will be killed if it is damaged too much.
Succubus	417		Damage booster	Spawns a flying familiar that bounces around the room with a black aura, dealing rapid damage to any enemies inside it. While standing in the aura, Isaac gains a 1.5x tear damage multiplier.
7 Seals	526		Lil harbingers!	Grants a random Harbinger familiar that changes every 10 seconds. Harbingers have different behaviors and spawn themed Locusts.
Death's List	530		Just hope you're not next...	Grants a reward if all enemies in a room are killed in the order they are marked.
Duality	498		You feel very balanced	Whenever a Devil or Angel Room would spawn after defeating a boss, both rooms spawn. Only one can be entered.
Lil Delirium	519		Delirious friend	Grants a familiar that transforms into another random familiar every 10 seconds.
Shade	468		It follows	Spawns a shadow familiar that follows Isaac's movements on a 1 second delay and deals contact damage to enemies. After dealing enough damage, it is absorbed by Isaac and spawns friendly Chargers.
2 Hearts Cost
Abaddon	230		Evil + DMG up + fear shot	Increases damage and speed, removes all Red Heart containers, grants six Black Hearts, and adds a chance to shoot fear tears.
Brimstone	118		Blood laser barrage	Tears are replaced by a laser beam that pierces through all enemies and obstacles in its path and deals high damage. Can only be fired after a short charge-up period.
Death's Touch	237		Penetrative shot + damage up	+1.5 damage, -0.3 tears. Tears are replaced with large piercing scythes.
Judas' Shadow	311		Sweet revenge	Adds an extra life; upon death, it respawns Isaac as Black Judas with only two black hearts.
Lil Brimstone	275		Evil Friend	A Familiar that shoots a thin Brimstone beam. Must charge like Brimstone before shooting.
Lord of the Pit	82		Demon wings	Grants flight and increases speed.
Mom's Knife	114		Stab stab stab	Isaac's tears are replaced by a knife that pierces enemies, can travel through obstacles and can hurt enemies while Isaac is holding it. Holding down the fire button before firing increases its range and power.
Spirit of the Night	159		Scary	Grants spectral tears and flight.
The Pact	80		DMG + Tears UP	Increases damage by 0.5, tears by 0.7 and grants two soul hearts upon pickup.
Incubus	360		Dark friend	A demonic familiar that follows Isaac and shoots tears identical to Isaac's in terms of damage, range, fire rate, and effects.
Maw of the Void	399		Consume thy enemy!	+1.0 Damage. Continuously firing for 2.5 seconds then releasing the fire button creates a black ring around Isaac that rapidly deals damage and can cause enemies to drop Black hearts.
Dark Prince's Crown	442		Loss is power	Increases range, tears, and shot speed when at exactly one red heart.
Eye of Belial	462		Possessed tears!	Grants piercing tears. After piercing one enemy, tears start homing and deal double damage.

Any items outside of the Devil Room item pool will have a price of 1 Red Heart or 3 Soul Hearts/Black Hearts. This can be caused either by obtaining Chaos or exhausting the item pool, making Breakfast appear.